Single cell type - TMEM183A - The Human Protein Atlas

TMEM183A

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMEM183A
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane protein 183A
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Spermatocytes & Spermatids - Spermatid development (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.28
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TMEM183A is part of cluster 70 Spermatocytes & Spermatids - Spermatid development with confidenceⁱ 1
376 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
C9orf40	Chromosome 9 open reading frame 40	0.4876	1
CDC20	Cell division cycle 20	0.4683	52
CCDC34	Coiled-coil domain containing 34	0.4588	52
BORA	BORA aurora kinase A activator	0.4481	70
ARV1	ARV1 homolog, fatty acid homeostasis modulator	0.4478	70
TOMM22	Translocase of outer mitochondrial membrane 22	0.4467	39
TRAF7	TNF receptor associated factor 7	0.4453	5
STK16	Serine/threonine kinase 16	0.4338	11
SAC3D1	SAC3 domain containing 1	0.4286	31
PA2G4	Proliferation-associated 2G4	0.4271	39
CTAGE9	CTAGE family member 9	0.4237	70
CENPW	Centromere protein W	0.4226	52
MCM4	Minichromosome maintenance complex component 4	0.4223	52
UROS	Uroporphyrinogen III synthase	0.4216	1
CDRT15	CMT1A duplicated region transcript 15	0.4214	36

IMMUNE CELLS

TMEM183A is part of cluster 45 Eosinophils - Unknown function with confidenceⁱ 0.98
257 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
R3HCC1	R3H domain and coiled-coil containing 1	1.0000	45
TRIM62	Tripartite motif containing 62	1.0000	45
PCBP1	Poly(rC) binding protein 1	1.0000	45
VPS26B	VPS26 retromer complex component B	1.0000	45
CIDEB	Cell death inducing DFFA like effector b	0.9762	45
ENSG00000290183	Novel protein	0.9762	45
RAB40C	RAB40C, member RAS oncogene family	0.9762	45
FHL3	Four and a half LIM domains 3	0.9762	45
EXOC3	Exocyst complex component 3	0.9762	45
ARMC10	Armadillo repeat containing 10	0.9762	45
CMTM8	CKLF like MARVEL transmembrane domain containing 8	0.9762	45
CPNE2	Copine 2	0.9762	45
HP1BP3	Heterochromatin protein 1 binding protein 3	0.9762	45
SH3BP1	SH3 domain binding protein 1	0.9762	45
ARHGAP10	Rho GTPase activating protein 10	0.9762	45

Adipocytes	39.4 nTPM
Breast	47.9 nTPM
Adipose tissue	30.8 nTPM

Alveolar cells type 1	35.9 nTPM
Lung	35.9 nTPM

Alveolar cells type 2	43.7 nTPM
Lung	43.7 nTPM

Astrocytes	3.4 nTPM
Brain	3.4 nTPM

B-cells	33.0 nTPM
Liver	43.5 nTPM
Skin	42.3 nTPM
Lymph node	39.5 nTPM
PBMC	36.9 nTPM
Spleen	35.7 nTPM
Stomach	33.7 nTPM
Adipose tissue	32.1 nTPM
Thymus	31.0 nTPM
Lung	30.9 nTPM
Bone marrow	28.5 nTPM
Kidney	26.0 nTPM
Salivary gland	25.5 nTPM
Esophagus	23.6 nTPM

Ciliated cells	33.4 nTPM
Bronchus	46.1 nTPM
Endometrium	32.2 nTPM
Lung	28.9 nTPM
Fallopian tube	26.5 nTPM

Club cells	49.0 nTPM
Bronchus	63.6 nTPM
Prostate	45.1 nTPM
Lung	38.3 nTPM

Dendritic cells	44.5 nTPM
Adipose tissue	49.5 nTPM
PBMC	39.6 nTPM

Endothelial cells	33.4 nTPM
Pancreas	46.5 nTPM
Lung	46.1 nTPM
Breast	44.8 nTPM
Testis	42.7 nTPM
Skin	38.9 nTPM
Placenta	37.5 nTPM
Fallopian tube	34.7 nTPM
Vascular	34.1 nTPM
Thymus	33.9 nTPM
Endometrium	31.7 nTPM
Tongue	29.9 nTPM
Skeletal muscle	28.9 nTPM
Prostate	28.5 nTPM
Liver	26.5 nTPM
Salivary gland	25.2 nTPM
Ovary	24.9 nTPM
Heart muscle	24.1 nTPM
Esophagus	21.1 nTPM

Enteroendocrine cells	69.7 nTPM
Colon	112.2 nTPM
Small intestine	58.4 nTPM
Rectum	38.6 nTPM

Erythroid cells	102.7 nTPM
Liver	132.9 nTPM
Bone marrow	72.6 nTPM

Fibroblasts	35.4 nTPM
Pancreas	62.0 nTPM
Placenta	45.5 nTPM
Breast	42.9 nTPM
Liver	41.5 nTPM
Adipose tissue	38.5 nTPM
Skin	37.9 nTPM
Thymus	36.0 nTPM
Lung	35.6 nTPM
Salivary gland	35.6 nTPM
Fallopian tube	34.7 nTPM
Vascular	33.8 nTPM
Skeletal muscle	29.7 nTPM
Esophagus	27.8 nTPM
Prostate	26.4 nTPM
Heart muscle	20.2 nTPM
Stomach	18.7 nTPM

Granulocytes	36.9 nTPM
Lung	40.8 nTPM
Fallopian tube	40.7 nTPM
Tongue	29.1 nTPM

Intestinal goblet cells	76.9 nTPM
Colon	108.0 nTPM
Rectum	68.7 nTPM
Small intestine	54.0 nTPM

Lymphatic endothelial cells	21.4 nTPM
Fallopian tube	31.9 nTPM
Ovary	10.9 nTPM

Basal keratinocytes	64.5 nTPM
Skin	75.4 nTPM
Tongue	53.7 nTPM

Basal respiratory cells	57.4 nTPM
Bronchus	57.4 nTPM

Basal squamous epithelial cells	51.6 nTPM
Esophagus	51.6 nTPM

Bipolar cells	21.6 nTPM
Eye	21.6 nTPM

Macrophages	42.8 nTPM
Pancreas	61.7 nTPM
Spleen	57.1 nTPM
Kidney	52.2 nTPM
Bone marrow	51.7 nTPM
Testis	47.1 nTPM
Lung	46.8 nTPM
Esophagus	46.2 nTPM
Adipose tissue	45.0 nTPM
Stomach	43.7 nTPM
Skeletal muscle	43.2 nTPM
Thymus	43.0 nTPM
Tongue	39.3 nTPM
Fallopian tube	36.4 nTPM
Breast	35.5 nTPM
Prostate	35.2 nTPM
Endometrium	33.8 nTPM
Vascular	33.2 nTPM
Salivary gland	32.4 nTPM
Skin	30.1 nTPM

Paneth cells	77.1 nTPM
Rectum	82.8 nTPM
Colon	76.0 nTPM
Small intestine	72.5 nTPM

Plasma cells	56.3 nTPM
Spleen	95.5 nTPM
Bone marrow	80.0 nTPM
Thymus	77.1 nTPM
Liver	62.1 nTPM
Stomach	48.6 nTPM
Esophagus	31.2 nTPM
Fallopian tube	30.6 nTPM
Salivary gland	25.5 nTPM

Schwann cells	28.7 nTPM
Adipose tissue	58.9 nTPM
Vascular	27.2 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	42.6 nTPM
Salivary gland	58.8 nTPM
Tongue	26.5 nTPM

Smooth muscle cells	38.0 nTPM
Salivary gland	50.7 nTPM
Breast	49.9 nTPM
Prostate	45.6 nTPM
Vascular	43.4 nTPM
Fallopian tube	42.5 nTPM
Thymus	41.3 nTPM
Skin	40.8 nTPM
Liver	40.3 nTPM
Placenta	37.1 nTPM
Ovary	35.6 nTPM
Esophagus	33.6 nTPM
Endometrium	31.4 nTPM
Adipose tissue	30.7 nTPM
Lung	29.4 nTPM
Skeletal muscle	28.1 nTPM
Tongue	27.5 nTPM

Suprabasal keratinocytes	74.5 nTPM
Skin	75.3 nTPM
Tongue	73.7 nTPM

T-cells	44.0 nTPM
Colon	59.5 nTPM
Adipose tissue	57.3 nTPM
Skin	54.7 nTPM
PBMC	54.6 nTPM
Liver	50.2 nTPM
Breast	49.5 nTPM
Fallopian tube	47.3 nTPM
Esophagus	46.2 nTPM
Thymus	43.0 nTPM
Spleen	42.9 nTPM
Stomach	41.4 nTPM
Lung	41.1 nTPM
Lymph node	41.0 nTPM
Kidney	40.8 nTPM
Prostate	39.5 nTPM
Bone marrow	39.2 nTPM
Endometrium	38.6 nTPM
Salivary gland	37.9 nTPM
Skeletal muscle	36.3 nTPM
Tongue	34.7 nTPM
Vascular	28.9 nTPM

Undifferentiated cells	86.8 nTPM
Colon	102.4 nTPM
Small intestine	93.7 nTPM
Rectum	64.1 nTPM

Amygdala excitatory	11.6 nTPM
Cerebral cortex	13.5 nTPM
Thalamus	11.8 nTPM
Hippocampus	11.7 nTPM
Amygdala	11.3 nTPM
Basal ganglia	10.8 nTPM
Hypothalamus	10.5 nTPM

Astrocyte	6.6 nTPM
Thalamus	8.2 nTPM
Cerebral cortex	8.0 nTPM
Amygdala	7.1 nTPM
Hippocampus	7.1 nTPM
Basal ganglia	7.0 nTPM
Pons	7.0 nTPM
Midbrain	6.4 nTPM
Cerebellum	6.2 nTPM
Hypothalamus	5.9 nTPM
Medulla oblongata	5.3 nTPM
Spinal cord	4.8 nTPM

Bergmann glia	8.8 nTPM
Cerebellum	9.2 nTPM
Pons	8.6 nTPM
Medulla oblongata	8.5 nTPM

Central nervous system macrophage	12.5 nTPM
Basal ganglia	14.0 nTPM
Thalamus	13.7 nTPM
Amygdala	13.5 nTPM
Cerebellum	12.8 nTPM
Pons	12.7 nTPM
Cerebral cortex	12.6 nTPM
Medulla oblongata	12.5 nTPM
Midbrain	12.4 nTPM
Hypothalamus	11.9 nTPM
Hippocampus	11.2 nTPM
Spinal cord	10.0 nTPM

Cerebellar inhibitory	14.1 nTPM
Cerebellum	15.9 nTPM
Midbrain	15.9 nTPM
Pons	15.8 nTPM
Medulla oblongata	14.5 nTPM
Spinal cord	8.2 nTPM

Cge interneuron	18.1 nTPM
Thalamus	23.0 nTPM
Cerebral cortex	19.0 nTPM
Midbrain	18.9 nTPM
Hippocampus	18.3 nTPM
Basal ganglia	17.7 nTPM
Amygdala	16.7 nTPM
Hypothalamus	13.2 nTPM

Choroid plexus epithelial cell	9.6 nTPM
Basal ganglia	12.5 nTPM
Hippocampus	11.1 nTPM
Medulla oblongata	9.5 nTPM
Thalamus	5.5 nTPM

Committed oligodendrocyte precursor	12.4 nTPM
Spinal cord	18.4 nTPM
Midbrain	16.0 nTPM
Thalamus	14.2 nTPM
Medulla oblongata	12.9 nTPM
Pons	12.4 nTPM
Cerebral cortex	12.0 nTPM
Hypothalamus	11.6 nTPM
Amygdala	11.3 nTPM
Basal ganglia	11.0 nTPM
Hippocampus	9.8 nTPM
Cerebellum	6.3 nTPM

Deep-layer corticothalamic and 6b	16.8 nTPM
Midbrain	26.6 nTPM
Basal ganglia	17.8 nTPM
Cerebral cortex	16.6 nTPM
Amygdala	15.4 nTPM
Hippocampus	15.1 nTPM
Hypothalamus	9.4 nTPM

Deep-layer intratelencephalic	16.7 nTPM
Cerebral cortex	20.8 nTPM
Hippocampus	18.7 nTPM
Basal ganglia	17.9 nTPM
Amygdala	15.2 nTPM
Hypothalamus	10.8 nTPM

Deep-layer near-projecting	21.0 nTPM
Hippocampus	35.5 nTPM
Cerebral cortex	21.4 nTPM
Basal ganglia	17.2 nTPM
Amygdala	17.1 nTPM
Hypothalamus	13.9 nTPM