Single cell type - WDR73 - The Human Protein Atlas

WDR73

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	WDR73
Gene descriptionⁱ Full gene name according to HGNC.	WD repeat domain 73
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Rod photoreceptor cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.38
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Rod photoreceptor cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

WDR73 is part of cluster 55 Non-specific - Transcription with confidenceⁱ 1
709 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PNKP	Polynucleotide kinase 3'-phosphatase	0.5208	55
PROSER3	Proline and serine rich 3	0.5174	31
CCDC180	Coiled-coil domain containing 180	0.5120	42
WDR90	WD repeat domain 90	0.5043	42
ZNF19	Zinc finger protein 19	0.5022	42
MKS1	MKS transition zone complex subunit 1	0.5013	42
GON4L	Gon-4 like	0.4814	55
CEP290	Centrosomal protein 290	0.4800	42
PIGO	Phosphatidylinositol glycan anchor biosynthesis class O	0.4785	39
RTL10	Retrotransposon Gag like 10	0.4752	40
DYNC2H1	Dynein cytoplasmic 2 heavy chain 1	0.4685	42
AP4M1	Adaptor related protein complex 4 subunit mu 1	0.4475	55
TSEN2	TRNA splicing endonuclease subunit 2	0.4438	55
MIEF2	Mitochondrial elongation factor 2	0.4433	45
DENND2B	DENN domain containing 2B	0.4392	66

IMMUNE CELLS

WDR73 is part of cluster 24 Non-specific - Transcription with confidenceⁱ 0.77
516 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SCRN3	Secernin 3	0.9762	24
HACD2	3-hydroxyacyl-CoA dehydratase 2	0.9762	24
ZBTB44	Zinc finger and BTB domain containing 44	0.9762	24
ZBTB5	Zinc finger and BTB domain containing 5	0.9762	24
ATP8A1	ATPase phospholipid transporting 8A1	0.9524	24
PDCD2L	Programmed cell death 2 like	0.9524	30
INTS1	Integrator complex subunit 1	0.9524	24
TWNK	Twinkle mtDNA helicase	0.9524	30
DHCR7	7-dehydrocholesterol reductase	0.9524	24
LMLN	Leishmanolysin like peptidase	0.9524	30
ARHGAP5	Rho GTPase activating protein 5	0.9524	24
PIGN	Phosphatidylinositol glycan anchor biosynthesis class N	0.9524	24
ZNF525	Zinc finger protein 525	0.9524	24
BRD1	Bromodomain containing 1	0.9524	24
CHST10	Carbohydrate sulfotransferase 10	0.9286	24

Adipocytes	15.9 nTPM
Breast	16.2 nTPM
Adipose tissue	15.6 nTPM

Alveolar cells type 1	21.8 nTPM
Lung	21.8 nTPM

Alveolar cells type 2	23.0 nTPM
Lung	23.0 nTPM

Astrocytes	20.7 nTPM
Brain	20.7 nTPM

B-cells	17.2 nTPM
PBMC	38.5 nTPM
Salivary gland	28.3 nTPM
Kidney	26.0 nTPM
Lung	21.5 nTPM
Liver	19.3 nTPM
Esophagus	17.7 nTPM
Adipose tissue	16.9 nTPM
Stomach	16.0 nTPM
Thymus	12.0 nTPM
Bone marrow	7.9 nTPM
Skin	6.8 nTPM
Lymph node	6.5 nTPM
Spleen	6.3 nTPM

Ciliated cells	55.6 nTPM
Bronchus	78.0 nTPM
Lung	64.8 nTPM
Fallopian tube	49.8 nTPM
Endometrium	29.7 nTPM

Club cells	21.9 nTPM
Prostate	24.0 nTPM
Bronchus	22.4 nTPM
Lung	19.1 nTPM

Dendritic cells	11.5 nTPM
Adipose tissue	12.2 nTPM
PBMC	10.8 nTPM

Endothelial cells	14.7 nTPM
Ovary	24.5 nTPM
Breast	23.7 nTPM
Placenta	17.6 nTPM
Skeletal muscle	17.4 nTPM
Testis	17.1 nTPM
Salivary gland	16.4 nTPM
Prostate	16.1 nTPM
Vascular	15.7 nTPM
Pancreas	15.5 nTPM
Endometrium	15.2 nTPM
Liver	15.1 nTPM
Lung	14.1 nTPM
Fallopian tube	13.5 nTPM
Tongue	12.4 nTPM
Esophagus	11.2 nTPM
Thymus	11.1 nTPM
Skin	7.5 nTPM
Heart muscle	0.8 nTPM

Enteroendocrine cells	14.8 nTPM
Rectum	20.1 nTPM
Colon	13.9 nTPM
Small intestine	10.3 nTPM

Fibroblasts	16.9 nTPM
Skeletal muscle	23.7 nTPM
Lung	23.4 nTPM
Salivary gland	22.9 nTPM
Liver	22.5 nTPM
Breast	22.1 nTPM
Adipose tissue	19.4 nTPM
Vascular	18.5 nTPM
Placenta	17.8 nTPM
Thymus	17.3 nTPM
Pancreas	17.2 nTPM
Fallopian tube	16.9 nTPM
Prostate	16.5 nTPM
Esophagus	14.3 nTPM
Skin	9.1 nTPM
Stomach	8.6 nTPM
Heart muscle	0.0 nTPM

Granulocytes	13.9 nTPM
Lung	19.2 nTPM
Fallopian tube	17.7 nTPM
Tongue	4.9 nTPM

Intestinal goblet cells	16.3 nTPM
Small intestine	19.4 nTPM
Colon	17.0 nTPM
Rectum	12.5 nTPM

Lymphatic endothelial cells	13.7 nTPM
Fallopian tube	16.4 nTPM
Ovary	10.9 nTPM

Macrophages	11.6 nTPM
Lung	28.2 nTPM
Breast	22.2 nTPM
Prostate	14.7 nTPM
Skeletal muscle	14.4 nTPM
Kidney	13.3 nTPM
Salivary gland	13.2 nTPM
Testis	11.2 nTPM
Adipose tissue	11.2 nTPM
Endometrium	11.1 nTPM
Vascular	10.8 nTPM
Stomach	10.3 nTPM
Thymus	9.9 nTPM
Fallopian tube	9.7 nTPM
Tongue	9.4 nTPM
Pancreas	8.2 nTPM
Bone marrow	8.1 nTPM
Esophagus	6.4 nTPM
Skin	4.5 nTPM
Spleen	4.0 nTPM

Basal squamous epithelial cells	9.5 nTPM
Esophagus	9.5 nTPM

Bipolar cells	46.4 nTPM
Eye	46.4 nTPM

Cholangiocytes	26.7 nTPM
Liver	26.7 nTPM

Collecting duct cells	29.2 nTPM
Kidney	29.2 nTPM

Paneth cells	12.7 nTPM
Small intestine	17.3 nTPM
Rectum	17.2 nTPM
Colon	3.6 nTPM

Plasma cells	9.5 nTPM
Salivary gland	16.1 nTPM
Fallopian tube	12.9 nTPM
Esophagus	10.4 nTPM
Stomach	10.1 nTPM
Thymus	10.1 nTPM
Liver	8.0 nTPM
Spleen	5.3 nTPM
Bone marrow	3.0 nTPM

Schwann cells	13.9 nTPM
Vascular	21.4 nTPM
Esophagus	12.0 nTPM
Adipose tissue	8.2 nTPM

Serous glandular cells	23.1 nTPM
Tongue	26.5 nTPM
Salivary gland	19.7 nTPM

Smooth muscle cells	19.0 nTPM
Lung	28.2 nTPM
Breast	25.7 nTPM
Ovary	24.9 nTPM
Skeletal muscle	24.5 nTPM
Endometrium	20.8 nTPM
Prostate	19.5 nTPM
Placenta	18.8 nTPM
Fallopian tube	18.2 nTPM
Vascular	17.7 nTPM
Adipose tissue	17.6 nTPM
Salivary gland	17.2 nTPM
Esophagus	16.8 nTPM
Tongue	16.2 nTPM
Liver	15.7 nTPM
Thymus	12.5 nTPM
Skin	10.6 nTPM

Suprabasal keratinocytes	10.7 nTPM
Tongue	14.3 nTPM
Skin	7.1 nTPM

T-cells	17.6 nTPM
PBMC	39.6 nTPM
Salivary gland	27.7 nTPM
Lung	27.6 nTPM
Kidney	26.6 nTPM
Prostate	22.8 nTPM
Fallopian tube	21.8 nTPM
Vascular	21.7 nTPM
Breast	20.2 nTPM
Endometrium	20.1 nTPM
Liver	18.8 nTPM
Tongue	17.1 nTPM
Colon	16.6 nTPM
Thymus	15.4 nTPM
Skeletal muscle	13.2 nTPM
Adipose tissue	13.1 nTPM
Stomach	9.6 nTPM
Bone marrow	9.4 nTPM
Skin	9.1 nTPM
Lymph node	9.1 nTPM
Spleen	5.3 nTPM
Esophagus	4.9 nTPM

Undifferentiated cells	15.3 nTPM
Colon	22.1 nTPM
Rectum	13.3 nTPM
Small intestine	10.6 nTPM

Amygdala excitatory	22.8 nTPM
Cerebral cortex	26.5 nTPM
Hippocampus	25.2 nTPM
Amygdala	24.2 nTPM
Thalamus	21.8 nTPM
Basal ganglia	21.3 nTPM
Hypothalamus	17.7 nTPM

Astrocyte	43.6 nTPM
Cerebellum	49.2 nTPM
Thalamus	48.6 nTPM
Pons	45.5 nTPM
Midbrain	45.3 nTPM
Cerebral cortex	44.0 nTPM
Medulla oblongata	43.5 nTPM
Basal ganglia	42.4 nTPM
Hypothalamus	42.0 nTPM
Spinal cord	41.5 nTPM
Hippocampus	39.1 nTPM
Amygdala	38.8 nTPM

Bergmann glia	37.5 nTPM
Cerebellum	45.4 nTPM
Medulla oblongata	38.4 nTPM
Pons	28.8 nTPM

Central nervous system macrophage	28.8 nTPM
Hypothalamus	31.7 nTPM
Cerebellum	30.9 nTPM
Midbrain	30.9 nTPM
Hippocampus	30.8 nTPM
Amygdala	30.1 nTPM
Medulla oblongata	29.8 nTPM
Basal ganglia	28.6 nTPM
Cerebral cortex	28.5 nTPM
Pons	27.7 nTPM
Thalamus	27.5 nTPM
Spinal cord	20.0 nTPM

Cerebellar inhibitory	24.4 nTPM
Medulla oblongata	30.4 nTPM
Cerebellum	28.3 nTPM
Pons	25.0 nTPM
Midbrain	21.8 nTPM
Spinal cord	16.5 nTPM

Cge interneuron	25.5 nTPM
Cerebral cortex	28.5 nTPM
Basal ganglia	27.8 nTPM
Amygdala	26.0 nTPM
Hippocampus	25.7 nTPM
Thalamus	24.4 nTPM
Hypothalamus	24.2 nTPM
Midbrain	21.8 nTPM

Choroid plexus epithelial cell	46.3 nTPM
Basal ganglia	70.8 nTPM
Medulla oblongata	53.7 nTPM
Hippocampus	30.5 nTPM
Thalamus	30.1 nTPM

Committed oligodendrocyte precursor	22.2 nTPM
Cerebellum	33.3 nTPM
Hypothalamus	28.0 nTPM
Amygdala	27.6 nTPM
Medulla oblongata	23.2 nTPM
Thalamus	22.7 nTPM
Hippocampus	22.5 nTPM
Pons	22.1 nTPM
Basal ganglia	19.7 nTPM
Cerebral cortex	16.5 nTPM
Spinal cord	14.7 nTPM
Midbrain	13.4 nTPM

Deep-layer corticothalamic and 6b	23.8 nTPM
Midbrain	31.1 nTPM
Basal ganglia	29.0 nTPM
Cerebral cortex	24.6 nTPM
Hippocampus	21.6 nTPM
Amygdala	21.5 nTPM
Hypothalamus	15.0 nTPM

Deep-layer intratelencephalic	23.0 nTPM
Basal ganglia	27.0 nTPM
Cerebral cortex	24.1 nTPM
Amygdala	23.8 nTPM
Hippocampus	22.9 nTPM
Hypothalamus	17.2 nTPM

Deep-layer near-projecting	24.6 nTPM
Basal ganglia	29.1 nTPM
Amygdala	28.4 nTPM
Cerebral cortex	25.0 nTPM
Hippocampus	24.7 nTPM
Hypothalamus	15.6 nTPM

Eccentric medium spiny neuron	26.8 nTPM
Hippocampus	30.3 nTPM
Basal ganglia	28.6 nTPM
Cerebral cortex	28.6 nTPM
Thalamus	25.2 nTPM
Amygdala	24.7 nTPM
Hypothalamus	23.6 nTPM