Single cell type - OXNAD1 - The Human Protein Atlas

OXNAD1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	OXNAD1
Gene descriptionⁱ Full gene name according to HGNC.	Oxidoreductase NAD binding domain containing 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	NK-cells & T-cells - Immune system & Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (T-cells, Excitatory neurons, Inhibitory neurons)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.52
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Leukocyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (naive CD4 T-cell)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (T-cells, Excitatory neurons, Inhibitory neurons)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Leukocyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (naive CD4 T-cell)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

OXNAD1 is part of cluster 78 NK-cells & T-cells - Immune system & Transcription with confidenceⁱ 1
392 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GPR171	G protein-coupled receptor 171	0.8434	78
ITK	IL2 inducible T cell kinase	0.8260	78
CD96	CD96 molecule	0.8172	78
TRAT1	T cell receptor associated transmembrane adaptor 1	0.7928	78
CD2	CD2 molecule	0.7780	78
IL7R	Interleukin 7 receptor	0.7669	78
CD3E	CD3 epsilon subunit of T-cell receptor complex	0.7666	7
PRKCQ	Protein kinase C theta	0.7657	78
CD3G	CD3 gamma subunit of T-cell receptor complex	0.7605	78
LEPROTL1	Leptin receptor overlapping transcript like 1	0.7543	78
CD6	CD6 molecule	0.7409	78
PARP8	Poly(ADP-ribose) polymerase family member 8	0.7339	78
CD3D	CD3 delta subunit of T-cell receptor complex	0.7290	78
ICOS	Inducible T cell costimulator	0.7280	78
PDCD1	Programmed cell death 1	0.7271	78

IMMUNE CELLS

OXNAD1 is part of cluster 43 Non-specific - Transcription & Translation with confidenceⁱ 0.93
433 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PCSK1N	Proprotein convertase subtilisin/kexin type 1 inhibitor	1.0000	43
TRABD2A	TraB domain containing 2A	1.0000	43
NAP1L3	Nucleosome assembly protein 1 like 3	1.0000	43
NELL2	Neural EGFL like 2	1.0000	43
TMEM30B	Transmembrane protein 30B	1.0000	43
PLA2G1B	Phospholipase A2 group IB	1.0000	43
LDLRAP1	Low density lipoprotein receptor adaptor protein 1	1.0000	43
HEMGN	Hemogen	1.0000	43
EPHX2	Epoxide hydrolase 2	1.0000	43
CLUAP1	Clusterin associated protein 1	1.0000	43
SNPH	Syntaphilin	1.0000	43
TSPAN6	Tetraspanin 6	0.9762	43
C3orf18	Chromosome 3 open reading frame 18	0.9762	43
DOCK9	Dedicator of cytokinesis 9	0.9762	11
TCF7	Transcription factor 7	0.9762	43

Adipocytes	4.5 nTPM
Breast	4.8 nTPM
Adipose tissue	4.2 nTPM

Alveolar cells type 1	5.0 nTPM
Lung	5.0 nTPM

Alveolar cells type 2	7.0 nTPM
Lung	7.0 nTPM

Astrocytes	33.8 nTPM
Brain	33.8 nTPM

B-cells	8.1 nTPM
PBMC	16.9 nTPM
Kidney	10.4 nTPM
Adipose tissue	10.3 nTPM
Liver	9.7 nTPM
Bone marrow	8.9 nTPM
Stomach	8.9 nTPM
Thymus	7.4 nTPM
Salivary gland	7.2 nTPM
Skin	6.8 nTPM
Lymph node	6.2 nTPM
Esophagus	5.9 nTPM
Spleen	5.4 nTPM
Lung	1.3 nTPM

Ciliated cells	5.5 nTPM
Lung	7.3 nTPM
Fallopian tube	6.3 nTPM
Bronchus	4.4 nTPM
Endometrium	4.0 nTPM

Club cells	5.6 nTPM
Lung	5.8 nTPM
Bronchus	5.6 nTPM
Prostate	5.4 nTPM

Endothelial cells	4.6 nTPM
Heart muscle	10.1 nTPM
Skeletal muscle	6.5 nTPM
Vascular	6.2 nTPM
Esophagus	5.6 nTPM
Tongue	5.4 nTPM
Breast	5.3 nTPM
Liver	5.0 nTPM
Salivary gland	5.0 nTPM
Ovary	4.9 nTPM
Thymus	4.5 nTPM
Endometrium	4.3 nTPM
Testis	4.0 nTPM
Lung	3.7 nTPM
Fallopian tube	3.7 nTPM
Prostate	3.6 nTPM
Skin	2.9 nTPM
Placenta	1.7 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	8.1 nTPM
Colon	15.9 nTPM
Small intestine	6.9 nTPM
Rectum	1.7 nTPM

Fibroblasts	4.7 nTPM
Pancreas	7.9 nTPM
Heart muscle	7.2 nTPM
Lung	6.7 nTPM
Prostate	5.9 nTPM
Salivary gland	4.9 nTPM
Vascular	4.9 nTPM
Thymus	4.8 nTPM
Placenta	4.6 nTPM
Skeletal muscle	4.3 nTPM
Fallopian tube	4.3 nTPM
Esophagus	4.0 nTPM
Breast	3.7 nTPM
Adipose tissue	3.6 nTPM
Skin	2.9 nTPM
Stomach	2.9 nTPM
Liver	2.4 nTPM

Granulocytes	30.2 nTPM
Tongue	43.7 nTPM
Lung	33.3 nTPM
Fallopian tube	13.6 nTPM

Intestinal goblet cells	7.7 nTPM
Colon	12.5 nTPM
Rectum	7.0 nTPM
Small intestine	3.7 nTPM

Lymphatic endothelial cells	3.1 nTPM
Fallopian tube	6.2 nTPM
Ovary	0.0 nTPM

Macrophages	6.0 nTPM
Salivary gland	18.6 nTPM
Tongue	11.4 nTPM
Stomach	10.3 nTPM
Fallopian tube	9.1 nTPM
Lung	8.7 nTPM
Prostate	8.4 nTPM
Pancreas	6.2 nTPM
Thymus	5.4 nTPM
Breast	5.2 nTPM
Vascular	5.0 nTPM
Endometrium	4.9 nTPM
Adipose tissue	4.9 nTPM
Esophagus	3.9 nTPM
Skeletal muscle	3.7 nTPM
Bone marrow	3.0 nTPM
Kidney	2.7 nTPM
Testis	1.9 nTPM
Spleen	1.0 nTPM
Skin	0.0 nTPM

Paneth cells	3.0 nTPM
Rectum	5.3 nTPM
Colon	3.6 nTPM
Small intestine	0.0 nTPM

Basal respiratory cells	7.5 nTPM
Bronchus	7.5 nTPM

Collecting duct cells	7.8 nTPM
Kidney	7.8 nTPM

Cytotrophoblasts	10.8 nTPM
Placenta	10.8 nTPM

Distal enterocytes	11.2 nTPM
Colon	11.3 nTPM
Rectum	11.1 nTPM

Plasma cells	15.4 nTPM
Stomach	26.4 nTPM
Spleen	21.2 nTPM
Bone marrow	19.6 nTPM
Thymus	18.0 nTPM
Liver	14.0 nTPM
Fallopian tube	11.6 nTPM
Salivary gland	7.6 nTPM
Esophagus	5.2 nTPM

Schwann cells	10.6 nTPM
Adipose tissue	15.6 nTPM
Esophagus	12.0 nTPM
Vascular	4.2 nTPM

Serous glandular cells	9.7 nTPM
Salivary gland	10.5 nTPM
Tongue	8.8 nTPM

Smooth muscle cells	4.3 nTPM
Salivary gland	6.9 nTPM
Prostate	6.7 nTPM
Breast	6.1 nTPM
Placenta	5.4 nTPM
Tongue	5.1 nTPM
Esophagus	4.8 nTPM
Lung	4.7 nTPM
Fallopian tube	4.3 nTPM
Ovary	4.2 nTPM
Endometrium	3.7 nTPM
Thymus	3.7 nTPM
Vascular	3.1 nTPM
Skeletal muscle	2.8 nTPM
Adipose tissue	2.7 nTPM
Liver	2.5 nTPM
Skin	2.0 nTPM

T-cells	113.3 nTPM
Fallopian tube	275.6 nTPM
Stomach	245.4 nTPM
Prostate	170.4 nTPM
Lung	140.1 nTPM
Thymus	140.0 nTPM
Vascular	137.9 nTPM
Adipose tissue	127.8 nTPM
Esophagus	124.1 nTPM
Colon	118.9 nTPM
PBMC	103.8 nTPM
Salivary gland	102.2 nTPM
Bone marrow	90.8 nTPM
Lymph node	90.6 nTPM
Spleen	85.9 nTPM
Tongue	78.3 nTPM
Endometrium	73.5 nTPM
Kidney	68.3 nTPM
Liver	67.4 nTPM
Breast	66.6 nTPM
Skeletal muscle	54.1 nTPM
Skin	18.2 nTPM

Undifferentiated cells	12.1 nTPM
Colon	15.4 nTPM
Small intestine	11.9 nTPM
Rectum	8.9 nTPM

Amygdala excitatory	48.1 nTPM
Cerebral cortex	53.2 nTPM
Basal ganglia	50.3 nTPM
Hippocampus	49.2 nTPM
Amygdala	45.9 nTPM
Thalamus	45.4 nTPM
Hypothalamus	44.5 nTPM

Astrocyte	56.7 nTPM
Amygdala	70.0 nTPM
Hypothalamus	69.5 nTPM
Basal ganglia	59.3 nTPM
Hippocampus	57.8 nTPM
Thalamus	57.3 nTPM
Midbrain	56.6 nTPM
Cerebral cortex	56.3 nTPM
Cerebellum	52.2 nTPM
Medulla oblongata	49.6 nTPM
Spinal cord	47.4 nTPM
Pons	47.3 nTPM

Bergmann glia	48.5 nTPM
Cerebellum	65.5 nTPM
Medulla oblongata	46.9 nTPM
Pons	33.1 nTPM

Central nervous system macrophage	54.7 nTPM
Amygdala	71.2 nTPM
Basal ganglia	61.0 nTPM
Hypothalamus	57.3 nTPM
Thalamus	57.1 nTPM
Hippocampus	55.5 nTPM
Midbrain	55.0 nTPM
Pons	52.7 nTPM
Spinal cord	51.2 nTPM
Cerebellum	50.0 nTPM
Cerebral cortex	47.9 nTPM
Medulla oblongata	42.3 nTPM

Cerebellar inhibitory	82.7 nTPM
Cerebellum	86.5 nTPM
Midbrain	83.1 nTPM
Medulla oblongata	83.0 nTPM
Spinal cord	82.5 nTPM
Pons	78.4 nTPM

Cge interneuron	42.2 nTPM
Thalamus	46.2 nTPM
Amygdala	43.1 nTPM
Cerebral cortex	42.6 nTPM
Hippocampus	41.9 nTPM
Hypothalamus	41.2 nTPM
Midbrain	40.9 nTPM
Basal ganglia	39.8 nTPM

Choroid plexus epithelial cell	141.1 nTPM
Basal ganglia	193.6 nTPM
Medulla oblongata	133.7 nTPM
Hippocampus	130.3 nTPM
Thalamus	106.9 nTPM

Committed oligodendrocyte precursor	48.2 nTPM
Thalamus	60.6 nTPM
Amygdala	58.1 nTPM
Hypothalamus	58.0 nTPM
Midbrain	52.1 nTPM
Hippocampus	51.2 nTPM
Cerebellum	50.7 nTPM
Cerebral cortex	48.8 nTPM
Basal ganglia	44.9 nTPM
Medulla oblongata	42.6 nTPM
Spinal cord	33.1 nTPM
Pons	30.1 nTPM

Deep-layer corticothalamic and 6b	53.8 nTPM
Cerebral cortex	59.0 nTPM
Midbrain	55.5 nTPM
Hippocampus	53.8 nTPM
Hypothalamus	52.3 nTPM
Amygdala	51.2 nTPM
Basal ganglia	50.8 nTPM

Deep-layer intratelencephalic	56.9 nTPM
Cerebral cortex	65.4 nTPM
Basal ganglia	60.0 nTPM
Hippocampus	58.9 nTPM
Amygdala	51.3 nTPM
Hypothalamus	48.8 nTPM

Deep-layer near-projecting	58.9 nTPM
Cerebral cortex	74.3 nTPM
Amygdala	63.5 nTPM
Hippocampus	60.8 nTPM
Basal ganglia	51.6 nTPM
Hypothalamus	44.5 nTPM

Eccentric medium spiny neuron	54.4 nTPM
Basal ganglia	56.8 nTPM
Thalamus	56.1 nTPM
Cerebral cortex	55.5 nTPM
Amygdala	53.7 nTPM
Hippocampus	53.1 nTPM
Hypothalamus	51.3 nTPM

Endothelial cell	36.9 nTPM
Basal ganglia	43.8 nTPM
Cerebral cortex	40.3 nTPM
Midbrain	39.7 nTPM
Amygdala	39.1 nTPM
Cerebellum	38.7 nTPM
Pons	37.4 nTPM
Hippocampus	37.2 nTPM
Hypothalamus	37.2 nTPM
Thalamus	35.6 nTPM
Spinal cord	29.3 nTPM
Medulla oblongata	27.7 nTPM

Ependymal cell	52.2 nTPM
Amygdala	67.7 nTPM
Hippocampus	59.4 nTPM
Hypothalamus	57.1 nTPM
Basal ganglia	50.3 nTPM
Pons	48.7 nTPM
Thalamus	48.6 nTPM
Midbrain	46.3 nTPM
Spinal cord	46.0 nTPM
Medulla oblongata	45.7 nTPM