Single cell type - SLC25A18 - The Human Protein Atlas

SLC25A18

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC25A18
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 25 member 18
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Metabolic proteins Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Astrocytes - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Astrocytes, Hepatocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.89
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enriched (Astrocyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Group enriched (Astrocytes, Hepatocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enriched (Astrocyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

SLC25A18 is part of cluster 47 Astrocytes - Unknown function with confidenceⁱ 1
196 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PRODH	Proline dehydrogenase 1	0.8489	47
PSD2	Pleckstrin and Sec7 domain containing 2	0.8473	47
NPFF	Neuropeptide FF-amide peptide precursor	0.8197	47
ADGRV1	Adhesion G protein-coupled receptor V1	0.8162	47
NTSR2	Neurotensin receptor 2	0.8156	47
GFAP	Glial fibrillary acidic protein	0.8146	47
PRSS50	Serine protease 50	0.8030	47
SLC1A2	Solute carrier family 1 member 2	0.8023	47
GPC5	Glypican 5	0.8021	47
SLCO1C1	Solute carrier organic anion transporter family member 1C1	0.8017	47
NCAN	Neurocan	0.7985	47
ZNRF3	Zinc and ring finger 3	0.7957	47
RANBP3L	RAN binding protein 3 like	0.7943	47
HEPACAM	Hepatic and glial cell adhesion molecule	0.7927	47
HPSE2	Heparanase 2 (inactive)	0.7833	47

Adipocytes	0.4 nTPM
Breast	0.9 nTPM
Adipose tissue	0.0 nTPM

Alveolar cells type 1	0.1 nTPM
Lung	0.1 nTPM

Alveolar cells type 2	0.1 nTPM
Lung	0.1 nTPM

B-cells	0.4 nTPM
Liver	4.8 nTPM
Salivary gland	0.1 nTPM
Thymus	0.1 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM

Basal keratinocytes	0.0 nTPM
Skin	0.0 nTPM
Tongue	0.0 nTPM

Ciliated cells	0.7 nTPM
Fallopian tube	2.1 nTPM
Bronchus	0.4 nTPM
Endometrium	0.3 nTPM
Lung	0.0 nTPM

Club cells	0.2 nTPM
Prostate	0.4 nTPM
Bronchus	0.3 nTPM
Lung	0.0 nTPM

Endothelial cells	0.7 nTPM
Liver	8.8 nTPM
Ovary	0.9 nTPM
Placenta	0.6 nTPM
Skin	0.6 nTPM
Tongue	0.5 nTPM
Lung	0.4 nTPM
Testis	0.3 nTPM
Prostate	0.3 nTPM
Endometrium	0.2 nTPM
Skeletal muscle	0.2 nTPM
Thymus	0.2 nTPM
Fallopian tube	0.2 nTPM
Vascular	0.1 nTPM
Heart muscle	0.0 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM
Salivary gland	0.0 nTPM
Breast	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	2.9 nTPM
Adipose tissue	11.0 nTPM
Salivary gland	7.1 nTPM
Fallopian tube	5.2 nTPM
Thymus	4.8 nTPM
Prostate	4.0 nTPM
Skeletal muscle	3.7 nTPM
Breast	3.4 nTPM
Heart muscle	2.5 nTPM
Stomach	1.4 nTPM
Liver	1.2 nTPM
Vascular	1.2 nTPM
Esophagus	0.8 nTPM
Skin	0.4 nTPM
Placenta	0.2 nTPM
Pancreas	0.0 nTPM
Lung	0.0 nTPM

Granulocytes	0.1 nTPM
Fallopian tube	0.2 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	0.2 nTPM
Small intestine	0.7 nTPM
Colon	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	0.1 nTPM
Fallopian tube	0.2 nTPM
Ovary	0.0 nTPM

Macrophages	0.2 nTPM
Testis	1.2 nTPM
Thymus	1.0 nTPM
Fallopian tube	0.5 nTPM
Adipose tissue	0.2 nTPM
Prostate	0.2 nTPM
Salivary gland	0.2 nTPM
Tongue	0.2 nTPM
Vascular	0.2 nTPM
Lung	0.1 nTPM
Breast	0.1 nTPM
Kidney	0.0 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	0.1 nTPM
Rectum	0.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Cholangiocytes	3.8 nTPM
Liver	3.8 nTPM

Excitatory neurons	1.9 nTPM
Brain	1.9 nTPM

Plasma cells	0.9 nTPM
Liver	6.0 nTPM
Fallopian tube	1.0 nTPM
Thymus	0.1 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM

Schwann cells	0.7 nTPM
Vascular	1.6 nTPM
Adipose tissue	0.4 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	0.8 nTPM
Salivary gland	1.6 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	2.1 nTPM
Adipose tissue	11.4 nTPM
Skeletal muscle	6.7 nTPM
Liver	4.2 nTPM
Salivary gland	2.4 nTPM
Thymus	2.1 nTPM
Tongue	1.5 nTPM
Lung	1.2 nTPM
Vascular	1.1 nTPM
Breast	1.0 nTPM
Fallopian tube	0.7 nTPM
Prostate	0.6 nTPM
Placenta	0.5 nTPM
Endometrium	0.5 nTPM
Ovary	0.5 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM

T-cells	0.3 nTPM
Liver	2.3 nTPM
Skeletal muscle	1.1 nTPM
Skin	0.7 nTPM
PBMC	0.4 nTPM
Endometrium	0.2 nTPM
Lymph node	0.2 nTPM
Salivary gland	0.2 nTPM
Tongue	0.2 nTPM
Adipose tissue	0.1 nTPM
Spleen	0.1 nTPM
Prostate	0.1 nTPM
Thymus	0.1 nTPM
Breast	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Vascular	0.0 nTPM
Fallopian tube	0.0 nTPM

Undifferentiated cells	0.1 nTPM
Small intestine	0.2 nTPM
Colon	0.0 nTPM
Rectum	0.0 nTPM

Amygdala excitatory	1.3 nTPM
Thalamus	2.7 nTPM
Amygdala	1.3 nTPM
Basal ganglia	1.3 nTPM
Cerebral cortex	0.9 nTPM
Hypothalamus	0.9 nTPM
Hippocampus	0.7 nTPM

Astrocyte	421.4 nTPM
Spinal cord	521.9 nTPM
Midbrain	467.1 nTPM
Pons	467.1 nTPM
Cerebral cortex	446.8 nTPM
Thalamus	437.5 nTPM
Hippocampus	427.7 nTPM
Cerebellum	395.5 nTPM
Amygdala	392.2 nTPM
Hypothalamus	387.6 nTPM
Basal ganglia	362.7 nTPM
Medulla oblongata	329.3 nTPM

Bergmann glia	104.1 nTPM
Cerebellum	115.2 nTPM
Medulla oblongata	110.8 nTPM
Pons	86.3 nTPM

Central nervous system macrophage	3.1 nTPM
Hippocampus	6.3 nTPM
Amygdala	4.3 nTPM
Basal ganglia	3.9 nTPM
Cerebellum	3.6 nTPM
Cerebral cortex	3.5 nTPM
Midbrain	3.0 nTPM
Spinal cord	2.9 nTPM
Pons	1.9 nTPM
Medulla oblongata	1.5 nTPM
Thalamus	1.4 nTPM
Hypothalamus	1.3 nTPM

Cerebellar inhibitory	1.8 nTPM
Medulla oblongata	2.8 nTPM
Cerebellum	2.2 nTPM
Pons	2.1 nTPM
Midbrain	1.9 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	2.0 nTPM
Cerebral cortex	2.7 nTPM
Hippocampus	2.5 nTPM
Hypothalamus	2.3 nTPM
Amygdala	2.0 nTPM
Basal ganglia	1.8 nTPM
Thalamus	1.2 nTPM
Midbrain	1.1 nTPM

Choroid plexus epithelial cell	35.0 nTPM
Medulla oblongata	50.4 nTPM
Hippocampus	38.8 nTPM
Thalamus	27.4 nTPM
Basal ganglia	23.5 nTPM

Committed oligodendrocyte precursor	10.2 nTPM
Basal ganglia	14.8 nTPM
Hippocampus	12.9 nTPM
Cerebral cortex	12.7 nTPM
Amygdala	11.3 nTPM
Cerebellum	11.1 nTPM
Spinal cord	11.0 nTPM
Thalamus	8.8 nTPM
Medulla oblongata	7.7 nTPM
Midbrain	7.6 nTPM
Pons	7.1 nTPM
Hypothalamus	6.8 nTPM

Deep-layer corticothalamic and 6b	1.2 nTPM
Hypothalamus	1.5 nTPM
Hippocampus	1.4 nTPM
Basal ganglia	1.2 nTPM
Midbrain	1.1 nTPM
Cerebral cortex	0.9 nTPM
Amygdala	0.8 nTPM

Deep-layer intratelencephalic	1.3 nTPM
Basal ganglia	2.0 nTPM
Cerebral cortex	1.6 nTPM
Amygdala	1.4 nTPM
Hippocampus	0.9 nTPM
Hypothalamus	0.7 nTPM

Deep-layer near-projecting	2.1 nTPM
Hippocampus	5.5 nTPM
Cerebral cortex	1.7 nTPM
Amygdala	1.4 nTPM
Hypothalamus	1.3 nTPM
Basal ganglia	0.7 nTPM

Eccentric medium spiny neuron	0.9 nTPM
Cerebral cortex	1.1 nTPM
Thalamus	1.0 nTPM
Amygdala	0.9 nTPM
Basal ganglia	0.9 nTPM
Hypothalamus	0.9 nTPM
Hippocampus	0.8 nTPM

Endothelial cell	2.8 nTPM
Cerebral cortex	5.8 nTPM
Hippocampus	5.1 nTPM
Basal ganglia	4.7 nTPM
Spinal cord	3.5 nTPM
Medulla oblongata	3.1 nTPM
Cerebellum	2.3 nTPM
Thalamus	2.3 nTPM
Hypothalamus	1.2 nTPM
Pons	1.2 nTPM
Amygdala	1.1 nTPM
Midbrain	0.0 nTPM

Ependymal cell	19.6 nTPM
Hippocampus	29.6 nTPM
Amygdala	29.0 nTPM
Basal ganglia	19.3 nTPM
Medulla oblongata	19.1 nTPM
Midbrain	17.8 nTPM
Thalamus	17.4 nTPM
Hypothalamus	17.0 nTPM
Pons	14.1 nTPM
Spinal cord	13.4 nTPM