Single cell type - IFFO2 - The Human Protein Atlas

IFFO2

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IFFO2
Gene descriptionⁱ Full gene name according to HGNC.	Intermediate filament family orphan 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Squamous epithelial cells - Keratinization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Basal keratinocytes, Suprabasal keratinocytes, Salivary duct cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.61
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enriched (basophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Basal keratinocytes, Suprabasal keratinocytes, Salivary duct cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enriched (basophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

IFFO2 is part of cluster 12 Squamous epithelial cells - Keratinization with confidenceⁱ 1
309 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KRT14	Keratin 14	0.7939	12
DSC3	Desmocollin 3	0.7784	12
MT4	Metallothionein 4	0.7669	12
KRT5	Keratin 5	0.7424	12
HEPHL1	Hephaestin like 1	0.7378	12
LTB4R	Leukotriene B4 receptor	0.7338	12
GSDMC	Gasdermin C	0.7337	12
FAM83G	Family with sequence similarity 83 member G	0.7297	12
COL17A1	Collagen type XVII alpha 1 chain	0.7284	12
CAPNS2	Calpain small subunit 2	0.7207	12
KLC3	Kinesin light chain 3	0.7191	12
LGALS7B	Galectin 7B	0.7139	12
S100A7	S100 calcium binding protein A7	0.7084	12
GJB5	Gap junction protein beta 5	0.6978	12
SERPINB5	Serpin family B member 5	0.6952	12

Adipocytes	3.8 nTPM
Breast	4.8 nTPM
Adipose tissue	2.8 nTPM

Alveolar cells type 1	5.2 nTPM
Lung	5.2 nTPM

Alveolar cells type 2	18.4 nTPM
Lung	18.4 nTPM

Astrocytes	5.3 nTPM
Brain	5.3 nTPM

B-cells	7.3 nTPM
Adipose tissue	23.0 nTPM
Skin	22.0 nTPM
Thymus	12.6 nTPM
Lung	6.7 nTPM
Salivary gland	6.6 nTPM
Lymph node	6.0 nTPM
Stomach	5.1 nTPM
Liver	4.8 nTPM
Spleen	4.3 nTPM
PBMC	3.1 nTPM
Bone marrow	0.7 nTPM
Kidney	0.0 nTPM
Esophagus	0.0 nTPM

Ciliated cells	26.3 nTPM
Bronchus	45.4 nTPM
Lung	24.4 nTPM
Endometrium	22.7 nTPM
Fallopian tube	12.8 nTPM

Club cells	12.2 nTPM
Lung	17.8 nTPM
Bronchus	12.5 nTPM
Prostate	6.3 nTPM

Endothelial cells	7.9 nTPM
Tongue	29.6 nTPM
Endometrium	14.7 nTPM
Lung	13.8 nTPM
Esophagus	9.9 nTPM
Liver	8.8 nTPM
Pancreas	7.8 nTPM
Salivary gland	7.5 nTPM
Thymus	7.2 nTPM
Fallopian tube	7.2 nTPM
Prostate	5.8 nTPM
Vascular	5.3 nTPM
Placenta	5.1 nTPM
Skeletal muscle	5.0 nTPM
Heart muscle	4.8 nTPM
Skin	4.8 nTPM
Ovary	2.8 nTPM
Breast	1.8 nTPM
Testis	0.9 nTPM

Enteroendocrine cells	1.6 nTPM
Rectum	3.4 nTPM
Colon	1.4 nTPM
Small intestine	0.0 nTPM

Fibroblasts	4.8 nTPM
Skin	13.0 nTPM
Pancreas	9.8 nTPM
Liver	7.1 nTPM
Lung	6.1 nTPM
Stomach	4.3 nTPM
Esophagus	4.1 nTPM
Prostate	4.0 nTPM
Breast	3.9 nTPM
Thymus	3.5 nTPM
Vascular	3.4 nTPM
Heart muscle	3.2 nTPM
Skeletal muscle	3.2 nTPM
Salivary gland	3.2 nTPM
Fallopian tube	3.2 nTPM
Adipose tissue	2.3 nTPM
Placenta	1.6 nTPM

Granulocytes	26.6 nTPM
Fallopian tube	42.5 nTPM
Tongue	29.1 nTPM
Lung	8.1 nTPM

Intestinal goblet cells	1.3 nTPM
Colon	2.7 nTPM
Rectum	1.2 nTPM
Small intestine	0.1 nTPM

Lymphatic endothelial cells	2.7 nTPM
Fallopian tube	5.3 nTPM
Ovary	0.0 nTPM

Macrophages	9.1 nTPM
Tongue	33.2 nTPM
Adipose tissue	18.8 nTPM
Endometrium	13.5 nTPM
Fallopian tube	13.5 nTPM
Skin	12.3 nTPM
Breast	11.1 nTPM
Stomach	10.3 nTPM
Skeletal muscle	9.7 nTPM
Pancreas	8.2 nTPM
Vascular	7.7 nTPM
Salivary gland	7.0 nTPM
Spleen	5.0 nTPM
Thymus	4.7 nTPM
Esophagus	3.9 nTPM
Kidney	3.5 nTPM
Prostate	3.1 nTPM
Testis	2.5 nTPM
Lung	2.5 nTPM
Bone marrow	2.0 nTPM

Paneth cells	2.1 nTPM
Small intestine	3.5 nTPM
Rectum	2.9 nTPM
Colon	0.0 nTPM

Basal keratinocytes	126.6 nTPM
Skin	161.4 nTPM
Tongue	91.7 nTPM

Basal prostatic cells	7.4 nTPM
Prostate	7.4 nTPM

Basal respiratory cells	25.1 nTPM
Bronchus	25.1 nTPM

Bipolar cells	7.4 nTPM
Eye	7.4 nTPM

Plasma cells	16.1 nTPM
Salivary gland	34.9 nTPM
Fallopian tube	33.1 nTPM
Esophagus	26.0 nTPM
Stomach	14.7 nTPM
Thymus	9.3 nTPM
Bone marrow	4.5 nTPM
Spleen	3.6 nTPM
Liver	3.0 nTPM

Schwann cells	8.0 nTPM
Adipose tissue	21.5 nTPM
Vascular	2.6 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	22.6 nTPM
Tongue	39.8 nTPM
Salivary gland	5.4 nTPM

Smooth muscle cells	8.9 nTPM
Tongue	22.2 nTPM
Salivary gland	19.9 nTPM
Thymus	12.7 nTPM
Endometrium	11.9 nTPM
Skin	11.5 nTPM
Breast	8.6 nTPM
Lung	8.2 nTPM
Fallopian tube	7.6 nTPM
Prostate	7.3 nTPM
Vascular	7.3 nTPM
Esophagus	6.0 nTPM
Adipose tissue	5.8 nTPM
Skeletal muscle	5.3 nTPM
Ovary	3.2 nTPM
Liver	3.0 nTPM
Placenta	2.5 nTPM

Suprabasal keratinocytes	118.6 nTPM
Skin	127.7 nTPM
Tongue	109.5 nTPM

T-cells	19.4 nTPM
Tongue	51.6 nTPM
Adipose tissue	34.3 nTPM
Breast	34.0 nTPM
Fallopian tube	29.8 nTPM
Esophagus	29.2 nTPM
Vascular	28.5 nTPM
Thymus	26.2 nTPM
Endometrium	23.3 nTPM
Salivary gland	23.1 nTPM
Skin	20.0 nTPM
Skeletal muscle	19.3 nTPM
Lymph node	13.0 nTPM
Spleen	12.9 nTPM
Stomach	12.6 nTPM
Lung	12.3 nTPM
PBMC	8.5 nTPM
Prostate	7.6 nTPM
Colon	6.8 nTPM
Liver	6.0 nTPM
Bone marrow	4.7 nTPM
Kidney	4.4 nTPM

Undifferentiated cells	1.9 nTPM
Colon	2.8 nTPM
Rectum	2.3 nTPM
Small intestine	0.7 nTPM

Amygdala excitatory	16.9 nTPM
Hypothalamus	23.5 nTPM
Hippocampus	18.7 nTPM
Basal ganglia	17.7 nTPM
Amygdala	17.5 nTPM
Cerebral cortex	15.7 nTPM
Thalamus	8.6 nTPM

Astrocyte	56.6 nTPM
Spinal cord	217.4 nTPM
Medulla oblongata	68.7 nTPM
Hypothalamus	50.8 nTPM
Pons	50.2 nTPM
Basal ganglia	46.5 nTPM
Midbrain	45.9 nTPM
Cerebellum	40.7 nTPM
Thalamus	31.3 nTPM
Amygdala	25.7 nTPM
Hippocampus	23.6 nTPM
Cerebral cortex	21.4 nTPM

Bergmann glia	11.5 nTPM
Pons	14.4 nTPM
Cerebellum	13.6 nTPM
Medulla oblongata	6.4 nTPM

Central nervous system macrophage	3.2 nTPM
Medulla oblongata	4.9 nTPM
Hypothalamus	3.7 nTPM
Thalamus	3.7 nTPM
Spinal cord	3.5 nTPM
Hippocampus	3.4 nTPM
Cerebellum	3.2 nTPM
Basal ganglia	2.8 nTPM
Amygdala	2.7 nTPM
Midbrain	2.6 nTPM
Cerebral cortex	2.3 nTPM
Pons	1.9 nTPM

Cerebellar inhibitory	43.3 nTPM
Spinal cord	63.2 nTPM
Cerebellum	49.3 nTPM
Medulla oblongata	41.2 nTPM
Midbrain	38.3 nTPM
Pons	24.5 nTPM

Cge interneuron	11.7 nTPM
Hypothalamus	20.0 nTPM
Hippocampus	12.8 nTPM
Cerebral cortex	12.3 nTPM
Amygdala	12.1 nTPM
Basal ganglia	10.7 nTPM
Midbrain	7.8 nTPM
Thalamus	6.3 nTPM

Choroid plexus epithelial cell	6.9 nTPM
Basal ganglia	9.4 nTPM
Thalamus	8.2 nTPM
Hippocampus	5.5 nTPM
Medulla oblongata	4.4 nTPM

Committed oligodendrocyte precursor	10.0 nTPM
Thalamus	17.1 nTPM
Amygdala	14.1 nTPM
Hypothalamus	10.9 nTPM
Medulla oblongata	10.3 nTPM
Cerebral cortex	10.1 nTPM
Hippocampus	9.8 nTPM
Midbrain	9.2 nTPM
Basal ganglia	8.8 nTPM
Spinal cord	7.4 nTPM
Cerebellum	6.3 nTPM
Pons	6.2 nTPM

Deep-layer corticothalamic and 6b	14.8 nTPM
Hypothalamus	23.5 nTPM
Hippocampus	16.6 nTPM
Amygdala	13.5 nTPM
Cerebral cortex	12.7 nTPM
Basal ganglia	11.8 nTPM
Midbrain	11.1 nTPM

Deep-layer intratelencephalic	15.9 nTPM
Hypothalamus	25.0 nTPM
Hippocampus	15.5 nTPM
Amygdala	14.0 nTPM
Cerebral cortex	13.7 nTPM
Basal ganglia	11.4 nTPM

Deep-layer near-projecting	16.6 nTPM
Hypothalamus	22.0 nTPM
Amygdala	16.6 nTPM
Basal ganglia	16.4 nTPM
Cerebral cortex	16.0 nTPM
Hippocampus	12.0 nTPM

Eccentric medium spiny neuron	14.6 nTPM
Cerebral cortex	17.0 nTPM
Hypothalamus	16.4 nTPM
Amygdala	14.9 nTPM
Thalamus	14.7 nTPM
Hippocampus	12.8 nTPM
Basal ganglia	11.8 nTPM

Endothelial cell	5.1 nTPM
Hypothalamus	8.7 nTPM
Basal ganglia	7.5 nTPM
Cerebral cortex	7.0 nTPM
Hippocampus	6.4 nTPM
Medulla oblongata	6.2 nTPM
Cerebellum	5.4 nTPM
Spinal cord	3.5 nTPM
Amygdala	3.4 nTPM
Pons	3.1 nTPM
Midbrain	2.8 nTPM
Thalamus	2.3 nTPM