Single cell type - ERAP2 - The Human Protein Atlas

ERAP2

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ERAP2
Gene descriptionⁱ Full gene name according to HGNC.	Endoplasmic reticulum aminopeptidase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Langerhans cells - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.43
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Leukocyte, Endothelial cell)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data.	Protein predicted to be secreted

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Leukocyte, Endothelial cell)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ERAP2 is part of cluster 14 Langerhans cells - Innate immune response with confidenceⁱ 1
131 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OAS2	2'-5'-oligoadenylate synthetase 2	0.5547	58
HLA-C	Major histocompatibility complex, class I, C	0.5492	14
FMO2	Flavin containing dimethylaniline monoxygenase 2	0.5292	41
TAPBP	TAP binding protein	0.5256	45
S1PR1	Sphingosine-1-phosphate receptor 1	0.5174	41
HLA-B	Major histocompatibility complex, class I, B	0.5124	14
TMC6	Transmembrane channel like 6	0.5033	58
KLF2	KLF transcription factor 2	0.5016	53
BTN3A3	Butyrophilin subfamily 3 member A3	0.4980	19
PSMB8	Proteasome 20S subunit beta 8	0.4964	14
SAMD9L	Sterile alpha motif domain containing 9 like	0.4943	58
NLRP1	NLR family pyrin domain containing 1	0.4872	19
TXNIP	Thioredoxin interacting protein	0.4831	53
APOL3	Apolipoprotein L3	0.4816	41
TRIM21	Tripartite motif containing 21	0.4788	58

IMMUNE CELLS

ERAP2 is part of cluster 5 Non-specific - Cell proliferation with confidenceⁱ 0.99
689 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MZT1	Mitotic spindle organizing protein 1	1.0000	5
DCLRE1A	DNA cross-link repair 1A	1.0000	5
ENSG00000249240	Novel protein	0.9762	16
CUL2	Cullin 2	0.9762	5
EEF2KMT	Eukaryotic elongation factor 2 lysine methyltransferase	0.9762	16
MRPL42	Mitochondrial ribosomal protein L42	0.9762	5
CCDC25	Coiled-coil domain containing 25	0.9762	5
DUT	Deoxyuridine triphosphatase	0.9524	5
SMIM35	Small integral membrane protein 35	0.9524	16
ENSG00000196826	Novel zinc finger protein	0.9524	5
PCSK7	Proprotein convertase subtilisin/kexin type 7	0.9524	5
CWC27	CWC27 spliceosome associated cyclophilin	0.9524	5
POLR2B	RNA polymerase II subunit B	0.9524	5
NDUFA5	NADH:ubiquinone oxidoreductase subunit A5	0.9524	5
IRF3	Interferon regulatory factor 3	0.9524	5

Adipocytes	42.6 nTPM
Adipose tissue	56.5 nTPM
Breast	28.6 nTPM

Alveolar cells type 1	28.2 nTPM
Lung	28.2 nTPM

Alveolar cells type 2	17.2 nTPM
Lung	17.2 nTPM

Astrocytes	11.1 nTPM
Brain	11.1 nTPM

B-cells	59.3 nTPM
Lung	79.1 nTPM
Adipose tissue	77.8 nTPM
Thymus	77.8 nTPM
Kidney	72.8 nTPM
Bone marrow	72.0 nTPM
Salivary gland	68.0 nTPM
Spleen	63.8 nTPM
Stomach	60.3 nTPM
Lymph node	58.4 nTPM
Liver	38.6 nTPM
PBMC	36.9 nTPM
Skin	35.6 nTPM
Esophagus	29.5 nTPM

Ciliated cells	11.4 nTPM
Bronchus	17.9 nTPM
Lung	15.2 nTPM
Endometrium	6.8 nTPM
Fallopian tube	5.6 nTPM

Club cells	16.2 nTPM
Lung	22.4 nTPM
Prostate	13.6 nTPM
Bronchus	12.5 nTPM

Dendritic cells	27.3 nTPM
Adipose tissue	43.8 nTPM
PBMC	10.8 nTPM

Endothelial cells	27.5 nTPM
Heart muscle	75.4 nTPM
Lung	46.0 nTPM
Vascular	37.5 nTPM
Salivary gland	36.8 nTPM
Prostate	34.9 nTPM
Tongue	32.7 nTPM
Skeletal muscle	32.2 nTPM
Placenta	30.1 nTPM
Thymus	26.2 nTPM
Esophagus	25.4 nTPM
Fallopian tube	22.4 nTPM
Ovary	20.8 nTPM
Skin	19.7 nTPM
Breast	16.7 nTPM
Testis	15.6 nTPM
Endometrium	9.6 nTPM
Pancreas	7.8 nTPM
Liver	6.3 nTPM

Enteroendocrine cells	12.2 nTPM
Colon	23.1 nTPM
Small intestine	6.9 nTPM
Rectum	6.7 nTPM

Fibroblasts	21.8 nTPM
Adipose tissue	43.3 nTPM
Esophagus	40.3 nTPM
Skeletal muscle	34.3 nTPM
Stomach	33.1 nTPM
Lung	26.6 nTPM
Fallopian tube	22.9 nTPM
Vascular	20.4 nTPM
Heart muscle	20.3 nTPM
Breast	18.9 nTPM
Salivary gland	18.7 nTPM
Thymus	18.3 nTPM
Liver	16.6 nTPM
Skin	13.0 nTPM
Pancreas	10.0 nTPM
Prostate	9.2 nTPM
Placenta	2.1 nTPM

Granulocytes	13.4 nTPM
Lung	19.2 nTPM
Tongue	14.6 nTPM
Fallopian tube	6.5 nTPM

Intestinal goblet cells	22.8 nTPM
Small intestine	29.2 nTPM
Colon	20.9 nTPM
Rectum	18.1 nTPM

Lymphatic endothelial cells	26.8 nTPM
Ovary	27.3 nTPM
Fallopian tube	26.3 nTPM

Macrophages	33.3 nTPM
Lung	93.2 nTPM
Kidney	46.9 nTPM
Spleen	44.1 nTPM
Adipose tissue	42.5 nTPM
Bone marrow	41.6 nTPM
Fallopian tube	39.9 nTPM
Salivary gland	36.3 nTPM
Skeletal muscle	34.8 nTPM
Tongue	32.3 nTPM
Esophagus	29.5 nTPM
Prostate	28.4 nTPM
Vascular	28.4 nTPM
Stomach	28.3 nTPM
Testis	25.4 nTPM
Thymus	23.5 nTPM
Skin	17.8 nTPM
Endometrium	16.6 nTPM
Breast	15.7 nTPM
Pancreas	8.2 nTPM

Basal prostatic cells	9.4 nTPM
Prostate	9.4 nTPM

Basal respiratory cells	23.6 nTPM
Bronchus	23.6 nTPM

Basal squamous epithelial cells	10.6 nTPM
Esophagus	10.6 nTPM

Bipolar cells	0.9 nTPM
Eye	0.9 nTPM

Paneth cells	23.1 nTPM
Colon	32.6 nTPM
Rectum	19.4 nTPM
Small intestine	17.3 nTPM

Plasma cells	57.2 nTPM
Salivary gland	96.7 nTPM
Fallopian tube	77.2 nTPM
Stomach	63.2 nTPM
Thymus	56.0 nTPM
Spleen	50.3 nTPM
Esophagus	41.6 nTPM
Bone marrow	40.8 nTPM
Liver	31.5 nTPM

Schwann cells	38.5 nTPM
Adipose tissue	82.8 nTPM
Vascular	20.9 nTPM
Esophagus	12.0 nTPM

Serous glandular cells	6.5 nTPM
Salivary gland	8.6 nTPM
Tongue	4.4 nTPM

Smooth muscle cells	12.4 nTPM
Liver	32.3 nTPM
Lung	27.0 nTPM
Adipose tissue	25.4 nTPM
Esophagus	18.0 nTPM
Placenta	16.3 nTPM
Tongue	13.5 nTPM
Vascular	10.9 nTPM
Skeletal muscle	10.2 nTPM
Thymus	9.7 nTPM
Breast	9.4 nTPM
Salivary gland	6.7 nTPM
Skin	6.5 nTPM
Fallopian tube	3.8 nTPM
Ovary	3.8 nTPM
Prostate	3.6 nTPM
Endometrium	2.2 nTPM

T-cells	54.1 nTPM
Lung	83.0 nTPM
Lymph node	82.7 nTPM
Spleen	82.0 nTPM
Bone marrow	76.0 nTPM
Thymus	73.7 nTPM
Vascular	69.1 nTPM
Adipose tissue	65.3 nTPM
Liver	63.4 nTPM
Kidney	57.6 nTPM
Salivary gland	57.3 nTPM
Prostate	56.4 nTPM
Stomach	54.8 nTPM
Fallopian tube	47.8 nTPM
Tongue	47.4 nTPM
Esophagus	41.4 nTPM
Skeletal muscle	39.7 nTPM
Colon	37.0 nTPM
PBMC	35.9 nTPM
Endometrium	33.0 nTPM
Breast	18.1 nTPM
Skin	15.1 nTPM

Undifferentiated cells	27.4 nTPM
Small intestine	35.0 nTPM
Colon	28.0 nTPM
Rectum	19.1 nTPM

Amygdala excitatory	2.0 nTPM
Basal ganglia	3.7 nTPM
Cerebral cortex	2.5 nTPM
Thalamus	2.3 nTPM
Amygdala	1.9 nTPM
Hippocampus	1.4 nTPM
Hypothalamus	0.2 nTPM

Astrocyte	14.3 nTPM
Amygdala	18.6 nTPM
Hypothalamus	16.5 nTPM
Basal ganglia	15.2 nTPM
Spinal cord	14.8 nTPM
Cerebral cortex	14.4 nTPM
Midbrain	14.2 nTPM
Cerebellum	13.8 nTPM
Hippocampus	13.7 nTPM
Thalamus	13.7 nTPM
Medulla oblongata	12.7 nTPM
Pons	9.8 nTPM

Bergmann glia	17.9 nTPM
Medulla oblongata	19.2 nTPM
Cerebellum	18.8 nTPM
Pons	15.8 nTPM

Central nervous system macrophage	49.3 nTPM
Hypothalamus	57.4 nTPM
Spinal cord	56.2 nTPM
Amygdala	53.7 nTPM
Basal ganglia	51.8 nTPM
Hippocampus	51.1 nTPM
Cerebellum	49.7 nTPM
Pons	48.5 nTPM
Thalamus	46.6 nTPM
Midbrain	44.7 nTPM
Medulla oblongata	41.1 nTPM
Cerebral cortex	41.0 nTPM

Cerebellar inhibitory	5.2 nTPM
Spinal cord	13.7 nTPM
Cerebellum	4.1 nTPM
Medulla oblongata	3.3 nTPM
Pons	2.8 nTPM
Midbrain	2.2 nTPM

Cge interneuron	4.4 nTPM
Thalamus	6.5 nTPM
Midbrain	6.3 nTPM
Basal ganglia	4.7 nTPM
Cerebral cortex	4.4 nTPM
Hippocampus	4.1 nTPM
Amygdala	3.7 nTPM
Hypothalamus	1.1 nTPM

Choroid plexus epithelial cell	5.6 nTPM
Basal ganglia	9.2 nTPM
Thalamus	8.2 nTPM
Medulla oblongata	4.9 nTPM
Hippocampus	0.0 nTPM

Committed oligodendrocyte precursor	4.7 nTPM
Spinal cord	18.4 nTPM
Thalamus	5.6 nTPM
Hypothalamus	5.5 nTPM
Cerebral cortex	5.1 nTPM
Basal ganglia	4.9 nTPM
Midbrain	3.4 nTPM
Amygdala	2.8 nTPM
Hippocampus	2.8 nTPM
Cerebellum	1.6 nTPM
Medulla oblongata	1.3 nTPM
Pons	0.0 nTPM

Deep-layer corticothalamic and 6b	6.3 nTPM
Basal ganglia	12.2 nTPM
Cerebral cortex	8.3 nTPM
Midbrain	5.5 nTPM
Amygdala	5.3 nTPM
Hippocampus	4.6 nTPM
Hypothalamus	1.8 nTPM

Deep-layer intratelencephalic	4.2 nTPM
Basal ganglia	7.3 nTPM
Cerebral cortex	5.3 nTPM
Hippocampus	4.4 nTPM
Amygdala	3.6 nTPM
Hypothalamus	0.6 nTPM

Deep-layer near-projecting	3.9 nTPM
Hippocampus	7.5 nTPM
Basal ganglia	5.3 nTPM
Cerebral cortex	3.6 nTPM
Amygdala	2.9 nTPM
Hypothalamus	0.4 nTPM

Eccentric medium spiny neuron	2.0 nTPM
Basal ganglia	3.0 nTPM
Cerebral cortex	2.6 nTPM
Amygdala	2.5 nTPM
Hypothalamus	1.4 nTPM
Thalamus	1.3 nTPM
Hippocampus	1.2 nTPM

Endothelial cell	58.8 nTPM
Midbrain	75.6 nTPM
Amygdala	70.4 nTPM
Basal ganglia	65.2 nTPM
Hippocampus	64.8 nTPM
Spinal cord	60.4 nTPM
Medulla oblongata	59.5 nTPM
Cerebral cortex	56.9 nTPM
Thalamus	54.2 nTPM
Pons	49.9 nTPM
Cerebellum	47.2 nTPM
Hypothalamus	42.2 nTPM