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The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
TSPAN7 is potential prognostic, high expression is favorable in Pancreatic Adenocarcinoma (TCGA)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
23.2
Number of samples
176
Samples
Sample
Description
TPM
TCGA-3A-A9IL-01A
0 years, female, white, stage:Stage I, alive, 2741 days
227.8
TCGA-3A-A9IJ-01A
0 years, male, white, stage:Stage IB, alive, 1854 days
212.6
TCGA-3A-A9IR-01A
0 years, female, white, stage:Stage IB, alive, 1542 days
201.6
TCGA-3A-A9IV-01A
0 years, female, white, stage:Stage IB, alive, 1103 days
171.3
TCGA-3A-A9IO-01A
0 years, male, white, stage:'--, alive, 1942 days
161.2
TCGA-HZ-7920-01A
0 years, male, white, stage:Stage IB, dead, 236 days
148.9
TCGA-IB-7897-01A
0 years, female, white, stage:Stage IIB, dead, 486 days
122.9
TCGA-HZ-8519-01A
0 years, male, white, stage:Stage IA, alive, 454 days
120.4
TCGA-2L-AAQM-01A
0 years, male, white, stage:Stage IIB, alive, 1383 days
115.8
TCGA-XD-AAUH-01A
0 years, female, white, stage:Stage IIB, alive, 395 days
96.1
TCGA-3A-A9IS-01A
0 years, male, white, stage:Stage IB, alive, 998 days
94.5
TCGA-3A-A9IN-01A
0 years, female, white, stage:Stage IB, alive, 2084 days
74.8
TCGA-IB-A5SQ-01A
0 years, female, white, stage:Stage IB, dead, 219 days
60.4
TCGA-IB-7888-01A
0 years, female, black or african american, stage:Stage IIA, dead, 1332 days
57.2
TCGA-HZ-7923-01A
0 years, male, white, stage:Stage IIA, alive, 314 days
51.9
TCGA-XD-AAUG-01A
0 years, female, white, stage:Stage IV, alive, 420 days
50.2
TCGA-IB-7645-01A
0 years, female, stage:Stage IIB, dead, 1502 days
45.9
TCGA-IB-AAUW-01A
0 years, female, white, stage:Stage IIB, dead, 230 days
43.5
TCGA-F2-7276-01A
0 years, male, white, stage:Stage IIB, dead, 216 days
39.1
TCGA-IB-AAUR-01A
0 years, male, white, stage:Stage IIB, alive, 338 days
38.7
TCGA-RB-AA9M-01A
0 years, male, white, stage:Stage IIB, alive, 286 days
38.6
TCGA-HZ-A77P-01A
0 years, male, white, stage:Stage IIB, alive, 330 days
38.5
TCGA-HZ-8001-01A
0 years, male, white, stage:Stage III, alive, 706 days
38.4
TCGA-F2-7273-01A
0 years, male, black or african american, stage:Stage IIB, dead, 592 days
36.7
TCGA-HZ-8002-01A
0 years, male, white, stage:Stage IIB, dead, 366 days
35.1
TCGA-XN-A8T5-01A
0 years, female, white, stage:Stage IB, alive, 720 days
34.9
TCGA-US-A77J-01A
0 years, female, white, stage:Stage IIB, dead, 568 days
33.0
TCGA-FB-AAPS-01A
0 years, female, white, stage:Stage IIB, alive, 228 days
31.5
TCGA-H6-A45N-01A
0 years, female, white, stage:Stage IIB, dead, 397 days
31.4
TCGA-HZ-7289-01A
0 years, male, white, stage:Stage IIB, dead, 661 days
30.9
TCGA-2J-AABK-01A
0 years, male, white, stage:Stage IIB, alive, 484 days
30.3
TCGA-FB-A4P5-01A
0 years, female, white, stage:Stage IIB, dead, 179 days
28.7
TCGA-3A-A9IX-01A
0 years, male, white, stage:Stage IA, alive, 1037 days
27.4
TCGA-HZ-7924-01A
0 years, female, white, stage:Stage IIA, alive, 840 days
27.0
TCGA-2J-AABT-01A
0 years, female, white, stage:Stage IIB, alive, 319 days
26.9
TCGA-HZ-A49H-01A
0 years, female, white, stage:Stage IIB, alive, 491 days
26.8
TCGA-IB-A5ST-01A
0 years, female, white, stage:Stage IIB, alive, 635 days
26.5
TCGA-HZ-A4BH-01A
0 years, male, white, stage:Stage IIB, alive, 194 days
25.9
TCGA-IB-AAUV-01A
0 years, male, white, stage:Stage IIB, alive, 404 days
25.7
TCGA-2J-AABR-01A
0 years, female, white, stage:Stage IIA, alive, 438 days
24.8
TCGA-IB-7649-01A
0 years, female, stage:Stage IIB, dead, 467 days
24.5
TCGA-HZ-8637-01A
0 years, female, white, stage:Stage IIB, dead, 517 days
24.3
TCGA-Z5-AAPL-01A
0 years, female, white, stage:Stage IIA, alive, 467 days
24.2
TCGA-FB-A4P6-01A
0 years, male, white, stage:Stage IIB, alive, 767 days
23.8
TCGA-XD-AAUI-01A
0 years, female, white, stage:Stage IIB, dead, 366 days
22.4
TCGA-HV-A5A5-01A
0 years, female, asian, stage:Stage IIB, alive, 289 days
22.2
TCGA-YB-A89D-01A
0 years, male, white, stage:Stage IIB, alive, 350 days
21.9
TCGA-3E-AAAY-01A
0 years, male, white, stage:Stage IIB, alive, 2285 days
21.4
TCGA-IB-A5SO-01A
0 years, male, white, stage:Stage IIB, dead, 365 days
21.3
TCGA-RL-AAAS-01A
0 years, female, white, stage:Stage IB, alive, 9 days
21.2
TCGA-HZ-8638-01A
0 years, female, white, stage:Stage IA, dead, 151 days
20.7
TCGA-3A-A9I5-01A
0 years, male, white, stage:'--, alive, 1794 days
20.1
TCGA-FB-AAQ2-01A
0 years, female, white, stage:Stage IIB, dead, 153 days
19.9
TCGA-IB-AAUP-01A
0 years, male, white, stage:Stage IIB, alive, 431 days
19.7
TCGA-IB-AAUQ-01A
0 years, male, white, stage:Stage IIB, dead, 183 days
19.5
TCGA-IB-AAUT-01A
0 years, male, white, stage:Stage IIB, alive, 287 days
19.3
TCGA-Q3-A5QY-01A
0 years, male, white, stage:Stage IIB, alive, 416 days
18.8
TCGA-HZ-A49G-01A
0 years, female, white, stage:Stage IIB, alive, 660 days
18.7
TCGA-HZ-7926-01A
0 years, male, black or african american, stage:Stage IIB, dead, 518 days
18.3
TCGA-FB-A7DR-01A
0 years, male, asian, stage:Stage IIA, dead, 353 days
18.2
TCGA-2J-AABF-01A
0 years, male, white, stage:Stage IIB, dead, 691 days
17.6
TCGA-IB-7889-01A
0 years, female, white, stage:Stage IIB, dead, 481 days
17.5
TCGA-2J-AABO-01A
0 years, male, white, stage:Stage IIB, alive, 440 days
17.5
TCGA-IB-7890-01A
0 years, male, stage:Stage IB, dead, 598 days
17.0
TCGA-2J-AAB4-01A
0 years, male, white, stage:Stage IIB, alive, 729 days
16.8
TCGA-IB-8126-01A
0 years, female, white, stage:Stage III, alive, 462 days
16.7
TCGA-IB-7891-01A
0 years, female, white, stage:Stage IIB, dead, 913 days
15.8
TCGA-HZ-8317-01A
0 years, female, white, stage:Stage IIB, dead, 378 days
15.8
TCGA-S4-A8RP-01A
0 years, female, white, stage:Stage IIB, dead, 702 days
15.3
TCGA-3A-A9I7-01A
0 years, male, black or african american, stage:Stage IIB, alive, 1323 days
15.1
TCGA-IB-AAUM-01A
0 years, male, white, stage:Stage IIB, alive, 8 days
15.0
TCGA-IB-7652-01A
0 years, female, asian, stage:Stage IIB, alive, 1116 days
14.8
TCGA-FB-AAPY-01A
0 years, male, white, stage:Stage IIB, dead, 1059 days
14.3
TCGA-HZ-8003-01A
0 years, female, white, stage:Stage IIB, dead, 596 days
14.1
TCGA-HZ-A77Q-01A
0 years, female, white, stage:Stage IIB, alive, 33 days
13.9
TCGA-2L-AAQI-01A
0 years, male, white, stage:Stage IIB, dead, 103 days
13.8
TCGA-IB-7654-01A
0 years, male, white, stage:Stage IIB, dead, 476 days
13.6
TCGA-2J-AAB1-01A
0 years, male, white, stage:Stage IIB, dead, 66 days
13.5
TCGA-2J-AAB9-01A
0 years, female, white, stage:Stage IIB, dead, 627 days
13.2
TCGA-HZ-7918-01A
0 years, male, white, stage:Stage IIB, alive, 969 days
13.0
TCGA-3A-A9IH-01A
0 years, female, white, stage:Stage IA, alive, 1021 days
12.7
TCGA-3E-AAAZ-01A
0 years, male, white, stage:Stage IIA, dead, 2182 days
12.7
TCGA-2J-AABH-01A
0 years, male, white, stage:Stage IIA, alive, 1287 days
12.6
TCGA-HV-A5A4-01A
0 years, female, asian, stage:Stage IIA, alive, 232 days
12.6
TCGA-FB-AAPZ-01A
0 years, male, white, stage:Stage IIB, alive, 716 days
12.5
TCGA-2J-AAB6-01A
0 years, male, white, stage:Stage IIA, dead, 293 days
12.4
TCGA-3A-A9I9-01A
0 years, male, white, stage:Stage IIA, dead, 634 days
12.3
TCGA-XN-A8T3-01A
0 years, male, white, stage:Stage IB, alive, 951 days
11.8
TCGA-IB-7893-01A
0 years, male, white, stage:Stage IIA, dead, 117 days
11.5
TCGA-IB-7885-01A
0 years, female, white, stage:Stage IIB, alive, 1257 days
11.4
TCGA-HZ-8636-01A
0 years, female, white, stage:Stage IV, dead, 545 days
11.3
TCGA-HZ-A4BK-01A
0 years, male, white, stage:Stage IIB, alive, 657 days
11.1
TCGA-2L-AAQL-01A
0 years, male, white, stage:Stage IIB, dead, 292 days
11.0
TCGA-HZ-7919-01A
0 years, female, white, stage:Stage IIB, dead, 593 days
11.0
TCGA-FB-AAPP-01A
0 years, male, white, stage:Stage IIB, dead, 485 days
10.4
TCGA-US-A774-01A
0 years, female, white, stage:Stage IIB, dead, 695 days
10.2
TCGA-HZ-A49I-01A
0 years, male, white, stage:Stage IIB, dead, 308 days
10.0
TCGA-F2-6880-01A
0 years, male, white, stage:Stage IIB, alive, 295 days
10.0
TCGA-IB-AAUU-01A
0 years, male, white, stage:Stage IIB, alive, 245 days
9.9
TCGA-HZ-7922-01A
0 years, female, white, stage:Stage IIB, alive, 4 days
9.9
TCGA-US-A779-01A
0 years, female, white, stage:Stage IIB, dead, 511 days
9.9
TCGA-FB-A5VM-01A
0 years, male, white, stage:Stage IB, dead, 498 days
9.8
TCGA-IB-AAUS-01A
0 years, female, white, stage:Stage IIB, alive, 225 days
9.8
TCGA-LB-A9Q5-01A
0 years, female, white, stage:Stage IIB, dead, 313 days
9.8
TCGA-F2-A44H-01A
0 years, male, white, stage:Stage IIA, alive, 586 days
9.7
TCGA-US-A776-01A
0 years, male, white, stage:Stage IIA, alive, 1216 days
9.3
TCGA-IB-A5SP-01A
0 years, male, white, stage:Stage IIA, alive, 482 days
9.1
TCGA-YH-A8SY-01A
0 years, female, white, stage:'--, alive, 388 days
8.9
TCGA-US-A77G-01A
0 years, male, white, stage:Stage IIB, dead, 12 days
8.6
TCGA-F2-A7TX-01A
0 years, male, white, stage:Stage IIB, dead, 95 days
8.4
TCGA-HZ-8315-01A
0 years, female, white, stage:Stage IIA, dead, 299 days
8.3
TCGA-YY-A8LH-01A
0 years, female, white, stage:Stage IIB, alive, 2016 days
8.1
TCGA-3A-A9IB-01A
0 years, female, white, stage:Stage IIB, dead, 224 days
8.0
TCGA-S4-A8RM-01A
0 years, male, white, stage:Stage IIB, alive, 737 days
7.8
TCGA-2J-AABA-01A
0 years, male, white, stage:Stage IIB, dead, 607 days
7.8
TCGA-IB-AAUN-01A
0 years, female, white, stage:Stage IB, dead, 144 days
7.6
TCGA-IB-A6UG-01A
0 years, male, white, stage:Stage IIB, dead, 41 days
7.4
TCGA-FB-A78T-01A
0 years, female, white, stage:Stage IIB, dead, 375 days
7.3
TCGA-FB-AAQ1-01A
0 years, male, white, stage:Stage IIB, dead, 123 days
7.1
TCGA-2L-AAQJ-01A
0 years, female, white, stage:Stage III, dead, 394 days
7.1
TCGA-LB-A7SX-01A
0 years, female, black or african american, stage:Stage IIB, dead, 393 days
6.9
TCGA-RB-A7B8-01A
0 years, female, white, stage:Stage IIB, dead, 466 days
6.7
TCGA-FB-AAQ6-01A
0 years, male, white, stage:Stage IA, dead, 244 days
6.7
TCGA-HZ-7925-01A
0 years, male, white, stage:Stage IIB, dead, 614 days
6.5
TCGA-FB-AAPQ-01A
0 years, male, white, stage:Stage IIB, dead, 1130 days
6.4
TCGA-2L-AAQE-01A
0 years, male, white, stage:Stage IIB, dead, 684 days
6.2
TCGA-XD-AAUL-01A
0 years, male, white, stage:Stage IIA, alive, 498 days
6.1
TCGA-H8-A6C1-01A
0 years, male, white, stage:Stage IIA, alive, 671 days
6.0
TCGA-S4-A8RO-01A
0 years, female, white, stage:Stage IIB, alive, 525 days
6.0
TCGA-HV-AA8V-01A
0 years, male, asian, stage:Stage IIB, alive, 920 days
5.8
TCGA-LB-A8F3-01A
0 years, female, black or african american, stage:Stage IIA, alive, 379 days
5.6
TCGA-HV-AA8X-01A
0 years, female, asian, stage:Stage IIB, dead, 532 days
5.4
TCGA-IB-7886-01A
0 years, male, white, stage:Stage IIB, dead, 123 days
5.3
TCGA-US-A77E-01A
0 years, male, white, stage:Stage IIB, dead, 430 days
5.0
TCGA-IB-7646-01A
0 years, male, white, stage:Stage IIB, dead, 145 days
5.0
TCGA-HZ-A8P1-01A
0 years, male, white, stage:Stage IB, alive, 7 days
5.0
TCGA-IB-8127-01A
0 years, male, white, stage:Stage IIB, alive, 522 days
4.8
TCGA-2J-AABE-01A
0 years, male, white, stage:Stage IIA, alive, 676 days
4.7
TCGA-IB-7651-01A
0 years, female, white, stage:Stage IIB, dead, 603 days
4.6
TCGA-3A-A9J0-01A
0 years, male, white, stage:Stage IIB, alive, 743 days
4.6
TCGA-IB-A7M4-01A
0 years, male, white, stage:Stage IIB, alive, 483 days
4.5
TCGA-IB-7644-01A
0 years, female, white, stage:Stage IV, dead, 394 days
4.4
TCGA-FB-A545-01A
0 years, female, white, stage:Stage IIB, dead, 732 days
4.4
TCGA-H6-8124-01A
0 years, female, white, stage:Stage IIB, alive, 392 days
4.2
TCGA-2J-AABP-01A
0 years, female, white, stage:Stage IIB, alive, 463 days
4.1
TCGA-IB-A6UF-01A
0 years, male, white, stage:Stage IIB, alive, 666 days
4.1
TCGA-F2-6879-01A
0 years, male, white, stage:Stage IIB, dead, 334 days
4.1
TCGA-HZ-A9TJ-01A
0 years, male, white, stage:Stage IV, alive, 603 days
4.1
TCGA-Q3-AA2A-01A
0 years, female, white, stage:Stage IB, alive, 95 days
4.0
TCGA-3A-A9IU-01A
0 years, male, white, stage:Stage IIB, dead, 458 days
3.9
TCGA-PZ-A5RE-01A
0 years, female, white, stage:Stage IIB, dead, 470 days
3.8
TCGA-2J-AAB8-01A
0 years, male, white, stage:Stage IIB, alive, 80 days
3.7
TCGA-HV-A7OP-01A
0 years, male, asian, stage:Stage IIB, alive, 978 days
3.6
TCGA-FB-AAQ3-01A
0 years, female, white, stage:Stage IIB, dead, 31 days
3.4
TCGA-L1-A7W4-01A
0 years, female, white, stage:Stage IIB, dead, 278 days
3.4
TCGA-HZ-8005-01A
0 years, male, white, stage:Stage IIB, dead, 120 days
3.3
TCGA-3A-A9IC-01A
0 years, female, white, stage:Stage IIB, dead, 738 days
3.3
TCGA-FB-AAPU-01A
0 years, female, asian, stage:Stage IIA, dead, 381 days
3.3
TCGA-2J-AABU-01A
0 years, male, white, stage:Stage IIB, dead, 277 days
3.2
TCGA-HZ-A77O-01A
0 years, female, white, stage:Stage IIB, dead, 160 days
3.2
TCGA-OE-A75W-01A
0 years, male, white, stage:Stage IIA, dead, 267 days
3.1
TCGA-HV-A7OL-01A
0 years, male, asian, stage:Stage IIA, alive, 252 days
3.1
TCGA-M8-A5N4-01A
0 years, female, stage:Stage IIA, alive, 584 days
2.7
TCGA-IB-A5SS-01A
0 years, female, white, stage:Stage IIB, dead, 460 days
2.6
TCGA-2J-AABI-01A
0 years, female, white, stage:Stage IIA, alive, 969 days
2.6
TCGA-F2-A8YN-01A
0 years, male, white, stage:Stage IIA, alive, 517 days
2.3
TCGA-IB-AAUO-01A
0 years, female, white, stage:Stage IIB, dead, 239 days
2.3
TCGA-F2-A44G-01A
0 years, female, white, stage:Stage IIB, dead, 233 days
2.1
TCGA-IB-A7LX-01A
0 years, male, white, stage:Stage IIB, dead, 250 days
2.1
TCGA-HV-A5A6-01A
0 years, female, asian, stage:Stage IIB, dead, 2036 days
2.0
TCGA-2L-AAQA-01A
0 years, male, white, stage:Stage IIB, dead, 143 days
1.7
TCGA-IB-7887-01A
0 years, female, white, stage:Stage IIB, dead, 110 days
1.4
TCGA-HV-A5A3-01A
0 years, male, asian, stage:Stage IIA, dead, 128 days
1.3
TCGA-3A-A9IZ-01A
0 years, male, white, stage:Stage IIB, dead, 308 days
1.2
TCGA-2J-AABV-01A
0 years, male, white, stage:Stage IIB, dead, 652 days
1.0
TCGA-FB-AAQ0-01A
0 years, male, white, stage:Stage IIA, dead, 473 days
The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
TSPAN7 is not prognostic in Pancreatic Adenocarcinoma (validation)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
3.0
Number of samples
80
Samples
Sample
Description
TPM
DO49076
0 years, male, NA, stage:, dead, 480 days
32.3
DO34728
0 years, female, NA, stage:, alive, 508 days
22.2
DO34961
0 years, male, NA, stage:, dead, 632 days
17.6
DO32900
0 years, male, NA, stage:, dead, 768 days
9.5
DO49137
0 years, female, NA, stage:, alive, 232 days
9.5
DO49181
0 years, male, NA, stage:, dead, 1534 days
7.2
DO33488
0 years, male, NA, stage:, alive, 844 days
6.1
DO49133
0 years, female, NA, stage:, alive, 188 days
5.2
DO49172
0 years, female, NA, stage:, dead, 1021 days
5.0
DO49113
0 years, female, NA, stage:, alive, 413 days
4.6
DO49164
0 years, male, NA, stage:, alive, 272 days
4.4
DO49127
0 years, female, NA, stage:, alive, 392 days
4.0
DO49080
0 years, male, NA, stage:, alive, 83 days
3.7
DO49135
0 years, male, NA, stage:, alive, 270 days
3.5
DO34680
0 years, male, NA, stage:, dead, 99 days
3.5
DO33168
0 years, female, NA, stage:, dead, 8 days
3.3
DO33408
0 years, female, NA, stage:, alive, 909 days
3.3
DO49168
0 years, male, NA, stage:, alive, 149 days
3.2
DO49078
0 years, male, NA, stage:, dead, 465 days
3.1
DO49193
0 years, male, NA, stage:, dead, 1 days
3.0
DO34616
0 years, female, NA, stage:, alive, 666 days
2.9
DO49129
0 years, male, NA, stage:, alive, 337 days
2.7
DO49178
0 years, male, NA, stage:, dead, 27 days
2.7
DO33336
0 years, female, NA, stage:, dead, 451 days
2.6
DO33344
0 years, male, NA, stage:, dead, 361 days
2.5
DO34600
0 years, male, NA, stage:, dead, 537 days
2.5
DO34656
0 years, female, NA, stage:, alive, 834 days
2.4
DO49185
0 years, male, NA, stage:, alive, 179 days
2.4
DO49087
0 years, female, NA, stage:, dead, 260 days
2.3
DO32829
0 years, female, NA, stage:T2N0MX, dead, 1874 days
2.3
DO34608
0 years, female, NA, stage:, dead, 709 days
2.3
DO34696
0 years, male, NA, stage:, alive, 689 days
2.2
DO33392
0 years, male, NA, stage:, alive, 1014 days
2.2
DO34264
0 years, female, NA, stage:, dead, 1144 days
2.2
DO33480
0 years, male, NA, stage:, alive, 1054 days
2.2
DO33984
0 years, male, NA, stage:, alive, 847 days
2.2
DO34368
0 years, female, NA, stage:, dead, 537 days
2.2
DO33544
0 years, female, NA, stage:, dead, 412 days
2.1
DO33600
0 years, female, NA, stage:, alive, 854 days
1.9
DO34785
0 years, female, NA, stage:, alive, 721 days
1.8
DO34640
0 years, female, NA, stage:, dead, 287 days
1.8
DO33472
0 years, female, NA, stage:, dead, 388 days
1.8
DO33376
0 years, female, NA, stage:, alive, 909 days
1.8
DO49170
0 years, male, NA, stage:, alive, 197 days
1.7
DO33368
0 years, male, NA, stage:, dead, 98 days
1.7
DO34801
0 years, male, NA, stage:, alive, 626 days
1.7
DO49204
0 years, male, NA, stage:, dead, 156 days
1.6
DO34849
0 years, female, NA, stage:, dead, 272 days
1.6
DO34288
0 years, female, NA, stage:, dead, 220 days
1.5
DO34432
0 years, female, NA, stage:, dead, 400 days
1.5
DO32860
0 years, male, NA, stage:, dead, 1259 days
1.4
DO49199
0 years, male, NA, stage:, dead, 1095 days
1.4
DO34817
0 years, female, NA, stage:, alive, 540 days
1.4
DO34504
0 years, male, NA, stage:, dead, 257 days
1.4
DO33128
0 years, male, NA, stage:, dead, 423 days
1.4
DO32875
0 years, male, NA, stage:, dead, 348 days
1.3
DO49130
0 years, female, NA, stage:, alive, 351 days
1.3
DO34448
0 years, female, NA, stage:, dead, 719 days
1.3
DO34312
0 years, female, NA, stage:, dead, 226 days
1.1
DO49090
0 years, female, NA, stage:, dead, 152 days
1.0
DO49198
0 years, female, NA, stage:, dead, 251 days
1.0
DO34720
0 years, male, NA, stage:, alive, 555 days
1.0
DO49138
0 years, male, NA, stage:, dead, 230 days
1.0
DO49183
0 years, female, NA, stage:, dead, 429 days
1.0
DO34240
0 years, male, NA, stage:, dead, 236 days
1.0
DO33512
female, NA, stage:, dead, 499 days
0.9
DO34793
0 years, male, NA, stage:, dead, 427 days
0.9
DO49184
0 years, male, NA, stage:, dead, 455 days
0.9
DO34809
0 years, female, NA, stage:, dead, 297 days
0.9
DO33400
0 years, female, NA, stage:, alive, 1043 days
0.9
DO32863
0 years, male, NA, stage:, dead, 715 days
0.9
DO34736
0 years, female, NA, stage:, dead, 203 days
0.8
DO32878
0 years, female, NA, stage:, dead, 260 days
0.7
DO49166
0 years, female, NA, stage:, alive, 222 days
0.6
DO49074
0 years, male, NA, stage:, dead, 168 days
0.5
DO34905
0 years, male, NA, stage:, alive, 1142 days
0.5
DO49175
0 years, male, NA, stage:, dead, 414 days
0.5
DO49079
0 years, male, NA, stage:, dead, 332 days
0.4
DO33552
0 years, female, NA, stage:, alive, 873 days
0.4
DO34336
0 years, female, NA, stage:, alive, 743 days
0.0
Show allShow less
PANCREATIC DUCTAL ADENOCARCINOMA - Protein relative expression (CPTAC)
Number of samples
235
Samples
Sample ID
Sample type
nRPX
CPT0174800003
Normal
3.5
CPT0014040003
Tumor
2.4
CPT0224460004
Tumor
2.4
CPT0186040004
Tumor
2.3
CPT0123750003
Tumor
1.8
CPT0093860003
Tumor
1.8
C3N-00709-06
Normal
1.6
CPT0066020003
Normal
1.5
CPT0236710004
Normal
1.4
C3L-00401-04
Normal
1.3
CPT0276030003
Normal
1.2
CPT0064110003
Normal
1.2
CPT0064570003
Normal
1.2
CPT0123770003
Normal
1.1
CPT0248620003
Normal
1.1
CPT0237910004
Tumor
1.1
CPT0347790002
Normal
1.0
CPT0123890003
Normal
0.9
CPT0248440003
Normal
0.9
CPT0355180003
Normal
0.9
CPT0094130004
Tumor
0.9
CPT0246840003
Tumor
0.9
CPT0093880003
Normal
0.9
CPT0123860003
Tumor
0.8
CPT0063580003
Normal
0.8
CPT0017130003
Normal
0.7
CPT0187540004
Normal
0.7
CPT0077930004
Tumor
0.6
CPT0276010003
Tumor
0.6
CPT0124410004
Tumor
0.6
CPT0089750004
Normal
0.6
CPT0355200003
Normal
0.6
CPT0347760002
Normal
0.6
CPT0236800004
Normal
0.6
CPT0094940004
Tumor
0.5
CPT0108930003
Tumor
0.5
CPT0209650004
Normal
0.5
C3L-03632-04
Normal
0.4
CPT0087890004
Tumor
0.4
CPT0218200004
Tumor
0.4
CPT0170260004
Normal
0.4
CPT0217700004
Tumor
0.4
CPT0246940003
Tumor
0.4
CPT0355190003
Normal
0.3
CPT0127290003
Normal
0.3
CPT0347850002
Normal
0.3
CPT0138990003
Normal
0.3
CPT0123650003
Tumor
0.3
CPT0126160004
Tumor
0.2
CPT0246950003
Normal
0.2
CPT0208690004
Tumor
0.2
CPT0000250017
Tumor
0.2
CPT0081360004
Tumor
0.2
WU-PDA1
Tumor
0.2
C3N-02573-03
Normal
0.2
CPT0108960003
Normal
0.2
CPT0123460003
Normal
0.1
KoreanReference1
Tumor
0.1
CPT0094630004
Tumor
0.1
CPT0248590004
Tumor
0.1
CPT0347880002
Normal
0.1
CPT0162760003
Tumor
0.1
CPT0065640003
Tumor
0.1
CPT0203850004
Tumor
0.1
CPT0019300004
Tumor
0.1
CPT0011540003
Normal
0.1
CPT0227930004
Tumor
0.1
CPT0254680003
Tumor
0.1
CPT0077790004
Tumor
0.0
CPT0241500004
Tumor
0.0
CPT0017040004
Tumor
0.0
CPT0208850004
Normal
0.0
CPT0166780004
Normal
0.0
CPT0226570004
Tumor
-0.1
CPT0241510004
Normal
-0.1
CPT0025750003
Tumor
-0.1
CPT0089720003
Tumor
-0.1
CPT0264150003
Tumor
-0.1
CPT0077810003
Normal
-0.1
KoreanReference2
Tumor
-0.1
CPT0218220004
Normal
-0.1
CPT0238740004
Normal
-0.1
CPT0108400003
Tumor
-0.1
CPT0238440005
Tumor
-0.2
CPT0063970004
Tumor
-0.2
CPT0198700005
Tumor
-0.2
CPT0187550004
Tumor
-0.2
CPT0209640005
Tumor
-0.2
CPT0236780005
Tumor
-0.3
CPT0094230004
Tumor
-0.3
CPT0247000003
Normal
-0.3
CPT0247090003
Tumor
-0.3
CPT0081060004
Tumor
-0.3
CPT0094180003
Tumor
-0.3
CPT0248410004
Tumor
-0.3
CPT0238710004
Tumor
-0.3
CPT0347820002
Normal
-0.4
CPT0063570003
Tumor
-0.4
CPT0125130003
Tumor
-0.4
CPT0008750003
Tumor
-0.4
CPT0109010004
Tumor
-0.4
CPT0236560004
Tumor
-0.4
CPT0162780004
Normal
-0.4
C3L-00189-04
Normal
-0.4
CPT0064090003
Tumor
-0.5
CPT0246260004
Tumor
-0.5
CPT0109300004
Tumor
-0.5
CPT0174700004
Tumor
-0.5
CPT0238640004
Normal
-0.5
CPT0209310004
Tumor
-0.6
CPT0185920004
Tumor
-0.6
CPT0091660003
Tumor
-0.6
CPT0208710004
Normal
-0.6
KoreanReference3
Tumor
-0.6
CPT0008800003
Tumor
-0.6
CPT0246220004
Normal
-0.6
CPT0241320005
Tumor
-0.6
CPT0238820005
Tumor
-0.6
CPT0208550005
Tumor
-0.6
CPT0238530005
Tumor
-0.6
CPT0077880003
Normal
-0.6
CPT0161990005
Tumor
-0.7
CPT0077860003
Tumor
-0.7
CPT0092630003
Tumor
-0.8
CPT0183450005
Tumor
-0.8
CPT0246990003
Tumor
-0.8
CPT0077950003
Normal
-0.8
CPT0078090004
Tumor
-0.8
CPT0226680005
Tumor
-0.8
CPT0125090003
Tumor
-0.8
CPT0088180004
Tumor
-0.8
CPT0123440003
Tumor
-0.9
CPT0170240004
Tumor
-0.9
CPT0236700005
Tumor
-0.9
CPT0083270003
Tumor
-1.0
CPT0127270003
Tumor
-1.0
CPT0208840004
Tumor
-1.0
CPT0246810003
Tumor
-1.0
CPT0086210003
Normal
-1.0
CPT0246210004
Tumor
-1.1
CPT0237840004
Tumor
-1.1
CPT0207780004
Tumor
-1.2
CPT0237920004
Normal
-1.2
CPT0019410004
Tumor
-1.2
CPT0086190004
Tumor
-1.3
CPT0139000004
Tumor
-1.4
CPT0238610009
Tumor
-1.4
CPT0064520004
Tumor
-1.5
CPT0025760003
Normal
-1.5
CPT0123670003
Normal
-1.6
CPT0011520003
Tumor
-1.6
CPT0081470004
Tumor
-1.9
CPT0091680003
Normal
-2.2
CPT0237850004
Normal
-2.5
CPT0166760004
Tumor
-2.7
CPT0081260004
Tumor
-2.9
CPT0093980004
Tumor
N/A
CPT0247050003
Normal
N/A
CPT0236340004
Tumor
N/A
CPT0207990004
Normal
N/A
CPT0198910005
Tumor
N/A
CPT0226650004
Tumor
N/A
CPT0088260004
Tumor
N/A
CPT0239140004
Normal
N/A
CPT0187930005
Tumor
N/A
CPT0124360003
Tumor
N/A
CPT0108410003
Normal
N/A
CPT0123990003
Tumor
N/A
CPT0078160004
Tumor
N/A
CPT0248320003
Normal
N/A
CPT0247040003
Tumor
N/A
CPT0125010003
Normal
N/A
CPT0094740004
Tumor
N/A
CPT0094030003
Tumor
N/A
CPT0166650006
Tumor
N/A
CPT0224470004
Normal
N/A
CPT0238940004
Normal
N/A
C3L-01687-04
Normal
N/A
CPT0198930003
Normal
N/A
CPT0239920004
Normal
N/A
CPT0162670004
Normal
N/A
CPT0226760004
Tumor
N/A
CPT0138890003
Normal
N/A
CPT0088320003
Tumor
N/A
CPT0109110004
Tumor
N/A
CPT0239100009
Tumor
N/A
CPT0078250003
Tumor
N/A
CPT0078030003
Normal
N/A
CPT0197440004
Normal
N/A
CPT0235230004
Tumor
N/A
CPT0001750003
Normal
N/A
CPT0237270005
Tumor
N/A
WU-pooled sample
Tumor
N/A
CPT0014060003
Normal
N/A
CPT0239910004
Tumor
N/A
CPT0109130003
Normal
N/A
CPT0238040005
Tumor
N/A
CPT0138900004
Tumor
N/A
CPT0246720003
Tumor
N/A
CPT0221250004
Normal
N/A
CPT0166680004
Normal
N/A
CPT0093930004
Tumor
N/A
CPT0226530004
Tumor
N/A
CPT0094760003
Normal
N/A
CPT0226610004
Normal
N/A
CPT0198420004
Tumor
N/A
CPT0183750005
Tumor
N/A
CPT0124530003
Normal
N/A
CPT0186050004
Normal
N/A
CPT0124610004
Tumor
N/A
CPT0237290004
Normal
N/A
CPT0198440004
Normal
N/A
CPT0226600004
Tumor
N/A
CPT0161770004
Tumor
N/A
CPT0264180003
Normal
N/A
CPT0065570003
Tumor
N/A
CPT0124980004
Tumor
N/A
CPT0221470005
Tumor
N/A
CPT0207980005
Tumor
N/A
CPT0109200004
Tumor
N/A
CPT0124500004
Tumor
N/A
CPT0063990003
Normal
N/A
CPT0124000003
Normal
N/A
CPT0183770004
Normal
N/A
CPT0162660004
Tumor
N/A
CPT0126200003
Normal
N/A
CPT0001730017
Tumor
N/A
CPT0197420004
Tumor
N/A
CPT0221240004
Tumor
N/A
CPT0226490004
Tumor
N/A
CPT0198730004
Normal
N/A
CPT0238920004
Tumor
N/A
CPT0078180003
Normal
N/A
CPT0236360004
Normal
N/A
CPT0078000003
Tumor
N/A
Show allShow less
PANCREATIC CANCER - Protein expressioni
A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.
Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells.
Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.
The Human Protein Atlas project is funded
