Single cell type - YWHAB - The Human Protein Atlas

YWHAB

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	YWHAB
Gene descriptionⁱ Full gene name according to HGNC.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.17
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

YWHAB is part of cluster 45 Non-specific - Mixed function with confidenceⁱ 1
349 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CFL1	Cofilin 1	0.6040	45
ARHGDIA	Rho GDP dissociation inhibitor alpha	0.5481	45
CLTB	Clathrin light chain B	0.5471	45
S100A11	S100 calcium binding protein A11	0.5246	45
GNB2	G protein subunit beta 2	0.5160	58
EIF6	Eukaryotic translation initiation factor 6	0.5081	45
FLII	FLII actin remodeling protein	0.4984	45
TPM3	Tropomyosin 3	0.4976	45
WSB2	WD repeat and SOCS box containing 2	0.4944	45
ACTR2	Actin related protein 2	0.4936	74
CAP1	Cyclase associated actin cytoskeleton regulatory protein 1	0.4932	45
RHOA	Ras homolog family member A	0.4902	29
SH3BGRL3	SH3 domain binding glutamate rich protein like 3	0.4892	45
CDC42	Cell division cycle 42	0.4868	45
BECN1	Beclin 1	0.4849	49

IMMUNE CELLS

YWHAB is part of cluster 42 Non-specific - Vesicular transport with confidenceⁱ 0.98
519 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KLHL12	Kelch like family member 12	0.9762	42
UBA7	Ubiquitin like modifier activating enzyme 7	0.9762	42
P2RX4	Purinergic receptor P2X 4	0.9762	42
VCP	Valosin containing protein	0.9762	42
DUSP6	Dual specificity phosphatase 6	0.9524	42
TMEM191B	Transmembrane protein 191B	0.9524	42
FPGT	Fucose-1-phosphate guanylyltransferase	0.9524	10
CHMP4A	Charged multivesicular body protein 4A	0.9524	42
TANGO2	Transport and golgi organization 2 homolog	0.9524	42
WASHC2C	WASH complex subunit 2C	0.9524	42
PMPCA	Peptidase, mitochondrial processing subunit alpha	0.9524	42
MED8	Mediator complex subunit 8	0.9524	10
TRAPPC3	Trafficking protein particle complex subunit 3	0.9524	42
UBQLN1	Ubiquilin 1	0.9524	42
TMED5	Transmembrane p24 trafficking protein 5	0.9524	42

Adipocytes	404.6 nTPM
Breast	440.3 nTPM
Adipose tissue	368.9 nTPM

Alveolar cells type 1	351.3 nTPM
Lung	351.3 nTPM

Alveolar cells type 2	322.6 nTPM
Lung	322.6 nTPM

Astrocytes	33.8 nTPM
Brain	33.8 nTPM

B-cells	303.8 nTPM
Salivary gland	422.5 nTPM
Lung	368.9 nTPM
Thymus	350.6 nTPM
Adipose tissue	324.3 nTPM
Stomach	319.7 nTPM
Spleen	319.4 nTPM
Bone marrow	294.1 nTPM
Lymph node	293.2 nTPM
Esophagus	289.1 nTPM
Skin	286.3 nTPM
PBMC	250.9 nTPM
Liver	217.4 nTPM
Kidney	213.2 nTPM

Basal squamous epithelial cells	218.5 nTPM
Esophagus	218.5 nTPM

Ciliated cells	181.6 nTPM
Lung	203.3 nTPM
Fallopian tube	197.1 nTPM
Endometrium	194.8 nTPM
Bronchus	131.1 nTPM

Club cells	294.0 nTPM
Prostate	415.9 nTPM
Lung	262.9 nTPM
Bronchus	203.1 nTPM

Dendritic cells	297.0 nTPM
Adipose tissue	335.1 nTPM
PBMC	259.0 nTPM

Endothelial cells	344.5 nTPM
Lung	498.8 nTPM
Pancreas	421.4 nTPM
Fallopian tube	403.5 nTPM
Thymus	383.7 nTPM
Vascular	378.9 nTPM
Heart muscle	371.4 nTPM
Breast	367.3 nTPM
Testis	356.2 nTPM
Endometrium	349.8 nTPM
Placenta	334.9 nTPM
Skeletal muscle	329.9 nTPM
Salivary gland	325.5 nTPM
Prostate	320.2 nTPM
Tongue	310.5 nTPM
Liver	287.2 nTPM
Skin	258.5 nTPM
Esophagus	257.5 nTPM
Ovary	246.3 nTPM

Enteroendocrine cells	317.0 nTPM
Colon	414.2 nTPM
Small intestine	302.1 nTPM
Rectum	234.8 nTPM

Erythroid cells	208.8 nTPM
Bone marrow	256.7 nTPM
Liver	160.8 nTPM

Fibroblasts	267.4 nTPM
Pancreas	428.8 nTPM
Heart muscle	346.5 nTPM
Adipose tissue	346.0 nTPM
Lung	287.5 nTPM
Skeletal muscle	284.1 nTPM
Liver	281.1 nTPM
Salivary gland	276.0 nTPM
Vascular	275.7 nTPM
Thymus	273.0 nTPM
Fallopian tube	248.3 nTPM
Prostate	240.3 nTPM
Breast	220.4 nTPM
Skin	214.4 nTPM
Esophagus	211.9 nTPM
Stomach	178.7 nTPM
Placenta	166.4 nTPM

Granulocytes	246.6 nTPM
Fallopian tube	307.3 nTPM
Lung	272.3 nTPM
Tongue	160.1 nTPM

Intestinal goblet cells	323.0 nTPM
Colon	412.6 nTPM
Rectum	293.5 nTPM
Small intestine	262.9 nTPM

Cholangiocytes	198.4 nTPM
Liver	198.4 nTPM

Collecting duct cells	235.3 nTPM
Kidney	235.3 nTPM

Cone photoreceptor cells	195.4 nTPM
Eye	195.4 nTPM

Cytotrophoblasts	384.3 nTPM
Placenta	384.3 nTPM

Lymphatic endothelial cells	266.6 nTPM
Fallopian tube	364.1 nTPM
Ovary	169.1 nTPM

Macrophages	428.6 nTPM
Lung	635.4 nTPM
Bone marrow	512.8 nTPM
Fallopian tube	495.7 nTPM
Skeletal muscle	493.2 nTPM
Adipose tissue	483.9 nTPM
Spleen	462.2 nTPM
Thymus	461.3 nTPM
Testis	448.8 nTPM
Stomach	445.0 nTPM
Kidney	430.1 nTPM
Vascular	421.6 nTPM
Prostate	402.9 nTPM
Tongue	397.9 nTPM
Pancreas	392.6 nTPM
Breast	360.2 nTPM
Salivary gland	355.5 nTPM
Esophagus	339.1 nTPM
Endometrium	332.1 nTPM
Skin	273.0 nTPM

Paneth cells	389.2 nTPM
Rectum	417.0 nTPM
Colon	405.3 nTPM
Small intestine	345.4 nTPM

Plasma cells	291.7 nTPM
Thymus	373.5 nTPM
Spleen	370.0 nTPM
Bone marrow	335.2 nTPM
Liver	306.4 nTPM
Esophagus	275.5 nTPM
Stomach	275.2 nTPM
Fallopian tube	219.0 nTPM
Salivary gland	178.6 nTPM

Schwann cells	300.5 nTPM
Adipose tissue	476.7 nTPM
Vascular	329.1 nTPM
Esophagus	95.8 nTPM

Serous glandular cells	228.1 nTPM
Tongue	234.2 nTPM
Salivary gland	222.1 nTPM

Smooth muscle cells	296.1 nTPM
Thymus	392.7 nTPM
Vascular	387.2 nTPM
Lung	352.7 nTPM
Skeletal muscle	332.9 nTPM
Prostate	325.4 nTPM
Fallopian tube	310.0 nTPM
Adipose tissue	298.6 nTPM
Breast	297.6 nTPM
Liver	296.3 nTPM
Esophagus	285.9 nTPM
Salivary gland	270.9 nTPM
Endometrium	268.0 nTPM
Tongue	261.4 nTPM
Ovary	250.4 nTPM
Placenta	210.7 nTPM
Skin	197.0 nTPM

Suprabasal keratinocytes	556.4 nTPM
Tongue	777.4 nTPM
Skin	335.3 nTPM

T-cells	397.8 nTPM
Adipose tissue	688.8 nTPM
Fallopian tube	642.8 nTPM
Thymus	496.9 nTPM
Lung	447.2 nTPM
Tongue	443.2 nTPM
Bone marrow	436.8 nTPM
Prostate	401.5 nTPM
Salivary gland	401.1 nTPM
Esophagus	391.8 nTPM
Stomach	386.2 nTPM
Skeletal muscle	380.3 nTPM
Spleen	372.6 nTPM
Skin	358.2 nTPM
Breast	344.7 nTPM
PBMC	325.7 nTPM
Liver	322.8 nTPM
Lymph node	318.5 nTPM
Vascular	309.5 nTPM
Kidney	307.7 nTPM
Colon	293.5 nTPM
Endometrium	284.9 nTPM

Undifferentiated cells	338.8 nTPM
Colon	426.7 nTPM
Small intestine	312.4 nTPM
Rectum	277.4 nTPM

Amygdala excitatory	142.8 nTPM
Hippocampus	173.2 nTPM
Hypothalamus	157.0 nTPM
Basal ganglia	151.4 nTPM
Cerebral cortex	128.8 nTPM
Amygdala	124.7 nTPM
Thalamus	121.6 nTPM

Astrocyte	39.4 nTPM
Thalamus	55.2 nTPM
Cerebral cortex	46.9 nTPM
Hippocampus	42.3 nTPM
Cerebellum	40.4 nTPM
Hypothalamus	38.5 nTPM
Midbrain	37.9 nTPM
Pons	37.8 nTPM
Amygdala	36.2 nTPM
Basal ganglia	35.0 nTPM
Medulla oblongata	33.3 nTPM
Spinal cord	29.5 nTPM

Bergmann glia	47.8 nTPM
Pons	63.3 nTPM
Cerebellum	41.7 nTPM
Medulla oblongata	38.4 nTPM

Central nervous system macrophage	103.1 nTPM
Thalamus	127.0 nTPM
Cerebral cortex	108.4 nTPM
Midbrain	105.1 nTPM
Hypothalamus	104.9 nTPM
Pons	104.2 nTPM
Hippocampus	102.4 nTPM
Amygdala	101.5 nTPM
Basal ganglia	99.9 nTPM
Medulla oblongata	96.8 nTPM
Cerebellum	93.2 nTPM
Spinal cord	91.0 nTPM

Cerebellar inhibitory	147.2 nTPM
Midbrain	195.3 nTPM
Pons	164.2 nTPM
Cerebellum	131.6 nTPM
Medulla oblongata	129.4 nTPM
Spinal cord	115.5 nTPM

Cge interneuron	157.1 nTPM
Thalamus	261.7 nTPM
Hippocampus	170.1 nTPM
Midbrain	160.0 nTPM
Basal ganglia	129.3 nTPM
Hypothalamus	128.5 nTPM
Amygdala	126.0 nTPM
Cerebral cortex	124.2 nTPM

Choroid plexus epithelial cell	52.3 nTPM
Thalamus	68.5 nTPM
Hippocampus	55.5 nTPM
Medulla oblongata	44.1 nTPM
Basal ganglia	41.2 nTPM

Committed oligodendrocyte precursor	75.8 nTPM
Thalamus	108.7 nTPM
Hypothalamus	90.8 nTPM
Cerebellum	76.1 nTPM
Pons	75.3 nTPM
Medulla oblongata	72.3 nTPM
Hippocampus	72.2 nTPM
Amygdala	69.9 nTPM
Basal ganglia	69.5 nTPM
Cerebral cortex	68.4 nTPM
Midbrain	68.0 nTPM
Spinal cord	62.5 nTPM

Deep-layer corticothalamic and 6b	156.3 nTPM
Hypothalamus	176.7 nTPM
Hippocampus	166.0 nTPM
Amygdala	161.3 nTPM
Midbrain	155.3 nTPM
Cerebral cortex	143.7 nTPM
Basal ganglia	134.7 nTPM

Deep-layer intratelencephalic	174.8 nTPM
Hippocampus	205.7 nTPM
Hypothalamus	203.7 nTPM
Cerebral cortex	171.0 nTPM
Amygdala	150.8 nTPM
Basal ganglia	142.6 nTPM