Single cell type - WNT7B - The Human Protein Atlas

WNT7B

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	WNT7B
Gene descriptionⁱ Full gene name according to HGNC.	Wnt family member 7B
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Basal squamous epithelial cells, Club cells, Basal keratinocytes, Squamous epithelial cells, Suprabasal keratinocytes, Alveolar cells type 2, Basal respiratory cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.78
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Oligodendrocyte precursor cell, Bergmann glia, Deep-layer near-projecting)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data.	Protein predicted to be secreted

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Basal squamous epithelial cells, Club cells, Basal keratinocytes, Squamous epithelial cells, Suprabasal keratinocytes, Alveolar cells type 2, Basal respiratory cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Oligodendrocyte precursor cell, Bergmann glia, Deep-layer near-projecting)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

WNT7B is part of cluster 45 Non-specific - Mixed function with confidenceⁱ 1
349 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ITGB6	Integrin subunit beta 6	0.8105	45
GJB4	Gap junction protein beta 4	0.7998	45
CDH3	Cadherin 3	0.7819	35
GJB3	Gap junction protein beta 3	0.7813	12
AJUBA	Ajuba LIM protein	0.7744	45
LAMB3	Laminin subunit beta 3	0.7658	45
CCND1	Cyclin D1	0.7381	45
ITGA2	Integrin subunit alpha 2	0.7339	45
TACSTD2	Tumor associated calcium signal transducer 2	0.7183	35
CDCP1	CUB domain containing protein 1	0.7118	45
S100A2	S100 calcium binding protein A2	0.7057	12
TGFA	Transforming growth factor alpha	0.6964	45
TNS4	Tensin 4	0.6917	12
SDC4	Syndecan 4	0.6705	45
ITGA3	Integrin subunit alpha 3	0.6570	45

Adipocytes	0.3 nTPM
Adipose tissue	0.4 nTPM
Breast	0.1 nTPM

Alveolar cells type 1	1.2 nTPM
Lung	1.2 nTPM

Alveolar cells type 2	17.0 nTPM
Lung	17.0 nTPM

Astrocytes	3.7 nTPM
Brain	3.7 nTPM

B-cells	0.0 nTPM
Salivary gland	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Thymus	0.0 nTPM

Ciliated cells	12.4 nTPM
Lung	27.5 nTPM
Bronchus	15.2 nTPM
Fallopian tube	5.3 nTPM
Endometrium	1.8 nTPM

Club cells	36.9 nTPM
Prostate	49.2 nTPM
Lung	39.5 nTPM
Bronchus	22.1 nTPM

Endothelial cells	0.6 nTPM
Tongue	4.8 nTPM
Esophagus	2.1 nTPM
Prostate	1.5 nTPM
Skin	1.4 nTPM
Lung	0.4 nTPM
Testis	0.3 nTPM
Endometrium	0.2 nTPM
Salivary gland	0.2 nTPM
Thymus	0.1 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM
Skeletal muscle	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM
Ovary	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	1.2 nTPM
Placenta	11.4 nTPM
Pancreas	2.2 nTPM
Skin	1.5 nTPM
Prostate	1.3 nTPM
Liver	1.2 nTPM
Salivary gland	0.4 nTPM
Lung	0.3 nTPM
Skeletal muscle	0.2 nTPM
Vascular	0.2 nTPM
Adipose tissue	0.1 nTPM
Thymus	0.1 nTPM
Breast	0.1 nTPM
Fallopian tube	0.1 nTPM
Heart muscle	0.0 nTPM
Esophagus	0.0 nTPM
Stomach	0.0 nTPM

Granulocytes	0.6 nTPM
Lung	1.5 nTPM
Fallopian tube	0.2 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	0.0 nTPM
Fallopian tube	0.0 nTPM
Ovary	0.0 nTPM

Macrophages	0.5 nTPM
Tongue	3.3 nTPM
Pancreas	2.1 nTPM
Endometrium	1.2 nTPM
Prostate	1.0 nTPM
Salivary gland	0.3 nTPM
Fallopian tube	0.3 nTPM
Vascular	0.2 nTPM
Adipose tissue	0.1 nTPM
Lung	0.1 nTPM
Breast	0.1 nTPM
Testis	0.0 nTPM
Kidney	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Thymus	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Bipolar cells	0.7 nTPM
Eye	0.7 nTPM

Cholangiocytes	9.5 nTPM
Liver	9.5 nTPM

Collecting duct cells	13.6 nTPM
Kidney	13.6 nTPM

Cytotrophoblasts	3.4 nTPM
Placenta	3.4 nTPM

Plasma cells	0.6 nTPM
Esophagus	5.2 nTPM
Liver	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Fallopian tube	0.0 nTPM

Schwann cells	0.2 nTPM
Vascular	0.5 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	2.2 nTPM
Tongue	4.4 nTPM
Salivary gland	0.1 nTPM

Smooth muscle cells	0.7 nTPM
Skin	7.2 nTPM
Lung	1.2 nTPM
Tongue	1.2 nTPM
Skeletal muscle	0.7 nTPM
Ovary	0.4 nTPM
Placenta	0.3 nTPM
Endometrium	0.2 nTPM
Breast	0.2 nTPM
Fallopian tube	0.2 nTPM
Thymus	0.1 nTPM
Vascular	0.1 nTPM
Liver	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM

Suprabasal keratinocytes	18.3 nTPM
Skin	23.3 nTPM
Tongue	13.3 nTPM

T-cells	0.3 nTPM
Tongue	2.3 nTPM
Colon	1.0 nTPM
Endometrium	0.5 nTPM
Prostate	0.5 nTPM
Skin	0.4 nTPM
Fallopian tube	0.4 nTPM
Liver	0.3 nTPM
Lung	0.3 nTPM
Adipose tissue	0.2 nTPM
Salivary gland	0.2 nTPM
Breast	0.2 nTPM
PBMC	0.1 nTPM
Thymus	0.1 nTPM
Kidney	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Vascular	0.0 nTPM

Undifferentiated cells	0.6 nTPM
Colon	1.5 nTPM
Rectum	0.2 nTPM
Small intestine	0.0 nTPM

Amygdala excitatory	1.8 nTPM
Hippocampus	3.3 nTPM
Thalamus	3.2 nTPM
Cerebral cortex	1.7 nTPM
Hypothalamus	1.1 nTPM
Basal ganglia	0.9 nTPM
Amygdala	0.7 nTPM

Astrocyte	8.5 nTPM
Cerebral cortex	26.3 nTPM
Amygdala	21.5 nTPM
Hippocampus	18.7 nTPM
Hypothalamus	8.4 nTPM
Basal ganglia	5.3 nTPM
Thalamus	4.9 nTPM
Midbrain	3.3 nTPM
Pons	2.7 nTPM
Cerebellum	1.5 nTPM
Medulla oblongata	0.5 nTPM
Spinal cord	0.5 nTPM

Bergmann glia	14.9 nTPM
Cerebellum	19.6 nTPM
Medulla oblongata	14.9 nTPM
Pons	10.1 nTPM

Central nervous system macrophage	0.2 nTPM
Cerebral cortex	0.5 nTPM
Hippocampus	0.4 nTPM
Hypothalamus	0.3 nTPM
Medulla oblongata	0.3 nTPM
Basal ganglia	0.2 nTPM
Midbrain	0.2 nTPM
Thalamus	0.2 nTPM
Amygdala	0.1 nTPM
Cerebellum	0.1 nTPM
Pons	0.1 nTPM
Spinal cord	0.0 nTPM

Cerebellar inhibitory	0.1 nTPM
Cerebellum	0.2 nTPM
Pons	0.2 nTPM
Medulla oblongata	0.0 nTPM
Midbrain	0.0 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	5.0 nTPM
Amygdala	7.0 nTPM
Hypothalamus	6.3 nTPM
Cerebral cortex	5.4 nTPM
Basal ganglia	4.8 nTPM
Hippocampus	4.8 nTPM
Midbrain	4.7 nTPM
Thalamus	2.2 nTPM

Choroid plexus epithelial cell	0.1 nTPM
Basal ganglia	0.2 nTPM
Medulla oblongata	0.1 nTPM
Hippocampus	0.0 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	6.4 nTPM
Midbrain	13.4 nTPM
Cerebral cortex	13.3 nTPM
Cerebellum	9.5 nTPM
Amygdala	7.3 nTPM
Basal ganglia	6.0 nTPM
Pons	5.3 nTPM
Hippocampus	5.2 nTPM
Hypothalamus	4.8 nTPM
Medulla oblongata	3.9 nTPM
Thalamus	1.6 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	1.7 nTPM
Hippocampus	6.9 nTPM
Midbrain	2.2 nTPM
Amygdala	0.4 nTPM
Hypothalamus	0.4 nTPM
Cerebral cortex	0.3 nTPM
Basal ganglia	0.2 nTPM

Deep-layer intratelencephalic	0.2 nTPM
Amygdala	0.4 nTPM
Cerebral cortex	0.2 nTPM
Hippocampus	0.2 nTPM
Hypothalamus	0.2 nTPM
Basal ganglia	0.1 nTPM

Deep-layer near-projecting	10.5 nTPM
Hypothalamus	16.3 nTPM
Basal ganglia	10.6 nTPM
Hippocampus	9.8 nTPM
Cerebral cortex	8.2 nTPM
Amygdala	7.7 nTPM

Eccentric medium spiny neuron	0.2 nTPM
Hippocampus	0.4 nTPM
Cerebral cortex	0.2 nTPM
Amygdala	0.1 nTPM
Basal ganglia	0.1 nTPM
Hypothalamus	0.1 nTPM
Thalamus	0.1 nTPM

Endothelial cell	0.1 nTPM
Midbrain	0.9 nTPM
Hippocampus	0.3 nTPM
Amygdala	0.0 nTPM
Basal ganglia	0.0 nTPM
Cerebellum	0.0 nTPM
Cerebral cortex	0.0 nTPM
Hypothalamus	0.0 nTPM
Medulla oblongata	0.0 nTPM
Pons	0.0 nTPM
Spinal cord	0.0 nTPM
Thalamus	0.0 nTPM