Single cell type - KAT14 - The Human Protein Atlas

KAT14

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KAT14
Gene descriptionⁱ Full gene name according to HGNC.	Lysine acetyltransferase 14
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Extravillous trophoblasts - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Extravillous trophoblasts)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.48
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Extravillous trophoblasts)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

KAT14 is part of cluster 4 Extravillous trophoblasts - Unknown function with confidenceⁱ 1
182 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GCSH	Glycine cleavage system protein H	0.6359	4
SCO1	Synthesis of cytochrome C oxidase 1	0.6173	4
ISM2	Isthmin 2	0.6141	4
GJA5	Gap junction protein alpha 5	0.6098	4
DLX4	Distal-less homeobox 4	0.6072	4
AADAT	Aminoadipate aminotransferase	0.6033	4
ERVH48-1	Endogenous retrovirus group 48 member 1	0.6010	4
CCNE1	Cyclin E1	0.5977	4
SKP2	S-phase kinase associated protein 2	0.5884	4
TRIM64B	Tripartite motif containing 64B	0.5821	4
DPPA2	Developmental pluripotency associated 2	0.5804	67
ASCL2	Achaete-scute family bHLH transcription factor 2	0.5790	4
RFPL4B	Ret finger protein like 4B	0.5771	4
KRTAP2-1	Keratin associated protein 2-1	0.5768	4
FANCE	FA complementation group E	0.5742	4

IMMUNE CELLS

KAT14 is part of cluster 24 Non-specific - Transcription with confidenceⁱ 0.68
516 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENSG00000286098	Novel protein	0.9762	24
NKIRAS1	NFKB inhibitor interacting Ras like 1	0.9762	24
UBQLN4	Ubiquilin 4	0.9524	43
RPL10A	Ribosomal protein L10a	0.9524	43
RPL14	Ribosomal protein L14	0.9524	43
INTS6L	Integrator complex subunit 6 like	0.9524	43
LIAS	Lipoic acid synthetase	0.9524	24
RPL22	Ribosomal protein L22	0.9524	43
ORC2	Origin recognition complex subunit 2	0.9524	24
HSP90AB1	Heat shock protein 90 alpha family class B member 1	0.9524	43
ZNF780B	Zinc finger protein 780B	0.9286	43
UBE2D2	Ubiquitin conjugating enzyme E2 D2	0.9286	24
DMAC1	Distal membrane arm assembly component 1	0.9286	24
ZNF382	Zinc finger protein 382	0.9286	24
NRN1L	Neuritin 1 like	0.9286	24

Adipocytes	4.3 nTPM
Breast	4.8 nTPM
Adipose tissue	3.8 nTPM

Alveolar cells type 1	8.9 nTPM
Lung	8.9 nTPM

Alveolar cells type 2	7.8 nTPM
Lung	7.8 nTPM

Astrocytes	7.1 nTPM
Brain	7.1 nTPM

B-cells	5.2 nTPM
Salivary gland	9.5 nTPM
PBMC	9.2 nTPM
Bone marrow	7.9 nTPM
Lymph node	7.2 nTPM
Esophagus	5.9 nTPM
Stomach	5.5 nTPM
Thymus	5.5 nTPM
Kidney	5.2 nTPM
Adipose tissue	4.9 nTPM
Spleen	4.4 nTPM
Lung	2.7 nTPM
Liver	0.0 nTPM
Skin	0.0 nTPM

Ciliated cells	6.8 nTPM
Endometrium	10.8 nTPM
Fallopian tube	7.4 nTPM
Lung	5.5 nTPM
Bronchus	3.4 nTPM

Club cells	5.6 nTPM
Prostate	7.5 nTPM
Lung	5.8 nTPM
Bronchus	3.4 nTPM

Endothelial cells	5.3 nTPM
Pancreas	10.3 nTPM
Liver	7.6 nTPM
Testis	7.3 nTPM
Endometrium	7.3 nTPM
Heart muscle	7.0 nTPM
Prostate	6.7 nTPM
Vascular	6.4 nTPM
Esophagus	5.2 nTPM
Lung	5.0 nTPM
Tongue	4.9 nTPM
Ovary	4.6 nTPM
Breast	4.4 nTPM
Placenta	4.0 nTPM
Salivary gland	3.8 nTPM
Thymus	3.7 nTPM
Skeletal muscle	3.2 nTPM
Fallopian tube	2.5 nTPM
Skin	1.1 nTPM

Enteroendocrine cells	10.3 nTPM
Rectum	15.1 nTPM
Colon	8.9 nTPM
Small intestine	6.9 nTPM

Fibroblasts	6.2 nTPM
Placenta	11.3 nTPM
Stomach	10.1 nTPM
Vascular	8.3 nTPM
Prostate	7.3 nTPM
Esophagus	7.2 nTPM
Salivary gland	6.4 nTPM
Lung	6.1 nTPM
Liver	5.9 nTPM
Adipose tissue	5.9 nTPM
Thymus	5.3 nTPM
Skeletal muscle	5.1 nTPM
Breast	5.1 nTPM
Pancreas	4.8 nTPM
Heart muscle	4.2 nTPM
Fallopian tube	3.6 nTPM
Skin	3.2 nTPM

Granulocytes	5.7 nTPM
Lung	7.1 nTPM
Fallopian tube	5.2 nTPM
Tongue	4.9 nTPM

Intestinal goblet cells	8.0 nTPM
Rectum	9.3 nTPM
Small intestine	7.7 nTPM
Colon	6.9 nTPM

Lymphatic endothelial cells	2.2 nTPM
Fallopian tube	4.4 nTPM
Ovary	0.0 nTPM

Macrophages	4.7 nTPM
Bone marrow	13.2 nTPM
Testis	7.4 nTPM
Prostate	7.0 nTPM
Salivary gland	6.9 nTPM
Esophagus	5.1 nTPM
Stomach	5.1 nTPM
Thymus	4.9 nTPM
Lung	4.7 nTPM
Tongue	4.4 nTPM
Vascular	4.3 nTPM
Breast	4.1 nTPM
Spleen	4.0 nTPM
Endometrium	3.7 nTPM
Skeletal muscle	2.9 nTPM
Adipose tissue	2.8 nTPM
Fallopian tube	2.7 nTPM
Pancreas	2.1 nTPM
Kidney	1.8 nTPM
Skin	1.1 nTPM

Paneth cells	4.6 nTPM
Rectum	6.8 nTPM
Colon	3.6 nTPM
Small intestine	3.5 nTPM

Basal squamous epithelial cells	8.4 nTPM
Esophagus	8.4 nTPM

Cholangiocytes	11.4 nTPM
Liver	11.4 nTPM

Collecting duct cells	3.9 nTPM
Kidney	3.9 nTPM

Cytotrophoblasts	18.7 nTPM
Placenta	18.7 nTPM

Plasma cells	9.5 nTPM
Bone marrow	16.6 nTPM
Esophagus	15.6 nTPM
Spleen	12.0 nTPM
Liver	8.0 nTPM
Thymus	7.4 nTPM
Stomach	7.1 nTPM
Fallopian tube	5.1 nTPM
Salivary gland	4.5 nTPM

Schwann cells	2.9 nTPM
Vascular	6.8 nTPM
Adipose tissue	2.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	6.8 nTPM
Salivary gland	9.1 nTPM
Tongue	4.4 nTPM

Smooth muscle cells	5.3 nTPM
Salivary gland	8.8 nTPM
Liver	7.6 nTPM
Vascular	7.0 nTPM
Esophagus	6.0 nTPM
Tongue	6.0 nTPM
Breast	5.6 nTPM
Endometrium	5.5 nTPM
Placenta	5.1 nTPM
Prostate	4.9 nTPM
Fallopian tube	4.9 nTPM
Skeletal muscle	4.8 nTPM
Lung	4.7 nTPM
Adipose tissue	4.2 nTPM
Ovary	4.2 nTPM
Thymus	3.0 nTPM
Skin	2.5 nTPM

T-cells	5.8 nTPM
Esophagus	9.7 nTPM
Salivary gland	9.2 nTPM
PBMC	8.2 nTPM
Bone marrow	7.9 nTPM
Prostate	7.6 nTPM
Lymph node	7.3 nTPM
Thymus	6.9 nTPM
Vascular	6.8 nTPM
Lung	6.5 nTPM
Liver	6.2 nTPM
Tongue	6.2 nTPM
Stomach	5.9 nTPM
Spleen	5.4 nTPM
Endometrium	4.8 nTPM
Breast	4.0 nTPM
Fallopian tube	3.8 nTPM
Skeletal muscle	3.4 nTPM
Adipose tissue	3.0 nTPM
Colon	2.9 nTPM
Kidney	2.7 nTPM
Skin	2.5 nTPM

Undifferentiated cells	10.1 nTPM
Small intestine	12.3 nTPM
Rectum	10.1 nTPM
Colon	7.9 nTPM

Amygdala excitatory	24.6 nTPM
Hypothalamus	27.7 nTPM
Thalamus	25.9 nTPM
Cerebral cortex	25.7 nTPM
Hippocampus	24.8 nTPM
Amygdala	21.8 nTPM
Basal ganglia	21.8 nTPM

Astrocyte	16.2 nTPM
Amygdala	19.8 nTPM
Cerebral cortex	18.4 nTPM
Hippocampus	17.3 nTPM
Thalamus	17.0 nTPM
Cerebellum	16.6 nTPM
Midbrain	16.2 nTPM
Pons	16.1 nTPM
Basal ganglia	15.9 nTPM
Hypothalamus	14.6 nTPM
Medulla oblongata	14.5 nTPM
Spinal cord	11.4 nTPM

Bergmann glia	18.1 nTPM
Pons	18.7 nTPM
Cerebellum	18.5 nTPM
Medulla oblongata	17.0 nTPM

Central nervous system macrophage	30.1 nTPM
Amygdala	38.4 nTPM
Midbrain	32.4 nTPM
Hypothalamus	31.7 nTPM
Hippocampus	31.3 nTPM
Cerebral cortex	29.9 nTPM
Thalamus	29.7 nTPM
Pons	29.6 nTPM
Medulla oblongata	29.2 nTPM
Basal ganglia	28.4 nTPM
Cerebellum	28.3 nTPM
Spinal cord	21.8 nTPM

Cerebellar inhibitory	26.1 nTPM
Spinal cord	33.0 nTPM
Cerebellum	25.2 nTPM
Midbrain	25.2 nTPM
Medulla oblongata	24.1 nTPM
Pons	23.2 nTPM

Cge interneuron	25.8 nTPM
Thalamus	29.1 nTPM
Hypothalamus	26.4 nTPM
Midbrain	25.9 nTPM
Amygdala	25.5 nTPM
Cerebral cortex	25.0 nTPM
Hippocampus	24.4 nTPM
Basal ganglia	24.0 nTPM

Choroid plexus epithelial cell	29.7 nTPM
Hippocampus	41.6 nTPM
Basal ganglia	29.8 nTPM
Medulla oblongata	25.4 nTPM
Thalamus	21.9 nTPM

Committed oligodendrocyte precursor	25.7 nTPM
Spinal cord	33.1 nTPM
Basal ganglia	30.7 nTPM
Cerebral cortex	29.1 nTPM
Hypothalamus	28.0 nTPM
Hippocampus	27.7 nTPM
Midbrain	24.4 nTPM
Thalamus	24.3 nTPM
Pons	23.9 nTPM
Cerebellum	23.8 nTPM
Amygdala	19.2 nTPM
Medulla oblongata	18.1 nTPM

Deep-layer corticothalamic and 6b	25.6 nTPM
Hippocampus	32.6 nTPM
Midbrain	26.6 nTPM
Hypothalamus	25.0 nTPM
Amygdala	24.4 nTPM
Cerebral cortex	22.6 nTPM
Basal ganglia	22.4 nTPM

Deep-layer intratelencephalic	27.2 nTPM
Hypothalamus	30.2 nTPM
Hippocampus	27.5 nTPM
Basal ganglia	27.0 nTPM
Cerebral cortex	26.1 nTPM
Amygdala	25.2 nTPM

Deep-layer near-projecting	41.9 nTPM
Basal ganglia	45.4 nTPM
Hypothalamus	44.7 nTPM
Amygdala	41.9 nTPM
Hippocampus	40.7 nTPM
Cerebral cortex	36.5 nTPM

Eccentric medium spiny neuron	23.2 nTPM
Hypothalamus	24.3 nTPM
Thalamus	23.8 nTPM
Basal ganglia	23.3 nTPM
Cerebral cortex	23.3 nTPM
Amygdala	23.0 nTPM
Hippocampus	21.6 nTPM

Endothelial cell	12.4 nTPM
Cerebral cortex	17.3 nTPM
Hippocampus	15.1 nTPM
Pons	15.0 nTPM
Thalamus	14.7 nTPM
Basal ganglia	12.1 nTPM
Spinal cord	12.1 nTPM
Medulla oblongata	11.3 nTPM
Cerebellum	10.8 nTPM
Amygdala	10.1 nTPM
Midbrain	9.5 nTPM
Hypothalamus	8.7 nTPM

Ependymal cell	15.6 nTPM
Midbrain	22.9 nTPM
Basal ganglia	18.1 nTPM
Spinal cord	17.2 nTPM
Medulla oblongata	15.8 nTPM
Pons	14.9 nTPM
Hippocampus	14.7 nTPM
Thalamus	14.6 nTPM
Hypothalamus	13.4 nTPM
Amygdala	9.1 nTPM