Single cell type - TPRA1 - The Human Protein Atlas

TPRA1

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TPRA1
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane protein adipocyte associated 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Dendritic cells - Antigen presentation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Langerhans cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.48
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Langerhans cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TPRA1 is part of cluster 28 Dendritic cells - Antigen presentation with confidenceⁱ 1
245 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CSF2RA	Colony stimulating factor 2 receptor subunit alpha	0.6662	28
GPAT3	Glycerol-3-phosphate acyltransferase 3	0.6550	28
GPR157	G protein-coupled receptor 157	0.6411	28
CLEC10A	C-type lectin domain containing 10A	0.6380	28
CD1B	CD1b molecule	0.6287	28
OR8B8	Olfactory receptor family 8 subfamily B member 8	0.6272	28
INSIG1	Insulin induced gene 1	0.6232	28
CST3	Cystatin C	0.6204	28
SERPINB9	Serpin family B member 9	0.6176	28
NFKBIE	NFKB inhibitor epsilon	0.6171	28
FCER1A	Fc epsilon receptor Ia	0.6141	28
CD1E	CD1e molecule	0.6128	28
CYP2S1	Cytochrome P450 family 2 subfamily S member 1	0.6052	28
CD1C	CD1c molecule	0.6039	28
TRAF1	TNF receptor associated factor 1	0.6008	14

IMMUNE CELLS

TPRA1 is part of cluster 29 Non-specific - Unknown function with confidenceⁱ 0.98
401 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
POLR2F	RNA polymerase II, I and III subunit F	0.9762	29
TMEM179B	Transmembrane protein 179B	0.9762	29
LZIC	Leucine zipper and CTNNBIP1 domain containing	0.9762	29
ZDHHC7	Zinc finger DHHC-type palmitoyltransferase 7	0.9762	29
DNAJC8	DnaJ heat shock protein family (Hsp40) member C8	0.9762	29
VPS25	Vacuolar protein sorting 25 homolog	0.9524	29
AP3S1	Adaptor related protein complex 3 subunit sigma 1	0.9524	25
PIN1	Peptidylprolyl cis/trans isomerase, NIMA-interacting 1	0.9524	29
PLA2G4A	Phospholipase A2 group IVA	0.9524	29
NAPA	NSF attachment protein alpha	0.9524	29
SLC35A2	Solute carrier family 35 member A2	0.9524	29
SPSB2	SplA/ryanodine receptor domain and SOCS box containing 2	0.9286	29
ATOX1	Antioxidant 1 copper chaperone	0.9286	29
IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta	0.9286	29
SLC25A20	Solute carrier family 25 member 20	0.9286	29

Adipocytes	16.8 nTPM
Breast	18.0 nTPM
Adipose tissue	15.6 nTPM

Alveolar cells type 1	26.5 nTPM
Lung	26.5 nTPM

Alveolar cells type 2	15.2 nTPM
Lung	15.2 nTPM

Astrocytes	12.4 nTPM
Brain	12.4 nTPM

B-cells	14.2 nTPM
Skin	66.1 nTPM
Liver	19.3 nTPM
Esophagus	17.7 nTPM
Thymus	17.5 nTPM
Lymph node	10.4 nTPM
Spleen	8.9 nTPM
Bone marrow	8.2 nTPM
PBMC	7.7 nTPM
Stomach	7.6 nTPM
Salivary gland	6.8 nTPM
Kidney	5.2 nTPM
Adipose tissue	4.9 nTPM
Lung	4.0 nTPM

Ciliated cells	16.9 nTPM
Endometrium	23.6 nTPM
Bronchus	18.5 nTPM
Fallopian tube	14.2 nTPM
Lung	11.2 nTPM

Club cells	16.9 nTPM
Bronchus	22.0 nTPM
Prostate	16.6 nTPM
Lung	12.1 nTPM

Endothelial cells	21.8 nTPM
Pancreas	41.4 nTPM
Skin	28.8 nTPM
Heart muscle	28.7 nTPM
Placenta	27.2 nTPM
Ovary	26.6 nTPM
Thymus	24.2 nTPM
Breast	23.7 nTPM
Liver	21.4 nTPM
Lung	21.1 nTPM
Tongue	20.5 nTPM
Testis	19.5 nTPM
Fallopian tube	18.9 nTPM
Skeletal muscle	18.6 nTPM
Esophagus	17.3 nTPM
Vascular	14.2 nTPM
Endometrium	13.8 nTPM
Salivary gland	13.5 nTPM
Prostate	12.6 nTPM

Enteroendocrine cells	17.2 nTPM
Colon	19.4 nTPM
Small intestine	17.2 nTPM
Rectum	15.1 nTPM

Fibroblasts	22.0 nTPM
Placenta	36.2 nTPM
Skin	34.3 nTPM
Adipose tissue	30.5 nTPM
Thymus	27.4 nTPM
Esophagus	24.7 nTPM
Pancreas	24.5 nTPM
Prostate	21.1 nTPM
Skeletal muscle	20.3 nTPM
Liver	19.0 nTPM
Stomach	18.7 nTPM
Breast	18.7 nTPM
Lung	17.8 nTPM
Salivary gland	17.5 nTPM
Fallopian tube	15.9 nTPM
Vascular	15.7 nTPM
Heart muscle	9.7 nTPM

Granulocytes	13.6 nTPM
Tongue	19.4 nTPM
Lung	14.1 nTPM
Fallopian tube	7.3 nTPM

Intestinal goblet cells	19.7 nTPM
Small intestine	25.8 nTPM
Rectum	17.8 nTPM
Colon	15.5 nTPM

Lymphatic endothelial cells	16.9 nTPM
Ovary	21.8 nTPM
Fallopian tube	12.0 nTPM

Macrophages	32.4 nTPM
Skin	90.3 nTPM
Adipose tissue	85.5 nTPM
Pancreas	78.1 nTPM
Fallopian tube	40.1 nTPM
Stomach	36.0 nTPM
Tongue	32.8 nTPM
Endometrium	32.0 nTPM
Vascular	28.3 nTPM
Breast	24.5 nTPM
Thymus	24.3 nTPM
Kidney	22.1 nTPM
Skeletal muscle	21.2 nTPM
Lung	20.1 nTPM
Esophagus	18.0 nTPM
Testis	16.1 nTPM
Salivary gland	15.2 nTPM
Spleen	13.0 nTPM
Prostate	9.4 nTPM
Bone marrow	9.1 nTPM

Paneth cells	18.7 nTPM
Small intestine	24.2 nTPM
Rectum	17.5 nTPM
Colon	14.5 nTPM

Basal prostatic cells	13.1 nTPM
Prostate	13.1 nTPM

Basal squamous epithelial cells	23.3 nTPM
Esophagus	23.3 nTPM

Bipolar cells	8.7 nTPM
Eye	8.7 nTPM

Cholangiocytes	11.4 nTPM
Liver	11.4 nTPM

Plasma cells	19.9 nTPM
Esophagus	26.0 nTPM
Thymus	26.0 nTPM
Bone marrow	21.1 nTPM
Liver	20.5 nTPM
Stomach	19.7 nTPM
Spleen	19.0 nTPM
Salivary gland	18.4 nTPM
Fallopian tube	8.4 nTPM

Schwann cells	27.9 nTPM
Esophagus	47.9 nTPM
Adipose tissue	20.7 nTPM
Vascular	15.1 nTPM

Serous glandular cells	8.8 nTPM
Salivary gland	13.2 nTPM
Tongue	4.4 nTPM

Smooth muscle cells	15.7 nTPM
Placenta	34.4 nTPM
Skin	24.1 nTPM
Ovary	19.5 nTPM
Liver	18.7 nTPM
Fallopian tube	18.2 nTPM
Skeletal muscle	17.9 nTPM
Thymus	17.8 nTPM
Adipose tissue	15.8 nTPM
Esophagus	13.2 nTPM
Breast	13.1 nTPM
Tongue	12.6 nTPM
Endometrium	10.5 nTPM
Vascular	10.0 nTPM
Prostate	9.1 nTPM
Salivary gland	8.7 nTPM
Lung	8.2 nTPM

Suprabasal keratinocytes	32.4 nTPM
Skin	48.0 nTPM
Tongue	16.8 nTPM

T-cells	12.8 nTPM
Colon	30.2 nTPM
Skin	20.0 nTPM
Thymus	19.8 nTPM
Esophagus	19.5 nTPM
Lymph node	14.7 nTPM
Kidney	14.2 nTPM
Breast	12.9 nTPM
PBMC	12.1 nTPM
Stomach	11.9 nTPM
Bone marrow	11.7 nTPM
Skeletal muscle	11.3 nTPM
Liver	11.0 nTPM
Endometrium	10.7 nTPM
Lung	10.0 nTPM
Spleen	9.8 nTPM
Tongue	9.7 nTPM
Adipose tissue	9.5 nTPM
Fallopian tube	8.8 nTPM
Prostate	8.2 nTPM
Salivary gland	7.3 nTPM
Vascular	6.4 nTPM

Undifferentiated cells	21.6 nTPM
Colon	23.0 nTPM
Small intestine	22.0 nTPM
Rectum	19.8 nTPM

Amygdala excitatory	15.2 nTPM
Hypothalamus	18.2 nTPM
Basal ganglia	16.5 nTPM
Hippocampus	16.2 nTPM
Amygdala	15.3 nTPM
Cerebral cortex	14.4 nTPM
Thalamus	10.4 nTPM

Astrocyte	17.0 nTPM
Cerebral cortex	20.7 nTPM
Cerebellum	19.9 nTPM
Hippocampus	19.5 nTPM
Pons	17.7 nTPM
Midbrain	17.6 nTPM
Spinal cord	16.6 nTPM
Thalamus	16.6 nTPM
Basal ganglia	15.2 nTPM
Amygdala	15.1 nTPM
Medulla oblongata	15.0 nTPM
Hypothalamus	12.8 nTPM

Bergmann glia	10.9 nTPM
Cerebellum	13.4 nTPM
Medulla oblongata	10.7 nTPM
Pons	8.6 nTPM

Central nervous system macrophage	14.4 nTPM
Cerebral cortex	18.1 nTPM
Hippocampus	16.9 nTPM
Cerebellum	16.0 nTPM
Midbrain	15.6 nTPM
Pons	14.4 nTPM
Spinal cord	14.4 nTPM
Thalamus	14.1 nTPM
Amygdala	13.3 nTPM
Medulla oblongata	12.4 nTPM
Basal ganglia	12.3 nTPM
Hypothalamus	11.1 nTPM

Cerebellar inhibitory	15.6 nTPM
Cerebellum	20.2 nTPM
Midbrain	17.7 nTPM
Pons	16.3 nTPM
Medulla oblongata	12.9 nTPM
Spinal cord	11.0 nTPM

Cge interneuron	14.7 nTPM
Hypothalamus	19.3 nTPM
Cerebral cortex	16.6 nTPM
Amygdala	14.9 nTPM
Hippocampus	14.6 nTPM
Basal ganglia	13.9 nTPM
Midbrain	12.7 nTPM
Thalamus	11.3 nTPM

Choroid plexus epithelial cell	12.9 nTPM
Thalamus	19.2 nTPM
Basal ganglia	14.1 nTPM
Medulla oblongata	10.1 nTPM
Hippocampus	8.3 nTPM

Committed oligodendrocyte precursor	20.9 nTPM
Spinal cord	36.8 nTPM
Pons	23.9 nTPM
Cerebral cortex	21.5 nTPM
Basal ganglia	21.4 nTPM
Hypothalamus	21.2 nTPM
Hippocampus	20.2 nTPM
Thalamus	19.4 nTPM
Cerebellum	19.0 nTPM
Medulla oblongata	18.1 nTPM
Midbrain	17.6 nTPM
Amygdala	11.3 nTPM

Deep-layer corticothalamic and 6b	15.8 nTPM
Hypothalamus	19.2 nTPM
Basal ganglia	17.0 nTPM
Cerebral cortex	16.7 nTPM
Amygdala	15.0 nTPM
Hippocampus	14.9 nTPM
Midbrain	12.2 nTPM

Deep-layer intratelencephalic	15.5 nTPM
Hypothalamus	19.7 nTPM
Cerebral cortex	14.9 nTPM
Basal ganglia	14.7 nTPM
Hippocampus	14.6 nTPM
Amygdala	13.6 nTPM

Deep-layer near-projecting	15.6 nTPM
Hypothalamus	18.8 nTPM
Amygdala	16.1 nTPM
Cerebral cortex	15.4 nTPM
Basal ganglia	14.7 nTPM
Hippocampus	13.0 nTPM

Eccentric medium spiny neuron	15.0 nTPM
Hippocampus	19.9 nTPM
Hypothalamus	14.9 nTPM
Cerebral cortex	14.3 nTPM
Amygdala	13.9 nTPM
Basal ganglia	13.8 nTPM
Thalamus	13.4 nTPM

Endothelial cell	19.0 nTPM
Cerebellum	31.0 nTPM
Cerebral cortex	26.9 nTPM
Hippocampus	26.9 nTPM
Amygdala	19.0 nTPM
Pons	18.7 nTPM
Medulla oblongata	18.5 nTPM
Spinal cord	17.3 nTPM
Midbrain	16.1 nTPM
Thalamus	14.1 nTPM
Basal ganglia	14.0 nTPM
Hypothalamus	6.2 nTPM