Single cell type - TMEM17 - The Human Protein Atlas

TMEM17

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMEM17
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane protein 17
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neurons - Neurotransmission & signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Early primary spermatocytes, Epididymal efferent duct ciliated cells, Fallopian tube ciliated cells, Respiratory ciliated cells, Platelets, Other brain neurons, Differentiating spermatogonia)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.64
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (plasmacytoid DC)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nCPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. * Single nuclei Read more
Single cell type groups RNA single cell type group specificity: Cell type enhanced (Spermatogenic cell types, Ciliated cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas HPA data, as well as data generated by Monaco et al and Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (plasmacytoid DC)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TMEM17 is part of cluster 98 Neurons - Neurotransmission & signaling with confidenceⁱ 1
318 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CALY	Calcyon neuron specific vesicular protein	0.5818	98
EID2B	EP300 interacting inhibitor of differentiation 2B	0.5374	98
UCHL1	Ubiquitin C-terminal hydrolase L1	0.5089	98
TMEM59L	Transmembrane protein 59 like	0.5033	98
CFC1	Cripto, FRL-1, cryptic family 1	0.5033	76
NGB	Neuroglobin	0.5000	98
SEZ6L2	Seizure related 6 homolog like 2	0.4970	76
LY6H	Lymphocyte antigen 6 family member H	0.4939	98
SLC22A17	Solute carrier family 22 member 17	0.4907	98
MISP3	MISP family member 3	0.4878	98
RIPPLY2	Ripply transcriptional repressor 2	0.4850	76
CTXN1	Cortexin 1	0.4837	98
BEX2	Brain expressed X-linked 2	0.4801	98
PNMA8A	PNMA family member 8A	0.4769	98
POU4F1	POU class 4 homeobox 1	0.4727	98

IMMUNE CELLS

TMEM17 is part of cluster 2 Dendritic cells - Unknown function with confidenceⁱ 0.66
342 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CALCRL	Calcitonin receptor like receptor	1.0000	2
NCKAP5L	NCK associated protein 5 like	1.0000	2
TRPM2	Transient receptor potential cation channel subfamily M member 2	1.0000	2
IGHV4-34	Immunoglobulin heavy variable 4-34	0.9762	2
GGTA1	Glycoprotein alpha-galactosyltransferase 1 (inactive)	0.9762	2
C19orf54	Chromosome 19 open reading frame 54	0.9762	2
TMEM144	Transmembrane protein 144	0.9762	2
NBPF20	NBPF member 20	0.9762	2
MAP2K6	Mitogen-activated protein kinase kinase 6	0.9762	2
CTSG	Cathepsin G	0.9762	2
SLC27A1	Solute carrier family 27 member 1	0.9524	2
GALNT2	Polypeptide N-acetylgalactosaminyltransferase 2	0.9524	2
SNCA	Synuclein alpha	0.9524	2
MXRA7	Matrix remodeling associated 7	0.9524	2
MAN2B1	Mannosidase alpha class 2B member 1	0.9286	2

	Lacrimal acinar cells	Salivary acinar cells	Pancreatic acinar cells
Eye	2.7
Salivary gland		3.5
Pancreas			2.9
Mean exp	2.7	3.5	2.9

	Adipocytes
Heart muscle	20.3
Skeletal muscle	4.6
Adipose tissue	5.2
Mean exp	10.0

	Adrenal cortex cells	Adrenal medulla cells
Adrenal gland	2.9	0.0
Mean exp	2.9	0.0

	Alveolar cells type 1	Alveolar cells type 2	Transitional alveolar cells
Lung	3.1	2.8	2.5
Mean exp	3.1	2.8	2.5

	Esophageal apical cells
Esophagus	5.1
Mean exp	5.1

	B-cells
Brain	7.9
Eye	0.4
Lung	0.0
Salivary gland	0.4
Esophagus	0.0
Stomach	1.0
Liver	0.0
Kidney	0.0
Urinary bladder	0.0
Breast	0.0
Endometrium	0.0
Adipose tissue	0.0
Blood	0.1
Bone marrow	0.0
Lymph node	0.1
Spleen	0.2
Thymus	0.1
Mean exp	0.6

	Ocular epithelial cells	Mesothelial cells	Urothelial cells	Epicardial cells	Prostatic hillock cells
Eye	3.7
Urinary bladder			1.3
Prostate					0.7
Heart muscle				2.3
Adipose tissue		2.1
Thymus		1.9
Mean exp	3.7	2.0	1.3	2.3	0.7

	Respiratory basal cells	Esophageal basal cells	Salivary basal cells	Basal keratinocytes	Epididymal basal cells	Basal prostatic cells
Lung	3.7
Tongue				7.1
Salivary gland			3.2
Esophagus		8.5
Epididymis					5.3
Prostate						2.1
Skin				4.8
Mean exp	3.7	8.5	3.2	5.9	5.3	2.1

	Ependymal cells	Choroid plexus epithelial cells	Respiratory ciliated cells	Respiratory deuterosomal cells	Epididymal efferent duct ciliated cells	Fallopian tube ciliated cells	Endometrial ciliated cells
Brain	11.2	2.6
Lung			22.7	5.2
Epididymis					23.9
Fallopian tube						23.3
Endometrium							14.1
Mean exp	11.2	2.6	22.7	5.2	23.9	23.3	14.1

	Cdc	Pdcs
Lung		0.0
Breast	1.6	5.2
Endometrium		0.0
Adipose tissue	0.0
Skin	0.9
Blood		0.0
Lymph node	0.7
Mean exp	0.8	1.3

	Salivary duct cells	Cholangiocytes	Pancreatic duct cells	Renal collecting duct intercalated cells	Renal collecting duct principal cells	Renal connecting tubule cells	Epididymal efferent duct absorptive cells
Salivary gland	2.8
Liver		0.0
Pancreas			3.6
Kidney				1.7	2.6	1.8
Epididymis							3.1
Mean exp	2.8	0.0	3.6	1.7	2.6	1.8	3.1

	Vascular endothelial cells	Lymphatic endothelial cells
Brain	1.0
Eye	2.6	5.8
Pituitary gland	1.4
Lung	1.4	7.1
Tongue	2.7	5.7
Salivary gland	2.0	4.9
Esophagus	4.5	0.0
Stomach	3.9
Liver	3.9
Pancreas	2.2
Kidney	1.4	0.0
Urinary bladder	1.0	3.8
Testis	2.0	0.0
Epididymis	1.4
Prostate	0.9	3.2
Breast	4.3	3.5
Ovary	2.1	0.0
Fallopian tube	2.1	4.8
Endometrium	1.8	0.0
Placenta	1.1
Heart muscle	9.1
Skeletal muscle	4.3
Vasculature	1.6	4.6
Adipose tissue	3.3	14.8
Skin	4.9	8.0
Lymph node	1.7	0.0
Thymus	1.9	6.7
Spleen		2.5
Mean exp	2.6	4.0

	Enterocytes	Colonocytes
Small intestine	0.6
Colon		0.3
Rectum		0.7
Mean exp	0.6	0.5

	Neuroendocrine cells
Stomach	1.9
Small intestine	0.0
Colon	5.8
Rectum	3.7
Mean exp	2.8

	Erythrocyte progenitors	Erythrocytes
Blood		0.0
Bone marrow	2.9	0.0
Spleen		0.0
Mean exp	2.9	0.0

	Astrocytes	Bergmann glia	Müller glia	Pituicytes/fscs	Oligodendrocyte progenitor cells	Oligodendrocytes	Schwann cells	Microglia
Brain	3.0	4.2			2.1	3.8		0.8
Eye			9.7				0.0
Pituitary gland				4.4
Tongue							9.0
Urinary bladder							7.9
Vasculature							20.9
Mean exp	3.0	4.2	9.7	4.4	2.1	3.8	9.5	0.8

	Fibro-adipogenic progenitors
Skeletal muscle	3.1
Adipose tissue	7.9
Mean exp	5.5

	Fibroblasts
Brain	1.9
Eye	3.9
Lung	2.3
Tongue	2.1
Salivary gland	2.2
Esophagus	7.9
Stomach	3.6
Pancreas	0.8
Kidney	0.9
Urinary bladder	2.2
Epididymis	3.6
Prostate	1.1
Breast	3.8
Fallopian tube	2.6
Placenta	4.2
Heart muscle	20.4
Vasculature	3.4
Skin	5.1
Lymph node	4.1
Thymus	2.0
Mean exp	3.9

	Foveolar cells	Mucous neck cells	Parietal cells	Gastric chief cells
Stomach	0.4	2.3	5.3	4.4
Mean exp	0.4	2.3	5.3	4.4

	Submucosal glandular cells	Prostatic glandular cells	Prostatic club cells	Endometrial glandular cells
Lung	0.0
Esophagus	5.6
Prostate		3.0	1.1
Endometrium				1.2
Mean exp	2.8	3.0	1.1	1.2

	Conjunctival goblet cells	Goblet cells
Eye	1.9
Small intestine		0.2
Colon		1.2
Rectum		1.1
Mean exp	1.9	0.8

	Innate lymphoid cells
Lung	0.0
Salivary gland	0.0
Urinary bladder	0.0
Breast	0.0
Fallopian tube	0.0
Endometrium	0.0
Lymph node	0.5
Spleen	0.0
Thymus	0.0
Mean exp	0.1

	Respiratory ionocytes	Salivary ionocytes
Lung	5.1
Salivary gland		2.5
Mean exp	5.1	2.5

	Breast hormone-responsive cells	Endometrial luminal cells
Breast	2.8
Endometrium		1.5
Mean exp	2.8	1.5

	Mast cells
Eye	11.1
Lung	1.1
Tongue	0.0
Salivary gland	0.0
Stomach	0.0
Pancreas	0.8
Urinary bladder	0.9
Epididymis	0.0
Fallopian tube	1.2
Vasculature	1.2
Adipose tissue	2.2
Lymph node	1.1
Mean exp	1.6

	Megakaryocyte progenitors	Megakaryocyte-erythroid progenitors	Megakaryocytes
Bone marrow	3.3	1.7	0.0
Mean exp	3.3	1.7	0.0

Acinar cells - 3.5 nCPM

Adipocytes - 10.0 nCPM

Adrenal endocrine cells - 2.9 nCPM

Alveolar cells - 3.1 nCPM

Apical squamous epithelial cells - 5.1 nCPM

B-cells - 0.6 nCPM

Barrier epithelial cells - 3.7 nCPM

Basal cells - 8.5 nCPM

Ciliated cells - 23.9 nCPM

Dendritic cells - 1.3 nCPM

Ductal cells - 3.6 nCPM

Endothelial cells - 4.0 nCPM

Enterocytes - 0.6 nCPM

Enteroendocrine cells - 2.8 nCPM

Erythrocytes - 2.9 nCPM

Fibro-adipogenic progenitors - 5.5 nCPM

Fibroblasts - 3.9 nCPM

Gastric glandular cells - 5.3 nCPM

Glandular cells - 3.0 nCPM

Glial cells - 9.7 nCPM

Goblet cells - 1.9 nCPM

Hepatocytes - 2.5 nCPM

Innate lymphoid cells - 0.1 nCPM

Ionocytes - 5.1 nCPM

Leydig cells - 3.7 nCPM

Luminal cells - 2.8 nCPM

Mast cells - 1.6 nCPM

Megakaryocytes - 3.3 nCPM

Mononuclear phagocytes - 4.0 nCPM

Mural cells - 1.9 nCPM

Myocytes - 7.0 nCPM

Neuronal cells - 22.2 nCPM

Neutrophils - 0.6 nCPM

Nk-cells - 0.2 nCPM

Oocytes - 0.0 nCPM

Pancreatic islet cells - 17.3 nCPM

Pigment cells - 9.4 nCPM

Pituitary endocrine cells - 6.4 nCPM

Plasma cells - 0.9 nCPM

Platelets - 22.6 nCPM

Proliferating cells - 1.8 nCPM

Renal nephron cells - 3.0 nCPM

Reproductive supporting cells - 8.1 nCPM

Secretory cells - 4.5 nCPM

Secretory gland support - 4.3 nCPM

Smooth muscle cells - 4.6 nCPM

Spermatogenic cell types - 39.8 nCPM

Stellate cells - 6.5 nCPM

Stem cells - 2.4 nCPM

Stromal cells - 5.4 nCPM

Suprabasal cells - 7.6 nCPM

T-cells - 1.7 nCPM

Trophoblast cells - 2.8 nCPM

	Monocyte progenitors	Monocytes	Macrophages	Kupffer cells	Hofbauer cells
Brain		2.3	0.0
Eye		0.0	1.1
Pituitary gland			2.0
Lung		0.4	0.9
Tongue		0.0	0.5
Salivary gland		0.0	0.6
Esophagus			2.0
Stomach		0.0	2.0
Liver		1.2	0.0	1.0
Pancreas		0.0	0.9
Kidney			0.9
Urinary bladder		0.2	0.5
Testis			1.2
Prostate		0.7	0.3
Breast		0.0	1.7
Ovary			0.0
Fallopian tube		0.5	0.5
Endometrium			0.0
Placenta					4.0
Heart muscle			3.3
Skeletal muscle			0.0
Vasculature		0.2	1.0
Adipose tissue			1.2
Skin			0.0
Blood		0.2
Bone marrow	0.6	0.3	0.0
Lymph node		0.0	0.7
Thymus		0.2	0.9
Spleen		0.3	0.7
Mean exp	0.6	0.4	0.8	1.0	4.0

	Pericytes	Vascular smooth muscle cells
Brain	1.6	1.0
Eye	5.2	0.8
Pituitary gland	0.0
Lung	1.9	2.6
Tongue	2.5	2.6
Salivary gland	0.0	1.7
Stomach	0.0	0.0
Pancreas	0.9
Kidney	1.9	0.9
Urinary bladder	2.1	1.4
Testis	4.2
Epididymis	0.0	1.0
Prostate	0.0	0.8
Breast	2.5	1.7
Ovary	1.8	2.2
Fallopian tube	0.0	2.9
Placenta	6.7
Heart muscle	1.5	0.0
Skeletal muscle	0.0	5.0
Vasculature	2.7	2.0
Adipose tissue	2.6	0.0
Skin	3.2	0.0
Thymus	1.3	1.0
Mean exp	1.9	1.5

	Cardiomyocytes	Myonuclei
Heart muscle	7.0
Skeletal muscle		1.6
Mean exp	7.0	1.6

	Brain excitatory neurons	Brain inhibitory neurons	Retinal amacrine cells	Retinal horizontal cells	Retinal ganglion cells	Retinal bipolar cells	Rod photoreceptor cells	Cone photoreceptor cells	Other brain neurons
Brain	6.0	8.2							22.2
Eye			3.4	8.0	0.0	12.5	2.2	10.4
Mean exp	6.0	8.2	3.4	8.0	0.0	12.5	2.2	10.4	22.2

	Neutrophil progenitors	Neutrophils
Eye		0.0
Lung		0.0
Salivary gland		0.0
Urinary bladder		0.0
Prostate		0.0
Vasculature		0.0
Blood	0.1	0.1
Bone marrow	1.5	0.2
Lymph node		0.0
Spleen	1.0	0.3
Thymus	0.0	0.4
Mean exp	0.6	0.1

	Nk-cells
Brain	0.0
Eye	0.0
Lung	0.7
Salivary gland	1.1
Stomach	0.0
Colon	0.0
Liver	0.0
Kidney	0.0
Urinary bladder	0.0
Prostate	0.0
Fallopian tube	0.5
Endometrium	0.6
Vasculature	0.0
Blood	0.0
Bone marrow	0.9
Lymph node	0.0
Spleen	0.2
Thymus	0.0
Mean exp	0.2

	Melanocytes	Retinal pigment epithelial cells
Eye	2.5	8.5
Skin	16.3
Mean exp	9.4	8.5

	Corticotrophs	Gonadotrophs	Lactotrophs	Somatotrophs	Thyrotrophs
Pituitary gland	6.4	4.3	4.5	3.7	3.6
Mean exp	6.4	4.3	4.5	3.7	3.6

	Plasma cells
Eye	0.4
Lung	0.0
Salivary gland	0.9
Stomach	1.7
Liver	2.2
Urinary bladder	0.8
Breast	0.0
Fallopian tube	1.3
Blood	1.3
Bone marrow	1.4
Lymph node	0.7
Spleen	1.0
Thymus	0.5
Mean exp	0.9

	Gastric progenitor cells	Enteric transient amplifying cells
Stomach	0.0
Small intestine		2.4
Colon		1.6
Rectum		1.4
Mean exp	0.0	1.8