Single cell type - BRSK2 - The Human Protein Atlas

BRSK2

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BRSK2
Gene descriptionⁱ Full gene name according to HGNC.	BR serine/threonine kinase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Horizontal & Bipolar cells - Neuronal signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Bipolar cells, Horizontal cells, Excitatory neurons, Rod photoreceptor cells, Inhibitory neurons, Astrocytes, Muller glia cells, Oligodendrocytes, Oligodendrocyte precursor cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.84
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Bipolar cells, Horizontal cells, Excitatory neurons, Rod photoreceptor cells, Inhibitory neurons, Astrocytes, Muller glia cells, Oligodendrocytes, Oligodendrocyte precursor cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

BRSK2 is part of cluster 71 Horizontal & Bipolar cells - Neuronal signaling with confidenceⁱ 1
205 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KIF1A	Kinesin family member 1A	0.7375	71
DRD1	Dopamine receptor D1	0.7303	71
IGSF9B	Immunoglobulin superfamily member 9B	0.7293	71
NPAS4	Neuronal PAS domain protein 4	0.7095	71
TMEM179	Transmembrane protein 179	0.7081	71
CACNA1G	Calcium voltage-gated channel subunit alpha1 G	0.6953	71
KIRREL2	Kirre like nephrin family adhesion molecule 2	0.6897	71
CABP2	Calcium binding protein 2	0.6838	25
KCNG4	Potassium voltage-gated channel modifier subfamily G member 4	0.6822	71
LHX3	LIM homeobox 3	0.6707	71
MAPK8IP2	Mitogen-activated protein kinase 8 interacting protein 2	0.6648	71
GABRR3	Gamma-aminobutyric acid type A receptor subunit rho3	0.6563	25
OR2M5	Olfactory receptor family 2 subfamily M member 5	0.6406	71
ZNF593OS	ZNF593 opposite strand	0.6401	10
BHLHE22	Basic helix-loop-helix family member e22	0.6373	71

Adipocytes	0.4 nTPM
Adipose tissue	0.4 nTPM
Breast	0.3 nTPM

Alveolar cells type 1	0.1 nTPM
Lung	0.1 nTPM

Alveolar cells type 2	0.2 nTPM
Lung	0.2 nTPM

B-cells	0.2 nTPM
Adipose tissue	0.8 nTPM
Lymph node	0.8 nTPM
Spleen	0.4 nTPM
Stomach	0.4 nTPM
Salivary gland	0.4 nTPM
Thymus	0.2 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Lung	0.0 nTPM

Basal keratinocytes	0.1 nTPM
Tongue	0.2 nTPM
Skin	0.0 nTPM

Ciliated cells	0.6 nTPM
Fallopian tube	2.1 nTPM
Lung	0.2 nTPM
Endometrium	0.1 nTPM
Bronchus	0.1 nTPM

Club cells	0.2 nTPM
Lung	0.5 nTPM
Bronchus	0.1 nTPM
Prostate	0.0 nTPM

Endothelial cells	0.5 nTPM
Breast	4.4 nTPM
Prostate	1.0 nTPM
Fallopian tube	0.7 nTPM
Placenta	0.6 nTPM
Skin	0.6 nTPM
Tongue	0.5 nTPM
Ovary	0.5 nTPM
Heart muscle	0.4 nTPM
Skeletal muscle	0.3 nTPM
Endometrium	0.2 nTPM
Salivary gland	0.2 nTPM
Thymus	0.2 nTPM
Vascular	0.2 nTPM
Lung	0.1 nTPM
Testis	0.0 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM

Enteroendocrine cells	4.1 nTPM
Small intestine	6.9 nTPM
Rectum	5.0 nTPM
Colon	0.4 nTPM

Fibroblasts	1.0 nTPM
Fallopian tube	4.2 nTPM
Prostate	2.6 nTPM
Lung	1.8 nTPM
Stomach	1.4 nTPM
Liver	1.2 nTPM
Thymus	1.1 nTPM
Esophagus	0.9 nTPM
Vascular	0.7 nTPM
Salivary gland	0.5 nTPM
Placenta	0.2 nTPM
Pancreas	0.2 nTPM
Skeletal muscle	0.2 nTPM
Skin	0.1 nTPM
Adipose tissue	0.1 nTPM
Breast	0.1 nTPM
Heart muscle	0.0 nTPM

Granulocytes	0.0 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM
Fallopian tube	0.0 nTPM

Intestinal goblet cells	0.2 nTPM
Small intestine	0.7 nTPM
Colon	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	1.2 nTPM
Fallopian tube	2.3 nTPM
Ovary	0.0 nTPM

Macrophages	0.0 nTPM
Salivary gland	0.3 nTPM
Prostate	0.2 nTPM
Breast	0.2 nTPM
Vascular	0.1 nTPM
Fallopian tube	0.1 nTPM
Testis	0.0 nTPM
Kidney	0.0 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Astrocytes	21.7 nTPM
Brain	21.7 nTPM

Cone photoreceptor cells	18.7 nTPM
Eye	18.7 nTPM

Plasma cells	0.1 nTPM
Fallopian tube	0.6 nTPM
Salivary gland	0.4 nTPM
Thymus	0.1 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Schwann cells	8.5 nTPM
Vascular	25.6 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	0.1 nTPM
Salivary gland	0.2 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	9.4 nTPM
Prostate	33.5 nTPM
Fallopian tube	30.0 nTPM
Esophagus	14.4 nTPM
Thymus	12.2 nTPM
Ovary	11.1 nTPM
Salivary gland	8.5 nTPM
Lung	8.2 nTPM
Tongue	8.1 nTPM
Vascular	6.6 nTPM
Skin	6.4 nTPM
Breast	5.1 nTPM
Adipose tissue	2.0 nTPM
Placenta	1.5 nTPM
Endometrium	1.2 nTPM
Skeletal muscle	1.0 nTPM
Liver	0.0 nTPM

T-cells	0.4 nTPM
Esophagus	2.4 nTPM
Skeletal muscle	1.1 nTPM
Thymus	0.5 nTPM
Skin	0.4 nTPM
Adipose tissue	0.4 nTPM
Salivary gland	0.4 nTPM
PBMC	0.3 nTPM
Prostate	0.3 nTPM
Breast	0.3 nTPM
Fallopian tube	0.3 nTPM
Endometrium	0.2 nTPM
Lymph node	0.2 nTPM
Tongue	0.2 nTPM
Bone marrow	0.1 nTPM
Spleen	0.1 nTPM
Stomach	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
Lung	0.0 nTPM
Vascular	0.0 nTPM

Undifferentiated cells	0.4 nTPM
Colon	0.8 nTPM
Small intestine	0.2 nTPM
Rectum	0.1 nTPM

Amygdala excitatory	72.1 nTPM
Hippocampus	84.6 nTPM
Hypothalamus	79.0 nTPM
Cerebral cortex	75.1 nTPM
Amygdala	73.8 nTPM
Basal ganglia	72.7 nTPM
Thalamus	47.2 nTPM

Astrocyte	34.1 nTPM
Pons	43.0 nTPM
Cerebellum	42.1 nTPM
Cerebral cortex	40.9 nTPM
Thalamus	40.0 nTPM
Hippocampus	37.7 nTPM
Midbrain	35.0 nTPM
Spinal cord	30.0 nTPM
Amygdala	29.8 nTPM
Basal ganglia	28.2 nTPM
Medulla oblongata	27.7 nTPM
Hypothalamus	20.7 nTPM

Bergmann glia	27.1 nTPM
Medulla oblongata	29.8 nTPM
Cerebellum	28.6 nTPM
Pons	23.0 nTPM

Central nervous system macrophage	2.8 nTPM
Cerebral cortex	4.8 nTPM
Hippocampus	4.1 nTPM
Thalamus	4.1 nTPM
Hypothalamus	3.7 nTPM
Amygdala	3.4 nTPM
Spinal cord	2.1 nTPM
Cerebellum	2.0 nTPM
Midbrain	1.9 nTPM
Medulla oblongata	1.8 nTPM
Pons	1.8 nTPM
Basal ganglia	1.3 nTPM

Cerebellar inhibitory	47.0 nTPM
Midbrain	61.0 nTPM
Pons	49.7 nTPM
Cerebellum	48.0 nTPM
Medulla oblongata	46.0 nTPM
Spinal cord	30.2 nTPM

Cge interneuron	53.3 nTPM
Hypothalamus	62.9 nTPM
Thalamus	60.6 nTPM
Amygdala	53.3 nTPM
Basal ganglia	51.9 nTPM
Midbrain	51.3 nTPM
Hippocampus	47.1 nTPM
Cerebral cortex	46.2 nTPM

Choroid plexus epithelial cell	2.2 nTPM
Thalamus	5.5 nTPM
Medulla oblongata	2.4 nTPM
Basal ganglia	1.0 nTPM
Hippocampus	0.0 nTPM

Committed oligodendrocyte precursor	46.3 nTPM
Cerebellum	69.8 nTPM
Hippocampus	60.3 nTPM
Spinal cord	55.2 nTPM
Cerebral cortex	51.9 nTPM
Thalamus	50.7 nTPM
Pons	49.6 nTPM
Hypothalamus	43.0 nTPM
Midbrain	37.0 nTPM
Basal ganglia	36.1 nTPM
Amygdala	35.0 nTPM
Medulla oblongata	20.7 nTPM

Deep-layer corticothalamic and 6b	74.9 nTPM
Hypothalamus	86.5 nTPM
Amygdala	81.9 nTPM
Hippocampus	76.2 nTPM
Cerebral cortex	71.6 nTPM
Basal ganglia	68.0 nTPM
Midbrain	65.5 nTPM

Deep-layer intratelencephalic	75.8 nTPM
Hypothalamus	96.6 nTPM
Amygdala	78.3 nTPM
Hippocampus	70.2 nTPM
Cerebral cortex	69.5 nTPM
Basal ganglia	64.6 nTPM

Deep-layer near-projecting	70.9 nTPM
Hypothalamus	96.3 nTPM
Amygdala	78.2 nTPM
Cerebral cortex	62.1 nTPM
Basal ganglia	61.1 nTPM
Hippocampus	56.9 nTPM

Eccentric medium spiny neuron	52.6 nTPM
Thalamus	55.7 nTPM
Cerebral cortex	53.9 nTPM
Amygdala	53.2 nTPM
Hypothalamus	52.5 nTPM
Basal ganglia	51.5 nTPM
Hippocampus	48.5 nTPM

Endothelial cell	3.2 nTPM
Hypothalamus	7.4 nTPM
Spinal cord	5.2 nTPM
Cerebellum	4.6 nTPM
Cerebral cortex	4.5 nTPM
Hippocampus	4.2 nTPM
Thalamus	4.0 nTPM
Amygdala	2.2 nTPM
Basal ganglia	1.9 nTPM
Midbrain	0.9 nTPM
Pons	0.6 nTPM
Medulla oblongata	0.0 nTPM

Ependymal cell	3.8 nTPM
Amygdala	6.3 nTPM
Spinal cord	5.7 nTPM
Hypothalamus	4.5 nTPM
Basal ganglia	4.2 nTPM
Hippocampus	3.4 nTPM
Midbrain	3.2 nTPM
Medulla oblongata	2.9 nTPM
Thalamus	2.4 nTPM
Pons	2.0 nTPM