Single cell type - PPP1R2 - The Human Protein Atlas

PPP1R2

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PPP1R2
Gene descriptionⁱ Full gene name according to HGNC.	Protein phosphatase 1 regulatory inhibitor subunit 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	NK-cells & T-cells - Immune system & Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Lymphatic endothelial cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.28
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Lymphatic endothelial cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

PPP1R2 is part of cluster 78 NK-cells & T-cells - Immune system & Transcription with confidenceⁱ 1
392 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LEPROTL1	Leptin receptor overlapping transcript like 1	0.6747	78
CD40LG	CD40 ligand	0.6655	78
ZNF831	Zinc finger protein 831	0.6639	78
ICOS	Inducible T cell costimulator	0.6526	78
IL7R	Interleukin 7 receptor	0.6506	78
CCR4	C-C motif chemokine receptor 4	0.6400	78
SARAF	Store-operated calcium entry associated regulatory factor	0.6355	78
PDCD1	Programmed cell death 1	0.6345	78
IL2	Interleukin 2	0.6339	78
PMCH	Pro-melanin concentrating hormone	0.6332	78
PBX4	PBX homeobox 4	0.6238	78
CD28	CD28 molecule	0.6145	78
ETS1	ETS proto-oncogene 1, transcription factor	0.6126	78
CRYBG1	Crystallin beta-gamma domain containing 1	0.6032	78
RGPD2	RANBP2 like and GRIP domain containing 2	0.6026	78

IMMUNE CELLS

PPP1R2 is part of cluster 36 Eosinophils - Protein ubiquitination with confidenceⁱ 0.35
179 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RWDD3	RWD domain containing 3	0.9762	36
ZNF174	Zinc finger protein 174	0.9524	36
MRPL32	Mitochondrial ribosomal protein L32	0.9524	22
SMIM8	Small integral membrane protein 8	0.9524	36
CHRNB1	Cholinergic receptor nicotinic beta 1 subunit	0.9524	36
NDFIP2	Nedd4 family interacting protein 2	0.9286	36
RPP21	Ribonuclease P/MRP subunit p21	0.9286	36
SMIM11	Small integral membrane protein 11	0.9286	3
DDX28	DEAD-box helicase 28	0.9286	3
DPY30	Dpy-30 histone methyltransferase complex regulatory subunit	0.9286	36
ANKRD55	Ankyrin repeat domain 55	0.9286	36
BBLN	Bublin coiled coil protein	0.9286	36
KBTBD3	Kelch repeat and BTB domain containing 3	0.9286	36
SHLD3	Shieldin complex subunit 3	0.9048	19
ACSM3	Acyl-CoA synthetase medium chain family member 3	0.9048	36

Adipocytes	106.0 nTPM
Adipose tissue	127.1 nTPM
Breast	84.9 nTPM

Alveolar cells type 1	34.9 nTPM
Lung	34.9 nTPM

Alveolar cells type 2	42.3 nTPM
Lung	42.3 nTPM

Astrocytes	12.4 nTPM
Brain	12.4 nTPM

B-cells	153.2 nTPM
Adipose tissue	239.9 nTPM
Skin	182.9 nTPM
Lymph node	181.0 nTPM
Lung	179.7 nTPM
Spleen	157.9 nTPM
Stomach	154.8 nTPM
Liver	149.7 nTPM
Esophagus	147.5 nTPM
Bone marrow	138.8 nTPM
Kidney	124.8 nTPM
PBMC	118.5 nTPM
Thymus	110.5 nTPM
Salivary gland	106.0 nTPM

Ciliated cells	93.1 nTPM
Endometrium	119.6 nTPM
Fallopian tube	99.9 nTPM
Lung	80.8 nTPM
Bronchus	72.1 nTPM

Club cells	62.3 nTPM
Prostate	72.8 nTPM
Bronchus	59.7 nTPM
Lung	54.5 nTPM

Dendritic cells	208.0 nTPM
Adipose tissue	286.4 nTPM
PBMC	129.5 nTPM

Endothelial cells	89.1 nTPM
Breast	310.2 nTPM
Skin	142.7 nTPM
Esophagus	135.3 nTPM
Fallopian tube	102.1 nTPM
Skeletal muscle	92.8 nTPM
Salivary gland	85.8 nTPM
Prostate	76.2 nTPM
Thymus	73.5 nTPM
Lung	70.2 nTPM
Testis	69.6 nTPM
Ovary	65.9 nTPM
Heart muscle	65.0 nTPM
Tongue	63.9 nTPM
Vascular	63.9 nTPM
Pancreas	59.5 nTPM
Endometrium	56.4 nTPM
Placenta	42.6 nTPM
Liver	27.7 nTPM

Enteroendocrine cells	64.0 nTPM
Small intestine	85.8 nTPM
Colon	59.2 nTPM
Rectum	47.0 nTPM

Fibroblasts	58.6 nTPM
Fallopian tube	87.7 nTPM
Stomach	76.4 nTPM
Prostate	71.3 nTPM
Esophagus	64.7 nTPM
Adipose tissue	64.3 nTPM
Skin	64.2 nTPM
Heart muscle	63.5 nTPM
Pancreas	61.2 nTPM
Salivary gland	53.0 nTPM
Vascular	52.1 nTPM
Breast	51.3 nTPM
Thymus	50.2 nTPM
Liver	49.8 nTPM
Skeletal muscle	46.4 nTPM
Lung	41.7 nTPM
Placenta	39.3 nTPM

Granulocytes	102.3 nTPM
Fallopian tube	127.4 nTPM
Lung	92.3 nTPM
Tongue	87.3 nTPM

Intestinal goblet cells	47.5 nTPM
Colon	51.7 nTPM
Small intestine	46.6 nTPM
Rectum	44.3 nTPM

Lymphatic endothelial cells	332.2 nTPM
Fallopian tube	424.3 nTPM
Ovary	240.0 nTPM

Macrophages	99.3 nTPM
Adipose tissue	158.4 nTPM
Fallopian tube	145.1 nTPM
Lung	131.5 nTPM
Endometrium	125.5 nTPM
Stomach	108.0 nTPM
Esophagus	106.6 nTPM
Skin	104.7 nTPM
Kidney	103.5 nTPM
Breast	96.6 nTPM
Spleen	95.2 nTPM
Tongue	91.5 nTPM
Bone marrow	91.2 nTPM
Skeletal muscle	90.0 nTPM
Prostate	85.8 nTPM
Testis	75.0 nTPM
Vascular	74.2 nTPM
Salivary gland	71.9 nTPM
Pancreas	67.8 nTPM
Thymus	64.0 nTPM

Basal keratinocytes	71.4 nTPM
Skin	88.2 nTPM
Tongue	54.7 nTPM

Basal prostatic cells	76.7 nTPM
Prostate	76.7 nTPM

Basal respiratory cells	66.6 nTPM
Bronchus	66.6 nTPM

Basal squamous epithelial cells	80.7 nTPM
Esophagus	80.7 nTPM

Paneth cells	58.1 nTPM
Small intestine	65.6 nTPM
Rectum	58.0 nTPM
Colon	50.7 nTPM

Plasma cells	159.7 nTPM
Stomach	236.6 nTPM
Spleen	204.5 nTPM
Salivary gland	164.7 nTPM
Fallopian tube	155.4 nTPM
Esophagus	150.7 nTPM
Thymus	139.4 nTPM
Bone marrow	123.8 nTPM
Liver	102.6 nTPM

Schwann cells	86.4 nTPM
Adipose tissue	195.6 nTPM
Vascular	39.7 nTPM
Esophagus	24.0 nTPM

Serous glandular cells	28.8 nTPM
Salivary gland	44.2 nTPM
Tongue	13.3 nTPM

Smooth muscle cells	63.4 nTPM
Skeletal muscle	86.4 nTPM
Fallopian tube	80.5 nTPM
Esophagus	78.1 nTPM
Lung	74.1 nTPM
Vascular	69.9 nTPM
Skin	66.8 nTPM
Endometrium	62.4 nTPM
Adipose tissue	61.9 nTPM
Breast	58.4 nTPM
Thymus	58.2 nTPM
Prostate	57.8 nTPM
Ovary	55.6 nTPM
Tongue	53.9 nTPM
Salivary gland	52.2 nTPM
Liver	48.8 nTPM
Placenta	48.8 nTPM

Suprabasal keratinocytes	83.6 nTPM
Tongue	95.3 nTPM
Skin	71.9 nTPM

T-cells	241.4 nTPM
Adipose tissue	491.0 nTPM
Prostate	349.1 nTPM
Esophagus	348.0 nTPM
Lymph node	345.4 nTPM
Skin	329.4 nTPM
Fallopian tube	322.5 nTPM
Thymus	264.2 nTPM
Spleen	263.9 nTPM
Stomach	238.3 nTPM
Salivary gland	224.3 nTPM
Tongue	221.4 nTPM
Lung	212.5 nTPM
Breast	209.2 nTPM
PBMC	187.2 nTPM
Colon	183.3 nTPM
Kidney	160.5 nTPM
Skeletal muscle	158.4 nTPM
Endometrium	158.3 nTPM
Bone marrow	141.0 nTPM
Vascular	134.3 nTPM
Liver	127.1 nTPM

Undifferentiated cells	53.3 nTPM
Small intestine	56.6 nTPM
Colon	54.9 nTPM
Rectum	48.3 nTPM

Amygdala excitatory	47.8 nTPM
Basal ganglia	49.6 nTPM
Hypothalamus	48.9 nTPM
Cerebral cortex	48.6 nTPM
Amygdala	47.5 nTPM
Thalamus	46.7 nTPM
Hippocampus	45.7 nTPM

Astrocyte	25.9 nTPM
Cerebral cortex	29.3 nTPM
Hypothalamus	29.1 nTPM
Hippocampus	28.5 nTPM
Basal ganglia	27.5 nTPM
Amygdala	27.4 nTPM
Thalamus	27.3 nTPM
Midbrain	25.6 nTPM
Cerebellum	25.1 nTPM
Pons	23.5 nTPM
Medulla oblongata	23.3 nTPM
Spinal cord	18.3 nTPM

Bergmann glia	29.6 nTPM
Cerebellum	33.0 nTPM
Medulla oblongata	29.8 nTPM
Pons	25.9 nTPM

Central nervous system macrophage	81.3 nTPM
Hypothalamus	91.3 nTPM
Medulla oblongata	85.1 nTPM
Amygdala	84.0 nTPM
Basal ganglia	81.5 nTPM
Spinal cord	81.5 nTPM
Hippocampus	80.6 nTPM
Midbrain	80.0 nTPM
Thalamus	79.3 nTPM
Cerebellum	77.5 nTPM
Pons	77.3 nTPM
Cerebral cortex	75.9 nTPM

Cerebellar inhibitory	59.7 nTPM
Spinal cord	77.0 nTPM
Cerebellum	63.2 nTPM
Medulla oblongata	56.5 nTPM
Midbrain	53.8 nTPM
Pons	48.1 nTPM

Cge interneuron	82.4 nTPM
Thalamus	115.9 nTPM
Midbrain	94.6 nTPM
Amygdala	76.2 nTPM
Basal ganglia	75.4 nTPM
Hippocampus	75.0 nTPM
Cerebral cortex	71.5 nTPM
Hypothalamus	67.9 nTPM

Choroid plexus epithelial cell	39.7 nTPM
Basal ganglia	51.7 nTPM
Hippocampus	41.6 nTPM
Medulla oblongata	40.8 nTPM
Thalamus	24.7 nTPM

Committed oligodendrocyte precursor	26.4 nTPM
Hypothalamus	35.5 nTPM
Thalamus	29.5 nTPM
Amygdala	29.3 nTPM
Medulla oblongata	28.4 nTPM
Midbrain	27.7 nTPM
Hippocampus	25.9 nTPM
Spinal cord	25.8 nTPM
Pons	25.7 nTPM
Basal ganglia	24.6 nTPM
Cerebral cortex	24.1 nTPM
Cerebellum	14.3 nTPM

Deep-layer corticothalamic and 6b	52.2 nTPM
Midbrain	73.2 nTPM
Basal ganglia	55.4 nTPM
Cerebral cortex	52.8 nTPM
Amygdala	45.8 nTPM
Hippocampus	43.9 nTPM
Hypothalamus	42.3 nTPM

Deep-layer intratelencephalic	44.5 nTPM
Basal ganglia	47.9 nTPM
Cerebral cortex	46.4 nTPM
Hippocampus	43.8 nTPM
Amygdala	42.5 nTPM
Hypothalamus	42.2 nTPM

Deep-layer near-projecting	49.8 nTPM
Hippocampus	59.5 nTPM
Cerebral cortex	51.6 nTPM
Basal ganglia	50.4 nTPM
Amygdala	45.0 nTPM
Hypothalamus	42.8 nTPM

Eccentric medium spiny neuron	63.0 nTPM
Basal ganglia	70.5 nTPM
Hypothalamus	68.0 nTPM
Cerebral cortex	67.0 nTPM
Amygdala	60.0 nTPM
Thalamus	59.7 nTPM
Hippocampus	52.6 nTPM