Single cell type - TBL1XR1 - The Human Protein Atlas

TBL1XR1

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(53 genes):

... STAM2 | TBC1D5 | TBL1XR1 | TCAP | TENT5A ...

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TBL1XR1
Gene descriptionⁱ Full gene name according to HGNC.	TBL1X/Y related 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Disease related genes Human disease related genes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	22

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.25
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TBL1XR1 is part of cluster 55 Non-specific - Transcription with confidenceⁱ 0.99
709 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MIB1	MIB E3 ubiquitin protein ligase 1	0.5592	55
IGF1R	Insulin like growth factor 1 receptor	0.5408	37
CMTM4	CKLF like MARVEL transmembrane domain containing 4	0.4579	16
GOLM2	Golgi membrane protein 2	0.4456	40
KIF13A	Kinesin family member 13A	0.4447	76
NFIA	Nuclear factor I A	0.4368	53
CYP4X1	Cytochrome P450 family 4 subfamily X member 1	0.4358	35
ZBTB41	Zinc finger and BTB domain containing 41	0.4351	55
FOXA1	Forkhead box A1	0.4326	40
ZKSCAN1	Zinc finger with KRAB and SCAN domains 1	0.4304	40
SEMA3C	Semaphorin 3C	0.4235	53
RHBDL2	Rhomboid like 2	0.4214	35
WAC	WW domain containing adaptor with coiled-coil	0.4165	55
NEO1	Neogenin 1	0.4154	16
RELCH	RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing	0.4125	51

IMMUNE CELLS

TBL1XR1 is part of cluster 30 Non-specific - DNA binding with confidenceⁱ 1
263 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HLCS	Holocarboxylase synthetase	1.0000	30
TARDBP	TAR DNA binding protein	1.0000	30
IRF2BPL	Interferon regulatory factor 2 binding protein like	0.9762	30
ZNF888	Zinc finger protein 888	0.9762	8
GSPT2	G1 to S phase transition 2	0.9762	30
SLC4A5	Solute carrier family 4 member 5	0.9762	30
PDILT	Protein disulfide isomerase like, testis expressed	0.9762	30
ARMC5	Armadillo repeat containing 5	0.9762	30
ESR2	Estrogen receptor 2	0.9762	30
KRI1	KRI1 homolog	0.9762	30
ABCB6	ATP binding cassette subfamily B member 6 (Langereis blood group)	0.9762	8
TENT4A	Terminal nucleotidyltransferase 4A	0.9762	30
MROH8	Maestro heat like repeat family member 8	0.9762	30
SERPIND1	Serpin family D member 1	0.9762	30
CUL7	Cullin 7	0.9762	30

Adipocytes	50.6 nTPM
Breast	51.4 nTPM
Adipose tissue	49.8 nTPM

Alveolar cells type 1	69.2 nTPM
Lung	69.2 nTPM

Alveolar cells type 2	66.8 nTPM
Lung	66.8 nTPM

Astrocytes	121.4 nTPM
Brain	121.4 nTPM

B-cells	65.4 nTPM
Esophagus	100.3 nTPM
Skin	89.8 nTPM
Salivary gland	78.3 nTPM
Lymph node	72.4 nTPM
Lung	72.4 nTPM
Stomach	67.9 nTPM
Adipose tissue	61.7 nTPM
Spleen	60.7 nTPM
Liver	58.0 nTPM
Bone marrow	56.2 nTPM
Thymus	50.5 nTPM
Kidney	41.6 nTPM
PBMC	40.0 nTPM

Ciliated cells	78.5 nTPM
Bronchus	104.8 nTPM
Endometrium	86.2 nTPM
Lung	67.2 nTPM
Fallopian tube	55.9 nTPM

Club cells	76.9 nTPM
Bronchus	90.8 nTPM
Prostate	80.0 nTPM
Lung	59.8 nTPM

Dendritic cells	96.2 nTPM
PBMC	100.7 nTPM
Adipose tissue	91.7 nTPM

Endothelial cells	56.8 nTPM
Endometrium	101.4 nTPM
Skin	98.2 nTPM
Heart muscle	78.2 nTPM
Salivary gland	73.1 nTPM
Esophagus	73.0 nTPM
Breast	64.2 nTPM
Prostate	55.7 nTPM
Vascular	55.7 nTPM
Lung	53.1 nTPM
Tongue	50.5 nTPM
Liver	45.3 nTPM
Fallopian tube	45.0 nTPM
Skeletal muscle	43.1 nTPM
Placenta	42.0 nTPM
Thymus	39.6 nTPM
Testis	38.8 nTPM
Pancreas	33.6 nTPM
Ovary	32.0 nTPM

Enteroendocrine cells	81.2 nTPM
Rectum	90.6 nTPM
Colon	80.8 nTPM
Small intestine	72.1 nTPM

Fibroblasts	72.2 nTPM
Skin	110.4 nTPM
Adipose tissue	103.3 nTPM
Breast	102.5 nTPM
Heart muscle	97.1 nTPM
Vascular	92.9 nTPM
Salivary gland	91.3 nTPM
Esophagus	88.9 nTPM
Skeletal muscle	79.3 nTPM
Prostate	71.3 nTPM
Thymus	54.9 nTPM
Fallopian tube	54.5 nTPM
Stomach	53.3 nTPM
Liver	43.9 nTPM
Lung	43.2 nTPM
Placenta	41.6 nTPM
Pancreas	26.8 nTPM

Granulocytes	46.7 nTPM
Tongue	67.9 nTPM
Lung	36.8 nTPM
Fallopian tube	35.4 nTPM

Intestinal goblet cells	64.8 nTPM
Rectum	90.4 nTPM
Small intestine	53.2 nTPM
Colon	50.7 nTPM

Lymphatic endothelial cells	65.9 nTPM
Fallopian tube	93.6 nTPM
Ovary	38.2 nTPM

Macrophages	74.0 nTPM
Esophagus	105.3 nTPM
Bone marrow	102.4 nTPM
Salivary gland	95.1 nTPM
Tongue	93.4 nTPM
Stomach	92.6 nTPM
Spleen	92.2 nTPM
Vascular	83.0 nTPM
Prostate	74.0 nTPM
Endometrium	73.8 nTPM
Kidney	73.5 nTPM
Testis	71.3 nTPM
Adipose tissue	70.6 nTPM
Fallopian tube	68.8 nTPM
Skeletal muscle	64.5 nTPM
Skin	60.2 nTPM
Thymus	58.7 nTPM
Breast	49.5 nTPM
Lung	45.9 nTPM
Pancreas	30.8 nTPM

Basal prostatic cells	54.7 nTPM
Prostate	54.7 nTPM

Basal respiratory cells	87.6 nTPM
Bronchus	87.6 nTPM

Collecting duct cells	95.3 nTPM
Kidney	95.3 nTPM

Cone photoreceptor cells	69.7 nTPM
Eye	69.7 nTPM

Paneth cells	43.0 nTPM
Rectum	82.6 nTPM
Colon	36.2 nTPM
Small intestine	10.4 nTPM

Plasma cells	72.5 nTPM
Esophagus	114.4 nTPM
Salivary gland	104.3 nTPM
Stomach	90.5 nTPM
Fallopian tube	72.7 nTPM
Spleen	61.8 nTPM
Thymus	51.0 nTPM
Liver	47.6 nTPM
Bone marrow	37.8 nTPM

Schwann cells	71.2 nTPM
Adipose tissue	93.7 nTPM
Esophagus	71.9 nTPM
Vascular	48.1 nTPM

Serous glandular cells	66.9 nTPM
Salivary gland	80.8 nTPM
Tongue	53.0 nTPM

Smooth muscle cells	57.2 nTPM
Adipose tissue	102.2 nTPM
Vascular	85.5 nTPM
Salivary gland	76.6 nTPM
Tongue	63.8 nTPM
Endometrium	62.7 nTPM
Prostate	56.6 nTPM
Skin	53.7 nTPM
Fallopian tube	48.7 nTPM
Placenta	48.3 nTPM
Esophagus	48.1 nTPM
Skeletal muscle	48.0 nTPM
Lung	47.0 nTPM
Liver	46.7 nTPM
Ovary	44.2 nTPM
Breast	42.6 nTPM
Thymus	40.1 nTPM

Suprabasal keratinocytes	83.6 nTPM
Skin	112.2 nTPM
Tongue	54.9 nTPM

T-cells	65.5 nTPM
Endometrium	89.5 nTPM
Tongue	89.5 nTPM
Salivary gland	81.4 nTPM
Skin	80.6 nTPM
Lymph node	79.8 nTPM
Adipose tissue	77.0 nTPM
Esophagus	75.4 nTPM
Fallopian tube	72.2 nTPM
Spleen	69.5 nTPM
Vascular	68.3 nTPM
Prostate	65.1 nTPM
Stomach	64.3 nTPM
Breast	62.6 nTPM
Skeletal muscle	61.6 nTPM
Thymus	53.3 nTPM
Lung	53.2 nTPM
Bone marrow	51.8 nTPM
Liver	50.8 nTPM
PBMC	47.3 nTPM
Kidney	45.2 nTPM
Colon	38.0 nTPM

Undifferentiated cells	74.2 nTPM
Rectum	87.2 nTPM
Small intestine	74.3 nTPM
Colon	61.1 nTPM

Amygdala excitatory	370.6 nTPM
Hypothalamus	496.9 nTPM
Cerebral cortex	372.7 nTPM
Amygdala	361.7 nTPM
Hippocampus	359.7 nTPM
Thalamus	318.5 nTPM
Basal ganglia	314.1 nTPM

Astrocyte	294.7 nTPM
Amygdala	419.4 nTPM
Basal ganglia	338.9 nTPM
Spinal cord	330.1 nTPM
Hypothalamus	293.7 nTPM
Cerebral cortex	287.5 nTPM
Hippocampus	283.1 nTPM
Cerebellum	270.2 nTPM
Medulla oblongata	267.1 nTPM
Midbrain	255.4 nTPM
Pons	251.1 nTPM
Thalamus	245.4 nTPM

Bergmann glia	389.3 nTPM
Medulla oblongata	445.4 nTPM
Cerebellum	400.1 nTPM
Pons	322.2 nTPM

Central nervous system macrophage	537.3 nTPM
Hypothalamus	690.7 nTPM
Amygdala	669.6 nTPM
Basal ganglia	590.1 nTPM
Thalamus	534.7 nTPM
Midbrain	528.3 nTPM
Hippocampus	519.3 nTPM
Pons	516.1 nTPM
Cerebral cortex	487.0 nTPM
Cerebellum	484.6 nTPM
Medulla oblongata	455.6 nTPM
Spinal cord	433.9 nTPM

Cerebellar inhibitory	221.3 nTPM
Spinal cord	266.7 nTPM
Medulla oblongata	236.6 nTPM
Midbrain	208.7 nTPM
Cerebellum	202.5 nTPM
Pons	191.9 nTPM

Cge interneuron	297.4 nTPM
Hypothalamus	345.9 nTPM
Amygdala	323.2 nTPM
Thalamus	309.1 nTPM
Hippocampus	297.3 nTPM
Basal ganglia	273.9 nTPM
Midbrain	273.3 nTPM
Cerebral cortex	259.0 nTPM

Choroid plexus epithelial cell	321.2 nTPM
Basal ganglia	422.0 nTPM
Medulla oblongata	322.6 nTPM
Thalamus	285.0 nTPM
Hippocampus	255.1 nTPM

Committed oligodendrocyte precursor	309.2 nTPM
Hypothalamus	409.0 nTPM
Amygdala	399.2 nTPM
Hippocampus	337.6 nTPM
Cerebellum	333.0 nTPM
Thalamus	325.5 nTPM
Cerebral cortex	324.9 nTPM
Basal ganglia	312.6 nTPM
Spinal cord	253.9 nTPM
Medulla oblongata	238.8 nTPM
Midbrain	237.7 nTPM
Pons	228.4 nTPM

Deep-layer corticothalamic and 6b	342.8 nTPM
Amygdala	414.9 nTPM
Hypothalamus	371.3 nTPM
Basal ganglia	355.7 nTPM
Cerebral cortex	349.3 nTPM
Midbrain	285.1 nTPM
Hippocampus	280.8 nTPM

Deep-layer intratelencephalic	377.8 nTPM
Hypothalamus	409.7 nTPM
Hippocampus	407.0 nTPM
Amygdala	405.5 nTPM
Cerebral cortex	344.6 nTPM
Basal ganglia	322.1 nTPM

Deep-layer near-projecting	252.2 nTPM
Hypothalamus	298.6 nTPM
Amygdala	253.9 nTPM
Basal ganglia	250.9 nTPM
Hippocampus	231.2 nTPM
Cerebral cortex	226.3 nTPM

Eccentric medium spiny neuron	382.5 nTPM
Thalamus	419.2 nTPM
Hypothalamus	397.4 nTPM
Amygdala	390.1 nTPM
Cerebral cortex	389.9 nTPM
Basal ganglia	388.0 nTPM
Hippocampus	310.5 nTPM