Single cell type - TARS3 - The Human Protein Atlas

TARS3

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TARS3
Gene descriptionⁱ Full gene name according to HGNC.	Threonyl-tRNA synthetase 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	NK-cells & T-cells - Immune system & Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oligodendrocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.41
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oligodendrocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TARS3 is part of cluster 78 NK-cells & T-cells - Immune system & Transcription with confidenceⁱ 1
392 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KAT6B	Lysine acetyltransferase 6B	0.6076	78
JMY	Junction mediating and regulatory protein, p53 cofactor	0.5967	78
RGPD2	RANBP2 like and GRIP domain containing 2	0.5964	78
PRDM1	PR/SET domain 1	0.5818	77
ANKRD28	Ankyrin repeat domain 28	0.5808	77
TSC22D3	TSC22 domain family member 3	0.5724	78
VAMP1	Vesicle associated membrane protein 1	0.5513	78
CNOT6L	CCR4-NOT transcription complex subunit 6 like	0.5352	78
ZFP36L2	ZFP36 ring finger protein like 2	0.5350	78
NSD3	Nuclear receptor binding SET domain protein 3	0.5343	78
ZNF831	Zinc finger protein 831	0.5334	78
BORCS5	BLOC-1 related complex subunit 5	0.5316	78
RAB30	RAB30, member RAS oncogene family	0.5210	77
OGT	O-linked N-acetylglucosamine (GlcNAc) transferase	0.5203	78
CENPC	Centromere protein C	0.5186	78

IMMUNE CELLS

TARS3 is part of cluster 24 Non-specific - Transcription with confidenceⁱ 0.95
516 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LYPLAL1	Lysophospholipase like 1	1.0000	24
VCPKMT	Valosin containing protein lysine methyltransferase	0.9762	24
ZNF502	Zinc finger protein 502	0.9762	24
ZFP82	ZFP82 zinc finger protein	0.9762	24
AXIN2	Axin 2	0.9762	24
NEIL2	Nei like DNA glycosylase 2	0.9762	24
ZFP14	ZFP14 zinc finger protein	0.9762	24
IFT22	Intraflagellar transport 22	0.9762	24
GPR18	G protein-coupled receptor 18	0.9762	24
TUBB4A	Tubulin beta 4A class IVa	0.9762	24
METTL16	Methyltransferase 16, N6-methyladenosine	0.9524	24
CNKSR2	Connector enhancer of kinase suppressor of Ras 2	0.9524	24
ZNF382	Zinc finger protein 382	0.9524	24
MAP9	Microtubule associated protein 9	0.9524	24
RIC3	RIC3 acetylcholine receptor chaperone	0.9524	24

Adipocytes	17.6 nTPM
Breast	18.1 nTPM
Adipose tissue	17.0 nTPM

Alveolar cells type 1	31.9 nTPM
Lung	31.9 nTPM

Alveolar cells type 2	14.1 nTPM
Lung	14.1 nTPM

Astrocytes	27.2 nTPM
Brain	27.2 nTPM

B-cells	43.6 nTPM
Adipose tissue	105.3 nTPM
Thymus	69.9 nTPM
Stomach	59.5 nTPM
Salivary gland	50.1 nTPM
Liver	48.3 nTPM
Esophagus	47.2 nTPM
PBMC	44.6 nTPM
Lymph node	41.3 nTPM
Kidney	26.0 nTPM
Spleen	25.7 nTPM
Bone marrow	24.1 nTPM
Lung	13.4 nTPM
Skin	11.9 nTPM

Ciliated cells	9.5 nTPM
Endometrium	13.5 nTPM
Fallopian tube	12.3 nTPM
Lung	7.7 nTPM
Bronchus	4.3 nTPM

Club cells	11.7 nTPM
Prostate	19.8 nTPM
Lung	10.7 nTPM
Bronchus	4.7 nTPM

Dendritic cells	25.3 nTPM
PBMC	28.8 nTPM
Adipose tissue	21.9 nTPM

Endothelial cells	14.8 nTPM
Breast	26.4 nTPM
Heart muscle	20.6 nTPM
Esophagus	20.3 nTPM
Prostate	20.2 nTPM
Salivary gland	18.4 nTPM
Ovary	18.4 nTPM
Liver	16.4 nTPM
Thymus	16.4 nTPM
Skin	14.6 nTPM
Fallopian tube	14.3 nTPM
Vascular	14.2 nTPM
Skeletal muscle	13.3 nTPM
Endometrium	12.8 nTPM
Tongue	12.2 nTPM
Testis	10.1 nTPM
Lung	9.7 nTPM
Pancreas	5.2 nTPM
Placenta	3.4 nTPM

Enteroendocrine cells	15.4 nTPM
Rectum	18.4 nTPM
Small intestine	17.2 nTPM
Colon	10.6 nTPM

Fibroblasts	16.7 nTPM
Breast	27.0 nTPM
Skin	25.7 nTPM
Esophagus	22.2 nTPM
Prostate	21.8 nTPM
Heart muscle	21.3 nTPM
Salivary gland	20.7 nTPM
Fallopian tube	20.2 nTPM
Vascular	18.0 nTPM
Adipose tissue	16.5 nTPM
Thymus	16.3 nTPM
Skeletal muscle	13.1 nTPM
Lung	12.0 nTPM
Pancreas	10.3 nTPM
Placenta	7.5 nTPM
Stomach	7.2 nTPM
Liver	7.1 nTPM

Granulocytes	41.2 nTPM
Tongue	53.4 nTPM
Fallopian tube	50.0 nTPM
Lung	20.2 nTPM

Intestinal goblet cells	15.9 nTPM
Colon	17.7 nTPM
Small intestine	17.0 nTPM
Rectum	12.9 nTPM

Lymphatic endothelial cells	27.3 nTPM
Ovary	32.7 nTPM
Fallopian tube	21.9 nTPM

Macrophages	12.0 nTPM
Salivary gland	36.0 nTPM
Breast	20.2 nTPM
Adipose tissue	17.1 nTPM
Tongue	15.4 nTPM
Thymus	15.2 nTPM
Endometrium	14.8 nTPM
Fallopian tube	14.7 nTPM
Prostate	14.4 nTPM
Esophagus	14.1 nTPM
Vascular	12.1 nTPM
Kidney	9.7 nTPM
Skeletal muscle	8.3 nTPM
Bone marrow	8.1 nTPM
Lung	6.4 nTPM
Testis	5.6 nTPM
Skin	5.6 nTPM
Stomach	5.1 nTPM
Spleen	5.0 nTPM
Pancreas	0.0 nTPM

Basal prostatic cells	22.7 nTPM
Prostate	22.7 nTPM

Basal respiratory cells	7.3 nTPM
Bronchus	7.3 nTPM

Basal squamous epithelial cells	24.4 nTPM
Esophagus	24.4 nTPM

Bipolar cells	43.9 nTPM
Eye	43.9 nTPM

Paneth cells	5.8 nTPM
Rectum	10.4 nTPM
Small intestine	6.9 nTPM
Colon	0.0 nTPM

Plasma cells	92.3 nTPM
Stomach	187.2 nTPM
Fallopian tube	163.7 nTPM
Salivary gland	128.5 nTPM
Esophagus	67.6 nTPM
Thymus	54.7 nTPM
Spleen	53.4 nTPM
Bone marrow	45.3 nTPM
Liver	38.1 nTPM

Schwann cells	55.5 nTPM
Vascular	72.1 nTPM
Esophagus	71.9 nTPM
Adipose tissue	22.6 nTPM

Serous glandular cells	29.0 nTPM
Salivary gland	40.4 nTPM
Tongue	17.7 nTPM

Smooth muscle cells	23.0 nTPM
Ovary	35.6 nTPM
Skin	32.8 nTPM
Salivary gland	31.3 nTPM
Esophagus	31.2 nTPM
Vascular	27.4 nTPM
Adipose tissue	24.5 nTPM
Thymus	22.7 nTPM
Breast	22.7 nTPM
Tongue	21.9 nTPM
Prostate	21.3 nTPM
Endometrium	20.3 nTPM
Fallopian tube	18.7 nTPM
Skeletal muscle	17.7 nTPM
Liver	16.1 nTPM
Lung	15.3 nTPM
Placenta	8.1 nTPM

Suprabasal keratinocytes	12.0 nTPM
Skin	14.3 nTPM
Tongue	9.7 nTPM

T-cells	60.8 nTPM
Adipose tissue	130.5 nTPM
Thymus	99.2 nTPM
Stomach	94.9 nTPM
Vascular	88.8 nTPM
Salivary gland	81.9 nTPM
Fallopian tube	79.6 nTPM
Tongue	78.1 nTPM
Prostate	69.8 nTPM
Esophagus	58.4 nTPM
Lung	57.0 nTPM
Breast	54.8 nTPM
Endometrium	46.6 nTPM
Skeletal muscle	46.5 nTPM
Skin	44.2 nTPM
PBMC	42.1 nTPM
Lymph node	42.1 nTPM
Liver	40.5 nTPM
Colon	40.0 nTPM
Spleen	35.7 nTPM
Bone marrow	27.5 nTPM
Kidney	17.7 nTPM

Undifferentiated cells	12.9 nTPM
Small intestine	19.7 nTPM
Rectum	10.4 nTPM
Colon	8.7 nTPM

Amygdala excitatory	97.2 nTPM
Cerebral cortex	108.5 nTPM
Hypothalamus	105.5 nTPM
Hippocampus	101.8 nTPM
Amygdala	96.4 nTPM
Thalamus	89.4 nTPM
Basal ganglia	81.9 nTPM

Astrocyte	66.8 nTPM
Basal ganglia	76.9 nTPM
Amygdala	75.7 nTPM
Pons	74.6 nTPM
Thalamus	74.2 nTPM
Midbrain	70.5 nTPM
Hypothalamus	69.2 nTPM
Cerebellum	66.6 nTPM
Medulla oblongata	61.7 nTPM
Hippocampus	58.9 nTPM
Cerebral cortex	55.3 nTPM
Spinal cord	51.3 nTPM

Bergmann glia	58.0 nTPM
Cerebellum	67.5 nTPM
Medulla oblongata	61.8 nTPM
Pons	44.6 nTPM

Central nervous system macrophage	53.6 nTPM
Amygdala	75.4 nTPM
Hypothalamus	63.3 nTPM
Thalamus	56.5 nTPM
Midbrain	54.4 nTPM
Basal ganglia	51.9 nTPM
Cerebral cortex	51.9 nTPM
Hippocampus	51.8 nTPM
Cerebellum	51.4 nTPM
Pons	50.0 nTPM
Medulla oblongata	42.8 nTPM
Spinal cord	40.0 nTPM

Cerebellar inhibitory	68.2 nTPM
Pons	74.9 nTPM
Medulla oblongata	69.8 nTPM
Cerebellum	69.4 nTPM
Midbrain	66.6 nTPM
Spinal cord	60.5 nTPM

Cge interneuron	98.1 nTPM
Amygdala	109.8 nTPM
Basal ganglia	103.2 nTPM
Hippocampus	100.0 nTPM
Hypothalamus	98.2 nTPM
Cerebral cortex	92.3 nTPM
Midbrain	92.3 nTPM
Thalamus	90.9 nTPM

Choroid plexus epithelial cell	51.4 nTPM
Basal ganglia	72.5 nTPM
Thalamus	54.8 nTPM
Medulla oblongata	42.1 nTPM
Hippocampus	36.1 nTPM

Committed oligodendrocyte precursor	131.8 nTPM
Hypothalamus	226.0 nTPM
Thalamus	218.4 nTPM
Amygdala	191.7 nTPM
Midbrain	125.2 nTPM
Cerebellum	111.0 nTPM
Basal ganglia	108.4 nTPM
Cerebral cortex	103.2 nTPM
Pons	97.4 nTPM
Medulla oblongata	95.5 nTPM
Hippocampus	92.4 nTPM
Spinal cord	80.9 nTPM

Deep-layer corticothalamic and 6b	64.5 nTPM
Cerebral cortex	67.5 nTPM
Hippocampus	67.5 nTPM
Basal ganglia	66.9 nTPM
Amygdala	66.2 nTPM
Hypothalamus	65.7 nTPM
Midbrain	53.3 nTPM

Deep-layer intratelencephalic	68.1 nTPM
Amygdala	72.2 nTPM
Hypothalamus	70.8 nTPM
Cerebral cortex	67.5 nTPM
Basal ganglia	66.0 nTPM
Hippocampus	63.7 nTPM

Deep-layer near-projecting	69.9 nTPM
Basal ganglia	74.4 nTPM
Hypothalamus	71.7 nTPM
Hippocampus	69.3 nTPM
Cerebral cortex	67.8 nTPM
Amygdala	66.2 nTPM

Eccentric medium spiny neuron	109.6 nTPM
Hypothalamus	124.2 nTPM
Amygdala	113.4 nTPM
Basal ganglia	106.9 nTPM
Thalamus	105.8 nTPM
Cerebral cortex	105.2 nTPM
Hippocampus	102.0 nTPM