Single cell type - KLF10 - The Human Protein Atlas

KLF10

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KLF10
Gene descriptionⁱ Full gene name according to HGNC.	KLF transcription factor 10
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Skeletal myocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.39
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Endothelial cell)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Skeletal myocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Endothelial cell)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

KLF10 is part of cluster 80 Non-specific - Transcription with confidenceⁱ 1
184 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
BAG3	BAG cochaperone 3	0.7191	80
KLHL15	Kelch like family member 15	0.6626	80
MAT2A	Methionine adenosyltransferase 2A	0.6523	80
MIDN	Midnolin	0.6392	80
NFKBIA	NFKB inhibitor alpha	0.6227	29
BCL3	BCL3 transcription coactivator	0.6054	41
ETS2	ETS proto-oncogene 2, transcription factor	0.5919	29
SERTAD1	SERTA domain containing 1	0.5837	80
GADD45B	Growth arrest and DNA damage inducible beta	0.5821	80
CEBPD	CCAAT enhancer binding protein delta	0.5768	80
EIF4A3	Eukaryotic translation initiation factor 4A3	0.5749	80
CCNL1	Cyclin L1	0.5698	80
HSPA1A	Heat shock protein family A (Hsp70) member 1A	0.5654	80
EGR3	Early growth response 3	0.5650	80
PPP1R15A	Protein phosphatase 1 regulatory subunit 15A	0.5573	80

IMMUNE CELLS

KLF10 is part of cluster 10 Non-specific - Membrane trafficking with confidenceⁱ 0.96
408 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NDUFS2	NADH:ubiquinone oxidoreductase core subunit S2	1.0000	10
KCNMB1	Potassium calcium-activated channel subfamily M regulatory beta subunit 1	1.0000	10
ARNT	Aryl hydrocarbon receptor nuclear translocator	0.9762	10
NELFE	Negative elongation factor complex member E	0.9762	10
NAGA	Alpha-N-acetylgalactosaminidase	0.9762	10
NIPSNAP2	Nipsnap homolog 2	0.9762	10
NSF	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	0.9762	10
COMMD9	COMM domain containing 9	0.9762	10
WDR83OS	WD repeat domain 83 opposite strand	0.9762	10
VPS35L	VPS35 endosomal protein sorting factor like	0.9762	10
RNF114	Ring finger protein 114	0.9524	10
PRPF4	Pre-mRNA processing factor 4	0.9524	10
COPA	COPI coat complex subunit alpha	0.9524	10
EIF4G2	Eukaryotic translation initiation factor 4 gamma 2	0.9524	40
STAT2	Signal transducer and activator of transcription 2	0.9524	40

Adipocytes	185.9 nTPM
Adipose tissue	241.2 nTPM
Breast	130.7 nTPM

Alveolar cells type 1	64.2 nTPM
Lung	64.2 nTPM

Alveolar cells type 2	31.8 nTPM
Lung	31.8 nTPM

Astrocytes	0.9 nTPM
Brain	0.9 nTPM

B-cells	54.1 nTPM
Esophagus	182.9 nTPM
Lymph node	157.0 nTPM
Skin	115.2 nTPM
Adipose tissue	72.0 nTPM
Stomach	37.5 nTPM
Thymus	28.8 nTPM
Spleen	27.9 nTPM
Bone marrow	22.7 nTPM
Kidney	20.8 nTPM
Salivary gland	15.0 nTPM
Liver	14.5 nTPM
Lung	5.4 nTPM
PBMC	3.1 nTPM

Basal squamous epithelial cells	269.9 nTPM
Esophagus	269.9 nTPM

Ciliated cells	71.5 nTPM
Fallopian tube	114.9 nTPM
Endometrium	108.2 nTPM
Bronchus	32.7 nTPM
Lung	30.0 nTPM

Club cells	35.8 nTPM
Bronchus	40.5 nTPM
Lung	38.6 nTPM
Prostate	28.3 nTPM

Dendritic cells	113.7 nTPM
Adipose tissue	216.6 nTPM
PBMC	10.8 nTPM

Endothelial cells	140.5 nTPM
Esophagus	396.2 nTPM
Endometrium	273.5 nTPM
Thymus	261.2 nTPM
Skeletal muscle	196.8 nTPM
Fallopian tube	189.4 nTPM
Salivary gland	155.7 nTPM
Breast	143.2 nTPM
Vascular	137.1 nTPM
Tongue	130.4 nTPM
Heart muscle	118.8 nTPM
Skin	110.3 nTPM
Lung	99.6 nTPM
Prostate	78.9 nTPM
Placenta	74.4 nTPM
Pancreas	59.5 nTPM
Ovary	45.0 nTPM
Liver	35.3 nTPM
Testis	24.4 nTPM

Enteroendocrine cells	51.1 nTPM
Colon	91.0 nTPM
Rectum	45.3 nTPM
Small intestine	17.2 nTPM

Fibroblasts	114.1 nTPM
Fallopian tube	245.9 nTPM
Skin	234.7 nTPM
Esophagus	167.0 nTPM
Thymus	163.5 nTPM
Stomach	149.9 nTPM
Skeletal muscle	135.9 nTPM
Liver	134.0 nTPM
Breast	79.9 nTPM
Lung	79.7 nTPM
Salivary gland	70.6 nTPM
Heart muscle	67.8 nTPM
Pancreas	67.4 nTPM
Adipose tissue	66.2 nTPM
Vascular	63.8 nTPM
Prostate	60.1 nTPM
Placenta	38.4 nTPM

Granulocytes	99.5 nTPM
Fallopian tube	189.9 nTPM
Tongue	97.0 nTPM
Lung	11.6 nTPM

Intestinal goblet cells	40.1 nTPM
Colon	70.4 nTPM
Rectum	44.4 nTPM
Small intestine	5.7 nTPM

Lymphatic endothelial cells	102.9 nTPM
Fallopian tube	189.3 nTPM
Ovary	16.4 nTPM

Bipolar cells	3.7 nTPM
Eye	3.7 nTPM

Cholangiocytes	42.0 nTPM
Liver	42.0 nTPM

Collecting duct cells	46.7 nTPM
Kidney	46.7 nTPM

Cone photoreceptor cells	3.4 nTPM
Eye	3.4 nTPM

Macrophages	130.2 nTPM
Adipose tissue	369.6 nTPM
Skin	240.7 nTPM
Esophagus	240.2 nTPM
Fallopian tube	189.8 nTPM
Endometrium	167.3 nTPM
Spleen	165.4 nTPM
Breast	156.9 nTPM
Tongue	154.4 nTPM
Vascular	128.1 nTPM
Skeletal muscle	113.3 nTPM
Stomach	105.5 nTPM
Thymus	96.6 nTPM
Salivary gland	94.1 nTPM
Testis	70.1 nTPM
Bone marrow	56.8 nTPM
Kidney	50.4 nTPM
Prostate	42.5 nTPM
Lung	23.5 nTPM
Pancreas	8.2 nTPM

Paneth cells	47.7 nTPM
Colon	76.0 nTPM
Rectum	49.8 nTPM
Small intestine	17.3 nTPM

Plasma cells	54.1 nTPM
Esophagus	114.4 nTPM
Fallopian tube	92.6 nTPM
Salivary gland	64.5 nTPM
Stomach	57.0 nTPM
Thymus	33.0 nTPM
Bone marrow	28.7 nTPM
Liver	21.5 nTPM
Spleen	20.9 nTPM

Schwann cells	81.1 nTPM
Esophagus	107.8 nTPM
Adipose tissue	85.9 nTPM
Vascular	49.6 nTPM

Serous glandular cells	145.7 nTPM
Salivary gland	225.2 nTPM
Tongue	66.3 nTPM

Smooth muscle cells	120.8 nTPM
Fallopian tube	331.0 nTPM
Esophagus	247.5 nTPM
Skin	155.1 nTPM
Salivary gland	148.8 nTPM
Endometrium	138.3 nTPM
Thymus	125.5 nTPM
Skeletal muscle	120.9 nTPM
Breast	117.8 nTPM
Tongue	114.4 nTPM
Liver	95.9 nTPM
Placenta	93.3 nTPM
Adipose tissue	92.6 nTPM
Prostate	42.6 nTPM
Lung	38.8 nTPM
Vascular	36.5 nTPM
Ovary	34.1 nTPM

Suprabasal keratinocytes	106.1 nTPM
Skin	166.4 nTPM
Tongue	45.8 nTPM

T-cells	41.2 nTPM
Esophagus	146.0 nTPM
Endometrium	90.9 nTPM
Lymph node	87.2 nTPM
Breast	64.6 nTPM
Colon	61.4 nTPM
Adipose tissue	54.1 nTPM
Skin	51.5 nTPM
Skeletal muscle	42.3 nTPM
Vascular	37.4 nTPM
Spleen	36.7 nTPM
Tongue	30.8 nTPM
Fallopian tube	29.5 nTPM
Stomach	23.2 nTPM
Bone marrow	19.9 nTPM
Liver	18.6 nTPM
Salivary gland	17.0 nTPM
Kidney	13.3 nTPM
Prostate	12.3 nTPM
Thymus	11.1 nTPM
Lung	9.2 nTPM
PBMC	7.9 nTPM

Undifferentiated cells	40.7 nTPM
Colon	55.7 nTPM
Rectum	36.5 nTPM
Small intestine	30.0 nTPM

Amygdala excitatory	9.3 nTPM
Hypothalamus	13.5 nTPM
Basal ganglia	12.2 nTPM
Hippocampus	9.4 nTPM
Amygdala	9.0 nTPM
Cerebral cortex	7.9 nTPM
Thalamus	3.6 nTPM

Astrocyte	4.0 nTPM
Spinal cord	19.1 nTPM
Medulla oblongata	5.9 nTPM
Hypothalamus	5.8 nTPM
Pons	2.9 nTPM
Basal ganglia	2.2 nTPM
Cerebellum	1.9 nTPM
Cerebral cortex	1.8 nTPM
Midbrain	1.3 nTPM
Hippocampus	1.2 nTPM
Amygdala	0.9 nTPM
Thalamus	0.8 nTPM

Bergmann glia	1.5 nTPM
Medulla oblongata	2.1 nTPM
Pons	1.4 nTPM
Cerebellum	1.1 nTPM

Central nervous system macrophage	5.3 nTPM
Cerebellum	8.0 nTPM
Hypothalamus	7.9 nTPM
Medulla oblongata	5.4 nTPM
Spinal cord	5.3 nTPM
Basal ganglia	5.1 nTPM
Thalamus	5.0 nTPM
Amygdala	4.9 nTPM
Pons	4.9 nTPM
Hippocampus	4.1 nTPM
Midbrain	3.9 nTPM
Cerebral cortex	3.8 nTPM

Cerebellar inhibitory	0.7 nTPM
Medulla oblongata	1.3 nTPM
Pons	1.1 nTPM
Midbrain	0.9 nTPM
Cerebellum	0.4 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	1.1 nTPM
Hypothalamus	1.7 nTPM
Cerebral cortex	1.2 nTPM
Basal ganglia	1.1 nTPM
Hippocampus	1.1 nTPM
Amygdala	0.9 nTPM
Thalamus	0.8 nTPM
Midbrain	0.5 nTPM

Choroid plexus epithelial cell	3.9 nTPM
Hippocampus	8.3 nTPM
Thalamus	2.7 nTPM
Medulla oblongata	2.4 nTPM
Basal ganglia	2.0 nTPM

Committed oligodendrocyte precursor	1.2 nTPM
Spinal cord	3.7 nTPM
Medulla oblongata	2.6 nTPM
Hippocampus	1.8 nTPM
Midbrain	1.7 nTPM
Hypothalamus	1.4 nTPM
Amygdala	0.6 nTPM
Cerebral cortex	0.6 nTPM
Thalamus	0.5 nTPM
Basal ganglia	0.0 nTPM
Cerebellum	0.0 nTPM
Pons	0.0 nTPM

Deep-layer corticothalamic and 6b	8.6 nTPM
Hypothalamus	12.7 nTPM
Amygdala	10.0 nTPM
Cerebral cortex	9.8 nTPM
Hippocampus	7.6 nTPM
Basal ganglia	7.1 nTPM
Midbrain	4.4 nTPM

Deep-layer intratelencephalic	13.9 nTPM
Hypothalamus	21.6 nTPM
Hippocampus	14.8 nTPM
Amygdala	12.2 nTPM
Cerebral cortex	11.2 nTPM
Basal ganglia	9.5 nTPM

Deep-layer near-projecting	1.9 nTPM
Hypothalamus	3.6 nTPM
Hippocampus	2.0 nTPM
Basal ganglia	1.4 nTPM
Amygdala	1.2 nTPM
Cerebral cortex	1.0 nTPM