Single cell type - FBXL7 - The Human Protein Atlas

FBXL7

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FBXL7
Gene descriptionⁱ Full gene name according to HGNC.	F-box and leucine rich repeat protein 7
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neurons - Synaptic function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Astrocytes, Oligodendrocytes, Oligodendrocyte precursor cells, Inhibitory neurons)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.82
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Astrocyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Group enriched (Astrocytes, Oligodendrocytes, Oligodendrocyte precursor cells, Inhibitory neurons)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Astrocyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

FBXL7 is part of cluster 65 Neurons - Synaptic function with confidenceⁱ 1
250 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CTXND1	Cortexin domain containing 1	0.8719	65
SLC6A1	Solute carrier family 6 member 1	0.8415	65
EYA4	EYA transcriptional coactivator and phosphatase 4	0.8104	65
CPLX3	Complexin 3	0.8039	65
ALK	ALK receptor tyrosine kinase	0.7969	65
TRPC3	Transient receptor potential cation channel subfamily C member 3	0.7654	65
PRELID2	PRELI domain containing 2	0.7607	65
MYO16	Myosin XVI	0.7452	65
FGF13	Fibroblast growth factor 13	0.7429	65
TACR1	Tachykinin receptor 1	0.7380	65
NTNG1	Netrin G1	0.7203	65
WWOX	WW domain containing oxidoreductase	0.7098	76
KCNIP1	Potassium voltage-gated channel interacting protein 1	0.7035	65
TPTEP2-CSNK1E	TPTEP2-CSNK1E readthrough	0.7012	47
LSAMP	Limbic system associated membrane protein	0.6989	47

Adipocytes	20.0 nTPM
Adipose tissue	25.5 nTPM
Breast	14.4 nTPM

Alveolar cells type 1	1.4 nTPM
Lung	1.4 nTPM

Alveolar cells type 2	1.0 nTPM
Lung	1.0 nTPM

B-cells	0.4 nTPM
Skin	3.4 nTPM
Thymus	1.1 nTPM
Salivary gland	0.6 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM

Basal keratinocytes	1.2 nTPM
Tongue	1.3 nTPM
Skin	1.0 nTPM

Ciliated cells	2.3 nTPM
Bronchus	4.7 nTPM
Fallopian tube	1.8 nTPM
Endometrium	1.4 nTPM
Lung	1.1 nTPM

Club cells	2.7 nTPM
Prostate	3.1 nTPM
Bronchus	2.5 nTPM
Lung	2.4 nTPM

Endothelial cells	15.6 nTPM
Skin	23.6 nTPM
Breast	22.8 nTPM
Liver	22.7 nTPM
Salivary gland	20.4 nTPM
Placenta	19.3 nTPM
Skeletal muscle	18.4 nTPM
Thymus	18.4 nTPM
Testis	18.0 nTPM
Lung	14.9 nTPM
Prostate	13.7 nTPM
Endometrium	13.5 nTPM
Vascular	13.3 nTPM
Heart muscle	12.2 nTPM
Esophagus	11.7 nTPM
Tongue	11.6 nTPM
Fallopian tube	9.5 nTPM
Ovary	9.5 nTPM
Pancreas	7.8 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	19.3 nTPM
Salivary gland	41.8 nTPM
Thymus	33.8 nTPM
Adipose tissue	30.9 nTPM
Prostate	27.1 nTPM
Skeletal muscle	24.4 nTPM
Vascular	22.7 nTPM
Liver	21.3 nTPM
Heart muscle	18.8 nTPM
Fallopian tube	17.4 nTPM
Breast	16.8 nTPM
Esophagus	14.6 nTPM
Skin	12.4 nTPM
Stomach	10.1 nTPM
Placenta	8.1 nTPM
Pancreas	4.5 nTPM
Lung	4.4 nTPM

Granulocytes	0.1 nTPM
Fallopian tube	0.4 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	16.2 nTPM
Fallopian tube	21.5 nTPM
Ovary	10.9 nTPM

Macrophages	0.5 nTPM
Vascular	2.3 nTPM
Thymus	2.1 nTPM
Skeletal muscle	1.3 nTPM
Testis	1.2 nTPM
Endometrium	1.2 nTPM
Fallopian tube	0.5 nTPM
Prostate	0.3 nTPM
Tongue	0.3 nTPM
Breast	0.2 nTPM
Adipose tissue	0.1 nTPM
Salivary gland	0.1 nTPM
Kidney	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Astrocytes	925.8 nTPM
Brain	925.8 nTPM

Bipolar cells	4.0 nTPM
Eye	4.0 nTPM

Endometrial stromal cells	11.5 nTPM
Endometrium	11.5 nTPM

Excitatory neurons	3.5 nTPM
Brain	3.5 nTPM

Plasma cells	1.1 nTPM
Esophagus	5.2 nTPM
Thymus	1.7 nTPM
Fallopian tube	1.3 nTPM
Salivary gland	0.4 nTPM
Liver	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Schwann cells	3.5 nTPM
Vascular	10.4 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	1.1 nTPM
Salivary gland	2.3 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	9.9 nTPM
Liver	22.5 nTPM
Tongue	18.3 nTPM
Thymus	14.4 nTPM
Vascular	13.9 nTPM
Skeletal muscle	9.2 nTPM
Salivary gland	8.4 nTPM
Fallopian tube	8.3 nTPM
Endometrium	8.1 nTPM
Ovary	7.7 nTPM
Adipose tissue	7.6 nTPM
Esophagus	7.2 nTPM
Placenta	7.0 nTPM
Prostate	6.7 nTPM
Skin	6.5 nTPM
Breast	6.1 nTPM
Lung	5.9 nTPM

T-cells	0.3 nTPM
Endometrium	1.4 nTPM
Skin	1.4 nTPM
Skeletal muscle	1.1 nTPM
Vascular	0.8 nTPM
Salivary gland	0.7 nTPM
Fallopian tube	0.4 nTPM
Lung	0.3 nTPM
Breast	0.3 nTPM
Lymph node	0.2 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Prostate	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM

Undifferentiated cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Amygdala excitatory	11.5 nTPM
Thalamus	26.8 nTPM
Basal ganglia	18.4 nTPM
Cerebral cortex	8.2 nTPM
Amygdala	7.7 nTPM
Hippocampus	4.0 nTPM
Hypothalamus	3.7 nTPM

Astrocyte	1466.4 nTPM
Amygdala	2537.9 nTPM
Hippocampus	2247.7 nTPM
Cerebral cortex	1890.4 nTPM
Basal ganglia	1694.1 nTPM
Hypothalamus	1308.3 nTPM
Thalamus	1241.5 nTPM
Spinal cord	1207.7 nTPM
Cerebellum	1152.6 nTPM
Midbrain	1011.3 nTPM
Pons	1010.3 nTPM
Medulla oblongata	828.5 nTPM

Bergmann glia	272.5 nTPM
Cerebellum	288.0 nTPM
Medulla oblongata	283.4 nTPM
Pons	246.0 nTPM

Central nervous system macrophage	11.1 nTPM
Spinal cord	18.3 nTPM
Hippocampus	17.7 nTPM
Amygdala	14.7 nTPM
Cerebellum	12.7 nTPM
Midbrain	11.8 nTPM
Basal ganglia	9.8 nTPM
Medulla oblongata	8.2 nTPM
Thalamus	8.0 nTPM
Cerebral cortex	7.6 nTPM
Pons	6.6 nTPM
Hypothalamus	6.5 nTPM

Cerebellar inhibitory	7.8 nTPM
Medulla oblongata	14.0 nTPM
Midbrain	9.0 nTPM
Pons	6.9 nTPM
Cerebellum	6.3 nTPM
Spinal cord	2.7 nTPM

Cge interneuron	591.2 nTPM
Thalamus	1077.9 nTPM
Midbrain	671.0 nTPM
Amygdala	655.0 nTPM
Hypothalamus	509.1 nTPM
Basal ganglia	456.8 nTPM
Cerebral cortex	427.5 nTPM
Hippocampus	341.1 nTPM

Choroid plexus epithelial cell	1244.8 nTPM
Basal ganglia	1870.7 nTPM
Medulla oblongata	1254.0 nTPM
Thalamus	983.8 nTPM
Hippocampus	870.8 nTPM

Committed oligodendrocyte precursor	625.5 nTPM
Hypothalamus	949.1 nTPM
Amygdala	906.1 nTPM
Thalamus	867.2 nTPM
Hippocampus	615.2 nTPM
Cerebral cortex	602.9 nTPM
Basal ganglia	591.3 nTPM
Spinal cord	566.6 nTPM
Midbrain	504.0 nTPM
Cerebellum	469.3 nTPM
Pons	415.2 nTPM
Medulla oblongata	393.8 nTPM

Deep-layer corticothalamic and 6b	3.6 nTPM
Basal ganglia	5.0 nTPM
Amygdala	4.9 nTPM
Hypothalamus	4.3 nTPM
Hippocampus	3.4 nTPM
Cerebral cortex	2.7 nTPM
Midbrain	1.1 nTPM

Deep-layer intratelencephalic	4.3 nTPM
Basal ganglia	5.3 nTPM
Amygdala	5.2 nTPM
Hypothalamus	4.2 nTPM
Hippocampus	3.9 nTPM
Cerebral cortex	3.1 nTPM

Deep-layer near-projecting	2.1 nTPM
Hippocampus	3.3 nTPM
Hypothalamus	2.4 nTPM
Basal ganglia	2.0 nTPM
Cerebral cortex	2.0 nTPM
Amygdala	1.1 nTPM

Eccentric medium spiny neuron	23.3 nTPM
Amygdala	49.6 nTPM
Cerebral cortex	41.8 nTPM
Thalamus	20.5 nTPM
Basal ganglia	17.6 nTPM
Hypothalamus	9.3 nTPM
Hippocampus	0.8 nTPM

Endothelial cell	402.2 nTPM
Basal ganglia	836.1 nTPM
Hypothalamus	545.9 nTPM
Cerebellum	461.5 nTPM
Medulla oblongata	346.6 nTPM
Thalamus	346.2 nTPM
Cerebral cortex	332.4 nTPM
Midbrain	325.1 nTPM
Spinal cord	317.6 nTPM
Hippocampus	311.0 nTPM
Pons	305.2 nTPM
Amygdala	296.2 nTPM

Ependymal cell	703.2 nTPM
Basal ganglia	1054.6 nTPM
Amygdala	957.9 nTPM
Hippocampus	839.0 nTPM
Spinal cord	801.1 nTPM
Thalamus	634.1 nTPM
Hypothalamus	603.2 nTPM
Midbrain	516.2 nTPM
Medulla oblongata	477.9 nTPM
Pons	444.7 nTPM