Single cell type - MUC20 - The Human Protein Atlas

MUC20

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MUC20
Gene descriptionⁱ Full gene name according to HGNC.	Mucin 20, cell surface associated
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Respiratory epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Ductal cells, Distal enterocytes, Ionocytes, Club cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.62
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data.	Protein predicted to be secreted

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Ductal cells, Distal enterocytes, Ionocytes, Club cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

MUC20 is part of cluster 35 Respiratory epithelial cells - Unknown function with confidenceⁱ 1
196 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ELF3	E74 like ETS transcription factor 3	0.6659	35
SH2D3A	SH2 domain containing 3A	0.6267	45
CXCL6	C-X-C motif chemokine ligand 6	0.6197	35
NEURL3	Neuralized E3 ubiquitin protein ligase 3	0.6078	45
BICDL2	BICD family like cargo adaptor 2	0.6046	5
RASSF7	Ras association domain family member 7	0.6037	5
CAPN13	Calpain 13	0.5915	35
CLDN7	Claudin 7	0.5785	5
CLDN9	Claudin 9	0.5757	42
ST14	ST14 transmembrane serine protease matriptase	0.5715	5
ADGRF1	Adhesion G protein-coupled receptor F1	0.5670	35
SLC4A11	Solute carrier family 4 member 11	0.5624	35
DUOXA2	Dual oxidase maturation factor 2	0.5600	45
GCNT3	Glucosaminyl (N-acetyl) transferase 3, mucin type	0.5524	5
KRT19	Keratin 19	0.5494	45

Adipocytes	1.3 nTPM
Breast	2.0 nTPM
Adipose tissue	0.6 nTPM

Alveolar cells type 1	2.2 nTPM
Lung	2.2 nTPM

Alveolar cells type 2	1.5 nTPM
Lung	1.5 nTPM

Astrocytes	15.8 nTPM
Brain	15.8 nTPM

B-cells	0.4 nTPM
Lung	2.7 nTPM
Salivary gland	1.4 nTPM
Lymph node	0.5 nTPM
Adipose tissue	0.4 nTPM
Thymus	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Ciliated cells	31.9 nTPM
Bronchus	68.2 nTPM
Lung	41.4 nTPM
Fallopian tube	12.5 nTPM
Endometrium	5.7 nTPM

Club cells	44.7 nTPM
Prostate	62.1 nTPM
Bronchus	45.6 nTPM
Lung	26.5 nTPM

Endothelial cells	1.8 nTPM
Pancreas	5.2 nTPM
Skeletal muscle	4.5 nTPM
Ovary	2.3 nTPM
Heart muscle	2.2 nTPM
Salivary gland	2.2 nTPM
Endometrium	2.1 nTPM
Skin	2.1 nTPM
Testis	1.8 nTPM
Breast	1.8 nTPM
Prostate	1.7 nTPM
Thymus	1.6 nTPM
Liver	1.3 nTPM
Placenta	1.1 nTPM
Tongue	0.9 nTPM
Fallopian tube	0.8 nTPM
Esophagus	0.5 nTPM
Lung	0.5 nTPM
Vascular	0.3 nTPM

Enteroendocrine cells	12.9 nTPM
Rectum	20.1 nTPM
Small intestine	10.3 nTPM
Colon	8.2 nTPM

Fibroblasts	2.5 nTPM
Liver	7.1 nTPM
Skeletal muscle	5.8 nTPM
Heart muscle	3.3 nTPM
Pancreas	3.1 nTPM
Breast	2.8 nTPM
Skin	2.7 nTPM
Salivary gland	2.6 nTPM
Esophagus	2.2 nTPM
Fallopian tube	2.1 nTPM
Placenta	1.6 nTPM
Adipose tissue	1.5 nTPM
Lung	1.5 nTPM
Prostate	1.3 nTPM
Thymus	1.1 nTPM
Vascular	0.7 nTPM
Stomach	0.0 nTPM

Granulocytes	1.0 nTPM
Fallopian tube	2.5 nTPM
Lung	0.5 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	5.4 nTPM
Rectum	8.9 nTPM
Small intestine	4.7 nTPM
Colon	2.7 nTPM

Lymphatic endothelial cells	3.5 nTPM
Ovary	5.5 nTPM
Fallopian tube	1.7 nTPM

Macrophages	1.1 nTPM
Lung	2.5 nTPM
Pancreas	2.1 nTPM
Testis	1.9 nTPM
Skeletal muscle	1.9 nTPM
Thymus	1.9 nTPM
Fallopian tube	1.9 nTPM
Breast	1.7 nTPM
Salivary gland	1.4 nTPM
Endometrium	1.2 nTPM
Bone marrow	1.0 nTPM
Kidney	0.9 nTPM
Tongue	0.9 nTPM
Adipose tissue	0.7 nTPM
Vascular	0.7 nTPM
Prostate	0.3 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	24.9 nTPM
Colon	47.0 nTPM
Rectum	20.6 nTPM
Small intestine	6.9 nTPM

Basal respiratory cells	5.1 nTPM
Bronchus	5.1 nTPM

Bipolar cells	24.4 nTPM
Eye	24.4 nTPM

Cholangiocytes	24.8 nTPM
Liver	24.8 nTPM

Collecting duct cells	27.2 nTPM
Kidney	27.2 nTPM

Plasma cells	1.7 nTPM
Fallopian tube	4.2 nTPM
Liver	3.5 nTPM
Bone marrow	3.0 nTPM
Spleen	1.2 nTPM
Salivary gland	0.9 nTPM
Stomach	0.8 nTPM
Thymus	0.2 nTPM
Esophagus	0.0 nTPM

Schwann cells	1.2 nTPM
Vascular	3.1 nTPM
Adipose tissue	0.4 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	0.7 nTPM
Salivary gland	1.5 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	1.8 nTPM
Skeletal muscle	5.7 nTPM
Liver	4.7 nTPM
Skin	3.1 nTPM
Lung	2.4 nTPM
Breast	2.4 nTPM
Ovary	2.2 nTPM
Fallopian tube	2.0 nTPM
Prostate	1.2 nTPM
Adipose tissue	0.9 nTPM
Tongue	0.9 nTPM
Endometrium	0.8 nTPM
Placenta	0.7 nTPM
Thymus	0.7 nTPM
Vascular	0.7 nTPM
Salivary gland	0.5 nTPM
Esophagus	0.0 nTPM

T-cells	1.1 nTPM
Colon	3.9 nTPM
Skeletal muscle	3.8 nTPM
Salivary gland	3.4 nTPM
Lung	1.6 nTPM
Liver	1.5 nTPM
Tongue	1.4 nTPM
Endometrium	1.3 nTPM
Breast	1.3 nTPM
Vascular	1.2 nTPM
Fallopian tube	0.8 nTPM
PBMC	0.7 nTPM
Lymph node	0.7 nTPM
Thymus	0.6 nTPM
Skin	0.4 nTPM
Prostate	0.4 nTPM
Adipose tissue	0.3 nTPM
Bone marrow	0.3 nTPM
Spleen	0.2 nTPM
Stomach	0.1 nTPM
Kidney	0.0 nTPM
Esophagus	0.0 nTPM

Undifferentiated cells	10.7 nTPM
Rectum	16.5 nTPM
Small intestine	12.9 nTPM
Colon	2.7 nTPM

Amygdala excitatory	2.4 nTPM
Basal ganglia	3.4 nTPM
Hypothalamus	2.9 nTPM
Amygdala	2.5 nTPM
Hippocampus	2.3 nTPM
Cerebral cortex	2.2 nTPM
Thalamus	1.4 nTPM

Astrocyte	3.0 nTPM
Cerebellum	4.2 nTPM
Medulla oblongata	3.5 nTPM
Hippocampus	3.4 nTPM
Basal ganglia	3.2 nTPM
Cerebral cortex	3.2 nTPM
Thalamus	3.2 nTPM
Midbrain	2.7 nTPM
Pons	2.6 nTPM
Spinal cord	2.6 nTPM
Amygdala	2.2 nTPM
Hypothalamus	2.2 nTPM

Bergmann glia	1.9 nTPM
Medulla oblongata	4.3 nTPM
Cerebellum	1.5 nTPM
Pons	0.0 nTPM

Central nervous system macrophage	0.5 nTPM
Cerebral cortex	1.1 nTPM
Cerebellum	0.7 nTPM
Medulla oblongata	0.7 nTPM
Pons	0.5 nTPM
Amygdala	0.4 nTPM
Hippocampus	0.4 nTPM
Midbrain	0.4 nTPM
Basal ganglia	0.3 nTPM
Hypothalamus	0.3 nTPM
Spinal cord	0.3 nTPM
Thalamus	0.3 nTPM

Cerebellar inhibitory	4.2 nTPM
Pons	5.4 nTPM
Cerebellum	5.3 nTPM
Medulla oblongata	4.4 nTPM
Midbrain	3.1 nTPM
Spinal cord	2.7 nTPM

Cge interneuron	2.6 nTPM
Thalamus	3.1 nTPM
Hypothalamus	2.7 nTPM
Midbrain	2.6 nTPM
Cerebral cortex	2.5 nTPM
Amygdala	2.4 nTPM
Basal ganglia	2.4 nTPM
Hippocampus	2.3 nTPM

Choroid plexus epithelial cell	6.5 nTPM
Thalamus	13.7 nTPM
Basal ganglia	5.4 nTPM
Medulla oblongata	4.3 nTPM
Hippocampus	2.8 nTPM

Committed oligodendrocyte precursor	1.1 nTPM
Hypothalamus	3.4 nTPM
Thalamus	2.0 nTPM
Pons	1.8 nTPM
Cerebellum	1.6 nTPM
Hippocampus	1.6 nTPM
Midbrain	0.8 nTPM
Basal ganglia	0.5 nTPM
Amygdala	0.0 nTPM
Cerebral cortex	0.0 nTPM
Medulla oblongata	0.0 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	3.3 nTPM
Midbrain	4.4 nTPM
Hypothalamus	4.2 nTPM
Hippocampus	3.0 nTPM
Cerebral cortex	2.9 nTPM
Amygdala	2.8 nTPM
Basal ganglia	2.7 nTPM

Deep-layer intratelencephalic	2.4 nTPM
Hypothalamus	2.7 nTPM
Amygdala	2.6 nTPM
Basal ganglia	2.4 nTPM
Cerebral cortex	2.4 nTPM
Hippocampus	2.0 nTPM

Deep-layer near-projecting	2.9 nTPM
Basal ganglia	3.8 nTPM
Amygdala	3.2 nTPM
Cerebral cortex	3.2 nTPM
Hypothalamus	3.2 nTPM
Hippocampus	1.0 nTPM

Eccentric medium spiny neuron	2.7 nTPM
Thalamus	3.4 nTPM
Basal ganglia	2.9 nTPM
Hippocampus	2.9 nTPM
Cerebral cortex	2.5 nTPM
Amygdala	2.2 nTPM
Hypothalamus	2.0 nTPM

Endothelial cell	0.6 nTPM
Thalamus	1.7 nTPM
Hippocampus	1.3 nTPM
Amygdala	1.1 nTPM
Medulla oblongata	1.0 nTPM
Cerebral cortex	0.6 nTPM
Pons	0.6 nTPM
Basal ganglia	0.0 nTPM
Cerebellum	0.0 nTPM
Hypothalamus	0.0 nTPM
Midbrain	0.0 nTPM
Spinal cord	0.0 nTPM

Ependymal cell	5.0 nTPM
Medulla oblongata	6.4 nTPM
Hippocampus	5.9 nTPM
Pons	5.9 nTPM
Amygdala	5.7 nTPM
Hypothalamus	5.4 nTPM
Basal ganglia	5.3 nTPM
Thalamus	4.5 nTPM
Midbrain	4.4 nTPM
Spinal cord	1.9 nTPM