Single cell type - CA5B - The Human Protein Atlas

CA5B

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CA5B
Gene descriptionⁱ Full gene name according to HGNC.	Carbonic anhydrase 5B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Enzymes FDA approved drug targets Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	NK-cells & T-cells - Immune system & Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (NK-cells, Muller glia cells, T-cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.54
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (NK-cells, Muller glia cells, T-cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

CA5B is part of cluster 78 NK-cells & T-cells - Immune system & Transcription with confidenceⁱ 1
392 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CNOT6L	CCR4-NOT transcription complex subunit 6 like	0.8559	78
ZBED4	Zinc finger BED-type containing 4	0.8253	78
ETS1	ETS proto-oncogene 1, transcription factor	0.8237	78
BRD1	Bromodomain containing 1	0.8018	78
RASGRP1	RAS guanyl releasing protein 1	0.7938	78
RNF19A	Ring finger protein 19A, RBR E3 ubiquitin protein ligase	0.7927	78
ZNF831	Zinc finger protein 831	0.7868	78
RNF125	Ring finger protein 125	0.7771	78
CASP8	Caspase 8	0.7757	78
RGPD2	RANBP2 like and GRIP domain containing 2	0.7727	78
CEMIP2	Cell migration inducing hyaluronidase 2	0.7657	78
IPCEF1	Interaction protein for cytohesin exchange factors 1	0.7330	78
CRYBG1	Crystallin beta-gamma domain containing 1	0.7277	78
CDC42SE2	CDC42 small effector 2	0.7275	78
PPP2R5C	Protein phosphatase 2 regulatory subunit B'gamma	0.7220	78

IMMUNE CELLS

CA5B is part of cluster 1 T-cells - Unknown function with confidenceⁱ 1
202 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ST6GALNAC6	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6	1.0000	1
TIAL1	TIA1 cytotoxic granule associated RNA binding protein like 1	0.9762	1
TSPAN5	Tetraspanin 5	0.9762	1
SLFN5	Schlafen family member 5	0.9762	1
PLEKHF1	Pleckstrin homology and FYVE domain containing 1	0.9762	1
DYNLT3	Dynein light chain Tctex-type 3	0.9762	1
EIF5A2	Eukaryotic translation initiation factor 5A2	0.9762	1
RALGDS	Ral guanine nucleotide dissociation stimulator	0.9762	5
CHODL	Chondrolectin	0.9762	1
OBI1	ORC ubiquitin ligase 1	0.9762	1
FYN	FYN proto-oncogene, Src family tyrosine kinase	0.9762	1
DOCK10	Dedicator of cytokinesis 10	0.9762	5
ZNF831	Zinc finger protein 831	0.9762	1
NFYB	Nuclear transcription factor Y subunit beta	0.9762	1
CD2	CD2 molecule	0.9762	1

Adipocytes	7.9 nTPM
Adipose tissue	10.3 nTPM
Breast	5.6 nTPM

Alveolar cells type 1	2.3 nTPM
Lung	2.3 nTPM

Alveolar cells type 2	2.7 nTPM
Lung	2.7 nTPM

Astrocytes	13.3 nTPM
Brain	13.3 nTPM

B-cells	14.0 nTPM
Adipose tissue	37.4 nTPM
Stomach	24.9 nTPM
Salivary gland	17.2 nTPM
Kidney	15.6 nTPM
PBMC	15.4 nTPM
Thymus	12.0 nTPM
Lymph node	11.6 nTPM
Skin	10.2 nTPM
Lung	9.4 nTPM
Bone marrow	9.3 nTPM
Spleen	7.8 nTPM
Esophagus	5.9 nTPM
Liver	4.8 nTPM

Ciliated cells	10.1 nTPM
Lung	14.5 nTPM
Fallopian tube	12.6 nTPM
Endometrium	7.3 nTPM
Bronchus	5.9 nTPM

Club cells	4.5 nTPM
Lung	5.8 nTPM
Prostate	4.9 nTPM
Bronchus	2.8 nTPM

Endothelial cells	11.6 nTPM
Esophagus	23.3 nTPM
Testis	20.8 nTPM
Ovary	18.7 nTPM
Skin	17.6 nTPM
Heart muscle	13.8 nTPM
Prostate	13.8 nTPM
Tongue	13.6 nTPM
Endometrium	11.6 nTPM
Fallopian tube	11.1 nTPM
Vascular	10.4 nTPM
Salivary gland	9.7 nTPM
Breast	9.7 nTPM
Lung	8.2 nTPM
Skeletal muscle	7.7 nTPM
Thymus	7.4 nTPM
Placenta	6.2 nTPM
Pancreas	2.6 nTPM
Liver	2.5 nTPM

Enteroendocrine cells	1.7 nTPM
Rectum	3.4 nTPM
Colon	1.7 nTPM
Small intestine	0.0 nTPM

Fibroblasts	7.3 nTPM
Skin	17.7 nTPM
Adipose tissue	15.9 nTPM
Vascular	11.0 nTPM
Skeletal muscle	10.8 nTPM
Fallopian tube	8.7 nTPM
Esophagus	8.3 nTPM
Heart muscle	7.0 nTPM
Salivary gland	7.0 nTPM
Breast	6.9 nTPM
Placenta	4.8 nTPM
Prostate	4.6 nTPM
Stomach	4.3 nTPM
Thymus	4.3 nTPM
Lung	3.8 nTPM
Pancreas	2.4 nTPM
Liver	0.0 nTPM

Granulocytes	7.6 nTPM
Tongue	9.7 nTPM
Fallopian tube	8.5 nTPM
Lung	4.5 nTPM

Intestinal goblet cells	2.1 nTPM
Colon	3.9 nTPM
Rectum	2.4 nTPM
Small intestine	0.0 nTPM

Lymphatic endothelial cells	12.2 nTPM
Fallopian tube	24.3 nTPM
Ovary	0.0 nTPM

Macrophages	8.7 nTPM
Adipose tissue	32.9 nTPM
Skeletal muscle	16.3 nTPM
Tongue	13.4 nTPM
Testis	12.4 nTPM
Salivary gland	10.8 nTPM
Stomach	10.3 nTPM
Fallopian tube	9.6 nTPM
Skin	7.8 nTPM
Vascular	6.5 nTPM
Kidney	6.2 nTPM
Breast	5.7 nTPM
Thymus	5.6 nTPM
Prostate	4.6 nTPM
Pancreas	4.1 nTPM
Bone marrow	4.1 nTPM
Esophagus	3.9 nTPM
Lung	3.8 nTPM
Endometrium	3.7 nTPM
Spleen	3.0 nTPM

Paneth cells	1.5 nTPM
Small intestine	3.5 nTPM
Rectum	1.0 nTPM
Colon	0.0 nTPM

Basal prostatic cells	4.2 nTPM
Prostate	4.2 nTPM

Bipolar cells	5.5 nTPM
Eye	5.5 nTPM

Distal tubular cells	3.1 nTPM
Kidney	3.1 nTPM

Early spermatids	0.8 nTPM
Testis	0.8 nTPM

Plasma cells	4.4 nTPM
Stomach	6.7 nTPM
Salivary gland	6.7 nTPM
Fallopian tube	6.4 nTPM
Esophagus	5.2 nTPM
Bone marrow	4.5 nTPM
Liver	2.5 nTPM
Thymus	2.5 nTPM
Spleen	0.5 nTPM

Schwann cells	12.0 nTPM
Adipose tissue	26.5 nTPM
Vascular	9.4 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	8.0 nTPM
Tongue	8.8 nTPM
Salivary gland	7.1 nTPM

Smooth muscle cells	6.0 nTPM
Prostate	9.7 nTPM
Vascular	9.6 nTPM
Tongue	8.4 nTPM
Ovary	7.8 nTPM
Salivary gland	7.4 nTPM
Breast	7.0 nTPM
Fallopian tube	6.4 nTPM
Endometrium	5.9 nTPM
Adipose tissue	5.8 nTPM
Liver	5.5 nTPM
Skeletal muscle	5.5 nTPM
Lung	4.7 nTPM
Skin	4.2 nTPM
Placenta	3.3 nTPM
Thymus	2.9 nTPM
Esophagus	1.2 nTPM

T-cells	28.2 nTPM
Adipose tissue	108.3 nTPM
Tongue	42.4 nTPM
Skin	39.6 nTPM
Salivary gland	38.6 nTPM
Skeletal muscle	36.7 nTPM
Thymus	35.6 nTPM
Lung	32.2 nTPM
Vascular	29.7 nTPM
Fallopian tube	29.4 nTPM
Stomach	24.7 nTPM
PBMC	24.3 nTPM
Breast	22.2 nTPM
Bone marrow	20.3 nTPM
Prostate	20.2 nTPM
Spleen	19.1 nTPM
Liver	14.1 nTPM
Endometrium	14.0 nTPM
Lymph node	13.8 nTPM
Kidney	12.4 nTPM
Esophagus	12.2 nTPM
Colon	1.9 nTPM

Undifferentiated cells	1.7 nTPM
Small intestine	2.0 nTPM
Rectum	2.0 nTPM
Colon	1.1 nTPM

Amygdala excitatory	38.3 nTPM
Hypothalamus	44.0 nTPM
Cerebral cortex	38.1 nTPM
Amygdala	37.8 nTPM
Basal ganglia	36.8 nTPM
Hippocampus	36.7 nTPM
Thalamus	36.3 nTPM

Astrocyte	56.7 nTPM
Amygdala	76.7 nTPM
Midbrain	65.7 nTPM
Medulla oblongata	63.5 nTPM
Pons	63.2 nTPM
Hypothalamus	57.6 nTPM
Thalamus	53.3 nTPM
Basal ganglia	52.2 nTPM
Spinal cord	52.1 nTPM
Hippocampus	47.5 nTPM
Cerebellum	46.2 nTPM
Cerebral cortex	45.7 nTPM

Bergmann glia	25.2 nTPM
Medulla oblongata	32.0 nTPM
Cerebellum	30.6 nTPM
Pons	12.9 nTPM

Central nervous system macrophage	43.2 nTPM
Amygdala	54.3 nTPM
Hypothalamus	49.1 nTPM
Cerebellum	43.4 nTPM
Medulla oblongata	43.4 nTPM
Basal ganglia	43.2 nTPM
Pons	43.0 nTPM
Midbrain	42.1 nTPM
Hippocampus	41.5 nTPM
Thalamus	39.1 nTPM
Spinal cord	38.0 nTPM
Cerebral cortex	37.5 nTPM

Cerebellar inhibitory	25.9 nTPM
Cerebellum	29.6 nTPM
Medulla oblongata	25.6 nTPM
Midbrain	24.9 nTPM
Pons	24.7 nTPM
Spinal cord	24.7 nTPM

Cge interneuron	30.8 nTPM
Hypothalamus	37.5 nTPM
Amygdala	34.9 nTPM
Basal ganglia	30.4 nTPM
Midbrain	28.8 nTPM
Cerebral cortex	28.7 nTPM
Hippocampus	28.3 nTPM
Thalamus	27.2 nTPM

Choroid plexus epithelial cell	81.7 nTPM
Hippocampus	88.7 nTPM
Thalamus	85.0 nTPM
Basal ganglia	81.5 nTPM
Medulla oblongata	71.6 nTPM

Committed oligodendrocyte precursor	19.8 nTPM
Cerebral cortex	27.2 nTPM
Cerebellum	22.2 nTPM
Midbrain	21.8 nTPM
Basal ganglia	21.4 nTPM
Hypothalamus	19.8 nTPM
Thalamus	19.6 nTPM
Pons	19.5 nTPM
Medulla oblongata	19.4 nTPM
Hippocampus	18.6 nTPM
Amygdala	17.5 nTPM
Spinal cord	11.0 nTPM

Deep-layer corticothalamic and 6b	33.2 nTPM
Hypothalamus	39.9 nTPM
Amygdala	37.5 nTPM
Hippocampus	32.3 nTPM
Cerebral cortex	31.0 nTPM
Basal ganglia	30.8 nTPM
Midbrain	27.7 nTPM

Deep-layer intratelencephalic	33.7 nTPM
Hypothalamus	38.5 nTPM
Amygdala	36.9 nTPM
Hippocampus	32.5 nTPM
Basal ganglia	31.7 nTPM
Cerebral cortex	28.8 nTPM

Deep-layer near-projecting	35.4 nTPM
Amygdala	36.9 nTPM
Basal ganglia	35.7 nTPM
Hypothalamus	35.5 nTPM
Hippocampus	35.1 nTPM
Cerebral cortex	33.7 nTPM

Eccentric medium spiny neuron	36.7 nTPM
Amygdala	38.8 nTPM
Hypothalamus	38.4 nTPM
Cerebral cortex	37.6 nTPM
Thalamus	36.1 nTPM
Hippocampus	34.8 nTPM
Basal ganglia	34.7 nTPM

Endothelial cell	65.9 nTPM
Cerebellum	72.8 nTPM
Cerebral cortex	72.2 nTPM
Amygdala	71.5 nTPM
Hippocampus	70.5 nTPM
Medulla oblongata	67.7 nTPM
Hypothalamus	65.8 nTPM
Spinal cord	65.6 nTPM
Pons	60.5 nTPM
Thalamus	60.4 nTPM
Midbrain	59.5 nTPM
Basal ganglia	58.7 nTPM

Ependymal cell	30.6 nTPM
Basal ganglia	39.9 nTPM
Hypothalamus	33.0 nTPM
Thalamus	32.8 nTPM
Hippocampus	31.9 nTPM
Amygdala	31.3 nTPM
Medulla oblongata	30.7 nTPM
Midbrain	29.8 nTPM
Spinal cord	26.8 nTPM
Pons	19.2 nTPM