Single cell type - DTWD2 - The Human Protein Atlas

DTWD2

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DTWD2
Gene descriptionⁱ Full gene name according to HGNC.	DTW domain containing 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neurons - Neuronal signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Excitatory neurons, Inhibitory neurons, Oligodendrocyte precursor cells, Oligodendrocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.51
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Excitatory neurons, Inhibitory neurons, Oligodendrocyte precursor cells, Oligodendrocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

DTWD2 is part of cluster 8 Neurons - Neuronal signaling with confidenceⁱ 0.99
265 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FAM81A	Family with sequence similarity 81 member A	0.5869	65
ELMOD1	ELMO domain containing 1	0.5819	8
TRPC5	Transient receptor potential cation channel subfamily C member 5	0.5750	8
SCN1A	Sodium voltage-gated channel alpha subunit 1	0.5571	8
TTBK2	Tau tubulin kinase 2	0.5461	8
CUX2	Cut like homeobox 2	0.5444	34
KLHL29	Kelch like family member 29	0.5402	8
HAPLN4	Hyaluronan and proteoglycan link protein 4	0.5386	8
ATRNL1	Attractin like 1	0.5379	34
AMPH	Amphiphysin	0.5335	65
OSBPL6	Oxysterol binding protein like 6	0.5304	8
PPARGC1A	PPARG coactivator 1 alpha	0.5293	8
FBXL17	F-box and leucine rich repeat protein 17	0.5244	8
TMEM178B	Transmembrane protein 178B	0.5219	65
FAM78B	Family with sequence similarity 78 member B	0.5147	8

IMMUNE CELLS

DTWD2 is part of cluster 24 Non-specific - Transcription with confidenceⁱ 0.59
516 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF233	Zinc finger protein 233	1.0000	24
H2BC14	H2B clustered histone 14	0.9762	24
RPAP2	RNA polymerase II associated protein 2	0.9762	24
CHI3L2	Chitinase 3 like 2	0.9524	24
ENSG00000268533	Novel protein	0.9524	34
ZFP2	ZFP2 zinc finger protein	0.9524	24
SPRY1	Sprouty RTK signaling antagonist 1	0.9524	34
PLCE1	Phospholipase C epsilon 1	0.9524	34
C19orf44	Chromosome 19 open reading frame 44	0.9524	34
TAF4B	TATA-box binding protein associated factor 4b	0.9286	34
FBXO5	F-box protein 5	0.9286	24
LPAR5	Lysophosphatidic acid receptor 5	0.9286	24
ZNF292	Zinc finger protein 292	0.9286	24
ZNF724	Zinc finger protein 724	0.9286	34
PRKDC	Protein kinase, DNA-activated, catalytic subunit	0.9286	24

Adipocytes	2.6 nTPM
Adipose tissue	2.8 nTPM
Breast	2.4 nTPM

Alveolar cells type 1	8.0 nTPM
Lung	8.0 nTPM

Alveolar cells type 2	9.8 nTPM
Lung	9.8 nTPM

Astrocytes	31.9 nTPM
Brain	31.9 nTPM

B-cells	6.1 nTPM
Lymph node	11.8 nTPM
Salivary gland	10.1 nTPM
Stomach	9.7 nTPM
Adipose tissue	8.6 nTPM
Spleen	7.4 nTPM
Thymus	7.1 nTPM
Bone marrow	7.0 nTPM
Lung	6.7 nTPM
PBMC	6.2 nTPM
Skin	5.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM

Ciliated cells	4.6 nTPM
Lung	5.1 nTPM
Fallopian tube	5.1 nTPM
Endometrium	5.0 nTPM
Bronchus	3.4 nTPM

Club cells	10.4 nTPM
Lung	14.1 nTPM
Prostate	10.0 nTPM
Bronchus	7.1 nTPM

Endothelial cells	3.3 nTPM
Breast	7.0 nTPM
Prostate	5.8 nTPM
Endometrium	4.9 nTPM
Lung	4.5 nTPM
Fallopian tube	3.9 nTPM
Liver	3.8 nTPM
Testis	3.7 nTPM
Thymus	3.7 nTPM
Ovary	3.7 nTPM
Esophagus	3.4 nTPM
Skin	3.2 nTPM
Vascular	3.0 nTPM
Tongue	2.4 nTPM
Skeletal muscle	2.3 nTPM
Salivary gland	2.0 nTPM
Heart muscle	0.9 nTPM
Placenta	0.6 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	6.0 nTPM
Colon	9.5 nTPM
Rectum	5.0 nTPM
Small intestine	3.4 nTPM

Fibroblasts	3.2 nTPM
Stomach	5.8 nTPM
Skeletal muscle	4.8 nTPM
Lung	4.7 nTPM
Thymus	4.0 nTPM
Vascular	3.9 nTPM
Fallopian tube	3.5 nTPM
Esophagus	3.4 nTPM
Skin	3.3 nTPM
Salivary gland	3.1 nTPM
Prostate	2.6 nTPM
Adipose tissue	2.5 nTPM
Liver	2.4 nTPM
Breast	2.2 nTPM
Pancreas	2.1 nTPM
Placenta	1.8 nTPM
Heart muscle	1.5 nTPM

Granulocytes	5.0 nTPM
Lung	8.1 nTPM
Fallopian tube	6.9 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	5.6 nTPM
Colon	7.6 nTPM
Rectum	5.7 nTPM
Small intestine	3.7 nTPM

Lymphatic endothelial cells	4.6 nTPM
Ovary	5.5 nTPM
Fallopian tube	3.9 nTPM

Macrophages	6.0 nTPM
Tongue	11.0 nTPM
Pancreas	10.3 nTPM
Breast	8.7 nTPM
Endometrium	8.0 nTPM
Spleen	8.0 nTPM
Salivary gland	7.6 nTPM
Prostate	7.5 nTPM
Lung	7.1 nTPM
Vascular	6.5 nTPM
Testis	6.2 nTPM
Skeletal muscle	6.0 nTPM
Adipose tissue	5.3 nTPM
Bone marrow	5.1 nTPM
Fallopian tube	4.8 nTPM
Thymus	4.3 nTPM
Skin	3.3 nTPM
Stomach	2.6 nTPM
Esophagus	1.3 nTPM
Kidney	0.9 nTPM

Paneth cells	9.4 nTPM
Colon	10.9 nTPM
Small intestine	10.4 nTPM
Rectum	7.0 nTPM

Basal prostatic cells	7.3 nTPM
Prostate	7.3 nTPM

Basal respiratory cells	4.2 nTPM
Bronchus	4.2 nTPM

Bipolar cells	12.2 nTPM
Eye	12.2 nTPM

Collecting duct cells	7.8 nTPM
Kidney	7.8 nTPM

Plasma cells	7.2 nTPM
Esophagus	10.4 nTPM
Fallopian tube	10.3 nTPM
Stomach	9.2 nTPM
Spleen	8.4 nTPM
Salivary gland	6.3 nTPM
Thymus	4.7 nTPM
Bone marrow	4.5 nTPM
Liver	3.5 nTPM

Schwann cells	2.5 nTPM
Vascular	6.8 nTPM
Adipose tissue	0.8 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	8.9 nTPM
Salivary gland	9.0 nTPM
Tongue	8.8 nTPM

Smooth muscle cells	4.4 nTPM
Prostate	6.7 nTPM
Fallopian tube	6.4 nTPM
Endometrium	6.1 nTPM
Vascular	5.7 nTPM
Skin	5.5 nTPM
Salivary gland	5.3 nTPM
Esophagus	4.8 nTPM
Breast	4.8 nTPM
Thymus	4.7 nTPM
Skeletal muscle	4.6 nTPM
Lung	3.5 nTPM
Tongue	3.0 nTPM
Ovary	2.8 nTPM
Adipose tissue	2.7 nTPM
Liver	2.1 nTPM
Placenta	1.4 nTPM

T-cells	3.7 nTPM
Thymus	5.7 nTPM
PBMC	5.5 nTPM
Prostate	5.5 nTPM
Lymph node	5.1 nTPM
Salivary gland	4.8 nTPM
Breast	4.7 nTPM
Stomach	4.6 nTPM
Fallopian tube	4.4 nTPM
Spleen	4.3 nTPM
Bone marrow	4.2 nTPM
Vascular	4.0 nTPM
Skin	3.9 nTPM
Endometrium	3.4 nTPM
Skeletal muscle	3.4 nTPM
Kidney	2.7 nTPM
Esophagus	2.4 nTPM
Adipose tissue	2.2 nTPM
Tongue	2.2 nTPM
Lung	2.1 nTPM
Colon	1.9 nTPM
Liver	0.8 nTPM

Undifferentiated cells	5.5 nTPM
Colon	7.0 nTPM
Small intestine	5.9 nTPM
Rectum	3.5 nTPM

Amygdala excitatory	85.4 nTPM
Cerebral cortex	102.1 nTPM
Hippocampus	91.5 nTPM
Thalamus	88.0 nTPM
Basal ganglia	79.2 nTPM
Amygdala	78.7 nTPM
Hypothalamus	73.1 nTPM

Astrocyte	60.5 nTPM
Amygdala	86.5 nTPM
Hypothalamus	78.4 nTPM
Cerebral cortex	70.6 nTPM
Hippocampus	68.7 nTPM
Basal ganglia	65.3 nTPM
Thalamus	58.5 nTPM
Medulla oblongata	53.6 nTPM
Spinal cord	53.2 nTPM
Midbrain	47.7 nTPM
Pons	45.4 nTPM
Cerebellum	37.7 nTPM

Bergmann glia	47.3 nTPM
Pons	61.9 nTPM
Cerebellum	45.9 nTPM
Medulla oblongata	34.1 nTPM

Central nervous system macrophage	69.8 nTPM
Hypothalamus	98.1 nTPM
Amygdala	88.6 nTPM
Basal ganglia	69.4 nTPM
Thalamus	68.1 nTPM
Midbrain	66.8 nTPM
Pons	65.4 nTPM
Hippocampus	63.7 nTPM
Spinal cord	63.0 nTPM
Cerebellum	62.7 nTPM
Cerebral cortex	62.2 nTPM
Medulla oblongata	59.4 nTPM

Cerebellar inhibitory	88.6 nTPM
Spinal cord	112.7 nTPM
Midbrain	93.3 nTPM
Cerebellum	82.9 nTPM
Medulla oblongata	82.9 nTPM
Pons	71.3 nTPM

Cge interneuron	65.4 nTPM
Thalamus	74.7 nTPM
Amygdala	73.3 nTPM
Midbrain	67.4 nTPM
Hypothalamus	65.1 nTPM
Basal ganglia	61.2 nTPM
Cerebral cortex	59.9 nTPM
Hippocampus	56.1 nTPM

Choroid plexus epithelial cell	97.4 nTPM
Basal ganglia	118.3 nTPM
Hippocampus	99.8 nTPM
Medulla oblongata	86.5 nTPM
Thalamus	85.0 nTPM

Committed oligodendrocyte precursor	57.7 nTPM
Cerebral cortex	69.0 nTPM
Hippocampus	64.2 nTPM
Amygdala	61.5 nTPM
Midbrain	60.5 nTPM
Spinal cord	58.9 nTPM
Medulla oblongata	58.1 nTPM
Hypothalamus	58.0 nTPM
Pons	54.9 nTPM
Thalamus	53.6 nTPM
Basal ganglia	49.8 nTPM
Cerebellum	46.0 nTPM

Deep-layer corticothalamic and 6b	51.4 nTPM
Midbrain	59.9 nTPM
Hippocampus	53.7 nTPM
Amygdala	53.2 nTPM
Cerebral cortex	51.0 nTPM
Basal ganglia	46.7 nTPM
Hypothalamus	43.9 nTPM

Deep-layer intratelencephalic	64.4 nTPM
Hippocampus	69.7 nTPM
Amygdala	67.8 nTPM
Cerebral cortex	63.3 nTPM
Basal ganglia	61.2 nTPM
Hypothalamus	60.1 nTPM

Deep-layer near-projecting	75.3 nTPM
Amygdala	79.8 nTPM
Cerebral cortex	76.0 nTPM
Hippocampus	74.5 nTPM
Hypothalamus	74.3 nTPM
Basal ganglia	71.8 nTPM

Eccentric medium spiny neuron	110.1 nTPM
Amygdala	137.1 nTPM
Cerebral cortex	127.1 nTPM
Hypothalamus	108.3 nTPM
Thalamus	102.0 nTPM
Basal ganglia	98.5 nTPM
Hippocampus	87.5 nTPM

Endothelial cell	42.5 nTPM
Thalamus	55.9 nTPM
Amygdala	46.9 nTPM
Spinal cord	46.6 nTPM
Hippocampus	44.2 nTPM
Cerebellum	43.4 nTPM
Medulla oblongata	41.0 nTPM
Pons	39.9 nTPM
Basal ganglia	39.1 nTPM
Midbrain	38.7 nTPM
Cerebral cortex	37.7 nTPM
Hypothalamus	33.5 nTPM

Ependymal cell	45.7 nTPM
Basal ganglia	53.9 nTPM
Thalamus	51.4 nTPM
Amygdala	49.5 nTPM
Hypothalamus	48.2 nTPM
Hippocampus	46.7 nTPM
Medulla oblongata	45.0 nTPM
Midbrain	44.4 nTPM
Pons	43.2 nTPM
Spinal cord	28.7 nTPM