Single cell type - ING2 - The Human Protein Atlas

ING2

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ING2
Gene descriptionⁱ Full gene name according to HGNC.	Inhibitor of growth family member 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Ovarian stromal cells - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Granulosa cells, Ovarian stromal cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.37
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Granulosa cells, Ovarian stromal cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ING2 is part of cluster 6 Ovarian stromal cells - Transcription with confidenceⁱ 1
188 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF556	Zinc finger protein 556	0.7486	6
STAR	Steroidogenic acute regulatory protein	0.7479	6
ENSG00000285218	Novel protein	0.7246	6
SPRR2F	Small proline rich protein 2F	0.7136	6
SIGLEC11	Sialic acid binding Ig like lectin 11	0.7132	6
NR5A1	Nuclear receptor subfamily 5 group A member 1	0.7131	6
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.6977	6
ST13	ST13 Hsp70 interacting protein	0.6907	6
DIRAS3	DIRAS family GTPase 3	0.6801	6
TCF23	Transcription factor 23	0.6706	6
HTR1A	5-hydroxytryptamine receptor 1A	0.6649	6
PROK1	Prokineticin 1	0.6559	6
KLHDC8A	Kelch domain containing 8A	0.6527	6
GREB1	Growth regulating estrogen receptor binding 1	0.6488	6
LRRC17	Leucine rich repeat containing 17	0.6447	6

IMMUNE CELLS

ING2 is part of cluster 12 Non-specific - Mitochondrial translation with confidenceⁱ 0.99
566 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRAF3	TNF receptor associated factor 3	0.9762	12
FBXO25	F-box protein 25	0.9286	12
RFC3	Replication factor C subunit 3	0.9048	12
ENSG00000250264	Novel protein, TAP2-HLA-DOB readthrough	0.9048	2
PPP1R3E	Protein phosphatase 1 regulatory subunit 3E	0.9048	12
RABL6	RAB, member RAS oncogene family like 6	0.9048	12
CDCA7L	Cell division cycle associated 7 like	0.9048	12
POU2F1	POU class 2 homeobox 1	0.9048	2
KDM5D	Lysine demethylase 5D	0.9048	12
LHPP	Phospholysine phosphohistidine inorganic pyrophosphate phosphatase	0.9048	12
CIAO3	Cytosolic iron-sulfur assembly component 3	0.9048	12
TELO2	Telomere maintenance 2	0.9048	12
TBC1D5	TBC1 domain family member 5	0.8810	24
MRPS25	Mitochondrial ribosomal protein S25	0.8810	12
IFT57	Intraflagellar transport 57	0.8810	12

Adipocytes	19.7 nTPM
Breast	20.4 nTPM
Adipose tissue	19.0 nTPM

Alveolar cells type 1	13.7 nTPM
Lung	13.7 nTPM

Alveolar cells type 2	33.3 nTPM
Lung	33.3 nTPM

Astrocytes	5.9 nTPM
Brain	5.9 nTPM

B-cells	19.8 nTPM
Esophagus	47.2 nTPM
Skin	45.7 nTPM
Lymph node	38.1 nTPM
Adipose tissue	35.0 nTPM
Salivary gland	15.8 nTPM
PBMC	13.9 nTPM
Lung	10.7 nTPM
Kidney	10.4 nTPM
Liver	9.7 nTPM
Stomach	9.7 nTPM
Thymus	9.6 nTPM
Spleen	7.8 nTPM
Bone marrow	4.0 nTPM

Ciliated cells	51.0 nTPM
Endometrium	88.5 nTPM
Fallopian tube	56.1 nTPM
Lung	44.1 nTPM
Bronchus	15.3 nTPM

Club cells	20.4 nTPM
Prostate	22.9 nTPM
Lung	20.9 nTPM
Bronchus	17.4 nTPM

Endothelial cells	19.6 nTPM
Ovary	51.8 nTPM
Endometrium	32.5 nTPM
Testis	29.0 nTPM
Skin	26.5 nTPM
Tongue	24.1 nTPM
Esophagus	21.9 nTPM
Fallopian tube	21.0 nTPM
Salivary gland	18.6 nTPM
Prostate	18.5 nTPM
Pancreas	18.1 nTPM
Vascular	13.8 nTPM
Placenta	12.5 nTPM
Skeletal muscle	12.1 nTPM
Breast	11.4 nTPM
Thymus	11.0 nTPM
Heart muscle	10.5 nTPM
Lung	10.4 nTPM
Liver	8.8 nTPM

Enteroendocrine cells	18.3 nTPM
Colon	22.7 nTPM
Small intestine	20.6 nTPM
Rectum	11.7 nTPM

Fibroblasts	26.0 nTPM
Fallopian tube	41.9 nTPM
Vascular	37.9 nTPM
Skin	37.2 nTPM
Breast	36.1 nTPM
Placenta	34.9 nTPM
Skeletal muscle	31.1 nTPM
Adipose tissue	30.2 nTPM
Thymus	29.2 nTPM
Salivary gland	27.3 nTPM
Prostate	24.4 nTPM
Esophagus	22.1 nTPM
Pancreas	18.0 nTPM
Lung	17.2 nTPM
Heart muscle	16.5 nTPM
Liver	10.7 nTPM
Stomach	1.4 nTPM

Granulocytes	48.7 nTPM
Tongue	53.4 nTPM
Fallopian tube	51.9 nTPM
Lung	40.8 nTPM

Intestinal goblet cells	21.2 nTPM
Colon	26.6 nTPM
Small intestine	21.9 nTPM
Rectum	15.1 nTPM

Lymphatic endothelial cells	15.8 nTPM
Fallopian tube	20.7 nTPM
Ovary	10.9 nTPM

Macrophages	24.0 nTPM
Lung	40.5 nTPM
Endometrium	35.7 nTPM
Skin	34.5 nTPM
Adipose tissue	33.5 nTPM
Vascular	29.5 nTPM
Pancreas	24.7 nTPM
Testis	24.2 nTPM
Skeletal muscle	23.8 nTPM
Fallopian tube	23.6 nTPM
Breast	23.4 nTPM
Esophagus	23.1 nTPM
Tongue	22.4 nTPM
Salivary gland	21.6 nTPM
Prostate	21.2 nTPM
Thymus	21.0 nTPM
Kidney	20.4 nTPM
Spleen	14.0 nTPM
Stomach	10.3 nTPM
Bone marrow	9.1 nTPM

Paneth cells	16.1 nTPM
Rectum	19.9 nTPM
Colon	14.5 nTPM
Small intestine	13.8 nTPM

Basal keratinocytes	47.6 nTPM
Skin	48.5 nTPM
Tongue	46.7 nTPM

Basal prostatic cells	32.3 nTPM
Prostate	32.3 nTPM

Basal squamous epithelial cells	90.4 nTPM
Esophagus	90.4 nTPM

Bipolar cells	29.6 nTPM
Eye	29.6 nTPM

Plasma cells	22.0 nTPM
Salivary gland	34.0 nTPM
Liver	32.0 nTPM
Esophagus	26.0 nTPM
Fallopian tube	21.9 nTPM
Spleen	19.2 nTPM
Thymus	18.9 nTPM
Stomach	13.0 nTPM
Bone marrow	10.6 nTPM

Schwann cells	18.0 nTPM
Adipose tissue	28.5 nTPM
Vascular	13.6 nTPM
Esophagus	12.0 nTPM

Serous glandular cells	25.6 nTPM
Salivary gland	38.0 nTPM
Tongue	13.3 nTPM

Smooth muscle cells	23.6 nTPM
Endometrium	35.7 nTPM
Ovary	35.0 nTPM
Fallopian tube	34.1 nTPM
Breast	32.4 nTPM
Skin	30.7 nTPM
Esophagus	30.0 nTPM
Adipose tissue	24.9 nTPM
Liver	20.4 nTPM
Skeletal muscle	20.3 nTPM
Salivary gland	18.9 nTPM
Tongue	18.6 nTPM
Vascular	18.1 nTPM
Prostate	17.6 nTPM
Placenta	17.0 nTPM
Lung	12.9 nTPM
Thymus	10.4 nTPM

Suprabasal keratinocytes	52.8 nTPM
Tongue	53.6 nTPM
Skin	52.1 nTPM

T-cells	26.5 nTPM
Esophagus	90.0 nTPM
Skin	48.0 nTPM
Endometrium	41.6 nTPM
Adipose tissue	41.5 nTPM
Prostate	36.1 nTPM
Breast	30.8 nTPM
Lymph node	29.0 nTPM
Tongue	28.0 nTPM
Fallopian tube	26.4 nTPM
Skeletal muscle	21.9 nTPM
Kidney	20.4 nTPM
Liver	19.6 nTPM
Colon	19.5 nTPM
Salivary gland	18.9 nTPM
Vascular	18.1 nTPM
Lung	16.8 nTPM
PBMC	15.6 nTPM
Thymus	10.5 nTPM
Stomach	9.1 nTPM
Spleen	8.3 nTPM
Bone marrow	6.6 nTPM

Undifferentiated cells	28.9 nTPM
Small intestine	33.3 nTPM
Colon	28.9 nTPM
Rectum	24.4 nTPM

Amygdala excitatory	12.5 nTPM
Cerebral cortex	15.4 nTPM
Hippocampus	15.4 nTPM
Amygdala	12.0 nTPM
Thalamus	11.8 nTPM
Basal ganglia	11.6 nTPM
Hypothalamus	8.9 nTPM

Astrocyte	7.7 nTPM
Basal ganglia	9.4 nTPM
Pons	8.4 nTPM
Midbrain	8.3 nTPM
Thalamus	8.3 nTPM
Amygdala	8.2 nTPM
Cerebral cortex	8.1 nTPM
Hippocampus	8.0 nTPM
Cerebellum	7.6 nTPM
Medulla oblongata	7.6 nTPM
Hypothalamus	6.2 nTPM
Spinal cord	5.2 nTPM

Bergmann glia	11.0 nTPM
Medulla oblongata	12.8 nTPM
Pons	11.5 nTPM
Cerebellum	8.6 nTPM

Central nervous system macrophage	8.7 nTPM
Medulla oblongata	9.9 nTPM
Pons	9.8 nTPM
Hippocampus	9.5 nTPM
Cerebral cortex	9.0 nTPM
Hypothalamus	8.8 nTPM
Spinal cord	8.8 nTPM
Amygdala	8.5 nTPM
Midbrain	8.4 nTPM
Basal ganglia	8.1 nTPM
Thalamus	8.1 nTPM
Cerebellum	7.3 nTPM

Cerebellar inhibitory	10.4 nTPM
Midbrain	12.4 nTPM
Spinal cord	11.0 nTPM
Medulla oblongata	10.3 nTPM
Pons	9.4 nTPM
Cerebellum	9.0 nTPM

Cge interneuron	10.5 nTPM
Thalamus	13.6 nTPM
Midbrain	12.7 nTPM
Hippocampus	10.8 nTPM
Basal ganglia	10.4 nTPM
Cerebral cortex	10.3 nTPM
Amygdala	8.4 nTPM
Hypothalamus	7.3 nTPM

Choroid plexus epithelial cell	8.8 nTPM
Medulla oblongata	14.2 nTPM
Hippocampus	8.3 nTPM
Thalamus	8.2 nTPM
Basal ganglia	4.5 nTPM

Committed oligodendrocyte precursor	11.3 nTPM
Pons	23.0 nTPM
Midbrain	16.0 nTPM
Hippocampus	13.5 nTPM
Cerebral cortex	13.3 nTPM
Cerebellum	12.7 nTPM
Medulla oblongata	10.3 nTPM
Basal ganglia	9.9 nTPM
Hypothalamus	8.2 nTPM
Amygdala	7.3 nTPM
Thalamus	7.0 nTPM
Spinal cord	3.7 nTPM

Deep-layer corticothalamic and 6b	10.7 nTPM
Hippocampus	12.4 nTPM
Midbrain	12.2 nTPM
Basal ganglia	12.1 nTPM
Amygdala	11.0 nTPM
Cerebral cortex	11.0 nTPM
Hypothalamus	5.5 nTPM

Deep-layer intratelencephalic	11.5 nTPM
Hippocampus	13.3 nTPM
Basal ganglia	12.5 nTPM
Cerebral cortex	12.3 nTPM
Amygdala	12.2 nTPM
Hypothalamus	7.2 nTPM

Deep-layer near-projecting	15.7 nTPM
Hippocampus	24.1 nTPM
Basal ganglia	17.5 nTPM
Cerebral cortex	15.3 nTPM
Amygdala	13.7 nTPM
Hypothalamus	7.9 nTPM

Eccentric medium spiny neuron	13.0 nTPM
Hypothalamus	14.4 nTPM
Basal ganglia	14.1 nTPM
Thalamus	14.0 nTPM
Amygdala	12.8 nTPM
Cerebral cortex	12.7 nTPM
Hippocampus	9.9 nTPM

Endothelial cell	6.5 nTPM
Medulla oblongata	12.3 nTPM
Thalamus	11.3 nTPM
Spinal cord	10.4 nTPM
Cerebral cortex	7.0 nTPM
Pons	6.9 nTPM
Cerebellum	5.4 nTPM
Amygdala	4.5 nTPM
Hippocampus	4.5 nTPM
Hypothalamus	3.7 nTPM
Basal ganglia	2.8 nTPM
Midbrain	2.8 nTPM