Single cell type - IER5L - The Human Protein Atlas

IER5L

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IER5L
Gene descriptionⁱ Full gene name according to HGNC.	Immediate early response 5 like
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Endometrial stromal cells, Adipocytes, Breast myoepithelial cells, Smooth muscle cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.48
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Endometrial stromal cells, Adipocytes, Breast myoepithelial cells, Smooth muscle cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

IER5L is part of cluster 80 Non-specific - Transcription with confidenceⁱ 1
184 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IER2	Immediate early response 2	0.7746	80
SERTAD1	SERTA domain containing 1	0.7039	80
UBE2S	Ubiquitin conjugating enzyme E2 S	0.6936	80
DNAJA1	DnaJ heat shock protein family (Hsp40) member A1	0.6828	80
PPP1R10	Protein phosphatase 1 regulatory subunit 10	0.6770	80
GADD45B	Growth arrest and DNA damage inducible beta	0.6625	80
H2AX	H2A.X variant histone	0.6396	80
JUNB	JunB proto-oncogene, AP-1 transcription factor subunit	0.6280	80
IFNA14	Interferon alpha 14	0.6213	58
KLHL15	Kelch like family member 15	0.6043	80
GTF2B	General transcription factor IIB	0.6032	80
NUFIP2	Nuclear FMR1 interacting protein 2	0.5994	80
ING1	Inhibitor of growth family member 1	0.5954	80
ARC	Activity regulated cytoskeleton associated protein	0.5945	80
CBX4	Chromobox 4	0.5902	80

Adipocytes	142.2 nTPM
Breast	177.9 nTPM
Adipose tissue	106.6 nTPM

Alveolar cells type 1	5.8 nTPM
Lung	5.8 nTPM

Alveolar cells type 2	17.1 nTPM
Lung	17.1 nTPM

Astrocytes	12.1 nTPM
Brain	12.1 nTPM

B-cells	8.2 nTPM
Adipose tissue	31.3 nTPM
Esophagus	17.7 nTPM
Thymus	14.0 nTPM
Skin	13.6 nTPM
Lymph node	10.4 nTPM
Spleen	6.6 nTPM
Salivary gland	6.6 nTPM
Lung	4.0 nTPM
Stomach	2.5 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM

Ciliated cells	45.3 nTPM
Endometrium	84.2 nTPM
Fallopian tube	59.1 nTPM
Bronchus	23.8 nTPM
Lung	14.1 nTPM

Club cells	35.3 nTPM
Prostate	61.1 nTPM
Lung	28.7 nTPM
Bronchus	16.2 nTPM

Endothelial cells	58.9 nTPM
Fallopian tube	184.9 nTPM
Prostate	159.3 nTPM
Endometrium	139.7 nTPM
Breast	101.1 nTPM
Thymus	90.8 nTPM
Tongue	66.4 nTPM
Skeletal muscle	46.6 nTPM
Esophagus	46.1 nTPM
Salivary gland	41.6 nTPM
Vascular	39.1 nTPM
Ovary	29.8 nTPM
Liver	27.7 nTPM
Lung	27.0 nTPM
Skin	18.6 nTPM
Pancreas	15.5 nTPM
Placenta	13.1 nTPM
Heart muscle	6.9 nTPM
Testis	6.7 nTPM

Enteroendocrine cells	15.6 nTPM
Small intestine	24.0 nTPM
Rectum	15.1 nTPM
Colon	7.6 nTPM

Fibroblasts	81.3 nTPM
Fallopian tube	304.4 nTPM
Prostate	202.6 nTPM
Breast	184.2 nTPM
Lung	98.7 nTPM
Thymus	91.1 nTPM
Adipose tissue	87.6 nTPM
Vascular	79.1 nTPM
Salivary gland	61.2 nTPM
Skeletal muscle	43.2 nTPM
Stomach	37.5 nTPM
Skin	32.6 nTPM
Esophagus	25.3 nTPM
Liver	24.9 nTPM
Pancreas	18.5 nTPM
Placenta	9.3 nTPM
Heart muscle	0.8 nTPM

Granulocytes	15.5 nTPM
Lung	19.7 nTPM
Fallopian tube	17.1 nTPM
Tongue	9.7 nTPM

Intestinal goblet cells	18.2 nTPM
Small intestine	20.6 nTPM
Rectum	17.5 nTPM
Colon	16.5 nTPM

Lymphatic endothelial cells	55.4 nTPM
Fallopian tube	110.8 nTPM
Ovary	0.0 nTPM

Macrophages	69.7 nTPM
Breast	554.8 nTPM
Endometrium	128.5 nTPM
Prostate	125.1 nTPM
Adipose tissue	67.2 nTPM
Fallopian tube	57.9 nTPM
Esophagus	52.7 nTPM
Vascular	50.1 nTPM
Skin	47.9 nTPM
Salivary gland	45.2 nTPM
Tongue	36.9 nTPM
Thymus	36.0 nTPM
Lung	30.3 nTPM
Skeletal muscle	25.9 nTPM
Stomach	15.4 nTPM
Spleen	15.0 nTPM
Pancreas	12.3 nTPM
Kidney	11.5 nTPM
Bone marrow	9.1 nTPM
Testis	2.5 nTPM

Paneth cells	12.4 nTPM
Colon	14.5 nTPM
Small intestine	13.8 nTPM
Rectum	9.0 nTPM

Basal keratinocytes	28.4 nTPM
Tongue	53.0 nTPM
Skin	3.7 nTPM

Basal prostatic cells	104.1 nTPM
Prostate	104.1 nTPM

Basal respiratory cells	11.0 nTPM
Bronchus	11.0 nTPM

Basal squamous epithelial cells	23.7 nTPM
Esophagus	23.7 nTPM

Plasma cells	9.4 nTPM
Fallopian tube	30.9 nTPM
Salivary gland	20.6 nTPM
Esophagus	10.4 nTPM
Thymus	5.7 nTPM
Stomach	4.2 nTPM
Liver	2.5 nTPM
Spleen	1.0 nTPM
Bone marrow	0.0 nTPM

Schwann cells	36.4 nTPM
Vascular	72.6 nTPM
Adipose tissue	36.7 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	26.1 nTPM
Tongue	30.9 nTPM
Salivary gland	21.3 nTPM

Smooth muscle cells	130.2 nTPM
Breast	396.5 nTPM
Fallopian tube	249.5 nTPM
Endometrium	198.1 nTPM
Thymus	177.8 nTPM
Adipose tissue	161.9 nTPM
Tongue	157.2 nTPM
Prostate	146.6 nTPM
Ovary	129.3 nTPM
Lung	104.6 nTPM
Vascular	72.5 nTPM
Skeletal muscle	71.2 nTPM
Salivary gland	69.4 nTPM
Esophagus	63.7 nTPM
Skin	49.8 nTPM
Liver	21.2 nTPM
Placenta	13.6 nTPM

Suprabasal keratinocytes	13.3 nTPM
Tongue	22.2 nTPM
Skin	4.5 nTPM

T-cells	61.8 nTPM
Breast	410.5 nTPM
Endometrium	172.3 nTPM
Prostate	142.6 nTPM
Adipose tissue	110.6 nTPM
Fallopian tube	101.5 nTPM
Vascular	51.9 nTPM
Skeletal muscle	50.7 nTPM
Tongue	50.3 nTPM
Esophagus	48.7 nTPM
Thymus	27.1 nTPM
Lung	24.2 nTPM
Salivary gland	23.3 nTPM
Colon	21.4 nTPM
Skin	18.6 nTPM
Lymph node	12.4 nTPM
Stomach	9.3 nTPM
Liver	9.0 nTPM
Kidney	7.1 nTPM
Spleen	5.3 nTPM
Bone marrow	1.4 nTPM
PBMC	0.6 nTPM

Undifferentiated cells	10.2 nTPM
Colon	14.2 nTPM
Rectum	10.7 nTPM
Small intestine	5.8 nTPM

Amygdala excitatory	12.1 nTPM
Basal ganglia	18.3 nTPM
Thalamus	15.4 nTPM
Hippocampus	11.7 nTPM
Amygdala	10.7 nTPM
Cerebral cortex	10.3 nTPM
Hypothalamus	6.1 nTPM

Astrocyte	34.7 nTPM
Spinal cord	90.4 nTPM
Pons	44.8 nTPM
Cerebellum	42.8 nTPM
Medulla oblongata	39.0 nTPM
Midbrain	32.1 nTPM
Basal ganglia	31.2 nTPM
Hypothalamus	27.4 nTPM
Thalamus	25.3 nTPM
Hippocampus	20.5 nTPM
Cerebral cortex	17.8 nTPM
Amygdala	10.7 nTPM

Bergmann glia	6.4 nTPM
Pons	8.6 nTPM
Cerebellum	6.2 nTPM
Medulla oblongata	4.3 nTPM

Central nervous system macrophage	20.3 nTPM
Spinal cord	28.3 nTPM
Medulla oblongata	26.9 nTPM
Pons	25.3 nTPM
Hippocampus	22.1 nTPM
Cerebellum	19.5 nTPM
Basal ganglia	19.4 nTPM
Cerebral cortex	18.6 nTPM
Midbrain	18.2 nTPM
Thalamus	16.8 nTPM
Hypothalamus	15.4 nTPM
Amygdala	12.6 nTPM

Cerebellar inhibitory	2.7 nTPM
Pons	5.6 nTPM
Cerebellum	2.9 nTPM
Midbrain	2.5 nTPM
Medulla oblongata	2.4 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	8.5 nTPM
Hippocampus	10.1 nTPM
Cerebral cortex	9.7 nTPM
Midbrain	9.6 nTPM
Thalamus	8.6 nTPM
Amygdala	8.0 nTPM
Basal ganglia	8.0 nTPM
Hypothalamus	5.8 nTPM

Choroid plexus epithelial cell	4.3 nTPM
Medulla oblongata	10.2 nTPM
Hippocampus	2.8 nTPM
Thalamus	2.7 nTPM
Basal ganglia	1.5 nTPM

Committed oligodendrocyte precursor	4.8 nTPM
Basal ganglia	8.2 nTPM
Medulla oblongata	7.7 nTPM
Spinal cord	7.4 nTPM
Hypothalamus	5.5 nTPM
Cerebral cortex	5.1 nTPM
Pons	4.4 nTPM
Hippocampus	3.4 nTPM
Midbrain	3.4 nTPM
Cerebellum	3.2 nTPM
Thalamus	2.7 nTPM
Amygdala	1.7 nTPM

Deep-layer corticothalamic and 6b	11.1 nTPM
Cerebral cortex	17.0 nTPM
Basal ganglia	16.4 nTPM
Amygdala	9.8 nTPM
Midbrain	8.9 nTPM
Hypothalamus	7.4 nTPM
Hippocampus	7.0 nTPM

Deep-layer intratelencephalic	16.9 nTPM
Basal ganglia	20.1 nTPM
Cerebral cortex	20.1 nTPM
Hippocampus	16.7 nTPM
Amygdala	16.0 nTPM
Hypothalamus	11.6 nTPM

Deep-layer near-projecting	12.6 nTPM
Hippocampus	18.5 nTPM
Basal ganglia	14.0 nTPM
Cerebral cortex	12.8 nTPM
Hypothalamus	9.0 nTPM
Amygdala	8.6 nTPM

Eccentric medium spiny neuron	8.6 nTPM
Hippocampus	12.0 nTPM
Basal ganglia	9.9 nTPM
Thalamus	8.9 nTPM
Cerebral cortex	7.3 nTPM
Amygdala	6.7 nTPM
Hypothalamus	6.5 nTPM

Endothelial cell	29.5 nTPM
Basal ganglia	40.1 nTPM
Medulla oblongata	39.0 nTPM
Cerebellum	36.4 nTPM
Pons	35.0 nTPM
Thalamus	31.1 nTPM
Spinal cord	27.6 nTPM
Midbrain	26.5 nTPM
Cerebral cortex	24.9 nTPM
Amygdala	24.6 nTPM
Hypothalamus	23.6 nTPM
Hippocampus	16.0 nTPM