Single cell type - MPP7 - The Human Protein Atlas

MPP7

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MPP7
Gene descriptionⁱ Full gene name according to HGNC.	MAGUK p55 scaffold protein 7
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Suprabasal keratinocytes - Cornification (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Lymphatic endothelial cells, Early spermatids, Suprabasal keratinocytes, Excitatory neurons)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.52
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Lymphatic endothelial cells, Early spermatids, Suprabasal keratinocytes, Excitatory neurons)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

MPP7 is part of cluster 59 Suprabasal keratinocytes - Cornification with confidenceⁱ 1
186 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CDKL5	Cyclin dependent kinase like 5	0.4959	34
PARD6G	Par-6 family cell polarity regulator gamma	0.4751	54
TMPRSS11F	Transmembrane serine protease 11F	0.4548	59
IL36RN	Interleukin 36 receptor antagonist	0.4518	59
EDDM13	Epididymal protein 13	0.4498	54
PHF24	PHD finger protein 24	0.4403	34
KIAA1671	KIAA1671	0.4381	34
PTPN14	Protein tyrosine phosphatase non-receptor type 14	0.4327	54
MAB21L3	Mab-21 like 3	0.4290	59
ARHGAP32	Rho GTPase activating protein 32	0.4267	34
PAK6	P21 (RAC1) activated kinase 6	0.4189	24
KCTD1	Potassium channel tetramerization domain containing 1	0.4163	34
EFNA5	Ephrin A5	0.4157	34
GLTP	Glycolipid transfer protein	0.4143	59
KIAA0753	KIAA0753	0.4143	21

IMMUNE CELLS

MPP7 is part of cluster 3 Non-specific - Nuclear processes with confidenceⁱ 0.94
471 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF282	Zinc finger protein 282	1.0000	3
PXYLP1	2-phosphoxylose phosphatase 1	0.9762	3
VAMP1	Vesicle associated membrane protein 1	0.9524	3
IPCEF1	Interaction protein for cytohesin exchange factors 1	0.9286	3
SMPD1	Sphingomyelin phosphodiesterase 1	0.9286	3
SCML1	Scm polycomb group protein like 1	0.9048	3
FAM217B	Family with sequence similarity 217 member B	0.9048	3
ARFGEF1	ADP ribosylation factor guanine nucleotide exchange factor 1	0.9048	3
TRMO	TRNA methyltransferase O	0.8810	3
RO60	Ro60, Y RNA binding protein	0.8810	3
ITPKB	Inositol-trisphosphate 3-kinase B	0.8810	3
SSBP3	Single stranded DNA binding protein 3	0.8810	3
SNIP1	Smad nuclear interacting protein 1	0.8571	3
LMBR1	Limb development membrane protein 1	0.8571	43
DEF6	DEF6 guanine nucleotide exchange factor	0.8571	33

Adipocytes	2.1 nTPM
Adipose tissue	3.4 nTPM
Breast	0.9 nTPM

Alveolar cells type 1	24.7 nTPM
Lung	24.7 nTPM

Alveolar cells type 2	59.6 nTPM
Lung	59.6 nTPM

Astrocytes	9.9 nTPM
Brain	9.9 nTPM

B-cells	4.4 nTPM
Adipose tissue	17.7 nTPM
Stomach	10.5 nTPM
PBMC	6.2 nTPM
Spleen	6.0 nTPM
Thymus	3.8 nTPM
Salivary gland	3.7 nTPM
Skin	3.4 nTPM
Lymph node	2.7 nTPM
Bone marrow	1.6 nTPM
Lung	1.3 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM

Ciliated cells	20.4 nTPM
Fallopian tube	30.2 nTPM
Lung	24.7 nTPM
Bronchus	16.9 nTPM
Endometrium	9.8 nTPM

Club cells	27.1 nTPM
Prostate	40.5 nTPM
Lung	21.9 nTPM
Bronchus	18.8 nTPM

Endothelial cells	14.1 nTPM
Breast	171.4 nTPM
Salivary gland	19.0 nTPM
Tongue	14.3 nTPM
Thymus	7.3 nTPM
Vascular	6.1 nTPM
Lung	4.8 nTPM
Skeletal muscle	4.4 nTPM
Prostate	4.3 nTPM
Fallopian tube	4.1 nTPM
Esophagus	3.2 nTPM
Testis	3.1 nTPM
Heart muscle	2.9 nTPM
Placenta	2.8 nTPM
Endometrium	2.1 nTPM
Skin	1.6 nTPM
Liver	1.3 nTPM
Ovary	0.6 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	8.2 nTPM
Colon	14.6 nTPM
Rectum	10.1 nTPM
Small intestine	0.0 nTPM

Fibroblasts	2.3 nTPM
Placenta	7.1 nTPM
Stomach	5.8 nTPM
Lung	4.1 nTPM
Vascular	2.8 nTPM
Adipose tissue	2.6 nTPM
Prostate	2.6 nTPM
Skeletal muscle	2.2 nTPM
Skin	1.5 nTPM
Fallopian tube	1.5 nTPM
Thymus	1.3 nTPM
Liver	1.2 nTPM
Pancreas	1.1 nTPM
Salivary gland	1.0 nTPM
Esophagus	0.8 nTPM
Heart muscle	0.5 nTPM
Breast	0.5 nTPM

Granulocytes	2.8 nTPM
Tongue	4.9 nTPM
Lung	2.5 nTPM
Fallopian tube	1.0 nTPM

Intestinal goblet cells	8.2 nTPM
Rectum	13.4 nTPM
Colon	6.2 nTPM
Small intestine	5.0 nTPM

Lymphatic endothelial cells	133.3 nTPM
Fallopian tube	146.6 nTPM
Ovary	120.0 nTPM

Macrophages	7.2 nTPM
Adipose tissue	28.6 nTPM
Skeletal muscle	20.8 nTPM
Spleen	15.0 nTPM
Fallopian tube	13.3 nTPM
Stomach	12.9 nTPM
Tongue	11.0 nTPM
Bone marrow	9.1 nTPM
Salivary gland	5.6 nTPM
Endometrium	4.9 nTPM
Lung	3.8 nTPM
Skin	3.3 nTPM
Testis	1.9 nTPM
Prostate	1.9 nTPM
Breast	1.9 nTPM
Thymus	1.4 nTPM
Esophagus	1.3 nTPM
Vascular	0.7 nTPM
Kidney	0.0 nTPM
Pancreas	0.0 nTPM

Paneth cells	12.4 nTPM
Colon	21.7 nTPM
Rectum	8.5 nTPM
Small intestine	6.9 nTPM

Basal respiratory cells	9.7 nTPM
Bronchus	9.7 nTPM

Basal squamous epithelial cells	16.0 nTPM
Esophagus	16.0 nTPM

Bipolar cells	0.2 nTPM
Eye	0.2 nTPM

Cholangiocytes	11.4 nTPM
Liver	11.4 nTPM

Plasma cells	1.7 nTPM
Esophagus	5.2 nTPM
Salivary gland	3.1 nTPM
Stomach	2.1 nTPM
Fallopian tube	1.3 nTPM
Spleen	0.7 nTPM
Thymus	0.7 nTPM
Liver	0.5 nTPM
Bone marrow	0.0 nTPM

Schwann cells	9.6 nTPM
Vascular	12.5 nTPM
Esophagus	12.0 nTPM
Adipose tissue	4.3 nTPM

Serous glandular cells	11.8 nTPM
Salivary gland	14.7 nTPM
Tongue	8.8 nTPM

Smooth muscle cells	12.4 nTPM
Vascular	43.4 nTPM
Fallopian tube	33.0 nTPM
Thymus	24.7 nTPM
Skin	16.5 nTPM
Salivary gland	16.5 nTPM
Breast	14.4 nTPM
Prostate	12.2 nTPM
Esophagus	9.6 nTPM
Tongue	8.7 nTPM
Lung	5.9 nTPM
Liver	3.4 nTPM
Ovary	3.2 nTPM
Skeletal muscle	3.1 nTPM
Adipose tissue	2.2 nTPM
Placenta	0.5 nTPM
Endometrium	0.3 nTPM

Suprabasal keratinocytes	82.5 nTPM
Tongue	107.9 nTPM
Skin	57.1 nTPM

T-cells	17.9 nTPM
Adipose tissue	52.1 nTPM
Fallopian tube	32.9 nTPM
Tongue	23.1 nTPM
Spleen	23.0 nTPM
Esophagus	21.9 nTPM
Thymus	21.1 nTPM
Salivary gland	20.7 nTPM
Stomach	20.2 nTPM
Lymph node	18.3 nTPM
PBMC	16.8 nTPM
Prostate	16.5 nTPM
Skeletal muscle	15.1 nTPM
Bone marrow	14.4 nTPM
Breast	14.0 nTPM
Skin	13.0 nTPM
Colon	12.7 nTPM
Lung	11.8 nTPM
Vascular	8.8 nTPM
Endometrium	8.3 nTPM
Liver	6.5 nTPM
Kidney	5.3 nTPM

Undifferentiated cells	11.3 nTPM
Colon	12.9 nTPM
Rectum	10.5 nTPM
Small intestine	10.4 nTPM

Amygdala excitatory	64.0 nTPM
Amygdala	151.2 nTPM
Cerebral cortex	66.4 nTPM
Hippocampus	57.5 nTPM
Basal ganglia	48.4 nTPM
Thalamus	33.6 nTPM
Hypothalamus	27.0 nTPM

Astrocyte	18.8 nTPM
Amygdala	29.8 nTPM
Hippocampus	25.4 nTPM
Basal ganglia	23.7 nTPM
Medulla oblongata	21.9 nTPM
Thalamus	19.4 nTPM
Cerebral cortex	19.0 nTPM
Spinal cord	16.4 nTPM
Midbrain	14.7 nTPM
Hypothalamus	14.1 nTPM
Pons	11.5 nTPM
Cerebellum	11.2 nTPM

Bergmann glia	4.9 nTPM
Medulla oblongata	6.4 nTPM
Pons	4.3 nTPM
Cerebellum	3.9 nTPM

Central nervous system macrophage	2.4 nTPM
Hypothalamus	4.4 nTPM
Cerebral cortex	3.9 nTPM
Amygdala	2.9 nTPM
Basal ganglia	2.4 nTPM
Cerebellum	2.0 nTPM
Medulla oblongata	2.0 nTPM
Pons	2.0 nTPM
Hippocampus	1.9 nTPM
Spinal cord	1.8 nTPM
Midbrain	1.6 nTPM
Thalamus	1.1 nTPM

Cerebellar inhibitory	20.7 nTPM
Pons	37.5 nTPM
Midbrain	25.5 nTPM
Medulla oblongata	18.8 nTPM
Cerebellum	16.1 nTPM
Spinal cord	5.5 nTPM

Cge interneuron	11.0 nTPM
Cerebral cortex	13.1 nTPM
Midbrain	11.9 nTPM
Hippocampus	11.1 nTPM
Basal ganglia	10.9 nTPM
Hypothalamus	10.9 nTPM
Amygdala	10.2 nTPM
Thalamus	8.8 nTPM

Choroid plexus epithelial cell	71.7 nTPM
Medulla oblongata	84.4 nTPM
Basal ganglia	83.8 nTPM
Hippocampus	63.8 nTPM
Thalamus	54.8 nTPM

Committed oligodendrocyte precursor	41.1 nTPM
Midbrain	78.1 nTPM
Spinal cord	66.2 nTPM
Cerebellum	50.7 nTPM
Amygdala	44.5 nTPM
Cerebral cortex	40.5 nTPM
Hippocampus	39.3 nTPM
Medulla oblongata	34.9 nTPM
Pons	30.1 nTPM
Basal ganglia	27.9 nTPM
Hypothalamus	26.6 nTPM
Thalamus	12.6 nTPM

Deep-layer corticothalamic and 6b	33.3 nTPM
Hypothalamus	41.6 nTPM
Amygdala	41.2 nTPM
Hippocampus	40.1 nTPM
Basal ganglia	32.8 nTPM
Cerebral cortex	22.8 nTPM
Midbrain	21.1 nTPM

Deep-layer intratelencephalic	85.5 nTPM
Amygdala	120.5 nTPM
Basal ganglia	100.9 nTPM
Cerebral cortex	93.5 nTPM
Hypothalamus	72.6 nTPM
Hippocampus	39.8 nTPM

Deep-layer near-projecting	273.1 nTPM
Hypothalamus	398.5 nTPM
Cerebral cortex	300.5 nTPM
Amygdala	265.2 nTPM
Basal ganglia	229.5 nTPM
Hippocampus	172.0 nTPM

Eccentric medium spiny neuron	139.8 nTPM
Hypothalamus	158.7 nTPM
Amygdala	150.1 nTPM
Cerebral cortex	149.2 nTPM
Basal ganglia	146.7 nTPM
Thalamus	138.8 nTPM
Hippocampus	95.3 nTPM

Endothelial cell	7.6 nTPM
Basal ganglia	14.0 nTPM
Thalamus	11.9 nTPM
Hypothalamus	9.9 nTPM
Pons	7.5 nTPM
Medulla oblongata	7.2 nTPM
Cerebellum	7.0 nTPM
Midbrain	6.6 nTPM
Cerebral cortex	6.4 nTPM
Hippocampus	5.8 nTPM
Amygdala	4.5 nTPM
Spinal cord	3.5 nTPM