Single cell type - SLC7A11 - The Human Protein Atlas

SLC7A11

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC7A11
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 7 member 11
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	FDA approved drug targets Metabolic proteins Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Astrocytes - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Astrocytes, Microglial cells, Dendritic cells, Langerhans cells, Gastric mucus-secreting cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.74
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Group enriched (Fibroblast, Astrocyte, Bergmann glia, Endothelial cell, Ependymal cell)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Astrocytes, Microglial cells, Dendritic cells, Langerhans cells, Gastric mucus-secreting cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Group enriched (Fibroblast, Astrocyte, Bergmann glia, Endothelial cell, Ependymal cell)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

SLC7A11 is part of cluster 47 Astrocytes - Unknown function with confidenceⁱ 1
196 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PSD2	Pleckstrin and Sec7 domain containing 2	0.7854	47
RGS20	Regulator of G protein signaling 20	0.7747	47
PRODH	Proline dehydrogenase 1	0.7725	47
ADGRV1	Adhesion G protein-coupled receptor V1	0.7661	47
PRSS50	Serine protease 50	0.7657	47
NTSR2	Neurotensin receptor 2	0.7639	47
NCAN	Neurocan	0.7531	47
NPFF	Neuropeptide FF-amide peptide precursor	0.7530	47
GPC5	Glypican 5	0.7507	47
GFAP	Glial fibrillary acidic protein	0.7460	47
SLC1A2	Solute carrier family 1 member 2	0.7453	47
SLCO1C1	Solute carrier organic anion transporter family member 1C1	0.7415	47
HPSE2	Heparanase 2 (inactive)	0.7367	47
GLIS3	GLIS family zinc finger 3	0.7346	47
NOTCH2NLB	Notch 2 N-terminal like B	0.7305	47

IMMUNE CELLS

SLC7A11 is part of cluster 8 Plasmacytoid DCs - Unknown function with confidenceⁱ 0.99
236 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PLP1	Proteolipid protein 1	1.0000	8
CFAP251	Cilia and flagella associated protein 251	1.0000	8
BEND6	BEN domain containing 6	1.0000	8
IGFBP3	Insulin like growth factor binding protein 3	1.0000	8
SIK1	Salt inducible kinase 1	1.0000	8
MYPN	Myopalladin	1.0000	8
CTSV	Cathepsin V	1.0000	8
CIB2	Calcium and integrin binding family member 2	1.0000	8
KCNK17	Potassium two pore domain channel subfamily K member 17	1.0000	8
PACSIN1	Protein kinase C and casein kinase substrate in neurons 1	1.0000	8
GUCA1A	Guanylate cyclase activator 1A	1.0000	8
DPPA4	Developmental pluripotency associated 4	1.0000	8
PROC	Protein C, inactivator of coagulation factors Va and VIIIa	1.0000	8
RTKN	Rhotekin	1.0000	8
PTGDS	Prostaglandin D2 synthase	1.0000	8

Adipocytes	0.5 nTPM
Adipose tissue	0.6 nTPM
Breast	0.4 nTPM

Alveolar cells type 1	5.4 nTPM
Lung	5.4 nTPM

Alveolar cells type 2	26.8 nTPM
Lung	26.8 nTPM

B-cells	7.0 nTPM
Skin	76.2 nTPM
Lung	8.0 nTPM
Kidney	5.2 nTPM
Stomach	1.3 nTPM
Spleen	0.4 nTPM
Salivary gland	0.2 nTPM
Thymus	0.1 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM

Basal keratinocytes	10.4 nTPM
Tongue	17.6 nTPM
Skin	3.1 nTPM

Ciliated cells	7.3 nTPM
Bronchus	14.7 nTPM
Fallopian tube	6.6 nTPM
Lung	4.8 nTPM
Endometrium	3.3 nTPM

Club cells	7.1 nTPM
Bronchus	10.2 nTPM
Lung	10.0 nTPM
Prostate	1.2 nTPM

Dendritic cells	75.1 nTPM
PBMC	75.5 nTPM
Adipose tissue	74.6 nTPM

Endothelial cells	3.5 nTPM
Pancreas	25.9 nTPM
Endometrium	11.9 nTPM
Lung	8.6 nTPM
Skin	5.0 nTPM
Tongue	4.6 nTPM
Skeletal muscle	1.9 nTPM
Testis	1.5 nTPM
Thymus	0.8 nTPM
Salivary gland	0.6 nTPM
Vascular	0.6 nTPM
Fallopian tube	0.6 nTPM
Ovary	0.6 nTPM
Heart muscle	0.4 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Esophagus	0.0 nTPM
Prostate	0.0 nTPM
Breast	0.0 nTPM

Enteroendocrine cells	13.7 nTPM
Rectum	38.6 nTPM
Colon	2.6 nTPM
Small intestine	0.0 nTPM

Fibroblasts	4.3 nTPM
Pancreas	24.8 nTPM
Esophagus	19.6 nTPM
Liver	4.7 nTPM
Stomach	4.3 nTPM
Vascular	4.0 nTPM
Skin	3.2 nTPM
Lung	2.3 nTPM
Placenta	1.3 nTPM
Prostate	1.3 nTPM
Thymus	1.0 nTPM
Skeletal muscle	0.6 nTPM
Fallopian tube	0.6 nTPM
Breast	0.3 nTPM
Heart muscle	0.2 nTPM
Adipose tissue	0.2 nTPM
Salivary gland	0.1 nTPM

Granulocytes	0.5 nTPM
Lung	1.0 nTPM
Fallopian tube	0.6 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	13.0 nTPM
Colon	18.7 nTPM
Rectum	10.4 nTPM
Small intestine	10.0 nTPM

Lymphatic endothelial cells	0.1 nTPM
Fallopian tube	0.3 nTPM
Ovary	0.0 nTPM

Macrophages	14.3 nTPM
Pancreas	139.8 nTPM
Skeletal muscle	27.2 nTPM
Endometrium	21.5 nTPM
Kidney	16.8 nTPM
Fallopian tube	13.5 nTPM
Skin	13.4 nTPM
Stomach	7.7 nTPM
Adipose tissue	5.3 nTPM
Spleen	5.0 nTPM
Thymus	4.5 nTPM
Tongue	3.7 nTPM
Breast	2.9 nTPM
Esophagus	2.6 nTPM
Lung	2.4 nTPM
Vascular	2.4 nTPM
Prostate	1.7 nTPM
Bone marrow	1.0 nTPM
Testis	0.6 nTPM
Salivary gland	0.4 nTPM

Bipolar cells	5.8 nTPM
Eye	5.8 nTPM

Distal enterocytes	3.9 nTPM
Colon	6.2 nTPM
Rectum	1.6 nTPM

Endometrial stromal cells	2.0 nTPM
Endometrium	2.0 nTPM

Paneth cells	0.5 nTPM
Rectum	1.5 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	4.6 nTPM
Stomach	13.4 nTPM
Thymus	7.6 nTPM
Fallopian tube	6.1 nTPM
Bone marrow	3.0 nTPM
Spleen	2.6 nTPM
Salivary gland	2.2 nTPM
Liver	2.0 nTPM
Esophagus	0.0 nTPM

Schwann cells	7.2 nTPM
Adipose tissue	21.5 nTPM
Esophagus	0.0 nTPM
Vascular	0.0 nTPM

Serous glandular cells	4.5 nTPM
Tongue	8.8 nTPM
Salivary gland	0.2 nTPM

Smooth muscle cells	1.1 nTPM
Tongue	5.7 nTPM
Lung	3.5 nTPM
Vascular	1.6 nTPM
Liver	1.3 nTPM
Adipose tissue	1.1 nTPM
Endometrium	0.9 nTPM
Fallopian tube	0.8 nTPM
Skin	0.6 nTPM
Placenta	0.5 nTPM
Skeletal muscle	0.5 nTPM
Thymus	0.5 nTPM
Salivary gland	0.4 nTPM
Esophagus	0.0 nTPM
Prostate	0.0 nTPM
Breast	0.0 nTPM
Ovary	0.0 nTPM

Suprabasal keratinocytes	19.4 nTPM
Tongue	35.6 nTPM
Skin	3.2 nTPM

T-cells	0.6 nTPM
Tongue	4.2 nTPM
Colon	1.9 nTPM
Endometrium	1.4 nTPM
Skin	1.1 nTPM
Skeletal muscle	0.8 nTPM
Lung	0.5 nTPM
Bone marrow	0.4 nTPM
Stomach	0.4 nTPM
Vascular	0.4 nTPM
Fallopian tube	0.4 nTPM
Liver	0.3 nTPM
PBMC	0.3 nTPM
Thymus	0.3 nTPM
Breast	0.2 nTPM
Adipose tissue	0.1 nTPM
Kidney	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Spleen	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM

Undifferentiated cells	2.9 nTPM
Colon	4.5 nTPM
Rectum	2.3 nTPM
Small intestine	1.9 nTPM

Amygdala excitatory	19.4 nTPM
Hypothalamus	81.0 nTPM
Amygdala	9.6 nTPM
Thalamus	6.8 nTPM
Basal ganglia	6.6 nTPM
Cerebral cortex	6.1 nTPM
Hippocampus	6.1 nTPM

Astrocyte	553.7 nTPM
Amygdala	838.2 nTPM
Hypothalamus	790.5 nTPM
Cerebral cortex	569.8 nTPM
Spinal cord	569.6 nTPM
Hippocampus	525.2 nTPM
Basal ganglia	524.2 nTPM
Thalamus	496.6 nTPM
Midbrain	482.3 nTPM
Medulla oblongata	456.8 nTPM
Pons	434.2 nTPM
Cerebellum	402.7 nTPM

Bergmann glia	403.5 nTPM
Pons	446.0 nTPM
Cerebellum	393.6 nTPM
Medulla oblongata	370.8 nTPM

Central nervous system macrophage	3.2 nTPM
Hippocampus	5.1 nTPM
Cerebellum	4.4 nTPM
Basal ganglia	3.7 nTPM
Amygdala	3.2 nTPM
Spinal cord	3.2 nTPM
Cerebral cortex	3.1 nTPM
Hypothalamus	3.0 nTPM
Thalamus	3.0 nTPM
Midbrain	2.6 nTPM
Medulla oblongata	2.0 nTPM
Pons	1.6 nTPM

Cerebellar inhibitory	7.0 nTPM
Pons	18.1 nTPM
Medulla oblongata	6.4 nTPM
Midbrain	4.4 nTPM
Cerebellum	3.2 nTPM
Spinal cord	2.7 nTPM

Cge interneuron	5.7 nTPM
Cerebral cortex	14.6 nTPM
Hippocampus	5.2 nTPM
Hypothalamus	5.0 nTPM
Midbrain	5.0 nTPM
Amygdala	4.6 nTPM
Basal ganglia	2.9 nTPM
Thalamus	2.7 nTPM

Choroid plexus epithelial cell	29.5 nTPM
Basal ganglia	58.3 nTPM
Hippocampus	27.7 nTPM
Medulla oblongata	18.2 nTPM
Thalamus	13.7 nTPM

Committed oligodendrocyte precursor	9.7 nTPM
Basal ganglia	20.8 nTPM
Thalamus	20.7 nTPM
Hypothalamus	13.0 nTPM
Cerebellum	12.7 nTPM
Spinal cord	11.0 nTPM
Medulla oblongata	9.0 nTPM
Amygdala	6.2 nTPM
Hippocampus	5.7 nTPM
Pons	2.7 nTPM
Cerebral cortex	2.5 nTPM
Midbrain	2.5 nTPM

Deep-layer corticothalamic and 6b	1.9 nTPM
Hypothalamus	5.3 nTPM
Amygdala	2.0 nTPM
Basal ganglia	1.5 nTPM
Hippocampus	1.5 nTPM
Cerebral cortex	1.3 nTPM
Midbrain	0.0 nTPM

Deep-layer intratelencephalic	11.9 nTPM
Basal ganglia	18.7 nTPM
Hypothalamus	18.3 nTPM
Cerebral cortex	8.9 nTPM
Amygdala	7.2 nTPM
Hippocampus	6.5 nTPM

Deep-layer near-projecting	1.9 nTPM
Basal ganglia	3.4 nTPM
Amygdala	2.3 nTPM
Hypothalamus	2.1 nTPM
Cerebral cortex	1.5 nTPM
Hippocampus	0.0 nTPM

Eccentric medium spiny neuron	2.0 nTPM
Hippocampus	3.3 nTPM
Amygdala	2.3 nTPM
Basal ganglia	2.2 nTPM
Cerebral cortex	1.7 nTPM
Thalamus	1.4 nTPM
Hypothalamus	0.9 nTPM