Single cell type - LUZP2 - The Human Protein Atlas

LUZP2

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LUZP2
Gene descriptionⁱ Full gene name according to HGNC.	Leucine zipper protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Oligodendrocyte precursor - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enriched (Oligodendrocyte precursor cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.91
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Oligodendrocyte precursor cell, Eccentric medium spiny neuron)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data.	Protein predicted to be secreted

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enriched (Oligodendrocyte precursor cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Oligodendrocyte precursor cell, Eccentric medium spiny neuron)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

LUZP2 is part of cluster 76 Oligodendrocyte precursor - Unknown function with confidenceⁱ 1
210 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SLC35F1	Solute carrier family 35 member F1	0.8473	76
TNR	Tenascin R	0.8288	76
NAV2	Neuron navigator 2	0.8212	76
PCDH15	Protocadherin related 15	0.7999	76
LHFPL3	LHFPL tetraspan subfamily member 3	0.7992	76
KLHL1	Kelch like family member 1	0.7983	76
PLPPR1	Phospholipid phosphatase related 1	0.7821	76
CHST11	Carbohydrate sulfotransferase 11	0.7767	76
SPDYE8	Speedy/RINGO cell cycle regulator family member E8	0.7744	76
LRRC4C	Leucine rich repeat containing 4C	0.7606	76
GPR17	G protein-coupled receptor 17	0.7529	76
STK32A	Serine/threonine kinase 32A	0.7463	76
DSCAM	DS cell adhesion molecule	0.7459	76
NLGN4X	Neuroligin 4 X-linked	0.7457	76
USP24	Ubiquitin specific peptidase 24	0.7421	76

Adipocytes	0.3 nTPM
Adipose tissue	0.4 nTPM
Breast	0.2 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	0.0 nTPM
Lung	0.0 nTPM

Astrocytes	10.8 nTPM
Brain	10.8 nTPM

B-cells	0.0 nTPM
Salivary gland	0.1 nTPM
Thymus	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM

Ciliated cells	0.1 nTPM
Endometrium	0.3 nTPM
Fallopian tube	0.2 nTPM
Bronchus	0.0 nTPM
Lung	0.0 nTPM

Club cells	3.1 nTPM
Prostate	9.1 nTPM
Lung	0.1 nTPM
Bronchus	0.0 nTPM

Endothelial cells	0.1 nTPM
Tongue	1.1 nTPM
Endometrium	0.1 nTPM
Testis	0.0 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM
Ovary	0.0 nTPM

Enteroendocrine cells	1.2 nTPM
Colon	3.5 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	1.7 nTPM
Adipose tissue	11.4 nTPM
Skeletal muscle	10.9 nTPM
Vascular	1.8 nTPM
Skin	1.0 nTPM
Salivary gland	1.0 nTPM
Esophagus	0.5 nTPM
Placenta	0.2 nTPM
Breast	0.2 nTPM
Thymus	0.1 nTPM
Fallopian tube	0.1 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM

Granulocytes	0.0 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM
Fallopian tube	0.0 nTPM

Intestinal goblet cells	1.9 nTPM
Rectum	3.0 nTPM
Colon	2.7 nTPM
Small intestine	0.0 nTPM

Lymphatic endothelial cells	0.0 nTPM
Fallopian tube	0.0 nTPM
Ovary	0.0 nTPM

Macrophages	0.1 nTPM
Endometrium	1.2 nTPM
Tongue	0.9 nTPM
Skeletal muscle	0.2 nTPM
Prostate	0.2 nTPM
Salivary gland	0.1 nTPM
Breast	0.1 nTPM
Testis	0.0 nTPM
Kidney	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Thymus	0.0 nTPM
Vascular	0.0 nTPM
Fallopian tube	0.0 nTPM

Paneth cells	28.3 nTPM
Colon	43.4 nTPM
Rectum	24.3 nTPM
Small intestine	17.3 nTPM

Collecting duct cells	3.9 nTPM
Kidney	3.9 nTPM

Early spermatids	42.0 nTPM
Testis	42.0 nTPM

Endometrial stromal cells	0.6 nTPM
Endometrium	0.6 nTPM

Excitatory neurons	143.2 nTPM
Brain	143.2 nTPM

Plasma cells	0.0 nTPM
Thymus	0.1 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM
Fallopian tube	0.0 nTPM

Schwann cells	0.9 nTPM
Vascular	2.6 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	0.0 nTPM
Salivary gland	0.0 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	0.3 nTPM
Salivary gland	0.9 nTPM
Placenta	0.7 nTPM
Vascular	0.7 nTPM
Skeletal muscle	0.6 nTPM
Tongue	0.6 nTPM
Adipose tissue	0.4 nTPM
Thymus	0.4 nTPM
Endometrium	0.3 nTPM
Liver	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM
Ovary	0.0 nTPM

T-cells	0.1 nTPM
Tongue	0.5 nTPM
PBMC	0.2 nTPM
Prostate	0.2 nTPM
Fallopian tube	0.2 nTPM
Endometrium	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM

Undifferentiated cells	1.2 nTPM
Colon	1.8 nTPM
Rectum	1.7 nTPM
Small intestine	0.0 nTPM

Amygdala excitatory	577.5 nTPM
Thalamus	854.4 nTPM
Amygdala	615.9 nTPM
Hippocampus	589.7 nTPM
Basal ganglia	534.4 nTPM
Cerebral cortex	496.7 nTPM
Hypothalamus	373.8 nTPM

Astrocyte	908.5 nTPM
Spinal cord	1704.3 nTPM
Thalamus	1546.3 nTPM
Midbrain	1486.3 nTPM
Pons	1315.7 nTPM
Hypothalamus	997.5 nTPM
Cerebellum	945.2 nTPM
Medulla oblongata	869.4 nTPM
Basal ganglia	467.2 nTPM
Amygdala	357.7 nTPM
Hippocampus	184.8 nTPM
Cerebral cortex	118.7 nTPM

Bergmann glia	6.0 nTPM
Medulla oblongata	10.7 nTPM
Pons	4.3 nTPM
Cerebellum	2.9 nTPM

Central nervous system macrophage	12.9 nTPM
Hypothalamus	21.6 nTPM
Amygdala	21.0 nTPM
Spinal cord	17.7 nTPM
Hippocampus	15.8 nTPM
Thalamus	12.6 nTPM
Cerebral cortex	11.3 nTPM
Midbrain	10.4 nTPM
Cerebellum	9.2 nTPM
Basal ganglia	7.9 nTPM
Pons	7.2 nTPM
Medulla oblongata	7.1 nTPM

Cerebellar inhibitory	285.0 nTPM
Pons	711.2 nTPM
Midbrain	403.4 nTPM
Cerebellum	162.7 nTPM
Medulla oblongata	144.9 nTPM
Spinal cord	2.7 nTPM

Cge interneuron	712.2 nTPM
Thalamus	1194.0 nTPM
Midbrain	808.7 nTPM
Amygdala	672.4 nTPM
Basal ganglia	646.9 nTPM
Hypothalamus	625.4 nTPM
Hippocampus	581.7 nTPM
Cerebral cortex	456.1 nTPM

Choroid plexus epithelial cell	5.6 nTPM
Thalamus	8.2 nTPM
Medulla oblongata	7.7 nTPM
Basal ganglia	6.4 nTPM
Hippocampus	0.0 nTPM

Committed oligodendrocyte precursor	1822.1 nTPM
Spinal cord	2950.7 nTPM
Hippocampus	2701.3 nTPM
Amygdala	2303.4 nTPM
Cerebral cortex	2141.3 nTPM
Midbrain	2106.8 nTPM
Cerebellum	2042.2 nTPM
Pons	1613.1 nTPM
Basal ganglia	1500.8 nTPM
Hypothalamus	1336.9 nTPM
Medulla oblongata	1084.4 nTPM
Thalamus	261.8 nTPM

Deep-layer corticothalamic and 6b	570.3 nTPM
Midbrain	844.3 nTPM
Hippocampus	780.3 nTPM
Cerebral cortex	488.5 nTPM
Basal ganglia	476.5 nTPM
Hypothalamus	455.2 nTPM
Amygdala	377.0 nTPM

Deep-layer intratelencephalic	303.0 nTPM
Amygdala	645.4 nTPM
Basal ganglia	331.2 nTPM
Hippocampus	205.4 nTPM
Hypothalamus	185.0 nTPM
Cerebral cortex	148.2 nTPM

Deep-layer near-projecting	624.3 nTPM
Cerebral cortex	756.8 nTPM
Amygdala	618.8 nTPM
Hippocampus	608.8 nTPM
Basal ganglia	607.7 nTPM
Hypothalamus	529.3 nTPM

Eccentric medium spiny neuron	2215.3 nTPM
Thalamus	3091.4 nTPM
Basal ganglia	2971.5 nTPM
Hypothalamus	2490.8 nTPM
Cerebral cortex	2142.3 nTPM
Amygdala	1625.1 nTPM
Hippocampus	970.8 nTPM

Endothelial cell	18.7 nTPM
Spinal cord	34.5 nTPM
Amygdala	31.3 nTPM
Hypothalamus	22.3 nTPM
Midbrain	20.8 nTPM
Cerebral cortex	17.3 nTPM
Thalamus	16.4 nTPM
Hippocampus	16.0 nTPM
Basal ganglia	14.9 nTPM
Medulla oblongata	11.3 nTPM
Pons	11.2 nTPM
Cerebellum	10.1 nTPM

Ependymal cell	98.4 nTPM
Amygdala	201.4 nTPM
Midbrain	134.6 nTPM
Basal ganglia	110.3 nTPM
Pons	101.7 nTPM
Thalamus	99.2 nTPM
Hippocampus	79.3 nTPM
Hypothalamus	77.6 nTPM
Spinal cord	42.2 nTPM
Medulla oblongata	39.1 nTPM