Single cell type - TMEM64 - The Human Protein Atlas

TMEM64

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMEM64
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane protein 64
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Fibroblasts - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Hepatocytes, Leydig cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.43
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Hepatocytes, Leydig cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TMEM64 is part of cluster 53 Fibroblasts - ECM organization with confidenceⁱ 1
305 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ISM1	Isthmin 1	0.4573	53
MAP1LC3C	Microtubule associated protein 1 light chain 3 gamma	0.4516	53
LRRC58	Leucine rich repeat containing 58	0.4479	39
CERS2	Ceramide synthase 2	0.4460	62
ELF1	E74 like ETS transcription factor 1	0.4449	78
FST	Follistatin	0.4404	53
KRTAP13-4	Keratin associated protein 13-4	0.4341	53
AKIRIN2	Akirin 2	0.4280	78
SMIM3	Small integral membrane protein 3	0.4270	57
CD99	CD99 molecule (Xg blood group)	0.4269	53
KDSR	3-ketodihydrosphingosine reductase	0.4248	53
PRR7	Proline rich 7, synaptic	0.4239	57
GSC	Goosecoid homeobox	0.4232	53
CXCL12	C-X-C motif chemokine ligand 12	0.4231	53
PCYOX1	Prenylcysteine oxidase 1	0.4208	75

IMMUNE CELLS

TMEM64 is part of cluster 24 Non-specific - Transcription with confidenceⁱ 0.86
516 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PWP2	PWP2 small subunit processome component	1.0000	24
EPHA4	EPH receptor A4	1.0000	24
PHLDB2	Pleckstrin homology like domain family B member 2	1.0000	24
ZNF266	Zinc finger protein 266	0.9762	3
KCTD7	Potassium channel tetramerization domain containing 7	0.9762	3
TRDV2	T cell receptor delta variable 2	0.9762	15
NCR3	Natural cytotoxicity triggering receptor 3	0.9762	24
STK39	Serine/threonine kinase 39	0.9762	15
ZNF485	Zinc finger protein 485	0.9762	24
NUGGC	Nuclear GTPase, germinal center associated	0.9762	24
ZFP69	ZFP69 zinc finger protein	0.9762	24
LHFPL1	LHFPL tetraspan subfamily member 1	0.9762	15
DMKN	Dermokine	0.9762	15
TMEM117	Transmembrane protein 117	0.9762	24
CAPRIN2	Caprin family member 2	0.9762	24

Adipocytes	15.6 nTPM
Adipose tissue	25.3 nTPM
Breast	5.9 nTPM

Alveolar cells type 1	20.3 nTPM
Lung	20.3 nTPM

Alveolar cells type 2	28.1 nTPM
Lung	28.1 nTPM

Astrocytes	5.0 nTPM
Brain	5.0 nTPM

B-cells	15.1 nTPM
Spleen	26.0 nTPM
Adipose tissue	24.7 nTPM
Lymph node	19.1 nTPM
Bone marrow	18.5 nTPM
Thymus	16.6 nTPM
Kidney	15.6 nTPM
Liver	14.5 nTPM
Lung	12.1 nTPM
Esophagus	11.8 nTPM
Salivary gland	11.5 nTPM
Stomach	9.3 nTPM
Skin	8.5 nTPM
PBMC	7.7 nTPM

Ciliated cells	3.5 nTPM
Fallopian tube	6.0 nTPM
Bronchus	2.9 nTPM
Endometrium	2.7 nTPM
Lung	2.6 nTPM

Club cells	4.8 nTPM
Lung	6.0 nTPM
Prostate	4.7 nTPM
Bronchus	3.7 nTPM

Endothelial cells	9.9 nTPM
Skeletal muscle	17.0 nTPM
Esophagus	16.8 nTPM
Skin	15.8 nTPM
Lung	15.0 nTPM
Fallopian tube	13.7 nTPM
Thymus	12.5 nTPM
Testis	11.0 nTPM
Salivary gland	10.1 nTPM
Tongue	10.1 nTPM
Endometrium	9.4 nTPM
Vascular	9.4 nTPM
Heart muscle	8.9 nTPM
Prostate	7.5 nTPM
Breast	7.0 nTPM
Placenta	6.2 nTPM
Ovary	4.5 nTPM
Liver	3.8 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	4.3 nTPM
Rectum	6.7 nTPM
Small intestine	3.4 nTPM
Colon	2.7 nTPM

Fibroblasts	17.0 nTPM
Adipose tissue	44.6 nTPM
Skin	27.5 nTPM
Prostate	27.1 nTPM
Salivary gland	20.2 nTPM
Vascular	18.5 nTPM
Esophagus	17.2 nTPM
Breast	16.9 nTPM
Thymus	15.7 nTPM
Skeletal muscle	14.8 nTPM
Stomach	13.0 nTPM
Lung	12.6 nTPM
Placenta	12.4 nTPM
Heart muscle	12.2 nTPM
Fallopian tube	10.1 nTPM
Pancreas	5.4 nTPM
Liver	4.7 nTPM

Granulocytes	14.0 nTPM
Fallopian tube	23.4 nTPM
Tongue	9.7 nTPM
Lung	9.1 nTPM

Intestinal goblet cells	4.2 nTPM
Small intestine	5.9 nTPM
Rectum	4.8 nTPM
Colon	1.7 nTPM

Lymphatic endothelial cells	3.3 nTPM
Fallopian tube	6.6 nTPM
Ovary	0.0 nTPM

Macrophages	9.1 nTPM
Adipose tissue	22.7 nTPM
Skin	20.1 nTPM
Spleen	19.0 nTPM
Fallopian tube	12.4 nTPM
Salivary gland	11.1 nTPM
Stomach	10.3 nTPM
Esophagus	9.0 nTPM
Thymus	8.9 nTPM
Skeletal muscle	8.7 nTPM
Vascular	8.2 nTPM
Tongue	7.7 nTPM
Lung	7.1 nTPM
Kidney	5.3 nTPM
Bone marrow	5.1 nTPM
Prostate	5.0 nTPM
Testis	4.3 nTPM
Breast	3.7 nTPM
Endometrium	2.5 nTPM
Pancreas	2.1 nTPM

Paneth cells	3.4 nTPM
Colon	3.6 nTPM
Small intestine	3.5 nTPM
Rectum	3.2 nTPM

Basal keratinocytes	23.8 nTPM
Skin	25.8 nTPM
Tongue	21.8 nTPM

Basal squamous epithelial cells	41.2 nTPM
Esophagus	41.2 nTPM

Bipolar cells	0.3 nTPM
Eye	0.3 nTPM

Cholangiocytes	7.6 nTPM
Liver	7.6 nTPM

Plasma cells	12.1 nTPM
Esophagus	26.0 nTPM
Fallopian tube	19.3 nTPM
Salivary gland	10.7 nTPM
Liver	10.5 nTPM
Spleen	9.9 nTPM
Thymus	8.1 nTPM
Bone marrow	7.6 nTPM
Stomach	4.6 nTPM

Schwann cells	11.1 nTPM
Vascular	25.1 nTPM
Adipose tissue	8.2 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	21.1 nTPM
Salivary gland	33.3 nTPM
Tongue	8.8 nTPM

Smooth muscle cells	13.0 nTPM
Tongue	31.4 nTPM
Adipose tissue	28.1 nTPM
Salivary gland	19.9 nTPM
Skin	18.1 nTPM
Vascular	13.6 nTPM
Thymus	12.1 nTPM
Placenta	11.9 nTPM
Esophagus	10.8 nTPM
Skeletal muscle	10.5 nTPM
Lung	9.4 nTPM
Endometrium	8.9 nTPM
Breast	8.6 nTPM
Ovary	8.2 nTPM
Fallopian tube	8.1 nTPM
Prostate	4.9 nTPM
Liver	4.2 nTPM

Suprabasal keratinocytes	16.8 nTPM
Skin	22.0 nTPM
Tongue	11.6 nTPM

T-cells	15.5 nTPM
Adipose tissue	30.6 nTPM
Tongue	24.5 nTPM
Spleen	24.0 nTPM
Thymus	20.0 nTPM
Vascular	17.3 nTPM
Esophagus	17.0 nTPM
Stomach	17.0 nTPM
Lung	16.9 nTPM
Prostate	15.6 nTPM
Skin	15.1 nTPM
Skeletal muscle	15.1 nTPM
Fallopian tube	14.9 nTPM
Endometrium	14.7 nTPM
Bone marrow	14.2 nTPM
Breast	12.2 nTPM
Lymph node	11.4 nTPM
Colon	10.7 nTPM
Salivary gland	10.3 nTPM
Liver	10.2 nTPM
Kidney	8.9 nTPM
PBMC	4.6 nTPM

Undifferentiated cells	9.3 nTPM
Small intestine	11.7 nTPM
Colon	11.3 nTPM
Rectum	4.9 nTPM

Amygdala excitatory	57.5 nTPM
Amygdala	69.0 nTPM
Cerebral cortex	67.5 nTPM
Basal ganglia	60.1 nTPM
Hippocampus	57.5 nTPM
Thalamus	54.0 nTPM
Hypothalamus	36.9 nTPM

Astrocyte	11.3 nTPM
Hypothalamus	14.8 nTPM
Spinal cord	14.3 nTPM
Amygdala	13.5 nTPM
Basal ganglia	11.5 nTPM
Hippocampus	11.1 nTPM
Cerebral cortex	10.9 nTPM
Medulla oblongata	10.6 nTPM
Thalamus	10.5 nTPM
Midbrain	10.0 nTPM
Cerebellum	9.0 nTPM
Pons	8.5 nTPM

Bergmann glia	7.9 nTPM
Medulla oblongata	10.7 nTPM
Cerebellum	8.9 nTPM
Pons	4.3 nTPM

Central nervous system macrophage	10.6 nTPM
Hypothalamus	14.2 nTPM
Amygdala	12.4 nTPM
Thalamus	11.8 nTPM
Midbrain	10.5 nTPM
Spinal cord	10.3 nTPM
Basal ganglia	10.2 nTPM
Medulla oblongata	10.2 nTPM
Pons	10.0 nTPM
Cerebellum	9.5 nTPM
Hippocampus	9.1 nTPM
Cerebral cortex	8.8 nTPM

Cerebellar inhibitory	10.5 nTPM
Medulla oblongata	12.3 nTPM
Midbrain	11.5 nTPM
Pons	10.7 nTPM
Cerebellum	9.9 nTPM
Spinal cord	8.2 nTPM

Cge interneuron	49.9 nTPM
Amygdala	67.8 nTPM
Hypothalamus	65.0 nTPM
Hippocampus	55.2 nTPM
Basal ganglia	46.2 nTPM
Cerebral cortex	42.4 nTPM
Midbrain	38.9 nTPM
Thalamus	33.5 nTPM

Choroid plexus epithelial cell	187.3 nTPM
Basal ganglia	291.4 nTPM
Hippocampus	174.7 nTPM
Thalamus	156.2 nTPM
Medulla oblongata	126.9 nTPM

Committed oligodendrocyte precursor	45.5 nTPM
Hypothalamus	92.9 nTPM
Thalamus	83.5 nTPM
Amygdala	69.4 nTPM
Basal ganglia	54.8 nTPM
Medulla oblongata	43.9 nTPM
Pons	37.2 nTPM
Cerebral cortex	29.8 nTPM
Cerebellum	28.5 nTPM
Midbrain	25.2 nTPM
Hippocampus	20.2 nTPM
Spinal cord	14.7 nTPM

Deep-layer corticothalamic and 6b	30.1 nTPM
Hippocampus	47.1 nTPM
Midbrain	32.2 nTPM
Hypothalamus	28.2 nTPM
Cerebral cortex	28.1 nTPM
Amygdala	23.1 nTPM
Basal ganglia	21.9 nTPM

Deep-layer intratelencephalic	66.2 nTPM
Amygdala	80.7 nTPM
Hypothalamus	73.6 nTPM
Hippocampus	62.5 nTPM
Basal ganglia	58.4 nTPM
Cerebral cortex	55.8 nTPM

Deep-layer near-projecting	17.0 nTPM
Hypothalamus	25.5 nTPM
Amygdala	15.9 nTPM
Hippocampus	15.6 nTPM
Basal ganglia	14.3 nTPM
Cerebral cortex	13.8 nTPM

Eccentric medium spiny neuron	81.5 nTPM
Amygdala	88.5 nTPM
Hypothalamus	85.1 nTPM
Cerebral cortex	82.5 nTPM
Basal ganglia	81.8 nTPM
Thalamus	77.5 nTPM
Hippocampus	73.8 nTPM

Endothelial cell	28.1 nTPM
Amygdala	43.6 nTPM
Hippocampus	35.3 nTPM
Thalamus	33.9 nTPM
Medulla oblongata	29.7 nTPM
Cerebral cortex	28.8 nTPM
Pons	28.1 nTPM
Cerebellum	24.8 nTPM
Midbrain	24.6 nTPM
Hypothalamus	23.6 nTPM
Spinal cord	20.7 nTPM
Basal ganglia	15.8 nTPM