Single cell type - KIF24 - The Human Protein Atlas

KIF24

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KIF24
Gene descriptionⁱ Full gene name according to HGNC.	Kinesin family member 24
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Late spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Late spermatids, Astrocytes, Early spermatids, Spermatocytes, Ciliated cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.83
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Ependymal cell)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enriched (basophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Late spermatids, Astrocytes, Early spermatids, Spermatocytes, Ciliated cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Ependymal cell)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enriched (basophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

KIF24 is part of cluster 11 Late spermatids - Unknown function with confidenceⁱ 1
430 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ADGRF3	Adhesion G protein-coupled receptor F3	0.6895	11
APLF	Aprataxin and PNKP like factor	0.5933	11
KRTAP9-7	Keratin associated protein 9-7	0.5735	11
GNA14	G protein subunit alpha 14	0.5674	47
ACP1	Acid phosphatase 1	0.5657	11
ENSG00000269547	Novel protein	0.5621	11
MC5R	Melanocortin 5 receptor	0.5538	11
RSPH14	Radial spoke head 14 homolog	0.5405	11
DEFB135	Defensin beta 135	0.5374	21
CYB5D1	Cytochrome b5 domain containing 1	0.5276	11
CNGA4	Cyclic nucleotide gated channel subunit alpha 4	0.5265	47
SFXN5	Sideroflexin 5	0.5263	47
IQCA1	IQ motif containing with AAA domain 1	0.5251	47
CEP112	Centrosomal protein 112	0.5240	11
PHF21B	PHD finger protein 21B	0.5224	47

Adipocytes	0.4 nTPM
Adipose tissue	0.6 nTPM
Breast	0.2 nTPM

Alveolar cells type 1	0.3 nTPM
Lung	0.3 nTPM

Alveolar cells type 2	0.7 nTPM
Lung	0.7 nTPM

B-cells	0.2 nTPM
Lung	1.3 nTPM
Salivary gland	0.3 nTPM
Lymph node	0.2 nTPM
Spleen	0.2 nTPM
Thymus	0.2 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM

Basal keratinocytes	0.7 nTPM
Tongue	1.2 nTPM
Skin	0.2 nTPM

Ciliated cells	10.3 nTPM
Lung	11.9 nTPM
Fallopian tube	11.9 nTPM
Bronchus	9.5 nTPM
Endometrium	7.9 nTPM

Club cells	0.9 nTPM
Lung	1.5 nTPM
Bronchus	0.6 nTPM
Prostate	0.5 nTPM

Endothelial cells	0.3 nTPM
Endometrium	1.5 nTPM
Heart muscle	0.7 nTPM
Placenta	0.6 nTPM
Tongue	0.5 nTPM
Fallopian tube	0.4 nTPM
Salivary gland	0.2 nTPM
Vascular	0.2 nTPM
Ovary	0.2 nTPM
Skeletal muscle	0.1 nTPM
Lung	0.1 nTPM
Thymus	0.1 nTPM
Testis	0.0 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Prostate	0.0 nTPM
Breast	0.0 nTPM

Enteroendocrine cells	0.1 nTPM
Colon	0.3 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	0.2 nTPM
Pancreas	0.7 nTPM
Placenta	0.4 nTPM
Vascular	0.4 nTPM
Skeletal muscle	0.3 nTPM
Adipose tissue	0.3 nTPM
Lung	0.3 nTPM
Thymus	0.3 nTPM
Fallopian tube	0.3 nTPM
Heart muscle	0.2 nTPM
Salivary gland	0.2 nTPM
Breast	0.2 nTPM
Skin	0.1 nTPM
Esophagus	0.1 nTPM
Liver	0.0 nTPM
Stomach	0.0 nTPM
Prostate	0.0 nTPM

Granulocytes	0.2 nTPM
Fallopian tube	0.6 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	0.6 nTPM
Small intestine	0.9 nTPM
Colon	0.5 nTPM
Rectum	0.3 nTPM

Lymphatic endothelial cells	0.2 nTPM
Fallopian tube	0.3 nTPM
Ovary	0.0 nTPM

Macrophages	0.5 nTPM
Tongue	2.8 nTPM
Testis	1.9 nTPM
Bone marrow	1.0 nTPM
Breast	0.9 nTPM
Prostate	0.7 nTPM
Endometrium	0.6 nTPM
Lung	0.5 nTPM
Salivary gland	0.4 nTPM
Thymus	0.4 nTPM
Adipose tissue	0.3 nTPM
Fallopian tube	0.3 nTPM
Vascular	0.2 nTPM
Kidney	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Astrocytes	30.7 nTPM
Brain	30.7 nTPM

Excitatory neurons	7.0 nTPM
Brain	7.0 nTPM

Plasma cells	1.6 nTPM
Bone marrow	4.5 nTPM
Thymus	4.3 nTPM
Spleen	3.4 nTPM
Liver	0.5 nTPM
Esophagus	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM
Fallopian tube	0.0 nTPM

Schwann cells	0.3 nTPM
Vascular	0.5 nTPM
Adipose tissue	0.4 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	0.1 nTPM
Salivary gland	0.2 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	0.3 nTPM
Endometrium	1.6 nTPM
Prostate	0.6 nTPM
Placenta	0.5 nTPM
Breast	0.5 nTPM
Fallopian tube	0.5 nTPM
Tongue	0.3 nTPM
Thymus	0.2 nTPM
Vascular	0.2 nTPM
Ovary	0.2 nTPM
Skeletal muscle	0.1 nTPM
Liver	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Salivary gland	0.0 nTPM

T-cells	0.4 nTPM
Endometrium	1.1 nTPM
Colon	1.0 nTPM
Liver	0.7 nTPM
Spleen	0.6 nTPM
Tongue	0.6 nTPM
Breast	0.5 nTPM
Skeletal muscle	0.4 nTPM
Adipose tissue	0.4 nTPM
Salivary gland	0.4 nTPM
Vascular	0.4 nTPM
Lymph node	0.3 nTPM
Thymus	0.3 nTPM
Fallopian tube	0.3 nTPM
Bone marrow	0.2 nTPM
Prostate	0.2 nTPM
Stomach	0.1 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM

Undifferentiated cells	1.6 nTPM
Colon	2.2 nTPM
Rectum	1.7 nTPM
Small intestine	0.8 nTPM

Amygdala excitatory	5.1 nTPM
Hypothalamus	6.7 nTPM
Amygdala	6.1 nTPM
Cerebral cortex	5.9 nTPM
Basal ganglia	5.2 nTPM
Hippocampus	4.4 nTPM
Thalamus	2.3 nTPM

Astrocyte	16.0 nTPM
Basal ganglia	21.1 nTPM
Cerebral cortex	18.6 nTPM
Amygdala	17.7 nTPM
Midbrain	17.7 nTPM
Hippocampus	16.7 nTPM
Pons	16.5 nTPM
Hypothalamus	15.6 nTPM
Medulla oblongata	15.6 nTPM
Thalamus	15.4 nTPM
Cerebellum	13.1 nTPM
Spinal cord	8.1 nTPM

Bergmann glia	12.3 nTPM
Cerebellum	21.0 nTPM
Pons	11.5 nTPM
Medulla oblongata	4.3 nTPM

Central nervous system macrophage	2.4 nTPM
Medulla oblongata	3.4 nTPM
Spinal cord	2.9 nTPM
Basal ganglia	2.8 nTPM
Hypothalamus	2.6 nTPM
Hippocampus	2.4 nTPM
Thalamus	2.4 nTPM
Midbrain	2.3 nTPM
Cerebellum	2.1 nTPM
Cerebral cortex	2.1 nTPM
Amygdala	2.0 nTPM
Pons	1.5 nTPM

Cerebellar inhibitory	1.9 nTPM
Midbrain	3.4 nTPM
Cerebellum	2.3 nTPM
Medulla oblongata	2.2 nTPM
Pons	1.5 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	1.1 nTPM
Amygdala	1.5 nTPM
Basal ganglia	1.4 nTPM
Hippocampus	1.2 nTPM
Cerebral cortex	1.1 nTPM
Hypothalamus	1.0 nTPM
Midbrain	0.7 nTPM
Thalamus	0.7 nTPM

Choroid plexus epithelial cell	28.5 nTPM
Basal ganglia	48.5 nTPM
Medulla oblongata	35.3 nTPM
Hippocampus	22.2 nTPM
Thalamus	8.2 nTPM

Committed oligodendrocyte precursor	3.9 nTPM
Medulla oblongata	11.6 nTPM
Basal ganglia	8.2 nTPM
Hypothalamus	4.1 nTPM
Cerebral cortex	3.8 nTPM
Spinal cord	3.7 nTPM
Pons	3.5 nTPM
Thalamus	2.5 nTPM
Hippocampus	1.8 nTPM
Amygdala	1.7 nTPM
Midbrain	1.7 nTPM
Cerebellum	0.0 nTPM

Deep-layer corticothalamic and 6b	2.6 nTPM
Hypothalamus	3.3 nTPM
Cerebral cortex	3.1 nTPM
Basal ganglia	3.0 nTPM
Amygdala	2.9 nTPM
Hippocampus	2.2 nTPM
Midbrain	1.1 nTPM

Deep-layer intratelencephalic	4.5 nTPM
Basal ganglia	5.1 nTPM
Amygdala	4.8 nTPM
Hypothalamus	4.7 nTPM
Cerebral cortex	4.5 nTPM
Hippocampus	3.4 nTPM

Deep-layer near-projecting	1.3 nTPM
Basal ganglia	2.1 nTPM
Amygdala	1.6 nTPM
Cerebral cortex	1.4 nTPM
Hippocampus	0.7 nTPM
Hypothalamus	0.6 nTPM

Eccentric medium spiny neuron	8.4 nTPM
Basal ganglia	9.9 nTPM
Hypothalamus	9.7 nTPM
Thalamus	9.5 nTPM
Cerebral cortex	7.5 nTPM
Amygdala	7.2 nTPM
Hippocampus	6.2 nTPM

Endothelial cell	2.9 nTPM
Midbrain	6.6 nTPM
Basal ganglia	3.7 nTPM
Hypothalamus	3.7 nTPM
Spinal cord	3.5 nTPM
Hippocampus	2.9 nTPM
Cerebral cortex	2.6 nTPM
Cerebellum	2.3 nTPM
Amygdala	2.2 nTPM
Medulla oblongata	2.1 nTPM
Pons	1.2 nTPM
Thalamus	1.1 nTPM

Ependymal cell	93.8 nTPM
Hypothalamus	126.7 nTPM
Medulla oblongata	119.6 nTPM
Basal ganglia	99.0 nTPM
Thalamus	97.2 nTPM
Midbrain	89.5 nTPM
Pons	89.2 nTPM
Hippocampus	82.7 nTPM
Spinal cord	78.6 nTPM
Amygdala	61.4 nTPM