Single cell type - TRIM36 - The Human Protein Atlas

TRIM36

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TRIM36
Gene descriptionⁱ Full gene name according to HGNC.	Tripartite motif containing 36
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Enzymes Human disease related genes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Late spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Late spermatids, Early spermatids)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.82
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (non-classical monocyte, myeloid DC)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Group enriched (Late spermatids, Early spermatids)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (non-classical monocyte, myeloid DC)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TRIM36 is part of cluster 11 Late spermatids - Unknown function with confidenceⁱ 1
430 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TXNDC8	Thioredoxin domain containing 8	0.8545	11
GARIN5B	Golgi associated RAB2 interactor family member 5B	0.8504	11
CCSER2	Coiled-coil serine rich protein 2	0.8400	11
IQCF1	IQ motif containing F1	0.8389	11
MS4A5	Membrane spanning 4-domains A5	0.8330	11
ENSG00000241690	Novel protein	0.8310	11
GARIN5A	Golgi associated RAB2 interactor 5A	0.8309	11
HMGB4	High mobility group box 4	0.8164	11
COX8C	Cytochrome c oxidase subunit 8C	0.8152	11
C10orf82	Chromosome 10 open reading frame 82	0.8118	11
GARIN2	Golgi associated RAB2 interactor family member 2	0.8108	11
OTUB2	OTU deubiquitinase, ubiquitin aldehyde binding 2	0.8094	11
TEX35	Testis expressed 35	0.8024	11
TIMD4	T cell immunoglobulin and mucin domain containing 4	0.8023	11
C8orf74	Chromosome 8 open reading frame 74	0.7981	11

IMMUNE CELLS

TRIM36 is part of cluster 10 Non-specific - Membrane trafficking with confidenceⁱ 0.91
408 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SMCO4	Single-pass membrane protein with coiled-coil domains 4	1.0000	10
TMEM165	Transmembrane protein 165	0.9762	10
DAPK1	Death associated protein kinase 1	0.9762	10
PLXNB2	Plexin B2	0.9762	10
LACC1	Laccase domain containing 1	0.9762	10
IFI35	Interferon induced protein 35	0.9762	10
MS4A4A	Membrane spanning 4-domains A4A	0.9762	10
EPHX3	Epoxide hydrolase 3	0.9762	10
VASH1	Vasohibin 1	0.9762	10
SIRT2	Sirtuin 2	0.9762	10
CDH23	Cadherin related 23	0.9524	10
SLC43A3	Solute carrier family 43 member 3	0.9524	10
FMNL2	Formin like 2	0.9524	10
FCER1G	Fc epsilon receptor Ig	0.9524	10
THAP8	THAP domain containing 8	0.9524	10

Adipocytes	0.3 nTPM
Breast	0.7 nTPM
Adipose tissue	0.0 nTPM

Alveolar cells type 1	1.4 nTPM
Lung	1.4 nTPM

Alveolar cells type 2	2.9 nTPM
Lung	2.9 nTPM

Astrocytes	0.9 nTPM
Brain	0.9 nTPM

B-cells	2.5 nTPM
Skin	23.7 nTPM
Esophagus	5.9 nTPM
Stomach	1.3 nTPM
Spleen	0.6 nTPM
Lymph node	0.5 nTPM
Thymus	0.3 nTPM
Salivary gland	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Bone marrow	0.0 nTPM
Lung	0.0 nTPM

Ciliated cells	3.4 nTPM
Lung	4.4 nTPM
Fallopian tube	3.7 nTPM
Endometrium	2.9 nTPM
Bronchus	2.6 nTPM

Club cells	0.8 nTPM
Prostate	1.0 nTPM
Lung	0.7 nTPM
Bronchus	0.6 nTPM

Endothelial cells	0.8 nTPM
Testis	9.8 nTPM
Ovary	1.2 nTPM
Esophagus	0.8 nTPM
Placenta	0.6 nTPM
Skin	0.6 nTPM
Endometrium	0.5 nTPM
Tongue	0.5 nTPM
Skeletal muscle	0.2 nTPM
Prostate	0.2 nTPM
Salivary gland	0.2 nTPM
Fallopian tube	0.2 nTPM
Thymus	0.1 nTPM
Vascular	0.1 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM
Lung	0.0 nTPM
Breast	0.0 nTPM

Enteroendocrine cells	8.6 nTPM
Small intestine	13.7 nTPM
Colon	12.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	0.2 nTPM
Lung	0.6 nTPM
Vascular	0.6 nTPM
Breast	0.5 nTPM
Placenta	0.4 nTPM
Esophagus	0.4 nTPM
Pancreas	0.3 nTPM
Skin	0.3 nTPM
Skeletal muscle	0.3 nTPM
Thymus	0.2 nTPM
Adipose tissue	0.1 nTPM
Salivary gland	0.1 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Stomach	0.0 nTPM
Prostate	0.0 nTPM
Fallopian tube	0.0 nTPM

Granulocytes	0.3 nTPM
Lung	0.5 nTPM
Fallopian tube	0.4 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	22.3 nTPM
Small intestine	44.8 nTPM
Colon	14.8 nTPM
Rectum	7.4 nTPM

Lymphatic endothelial cells	0.3 nTPM
Fallopian tube	0.6 nTPM
Ovary	0.0 nTPM

Macrophages	6.4 nTPM
Testis	24.2 nTPM
Breast	21.0 nTPM
Skin	11.1 nTPM
Prostate	10.4 nTPM
Adipose tissue	7.4 nTPM
Tongue	6.8 nTPM
Salivary gland	5.7 nTPM
Esophagus	5.1 nTPM
Fallopian tube	5.1 nTPM
Vascular	4.2 nTPM
Pancreas	4.1 nTPM
Endometrium	3.7 nTPM
Lung	3.4 nTPM
Skeletal muscle	3.3 nTPM
Stomach	2.6 nTPM
Kidney	1.8 nTPM
Bone marrow	1.0 nTPM
Thymus	0.8 nTPM
Spleen	0.0 nTPM

Paneth cells	19.2 nTPM
Small intestine	38.0 nTPM
Colon	10.9 nTPM
Rectum	8.7 nTPM

Collecting duct cells	1.9 nTPM
Kidney	1.9 nTPM

Cone photoreceptor cells	61.2 nTPM
Eye	61.2 nTPM

Plasma cells	0.8 nTPM
Fallopian tube	3.9 nTPM
Salivary gland	2.2 nTPM
Thymus	0.4 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Schwann cells	7.0 nTPM
Esophagus	12.0 nTPM
Adipose tissue	7.0 nTPM
Vascular	2.1 nTPM

Serous glandular cells	0.1 nTPM
Salivary gland	0.3 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	2.0 nTPM
Vascular	7.5 nTPM
Prostate	6.7 nTPM
Ovary	4.7 nTPM
Breast	3.7 nTPM
Skin	2.0 nTPM
Fallopian tube	1.6 nTPM
Thymus	1.3 nTPM
Skeletal muscle	1.0 nTPM
Endometrium	0.9 nTPM
Salivary gland	0.9 nTPM
Tongue	0.6 nTPM
Adipose tissue	0.4 nTPM
Placenta	0.1 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM

T-cells	0.4 nTPM
Skeletal muscle	1.5 nTPM
Skin	1.4 nTPM
Breast	1.3 nTPM
Colon	1.0 nTPM
Adipose tissue	0.9 nTPM
Lung	0.8 nTPM
Tongue	0.7 nTPM
Prostate	0.6 nTPM
Vascular	0.4 nTPM
Fallopian tube	0.3 nTPM
Endometrium	0.2 nTPM
PBMC	0.1 nTPM
Thymus	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM

Undifferentiated cells	8.1 nTPM
Small intestine	11.1 nTPM
Colon	8.7 nTPM
Rectum	4.5 nTPM

Amygdala excitatory	90.4 nTPM
Hypothalamus	111.0 nTPM
Basal ganglia	109.2 nTPM
Cerebral cortex	107.0 nTPM
Hippocampus	92.7 nTPM
Amygdala	81.8 nTPM
Thalamus	40.4 nTPM

Astrocyte	3.2 nTPM
Hypothalamus	5.9 nTPM
Medulla oblongata	4.9 nTPM
Thalamus	3.5 nTPM
Cerebellum	3.2 nTPM
Midbrain	2.9 nTPM
Pons	2.7 nTPM
Amygdala	2.6 nTPM
Basal ganglia	2.6 nTPM
Hippocampus	2.3 nTPM
Spinal cord	2.2 nTPM
Cerebral cortex	2.0 nTPM

Bergmann glia	1.4 nTPM
Medulla oblongata	2.1 nTPM
Pons	1.4 nTPM
Cerebellum	0.8 nTPM

Central nervous system macrophage	103.0 nTPM
Amygdala	122.9 nTPM
Basal ganglia	118.6 nTPM
Hypothalamus	105.2 nTPM
Midbrain	104.9 nTPM
Pons	104.0 nTPM
Cerebellum	101.5 nTPM
Thalamus	100.9 nTPM
Medulla oblongata	95.9 nTPM
Hippocampus	95.6 nTPM
Spinal cord	92.1 nTPM
Cerebral cortex	91.3 nTPM

Cerebellar inhibitory	2.4 nTPM
Pons	5.6 nTPM
Spinal cord	2.7 nTPM
Midbrain	1.9 nTPM
Medulla oblongata	1.3 nTPM
Cerebellum	0.7 nTPM

Cge interneuron	73.5 nTPM
Amygdala	87.6 nTPM
Hypothalamus	86.8 nTPM
Hippocampus	79.5 nTPM
Basal ganglia	76.2 nTPM
Midbrain	67.6 nTPM
Cerebral cortex	64.3 nTPM
Thalamus	52.4 nTPM

Choroid plexus epithelial cell	41.6 nTPM
Hippocampus	61.0 nTPM
Basal ganglia	37.6 nTPM
Thalamus	35.6 nTPM
Medulla oblongata	32.2 nTPM

Committed oligodendrocyte precursor	10.4 nTPM
Thalamus	19.6 nTPM
Pons	16.8 nTPM
Hypothalamus	16.4 nTPM
Medulla oblongata	15.5 nTPM
Basal ganglia	9.3 nTPM
Amygdala	9.0 nTPM
Hippocampus	7.8 nTPM
Cerebellum	6.3 nTPM
Midbrain	5.0 nTPM
Cerebral cortex	4.4 nTPM
Spinal cord	3.7 nTPM

Deep-layer corticothalamic and 6b	72.8 nTPM
Amygdala	92.7 nTPM
Hippocampus	87.1 nTPM
Basal ganglia	82.2 nTPM
Hypothalamus	63.3 nTPM
Cerebral cortex	62.9 nTPM
Midbrain	48.8 nTPM

Deep-layer intratelencephalic	94.0 nTPM
Hippocampus	114.0 nTPM
Amygdala	106.4 nTPM
Basal ganglia	89.9 nTPM
Hypothalamus	81.5 nTPM
Cerebral cortex	78.2 nTPM

Deep-layer near-projecting	7.9 nTPM
Basal ganglia	16.8 nTPM
Hypothalamus	9.4 nTPM
Amygdala	5.0 nTPM
Hippocampus	4.6 nTPM
Cerebral cortex	3.7 nTPM

Eccentric medium spiny neuron	27.3 nTPM
Hippocampus	43.1 nTPM
Hypothalamus	27.4 nTPM
Thalamus	26.3 nTPM
Amygdala	25.8 nTPM
Basal ganglia	22.9 nTPM
Cerebral cortex	18.3 nTPM

Endothelial cell	2.2 nTPM
Hypothalamus	5.0 nTPM
Hippocampus	4.8 nTPM
Spinal cord	3.5 nTPM
Basal ganglia	2.8 nTPM
Thalamus	2.8 nTPM
Pons	2.5 nTPM
Cerebral cortex	1.3 nTPM
Midbrain	0.9 nTPM
Cerebellum	0.8 nTPM
Amygdala	0.0 nTPM
Medulla oblongata	0.0 nTPM

Ependymal cell	50.3 nTPM
Thalamus	64.4 nTPM
Midbrain	60.3 nTPM
Hypothalamus	57.1 nTPM
Pons	52.2 nTPM
Basal ganglia	51.8 nTPM
Amygdala	50.1 nTPM
Hippocampus	43.6 nTPM
Medulla oblongata	40.8 nTPM
Spinal cord	32.6 nTPM