Single cell type - SNORC - The Human Protein Atlas

SNORC

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SNORC
Gene descriptionⁱ Full gene name according to HGNC.	Secondary ossification center associated regulator of chondrocyte maturation
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Breast glandular cells - Lactation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Breast glandular cells, Breast myoepithelial cells, Melanocytes, Intestinal goblet cells, Distal enterocytes, Hepatocytes, Undifferentiated cells, Muller glia cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.76
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Astrocyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enriched (basophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Breast glandular cells, Breast myoepithelial cells, Melanocytes, Intestinal goblet cells, Distal enterocytes, Hepatocytes, Undifferentiated cells, Muller glia cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Astrocyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enriched (basophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

SNORC is part of cluster 17 Breast glandular cells - Lactation with confidenceⁱ 1
115 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SYCE1L	Synaptonemal complex central element protein 1 like	0.6388	17
OBP2B	Odorant binding protein 2B	0.6326	17
IL22RA2	Interleukin 22 receptor subunit alpha 2	0.5510	17
CRACR2B	Calcium release activated channel regulator 2B	0.5436	75
EPHB3	EPH receptor B3	0.5391	12
SCGB2A2	Secretoglobin family 2A member 2	0.5350	17
CDC42EP5	CDC42 effector protein 5	0.5280	16
UGT2B11	UDP glucuronosyltransferase family 2 member B11	0.5253	17
MESP1	Mesoderm posterior bHLH transcription factor 1	0.5141	40
MUCL1	Mucin like 1	0.5084	17
IRX1	Iroquois homeobox 1	0.5025	17
RPL41	Ribosomal protein L41	0.4988	64
C9orf152	Chromosome 9 open reading frame 152	0.4946	16
RPS18	Ribosomal protein S18	0.4933	64
FOXI1	Forkhead box I1	0.4925	39

Adipocytes	14.9 nTPM
Breast	29.8 nTPM
Adipose tissue	0.0 nTPM

Alveolar cells type 1	0.2 nTPM
Lung	0.2 nTPM

Alveolar cells type 2	0.3 nTPM
Lung	0.3 nTPM

Astrocytes	23.8 nTPM
Brain	23.8 nTPM

B-cells	0.2 nTPM
Skin	1.7 nTPM
Lymph node	0.3 nTPM
Salivary gland	0.3 nTPM
Thymus	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM

Ciliated cells	4.4 nTPM
Bronchus	12.0 nTPM
Endometrium	3.8 nTPM
Lung	1.3 nTPM
Fallopian tube	0.5 nTPM

Club cells	1.5 nTPM
Bronchus	2.4 nTPM
Prostate	1.7 nTPM
Lung	0.4 nTPM

Endothelial cells	1.8 nTPM
Liver	20.2 nTPM
Breast	8.8 nTPM
Skin	0.6 nTPM
Endometrium	0.5 nTPM
Lung	0.4 nTPM
Skeletal muscle	0.3 nTPM
Tongue	0.3 nTPM
Prostate	0.2 nTPM
Salivary gland	0.2 nTPM
Thymus	0.2 nTPM
Fallopian tube	0.2 nTPM
Ovary	0.2 nTPM
Heart muscle	0.1 nTPM
Vascular	0.1 nTPM
Testis	0.0 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM

Enteroendocrine cells	43.6 nTPM
Colon	100.4 nTPM
Rectum	16.8 nTPM
Small intestine	13.7 nTPM

Fibroblasts	1.5 nTPM
Breast	10.5 nTPM
Liver	5.9 nTPM
Placenta	1.9 nTPM
Heart muscle	1.5 nTPM
Stomach	1.4 nTPM
Thymus	1.3 nTPM
Skin	0.5 nTPM
Vascular	0.5 nTPM
Adipose tissue	0.3 nTPM
Fallopian tube	0.2 nTPM
Pancreas	0.1 nTPM
Skeletal muscle	0.1 nTPM
Salivary gland	0.1 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM

Granulocytes	0.0 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM
Fallopian tube	0.0 nTPM

Intestinal goblet cells	129.9 nTPM
Rectum	186.6 nTPM
Colon	176.2 nTPM
Small intestine	26.9 nTPM

Lymphatic endothelial cells	0.0 nTPM
Fallopian tube	0.1 nTPM
Ovary	0.0 nTPM

Macrophages	1.1 nTPM
Breast	11.0 nTPM
Skin	2.2 nTPM
Kidney	1.8 nTPM
Bone marrow	1.0 nTPM
Spleen	1.0 nTPM
Tongue	0.9 nTPM
Testis	0.6 nTPM
Salivary gland	0.4 nTPM
Vascular	0.3 nTPM
Fallopian tube	0.3 nTPM
Adipose tissue	0.2 nTPM
Lung	0.1 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM
Stomach	0.0 nTPM
Prostate	0.0 nTPM
Thymus	0.0 nTPM

Paneth cells	69.6 nTPM
Rectum	112.4 nTPM
Colon	68.8 nTPM
Small intestine	27.6 nTPM

Cholangiocytes	5.7 nTPM
Liver	5.7 nTPM

Early spermatids	12.4 nTPM
Testis	12.4 nTPM

Excitatory neurons	3.3 nTPM
Brain	3.3 nTPM

Plasma cells	1.0 nTPM
Liver	6.0 nTPM
Salivary gland	0.9 nTPM
Spleen	0.7 nTPM
Thymus	0.3 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM
Fallopian tube	0.0 nTPM

Schwann cells	18.4 nTPM
Vascular	54.8 nTPM
Adipose tissue	0.4 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	0.5 nTPM
Salivary gland	1.0 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	1.2 nTPM
Breast	9.4 nTPM
Skin	5.2 nTPM
Liver	1.3 nTPM
Prostate	0.6 nTPM
Fallopian tube	0.6 nTPM
Vascular	0.4 nTPM
Thymus	0.3 nTPM
Tongue	0.3 nTPM
Ovary	0.3 nTPM
Placenta	0.2 nTPM
Endometrium	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Salivary gland	0.0 nTPM

T-cells	2.3 nTPM
Breast	32.2 nTPM
Colon	5.8 nTPM
Liver	3.9 nTPM
Skin	2.8 nTPM
Endometrium	1.0 nTPM
Vascular	0.8 nTPM
Skeletal muscle	0.4 nTPM
Stomach	0.4 nTPM
Prostate	0.4 nTPM
Tongue	0.4 nTPM
Fallopian tube	0.3 nTPM
Adipose tissue	0.2 nTPM
Lymph node	0.2 nTPM
Salivary gland	0.2 nTPM
Thymus	0.2 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Lung	0.0 nTPM

Undifferentiated cells	107.4 nTPM
Rectum	125.9 nTPM
Small intestine	116.7 nTPM
Colon	79.7 nTPM

Amygdala excitatory	20.4 nTPM
Hypothalamus	22.3 nTPM
Amygdala	21.9 nTPM
Hippocampus	21.4 nTPM
Basal ganglia	19.5 nTPM
Thalamus	19.1 nTPM
Cerebral cortex	18.5 nTPM

Astrocyte	87.0 nTPM
Pons	155.5 nTPM
Spinal cord	119.0 nTPM
Cerebellum	112.8 nTPM
Medulla oblongata	111.2 nTPM
Hippocampus	83.9 nTPM
Thalamus	82.1 nTPM
Midbrain	78.5 nTPM
Basal ganglia	73.5 nTPM
Cerebral cortex	58.5 nTPM
Hypothalamus	56.5 nTPM
Amygdala	25.1 nTPM

Bergmann glia	18.9 nTPM
Medulla oblongata	27.7 nTPM
Cerebellum	14.7 nTPM
Pons	14.4 nTPM

Central nervous system macrophage	9.4 nTPM
Spinal cord	15.3 nTPM
Basal ganglia	10.9 nTPM
Midbrain	10.8 nTPM
Medulla oblongata	10.2 nTPM
Cerebellum	9.6 nTPM
Pons	9.3 nTPM
Hippocampus	9.1 nTPM
Amygdala	7.6 nTPM
Thalamus	7.0 nTPM
Hypothalamus	6.9 nTPM
Cerebral cortex	6.4 nTPM

Cerebellar inhibitory	13.9 nTPM
Medulla oblongata	18.2 nTPM
Midbrain	16.5 nTPM
Pons	15.5 nTPM
Cerebellum	13.8 nTPM
Spinal cord	5.5 nTPM

Cge interneuron	17.6 nTPM
Thalamus	22.3 nTPM
Hypothalamus	20.5 nTPM
Midbrain	19.0 nTPM
Amygdala	16.4 nTPM
Hippocampus	15.5 nTPM
Cerebral cortex	14.9 nTPM
Basal ganglia	14.8 nTPM

Choroid plexus epithelial cell	11.2 nTPM
Thalamus	19.2 nTPM
Medulla oblongata	10.1 nTPM
Basal ganglia	10.0 nTPM
Hippocampus	5.5 nTPM

Committed oligodendrocyte precursor	20.9 nTPM
Cerebellum	42.8 nTPM
Medulla oblongata	27.1 nTPM
Midbrain	25.2 nTPM
Basal ganglia	23.0 nTPM
Hippocampus	20.7 nTPM
Pons	20.4 nTPM
Amygdala	15.2 nTPM
Spinal cord	14.7 nTPM
Thalamus	14.6 nTPM
Cerebral cortex	13.3 nTPM
Hypothalamus	13.0 nTPM

Deep-layer corticothalamic and 6b	25.5 nTPM
Midbrain	31.1 nTPM
Basal ganglia	26.2 nTPM
Hypothalamus	26.0 nTPM
Amygdala	25.7 nTPM
Cerebral cortex	24.0 nTPM
Hippocampus	19.9 nTPM

Deep-layer intratelencephalic	17.0 nTPM
Hypothalamus	19.3 nTPM
Amygdala	19.2 nTPM
Hippocampus	17.5 nTPM
Basal ganglia	14.6 nTPM
Cerebral cortex	14.4 nTPM

Deep-layer near-projecting	15.1 nTPM
Amygdala	17.1 nTPM
Hypothalamus	15.6 nTPM
Basal ganglia	15.5 nTPM
Hippocampus	14.0 nTPM
Cerebral cortex	13.4 nTPM

Eccentric medium spiny neuron	17.2 nTPM
Thalamus	18.0 nTPM
Basal ganglia	17.6 nTPM
Hippocampus	17.4 nTPM
Cerebral cortex	17.2 nTPM
Amygdala	17.1 nTPM
Hypothalamus	16.2 nTPM

Endothelial cell	6.9 nTPM
Spinal cord	20.7 nTPM
Hypothalamus	12.4 nTPM
Pons	6.2 nTPM
Hippocampus	6.1 nTPM
Basal ganglia	5.6 nTPM
Thalamus	5.6 nTPM
Midbrain	4.7 nTPM
Amygdala	4.5 nTPM
Cerebral cortex	4.5 nTPM
Medulla oblongata	4.1 nTPM
Cerebellum	1.5 nTPM

Ependymal cell	12.7 nTPM
Amygdala	17.6 nTPM
Thalamus	15.4 nTPM
Pons	14.9 nTPM
Hippocampus	12.8 nTPM
Medulla oblongata	12.5 nTPM
Midbrain	12.1 nTPM
Hypothalamus	10.7 nTPM
Spinal cord	9.6 nTPM
Basal ganglia	9.0 nTPM