Single cell type - DYNC1I1 - The Human Protein Atlas

DYNC1I1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DYNC1I1
Gene descriptionⁱ Full gene name according to HGNC.	Dynein cytoplasmic 1 intermediate chain 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Pituitary endocrine cells - Neuroendocrine signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Choroid plexus epithelial cells, Corticotrophs, Müller glia, Adrenal medulla cells, Podocytes, Lactotrophs, Brain excitatory neurons, Somatotrophs, Retinal pigment epithelial cells, Brain inhibitory neurons, Other brain neurons, Gonadotrophs, Retinal ganglion cells, Thyrotrophs)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.60
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (neutrophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nCPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. * Single nuclei Read more
Single cell type groups RNA single cell type group specificity: Cell type enhanced (Ciliated cells, Pituitary endocrine cells, Glial cells, Adrenal endocrine cells, Renal nephron cells, Neuronal cells, Pigment cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas HPA data, as well as data generated by Monaco et al and Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (neutrophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

DYNC1I1 is part of cluster 59 Pituitary endocrine cells - Neuroendocrine signaling with confidenceⁱ 1
213 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ATP8A2	ATPase phospholipid transporting 8A2	0.5273	59
CLVS1	Clavesin 1	0.5255	109
NALF1	NALCN channel auxiliary factor 1	0.5142	59
SNAP91	Synaptosome associated protein 91	0.5099	59
NRG1	Neuregulin 1	0.5081	59
SLC6A15	Solute carrier family 6 member 15	0.4980	59
GDAP1	Ganglioside induced differentiation associated protein 1	0.4926	35
SGSM1	Small G protein signaling modulator 1	0.4840	59
ANKRD34C	Ankyrin repeat domain 34C	0.4818	109
CSRNP3	Cysteine and serine rich nuclear protein 3	0.4791	59
SCN8A	Sodium voltage-gated channel alpha subunit 8	0.4788	35
PAK3	P21 (RAC1) activated kinase 3	0.4776	59
HS6ST3	Heparan sulfate 6-O-sulfotransferase 3	0.4768	35
ROBO1	Roundabout guidance receptor 1	0.4745	59
OR2L3	Olfactory receptor family 2 subfamily L member 3	0.4742	109

IMMUNE CELLS

DYNC1I1 is part of cluster 35 Neutrophils - Protein binding with confidenceⁱ 0.87
504 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GET1	Guided entry of tail-anchored proteins factor 1	1.0000	35
ENSG00000286165	Novel protein	0.9286	2
STRADA	STE20 related adaptor alpha	0.9048	35
ST3GAL4	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	0.9048	41
ASPH	Aspartate beta-hydroxylase	0.9048	2
SULF2	Sulfatase 2	0.8810	10
DDX17	DEAD-box helicase 17	0.8810	35
BRD3	Bromodomain containing 3	0.8571	2
PHF2	PHD finger protein 2	0.8571	35
ZNF114	Zinc finger protein 114	0.8571	35
TRIM8	Tripartite motif containing 8	0.8571	35
KRT8	Keratin 8	0.8571	10
INPPL1	Inositol polyphosphate phosphatase like 1	0.8571	10
HESX1	HESX homeobox 1	0.8571	38
SCHIP1	Schwannomin interacting protein 1	0.8571	10

	Lacrimal acinar cells	Salivary acinar cells	Pancreatic acinar cells
Eye	6.3
Salivary gland		3.4
Pancreas			9.8
Mean exp	6.3	3.4	9.8

	Adipocytes
Heart muscle	20.3
Skeletal muscle	27.8
Adipose tissue	51.0
Mean exp	33.1

	Adrenal cortex cells	Adrenal medulla cells
Adrenal gland	27.6	702.0
Mean exp	27.6	702.0

	Alveolar cells type 1	Alveolar cells type 2	Transitional alveolar cells
Lung	6.0	4.0	2.1
Mean exp	6.0	4.0	2.1

	Esophageal apical cells
Esophagus	1.0
Mean exp	1.0

	B-cells
Brain	15.8
Eye	0.7
Lung	1.0
Salivary gland	1.4
Esophagus	0.0
Stomach	2.0
Liver	0.0
Kidney	2.4
Urinary bladder	0.7
Breast	3.2
Endometrium	3.0
Adipose tissue	9.9
Blood	0.3
Bone marrow	0.6
Lymph node	0.3
Thymus	1.2
Spleen	0.2
Mean exp	2.5

	Ocular epithelial cells	Mesothelial cells	Urothelial cells	Epicardial cells	Prostatic hillock cells
Eye	2.9
Urinary bladder			2.1
Prostate					7.7
Heart muscle				72.8
Adipose tissue		47.4
Thymus		50.4
Mean exp	2.9	48.9	2.1	72.8	7.7

	Respiratory basal cells	Esophageal basal cells	Salivary basal cells	Basal keratinocytes	Epididymal basal cells	Basal prostatic cells
Lung	12.2
Tongue				9.9
Salivary gland			21.0
Esophagus		2.3
Epididymis					6.5
Prostate						25.9
Skin				5.8
Mean exp	12.2	2.3	21.0	7.8	6.5	25.9

	Ependymal cells	Choroid plexus epithelial cells	Respiratory ciliated cells	Respiratory deuterosomal cells	Epididymal efferent duct ciliated cells	Fallopian tube ciliated cells	Endometrial ciliated cells
Brain	13.6	862.8
Lung			0.6	0.0
Epididymis					3.8
Fallopian tube						0.6
Endometrium							98.8
Mean exp	13.6	862.8	0.6	0.0	3.8	0.6	98.8

	Cdc	Pdcs
Lung		21.8
Breast	1.0	5.2
Endometrium		0.0
Adipose tissue	19.4
Skin	2.8
Blood		0.0
Lymph node	26.0
Mean exp	12.3	6.8

	Salivary duct cells	Cholangiocytes	Pancreatic duct cells	Renal collecting duct intercalated cells	Renal collecting duct principal cells	Renal connecting tubule cells	Epididymal efferent duct absorptive cells
Salivary gland	0.8
Liver		0.0
Pancreas			1.5
Kidney				2.3	1.9	4.4
Epididymis							27.9
Mean exp	0.8	0.0	1.5	2.3	1.9	4.4	27.9

	Vascular endothelial cells	Lymphatic endothelial cells
Brain	21.5
Eye	20.9	250.8
Pituitary gland	146.2
Lung	20.0	186.8
Tongue	7.5	92.5
Salivary gland	36.6	285.0
Esophagus	5.1	79.3
Stomach	19.1
Liver	106.0
Pancreas	11.5
Kidney	35.5	70.6
Urinary bladder	14.3	298.3
Testis	30.1	181.5
Epididymis	13.9
Prostate	16.1	227.4
Breast	5.6	104.9
Ovary	17.3	106.0
Fallopian tube	5.2	14.7
Endometrium	4.9	7.4
Placenta	0.0
Heart muscle	53.8
Skeletal muscle	35.9
Vasculature	34.2	193.3
Adipose tissue	31.1	211.0
Skin	7.9	50.4
Lymph node	10.1	377.4
Thymus	16.9	253.3
Spleen		33.4
Mean exp	26.9	159.2

	Enterocytes	Colonocytes
Small intestine	0.5
Colon		0.8
Rectum		0.2
Mean exp	0.5	0.5

	Neuroendocrine cells
Stomach	44.9
Small intestine	0.0
Colon	17.4
Rectum	3.7
Mean exp	16.5

	Erythrocyte progenitors	Erythrocytes
Blood		0.1
Bone marrow	2.2	0.0
Spleen		0.0
Mean exp	2.2	0.0

	Astrocytes	Bergmann glia	Müller glia	Pituicytes/fscs	Oligodendrocyte progenitor cells	Oligodendrocytes	Schwann cells	Microglia
Brain	35.6	36.3			136.8	217.7		8.8
Eye			705.2				8.3
Pituitary gland				277.0
Tongue							23.3
Urinary bladder							37.6
Vasculature							4.7
Mean exp	35.6	36.3	705.2	277.0	136.8	217.7	18.5	8.8

	Hepatocytes
Liver	3.9
Mean exp	3.9

	Fibro-adipogenic progenitors
Skeletal muscle	117.8
Adipose tissue	35.5
Mean exp	76.7

	Fibroblasts
Brain	36.5
Eye	28.0
Lung	39.5
Tongue	37.5
Salivary gland	176.7
Esophagus	11.1
Stomach	26.4
Pancreas	14.0
Kidney	61.2
Urinary bladder	39.1
Epididymis	70.5
Prostate	131.5
Breast	23.5
Fallopian tube	9.3
Placenta	4.3
Heart muscle	82.5
Vasculature	61.8
Skin	9.2
Lymph node	88.7
Thymus	55.3
Mean exp	50.3

	Foveolar cells	Mucous neck cells	Parietal cells	Gastric chief cells
Stomach	3.4	4.3	0.0	1.1
Mean exp	3.4	4.3	0.0	1.1

	Submucosal glandular cells	Prostatic glandular cells	Prostatic club cells	Endometrial glandular cells
Lung	2.2
Esophagus	0.5
Prostate		16.4	0.5
Endometrium				129.6
Mean exp	1.3	16.4	0.5	129.6

	Conjunctival goblet cells	Goblet cells
Eye	2.9
Small intestine		0.0
Colon		1.9
Rectum		0.0
Mean exp	2.9	0.6

	Innate lymphoid cells
Lung	0.0
Salivary gland	1.2
Urinary bladder	0.0
Breast	0.0
Fallopian tube	3.2
Endometrium	3.6
Lymph node	3.0
Thymus	9.6
Spleen	2.6
Mean exp	2.6

	Respiratory ionocytes	Salivary ionocytes
Lung	0.0
Salivary gland		2.9
Mean exp	0.0	2.9

	Breast hormone-responsive cells	Endometrial luminal cells
Breast	1.9
Endometrium		126.3
Mean exp	1.9	126.3

	Mast cells
Eye	5.5
Lung	9.6
Tongue	9.9
Salivary gland	11.6
Stomach	10.3
Pancreas	5.9
Urinary bladder	3.1
Epididymis	9.0
Fallopian tube	6.9
Vasculature	12.0
Adipose tissue	45.3
Lymph node	4.5
Mean exp	11.1

	Megakaryocyte progenitors	Megakaryocyte-erythroid progenitors	Megakaryocytes
Bone marrow	13.9	16.5	30.9
Mean exp	13.9	16.5	30.9

Acinar cells - 9.8 nCPM

Adipocytes - 33.1 nCPM

Adrenal endocrine cells - 702.0 nCPM

Alveolar cells - 6.0 nCPM

Apical squamous epithelial cells - 1.0 nCPM

B-cells - 2.5 nCPM

Barrier epithelial cells - 72.8 nCPM

Basal cells - 25.9 nCPM

Ciliated cells - 862.8 nCPM

Dendritic cells - 12.3 nCPM

Ductal cells - 27.9 nCPM

Endothelial cells - 159.2 nCPM

Enterocytes - 0.5 nCPM

Enteroendocrine cells - 16.5 nCPM

Erythrocytes - 2.2 nCPM

Fibro-adipogenic progenitors - 76.7 nCPM

Fibroblasts - 50.3 nCPM

Gastric glandular cells - 4.3 nCPM

Glandular cells - 129.6 nCPM

Glial cells - 705.2 nCPM

Goblet cells - 2.9 nCPM

Hepatocytes - 3.9 nCPM

Innate lymphoid cells - 2.6 nCPM

Ionocytes - 2.9 nCPM

Leydig cells - 253.4 nCPM

Luminal cells - 126.3 nCPM

Mast cells - 11.1 nCPM

Megakaryocytes - 30.9 nCPM

Mononuclear phagocytes - 4.7 nCPM

Mural cells - 215.2 nCPM

Myocytes - 305.2 nCPM

Neuronal cells - 633.1 nCPM

Neutrophils - 34.9 nCPM

Nk-cells - 2.1 nCPM

Oocytes - 36.8 nCPM

Pancreatic islet cells - 142.4 nCPM

Pigment cells - 588.3 nCPM

Pituitary endocrine cells - 861.3 nCPM

Plasma cells - 7.1 nCPM

Platelets - 9.8 nCPM

Proliferating cells - 2.6 nCPM

Renal nephron cells - 687.1 nCPM

Reproductive supporting cells - 52.5 nCPM

Secretory cells - 25.3 nCPM

Secretory gland support - 63.6 nCPM

Smooth muscle cells - 283.4 nCPM

Spermatogenic cell types - 39.0 nCPM

Stellate cells - 12.9 nCPM

Stem cells - 303.9 nCPM

Stromal cells - 121.7 nCPM

Suprabasal cells - 13.6 nCPM

T-cells - 5.9 nCPM

Trophoblast cells - 2.8 nCPM

	Monocyte progenitors	Monocytes	Macrophages	Kupffer cells	Hofbauer cells
Brain		6.9	19.0
Eye		0.6	2.9
Pituitary gland			8.0
Lung		1.1	2.8
Tongue		7.3	4.4
Salivary gland		0.5	4.0
Esophagus			2.0
Stomach		0.0	5.1
Liver		0.0	0.8	0.0
Pancreas		1.5	3.0
Kidney			3.4
Urinary bladder		1.7	1.9
Testis			0.0
Prostate		0.0	1.4
Breast		0.0	0.4
Ovary			5.3
Fallopian tube		0.5	1.0
Endometrium			3.4
Placenta					0.7
Heart muscle			14.1
Skeletal muscle			0.6
Vasculature		4.5	5.7
Adipose tissue			6.5
Skin			0.0
Blood		1.7
Bone marrow	2.5	3.2	1.2
Lymph node		2.8	20.0
Thymus		1.3	7.4
Spleen		1.7	2.3
Mean exp	2.5	2.0	4.7	0.0	0.7

	Pericytes	Vascular smooth muscle cells
Brain	224.6	505.3
Eye	281.0	217.5
Pituitary gland	56.8
Lung	36.0	42.2
Tongue	221.8	247.1
Salivary gland	232.3	170.9
Stomach	85.5	253.8
Pancreas	32.4
Kidney	276.6	265.9
Urinary bladder	23.6	186.7
Testis	92.5
Epididymis	18.4	262.5
Prostate	169.8	280.8
Breast	38.6	64.1
Ovary	38.4	121.4
Fallopian tube	70.1	104.8
Placenta	5.4
Heart muscle	98.5	184.5
Skeletal muscle	74.9	467.7
Vasculature	80.2	100.3
Adipose tissue	116.2	374.3
Skin	38.6	64.8
Thymus	97.6	173.2
Mean exp	104.8	215.2

	Cardiomyocytes	Myonuclei
Heart muscle	305.2
Skeletal muscle		49.8
Mean exp	305.2	49.8

	Brain excitatory neurons	Brain inhibitory neurons	Retinal amacrine cells	Retinal horizontal cells	Retinal ganglion cells	Retinal bipolar cells	Rod photoreceptor cells	Cone photoreceptor cells	Other brain neurons
Brain	633.1	579.0							573.7
Eye			241.7	24.0	475.1	299.6	88.5	269.1
Mean exp	633.1	579.0	241.7	24.0	475.1	299.6	88.5	269.1	573.7

	Neutrophil progenitors	Neutrophils
Eye		15.8
Lung		9.4
Salivary gland		60.6
Urinary bladder		3.0
Prostate		44.7
Vasculature		50.6
Blood	1.6	82.9
Bone marrow	2.0	27.6
Lymph node		1.9
Spleen	6.8	40.7
Thymus	3.8	47.1
Mean exp	3.5	34.9

	Nk-cells
Brain	11.0
Eye	0.0
Lung	0.7
Salivary gland	0.0
Stomach	0.0
Colon	0.0
Liver	0.7
Kidney	4.8
Urinary bladder	0.5
Prostate	3.1
Fallopian tube	0.0
Endometrium	13.0
Vasculature	0.8
Blood	0.1
Bone marrow	0.3
Lymph node	0.3
Thymus	1.3
Spleen	0.6
Mean exp	2.1

	Melanocytes	Retinal pigment epithelial cells
Eye	195.2	588.3
Skin	44.8
Mean exp	120.0	588.3

	Corticotrophs	Gonadotrophs	Lactotrophs	Somatotrophs	Thyrotrophs
Pituitary gland	861.3	522.8	653.6	606.7	429.3
Mean exp	861.3	522.8	653.6	606.7	429.3

	Plasma cells
Eye	8.7
Lung	0.0
Salivary gland	31.2
Stomach	3.1
Liver	5.6
Urinary bladder	4.9
Breast	6.3
Fallopian tube	10.1
Blood	0.0
Bone marrow	17.9
Lymph node	0.9
Thymus	1.9
Spleen	1.8
Mean exp	7.1

	Gastric progenitor cells	Enteric transient amplifying cells
Stomach	2.6
Small intestine		0.4
Colon		0.5
Rectum		0.0
Mean exp	2.6	0.3