Single cell type - NPPC - The Human Protein Atlas

NPPC

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NPPC
Gene descriptionⁱ Full gene name according to HGNC.	Natriuretic peptide C
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Basal squamous epithelial cells, Cone photoreceptor cells, Breast myoepithelial cells, Fibroblasts)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.80
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Midbrain-derived inhibitory, LAMP5-LHX6 and Chandelier)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data.	Protein predicted to be secreted

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Basal squamous epithelial cells, Cone photoreceptor cells, Breast myoepithelial cells, Fibroblasts)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Midbrain-derived inhibitory, LAMP5-LHX6 and Chandelier)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

NPPC is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
835 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SFRP4	Secreted frizzled related protein 4	0.7125	9
MYF5	Myogenic factor 5	0.7022	2
NOLC1	Nucleolar and coiled-body phosphoprotein 1	0.6417	39
IRF1	Interferon regulatory factor 1	0.6372	80
CCN4	Cellular communication network factor 4	0.6363	9
SFPQ	Splicing factor proline and glutamine rich	0.6295	80
ZBTB21	Zinc finger and BTB domain containing 21	0.6204	39
OTOR	Otoraplin	0.6116	37
AGTR2	Angiotensin II receptor type 2	0.6047	72
PAX7	Paired box 7	0.6023	2
SERTAD1	SERTA domain containing 1	0.5981	80
HIC1	HIC ZBTB transcriptional repressor 1	0.5967	53
PPRC1	PPARG related coactivator 1	0.5952	39
ZCCHC12	Zinc finger CCHC-type containing 12	0.5895	37
NCL	Nucleolin	0.5875	39

Adipocytes	1.9 nTPM
Breast	2.0 nTPM
Adipose tissue	1.8 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	0.1 nTPM
Lung	0.1 nTPM

Astrocytes	0.6 nTPM
Brain	0.6 nTPM

B-cells	1.2 nTPM
Skin	6.8 nTPM
Lung	5.4 nTPM
Adipose tissue	2.1 nTPM
Salivary gland	0.3 nTPM
Lymph node	0.2 nTPM
Thymus	0.2 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Ciliated cells	2.6 nTPM
Fallopian tube	6.1 nTPM
Endometrium	3.7 nTPM
Lung	0.5 nTPM
Bronchus	0.1 nTPM

Club cells	2.1 nTPM
Prostate	5.0 nTPM
Lung	1.0 nTPM
Bronchus	0.3 nTPM

Endothelial cells	3.1 nTPM
Tongue	15.1 nTPM
Breast	10.5 nTPM
Salivary gland	8.1 nTPM
Skin	5.2 nTPM
Thymus	4.0 nTPM
Placenta	2.3 nTPM
Endometrium	1.8 nTPM
Ovary	1.6 nTPM
Skeletal muscle	1.4 nTPM
Vascular	1.2 nTPM
Fallopian tube	1.2 nTPM
Heart muscle	1.0 nTPM
Lung	0.6 nTPM
Esophagus	0.5 nTPM
Prostate	0.5 nTPM
Testis	0.3 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	1.8 nTPM
Small intestine	3.4 nTPM
Colon	2.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	20.2 nTPM
Fallopian tube	222.8 nTPM
Stomach	37.5 nTPM
Heart muscle	30.7 nTPM
Breast	13.6 nTPM
Skeletal muscle	6.7 nTPM
Esophagus	5.9 nTPM
Salivary gland	3.9 nTPM
Vascular	0.8 nTPM
Adipose tissue	0.7 nTPM
Skin	0.6 nTPM
Thymus	0.3 nTPM
Placenta	0.2 nTPM
Pancreas	0.1 nTPM
Liver	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM

Granulocytes	4.3 nTPM
Fallopian tube	7.9 nTPM
Tongue	4.9 nTPM
Lung	0.0 nTPM

Intestinal goblet cells	1.1 nTPM
Colon	2.2 nTPM
Small intestine	0.7 nTPM
Rectum	0.4 nTPM

Lymphatic endothelial cells	7.9 nTPM
Fallopian tube	10.3 nTPM
Ovary	5.5 nTPM

Macrophages	1.4 nTPM
Breast	11.7 nTPM
Endometrium	4.3 nTPM
Skeletal muscle	3.4 nTPM
Tongue	3.3 nTPM
Fallopian tube	2.0 nTPM
Prostate	1.0 nTPM
Testis	0.6 nTPM
Adipose tissue	0.6 nTPM
Lung	0.1 nTPM
Salivary gland	0.1 nTPM
Vascular	0.1 nTPM
Kidney	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Thymus	0.0 nTPM

Paneth cells	1.1 nTPM
Rectum	3.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Basal respiratory cells	4.7 nTPM
Bronchus	4.7 nTPM

Plasma cells	3.9 nTPM
Esophagus	20.8 nTPM
Fallopian tube	9.0 nTPM
Stomach	1.3 nTPM
Spleen	0.2 nTPM
Thymus	0.1 nTPM
Liver	0.0 nTPM
Bone marrow	0.0 nTPM
Salivary gland	0.0 nTPM

Schwann cells	0.7 nTPM
Adipose tissue	2.0 nTPM
Esophagus	0.0 nTPM
Vascular	0.0 nTPM

Serous glandular cells	2.3 nTPM
Tongue	4.4 nTPM
Salivary gland	0.2 nTPM

Smooth muscle cells	1.8 nTPM
Fallopian tube	6.5 nTPM
Tongue	5.1 nTPM
Skeletal muscle	4.2 nTPM
Breast	3.5 nTPM
Salivary gland	2.9 nTPM
Endometrium	1.2 nTPM
Esophagus	1.2 nTPM
Skin	1.1 nTPM
Adipose tissue	0.9 nTPM
Liver	0.4 nTPM
Placenta	0.4 nTPM
Ovary	0.2 nTPM
Thymus	0.1 nTPM
Vascular	0.1 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM

T-cells	1.7 nTPM
Skin	13.3 nTPM
Breast	6.1 nTPM
Skeletal muscle	4.2 nTPM
Endometrium	3.3 nTPM
Fallopian tube	2.7 nTPM
Tongue	2.6 nTPM
Vascular	1.2 nTPM
Adipose tissue	0.8 nTPM
Lymph node	0.6 nTPM
Thymus	0.6 nTPM
Spleen	0.4 nTPM
Salivary gland	0.4 nTPM
Stomach	0.3 nTPM
Prostate	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Lung	0.0 nTPM

Undifferentiated cells	2.2 nTPM
Colon	5.2 nTPM
Rectum	0.7 nTPM
Small intestine	0.6 nTPM

Amygdala excitatory	0.9 nTPM
Thalamus	2.3 nTPM
Hypothalamus	1.0 nTPM
Cerebral cortex	0.7 nTPM
Amygdala	0.6 nTPM
Basal ganglia	0.6 nTPM
Hippocampus	0.5 nTPM

Astrocyte	14.8 nTPM
Spinal cord	63.2 nTPM
Medulla oblongata	59.9 nTPM
Cerebellum	18.0 nTPM
Pons	7.7 nTPM
Thalamus	6.1 nTPM
Basal ganglia	2.3 nTPM
Midbrain	2.2 nTPM
Hypothalamus	1.3 nTPM
Hippocampus	1.2 nTPM
Cerebral cortex	1.0 nTPM
Amygdala	0.2 nTPM

Bergmann glia	1.0 nTPM
Medulla oblongata	2.1 nTPM
Cerebellum	0.7 nTPM
Pons	0.0 nTPM

Central nervous system macrophage	1.3 nTPM
Thalamus	5.0 nTPM
Spinal cord	2.6 nTPM
Medulla oblongata	1.5 nTPM
Hypothalamus	1.4 nTPM
Hippocampus	1.0 nTPM
Midbrain	0.9 nTPM
Cerebral cortex	0.8 nTPM
Cerebellum	0.4 nTPM
Basal ganglia	0.3 nTPM
Amygdala	0.2 nTPM
Pons	0.2 nTPM

Cerebellar inhibitory	42.1 nTPM
Spinal cord	74.2 nTPM
Medulla oblongata	59.5 nTPM
Cerebellum	30.9 nTPM
Pons	24.6 nTPM
Midbrain	21.5 nTPM

Cge interneuron	20.7 nTPM
Midbrain	34.0 nTPM
Thalamus	29.7 nTPM
Basal ganglia	21.3 nTPM
Cerebral cortex	19.4 nTPM
Hippocampus	19.2 nTPM
Amygdala	15.0 nTPM
Hypothalamus	6.6 nTPM

Choroid plexus epithelial cell	1.0 nTPM
Thalamus	2.7 nTPM
Medulla oblongata	1.3 nTPM
Basal ganglia	0.0 nTPM
Hippocampus	0.0 nTPM

Committed oligodendrocyte precursor	3.1 nTPM
Medulla oblongata	14.2 nTPM
Thalamus	9.2 nTPM
Cerebellum	3.2 nTPM
Cerebral cortex	1.9 nTPM
Pons	1.8 nTPM
Basal ganglia	1.1 nTPM
Hippocampus	1.0 nTPM
Midbrain	0.8 nTPM
Hypothalamus	0.7 nTPM
Amygdala	0.6 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	0.7 nTPM
Hypothalamus	1.7 nTPM
Basal ganglia	0.7 nTPM
Amygdala	0.6 nTPM
Hippocampus	0.6 nTPM
Cerebral cortex	0.5 nTPM
Midbrain	0.0 nTPM

Deep-layer intratelencephalic	0.5 nTPM
Basal ganglia	0.9 nTPM
Amygdala	0.8 nTPM
Cerebral cortex	0.4 nTPM
Hippocampus	0.3 nTPM
Hypothalamus	0.2 nTPM

Deep-layer near-projecting	0.2 nTPM
Cerebral cortex	0.4 nTPM
Hippocampus	0.3 nTPM
Amygdala	0.2 nTPM
Hypothalamus	0.2 nTPM
Basal ganglia	0.1 nTPM

Eccentric medium spiny neuron	2.6 nTPM
Cerebral cortex	3.5 nTPM
Hypothalamus	3.4 nTPM
Thalamus	3.1 nTPM
Amygdala	2.8 nTPM
Basal ganglia	2.0 nTPM
Hippocampus	0.8 nTPM

Endothelial cell	1.4 nTPM
Thalamus	6.2 nTPM
Medulla oblongata	3.1 nTPM
Midbrain	1.9 nTPM
Cerebellum	1.5 nTPM
Hypothalamus	1.2 nTPM
Cerebral cortex	0.6 nTPM
Hippocampus	0.3 nTPM
Amygdala	0.0 nTPM
Basal ganglia	0.0 nTPM
Pons	0.0 nTPM
Spinal cord	0.0 nTPM

Ependymal cell	3.5 nTPM
Medulla oblongata	15.6 nTPM
Pons	7.1 nTPM
Thalamus	4.5 nTPM
Spinal cord	1.9 nTPM
Hypothalamus	0.9 nTPM
Hippocampus	0.8 nTPM
Amygdala	0.6 nTPM
Basal ganglia	0.5 nTPM
Midbrain	0.0 nTPM