Single cell type - ZBTB34 - The Human Protein Atlas

ZBTB34

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZBTB34
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger and BTB domain containing 34
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Late spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Late spermatids)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.54
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Late spermatids)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ZBTB34 is part of cluster 63 Late spermatids - Spermatogenesis with confidenceⁱ 1
383 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
H2AB1	H2A.B variant histone 1	0.6034	63
FAM229B	Family with sequence similarity 229 member B	0.5877	63
KRT74	Keratin 74	0.5824	63
ENSG00000260861	Novel protein, SIRPB1-SIRPD readthrough	0.5800	63
FAM187B	Family with sequence similarity 187 member B	0.5791	63
TEX46	Testis expressed 46	0.5791	63
NFILZ	NFIL3 like basic leucine zipper	0.5787	63
SPATA6	Spermatogenesis associated 6	0.5755	63
TMEM269	Transmembrane protein 269	0.5750	63
WBP2NL	WBP2 N-terminal like	0.5750	63
TEX37	Testis expressed 37	0.5638	63
ACP4	Acid phosphatase 4	0.5637	63
CXorf51B	Chromosome X open reading frame 51B	0.5630	63
LYPD6	LY6/PLAUR domain containing 6	0.5597	63
C20orf141	Chromosome 20 open reading frame 141	0.5580	63

IMMUNE CELLS

ZBTB34 is part of cluster 22 Eosinophils - Transcription with confidenceⁱ 0.97
357 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RICTOR	RPTOR independent companion of MTOR complex 2	0.9762	22
DDX46	DEAD-box helicase 46	0.9762	22
SPECC1	Sperm antigen with calponin homology and coiled-coil domains 1	0.9762	22
GIGYF2	GRB10 interacting GYF protein 2	0.9524	22
CTDSP2	CTD small phosphatase 2	0.9524	41
HEXIM2	HEXIM P-TEFb complex subunit 2	0.9524	22
LYSMD1	LysM domain containing 1	0.9524	41
FLVCR1	FLVCR heme transporter 1	0.9524	22
FXR2	FMR1 autosomal homolog 2	0.9524	22
RTN2	Reticulon 2	0.9524	41
ITPR2	Inositol 1,4,5-trisphosphate receptor type 2	0.9524	41
MED13L	Mediator complex subunit 13L	0.9524	22
ATAD2B	ATPase family AAA domain containing 2B	0.9524	41
NUFIP2	Nuclear FMR1 interacting protein 2	0.9286	22
ANKRD11	Ankyrin repeat domain containing 11	0.9286	41

Adipocytes	5.6 nTPM
Adipose tissue	6.3 nTPM
Breast	4.9 nTPM

Alveolar cells type 1	6.3 nTPM
Lung	6.3 nTPM

Alveolar cells type 2	3.7 nTPM
Lung	3.7 nTPM

Astrocytes	5.0 nTPM
Brain	5.0 nTPM

B-cells	3.2 nTPM
Skin	10.2 nTPM
Esophagus	5.9 nTPM
Lung	5.4 nTPM
Liver	4.8 nTPM
Thymus	3.1 nTPM
Salivary gland	3.0 nTPM
Lymph node	2.8 nTPM
Spleen	1.9 nTPM
PBMC	1.5 nTPM
Stomach	1.3 nTPM
Adipose tissue	1.2 nTPM
Bone marrow	0.2 nTPM
Kidney	0.0 nTPM

Ciliated cells	3.2 nTPM
Bronchus	4.1 nTPM
Lung	3.7 nTPM
Fallopian tube	2.8 nTPM
Endometrium	2.3 nTPM

Club cells	3.2 nTPM
Bronchus	4.0 nTPM
Prostate	3.2 nTPM
Lung	2.4 nTPM

Endothelial cells	5.4 nTPM
Heart muscle	12.5 nTPM
Liver	8.8 nTPM
Salivary gland	8.3 nTPM
Endometrium	6.4 nTPM
Skin	6.3 nTPM
Prostate	6.2 nTPM
Skeletal muscle	6.0 nTPM
Esophagus	6.0 nTPM
Thymus	5.6 nTPM
Lung	5.3 nTPM
Fallopian tube	4.9 nTPM
Vascular	4.8 nTPM
Placenta	4.5 nTPM
Tongue	3.1 nTPM
Pancreas	2.6 nTPM
Breast	2.6 nTPM
Ovary	2.3 nTPM
Testis	1.5 nTPM

Enteroendocrine cells	3.0 nTPM
Small intestine	3.4 nTPM
Rectum	3.4 nTPM
Colon	2.2 nTPM

Fibroblasts	4.4 nTPM
Skin	8.3 nTPM
Placenta	6.2 nTPM
Salivary gland	5.6 nTPM
Skeletal muscle	5.0 nTPM
Esophagus	4.6 nTPM
Prostate	4.6 nTPM
Heart muscle	4.5 nTPM
Vascular	4.4 nTPM
Stomach	4.3 nTPM
Adipose tissue	4.2 nTPM
Liver	3.6 nTPM
Breast	3.6 nTPM
Fallopian tube	3.4 nTPM
Thymus	3.3 nTPM
Lung	2.3 nTPM
Pancreas	1.9 nTPM

Granulocytes	5.6 nTPM
Tongue	9.7 nTPM
Lung	4.0 nTPM
Fallopian tube	3.1 nTPM

Intestinal goblet cells	4.2 nTPM
Rectum	5.1 nTPM
Small intestine	4.8 nTPM
Colon	2.7 nTPM

Lymphatic endothelial cells	5.4 nTPM
Ovary	5.5 nTPM
Fallopian tube	5.4 nTPM

Macrophages	8.1 nTPM
Skin	15.6 nTPM
Esophagus	12.8 nTPM
Stomach	10.3 nTPM
Thymus	10.1 nTPM
Adipose tissue	9.5 nTPM
Bone marrow	9.1 nTPM
Fallopian tube	9.0 nTPM
Salivary gland	8.8 nTPM
Vascular	8.2 nTPM
Lung	7.8 nTPM
Spleen	7.0 nTPM
Prostate	7.0 nTPM
Skeletal muscle	6.4 nTPM
Kidney	6.2 nTPM
Pancreas	6.2 nTPM
Tongue	5.2 nTPM
Endometrium	4.9 nTPM
Breast	4.4 nTPM
Testis	4.3 nTPM

Paneth cells	5.2 nTPM
Colon	10.9 nTPM
Rectum	4.6 nTPM
Small intestine	0.0 nTPM

Basal respiratory cells	1.6 nTPM
Bronchus	1.6 nTPM

Cholangiocytes	3.8 nTPM
Liver	3.8 nTPM

Cone photoreceptor cells	13.6 nTPM
Eye	13.6 nTPM

Plasma cells	1.5 nTPM
Salivary gland	3.1 nTPM
Liver	2.5 nTPM
Thymus	1.8 nTPM
Spleen	1.7 nTPM
Stomach	1.7 nTPM
Fallopian tube	1.6 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Schwann cells	8.6 nTPM
Esophagus	12.0 nTPM
Adipose tissue	8.2 nTPM
Vascular	5.7 nTPM

Serous glandular cells	3.6 nTPM
Salivary gland	7.1 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	5.1 nTPM
Esophagus	12.0 nTPM
Liver	8.9 nTPM
Lung	5.9 nTPM
Skin	5.7 nTPM
Adipose tissue	5.6 nTPM
Prostate	5.5 nTPM
Tongue	5.4 nTPM
Endometrium	5.3 nTPM
Placenta	5.0 nTPM
Salivary gland	4.8 nTPM
Vascular	4.2 nTPM
Skeletal muscle	2.9 nTPM
Breast	2.9 nTPM
Ovary	2.7 nTPM
Fallopian tube	2.5 nTPM
Thymus	2.0 nTPM

T-cells	2.3 nTPM
Prostate	4.1 nTPM
Skin	3.9 nTPM
Salivary gland	3.8 nTPM
Liver	3.4 nTPM
Adipose tissue	3.4 nTPM
Skeletal muscle	3.0 nTPM
Endometrium	2.8 nTPM
Breast	2.6 nTPM
Stomach	2.5 nTPM
Tongue	2.5 nTPM
Fallopian tube	2.3 nTPM
Lymph node	2.0 nTPM
Colon	1.9 nTPM
Spleen	1.9 nTPM
Thymus	1.9 nTPM
Bone marrow	1.6 nTPM
Lung	1.6 nTPM
Vascular	1.6 nTPM
PBMC	1.2 nTPM
Kidney	0.0 nTPM
Esophagus	0.0 nTPM

Undifferentiated cells	2.1 nTPM
Rectum	3.4 nTPM
Colon	1.8 nTPM
Small intestine	1.2 nTPM

Amygdala excitatory	9.1 nTPM
Hypothalamus	12.9 nTPM
Thalamus	10.9 nTPM
Amygdala	8.3 nTPM
Cerebral cortex	8.0 nTPM
Hippocampus	7.5 nTPM
Basal ganglia	7.3 nTPM

Astrocyte	13.9 nTPM
Midbrain	16.8 nTPM
Amygdala	15.9 nTPM
Thalamus	15.9 nTPM
Basal ganglia	15.2 nTPM
Spinal cord	14.7 nTPM
Hippocampus	14.4 nTPM
Cerebral cortex	13.4 nTPM
Hypothalamus	12.1 nTPM
Pons	11.9 nTPM
Medulla oblongata	11.6 nTPM
Cerebellum	10.5 nTPM

Bergmann glia	12.4 nTPM
Cerebellum	12.8 nTPM
Medulla oblongata	12.8 nTPM
Pons	11.5 nTPM

Central nervous system macrophage	27.1 nTPM
Amygdala	37.0 nTPM
Hippocampus	30.5 nTPM
Thalamus	30.2 nTPM
Basal ganglia	29.6 nTPM
Cerebral cortex	28.9 nTPM
Midbrain	28.7 nTPM
Hypothalamus	25.2 nTPM
Pons	24.7 nTPM
Cerebellum	24.5 nTPM
Medulla oblongata	22.7 nTPM
Spinal cord	16.2 nTPM

Cerebellar inhibitory	8.2 nTPM
Midbrain	8.7 nTPM
Spinal cord	8.2 nTPM
Medulla oblongata	8.1 nTPM
Cerebellum	8.0 nTPM
Pons	7.7 nTPM

Cge interneuron	11.9 nTPM
Hypothalamus	15.8 nTPM
Thalamus	12.5 nTPM
Midbrain	12.4 nTPM
Amygdala	11.6 nTPM
Basal ganglia	10.7 nTPM
Hippocampus	10.2 nTPM
Cerebral cortex	10.1 nTPM

Choroid plexus epithelial cell	10.2 nTPM
Basal ganglia	15.5 nTPM
Thalamus	13.7 nTPM
Medulla oblongata	8.9 nTPM
Hippocampus	2.8 nTPM

Committed oligodendrocyte precursor	12.1 nTPM
Spinal cord	22.1 nTPM
Hypothalamus	20.5 nTPM
Thalamus	15.1 nTPM
Pons	12.4 nTPM
Amygdala	11.8 nTPM
Basal ganglia	11.0 nTPM
Hippocampus	10.1 nTPM
Midbrain	8.4 nTPM
Cerebral cortex	8.2 nTPM
Cerebellum	7.9 nTPM
Medulla oblongata	5.2 nTPM

Deep-layer corticothalamic and 6b	8.1 nTPM
Hypothalamus	10.3 nTPM
Amygdala	9.2 nTPM
Midbrain	7.8 nTPM
Cerebral cortex	7.5 nTPM
Hippocampus	7.4 nTPM
Basal ganglia	6.4 nTPM

Deep-layer intratelencephalic	7.8 nTPM
Hypothalamus	11.4 nTPM
Amygdala	7.9 nTPM
Cerebral cortex	6.9 nTPM
Hippocampus	6.7 nTPM
Basal ganglia	6.2 nTPM

Deep-layer near-projecting	6.9 nTPM
Hypothalamus	11.6 nTPM
Amygdala	6.8 nTPM
Cerebral cortex	6.6 nTPM
Basal ganglia	5.2 nTPM
Hippocampus	4.6 nTPM

Eccentric medium spiny neuron	11.1 nTPM
Hippocampus	13.3 nTPM
Amygdala	11.8 nTPM
Hypothalamus	11.2 nTPM
Cerebral cortex	11.0 nTPM
Thalamus	9.8 nTPM
Basal ganglia	9.6 nTPM

Endothelial cell	12.0 nTPM
Spinal cord	19.0 nTPM
Thalamus	14.7 nTPM
Hippocampus	13.1 nTPM
Pons	13.1 nTPM
Basal ganglia	13.0 nTPM
Cerebral cortex	12.1 nTPM
Amygdala	11.2 nTPM
Cerebellum	10.8 nTPM
Midbrain	9.5 nTPM
Hypothalamus	8.7 nTPM
Medulla oblongata	7.2 nTPM

Ependymal cell	8.9 nTPM
Spinal cord	23.0 nTPM
Amygdala	10.2 nTPM
Midbrain	8.9 nTPM
Hippocampus	7.5 nTPM
Thalamus	6.9 nTPM
Basal ganglia	6.5 nTPM
Hypothalamus	6.2 nTPM
Medulla oblongata	5.7 nTPM
Pons	4.7 nTPM