Single cell type - ADAM33 - The Human Protein Atlas

ADAM33

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ADAM33
Gene descriptionⁱ Full gene name according to HGNC.	ADAM metallopeptidase domain 33
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Fibroblasts - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Fibroblasts, Endometrial stromal cells, Leydig cells, Smooth muscle cells, Microglial cells, Mesothelial cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.82
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Committed oligodendrocyte precursor, Fibroblast, Pericyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Fibroblasts, Endometrial stromal cells, Leydig cells, Smooth muscle cells, Microglial cells, Mesothelial cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Committed oligodendrocyte precursor, Fibroblast, Pericyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ADAM33 is part of cluster 53 Fibroblasts - ECM organization with confidenceⁱ 1
305 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CD248	CD248 molecule	0.7516	53
FGF7	Fibroblast growth factor 7	0.7440	53
CTSK	Cathepsin K	0.7213	53
FBLN1	Fibulin 1	0.7035	53
ISLR	Immunoglobulin superfamily containing leucine rich repeat	0.7011	53
TWIST1	Twist family bHLH transcription factor 1	0.6865	53
MMP2	Matrix metallopeptidase 2	0.6854	53
TMEM119	Transmembrane protein 119	0.6775	53
MXRA8	Matrix remodeling associated 8	0.6661	53
CXCL12	C-X-C motif chemokine ligand 12	0.6646	53
COL6A3	Collagen type VI alpha 3 chain	0.6606	53
PCDH18	Protocadherin 18	0.6492	53
ADGRD1	Adhesion G protein-coupled receptor D1	0.6453	53
APOD	Apolipoprotein D	0.6395	53
EBF1	EBF transcription factor 1	0.6350	53

Adipocytes	2.4 nTPM
Breast	2.6 nTPM
Adipose tissue	2.2 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	0.0 nTPM
Lung	0.0 nTPM

Astrocytes	6.8 nTPM
Brain	6.8 nTPM

B-cells	0.8 nTPM
Esophagus	5.9 nTPM
Thymus	3.0 nTPM
Adipose tissue	0.8 nTPM
Salivary gland	0.6 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM

Ciliated cells	1.8 nTPM
Fallopian tube	4.7 nTPM
Endometrium	2.3 nTPM
Lung	0.2 nTPM
Bronchus	0.0 nTPM

Club cells	0.0 nTPM
Prostate	0.1 nTPM
Bronchus	0.0 nTPM
Lung	0.0 nTPM

Endothelial cells	1.5 nTPM
Breast	7.9 nTPM
Heart muscle	4.9 nTPM
Endometrium	2.7 nTPM
Skin	2.7 nTPM
Thymus	1.8 nTPM
Ovary	1.2 nTPM
Vascular	1.1 nTPM
Testis	0.9 nTPM
Skeletal muscle	0.9 nTPM
Esophagus	0.9 nTPM
Tongue	0.9 nTPM
Fallopian tube	0.7 nTPM
Placenta	0.6 nTPM
Salivary gland	0.4 nTPM
Prostate	0.2 nTPM
Lung	0.1 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	39.2 nTPM
Breast	90.5 nTPM
Adipose tissue	72.1 nTPM
Esophagus	70.5 nTPM
Skin	61.3 nTPM
Thymus	58.3 nTPM
Heart muscle	51.5 nTPM
Skeletal muscle	45.1 nTPM
Stomach	41.8 nTPM
Fallopian tube	35.4 nTPM
Salivary gland	31.4 nTPM
Vascular	30.6 nTPM
Prostate	19.8 nTPM
Lung	10.2 nTPM
Placenta	8.0 nTPM
Pancreas	1.0 nTPM
Liver	0.0 nTPM

Granulocytes	0.6 nTPM
Fallopian tube	1.7 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	7.0 nTPM
Ovary	10.9 nTPM
Fallopian tube	3.1 nTPM

Macrophages	0.9 nTPM
Esophagus	2.6 nTPM
Vascular	2.6 nTPM
Skin	2.2 nTPM
Skeletal muscle	2.2 nTPM
Thymus	2.1 nTPM
Endometrium	1.8 nTPM
Fallopian tube	1.3 nTPM
Breast	0.9 nTPM
Salivary gland	0.4 nTPM
Adipose tissue	0.3 nTPM
Prostate	0.2 nTPM
Testis	0.0 nTPM
Kidney	0.0 nTPM
Pancreas	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Bipolar cells	0.5 nTPM
Eye	0.5 nTPM

Plasma cells	0.8 nTPM
Fallopian tube	3.2 nTPM
Thymus	2.0 nTPM
Salivary gland	0.9 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Schwann cells	4.0 nTPM
Vascular	11.5 nTPM
Adipose tissue	0.4 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	1.6 nTPM
Salivary gland	3.3 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	21.7 nTPM
Thymus	59.4 nTPM
Tongue	39.5 nTPM
Skin	32.0 nTPM
Esophagus	30.0 nTPM
Lung	25.9 nTPM
Skeletal muscle	23.0 nTPM
Breast	22.8 nTPM
Placenta	21.4 nTPM
Vascular	21.0 nTPM
Adipose tissue	19.8 nTPM
Fallopian tube	16.1 nTPM
Prostate	11.6 nTPM
Endometrium	11.4 nTPM
Salivary gland	8.0 nTPM
Liver	3.0 nTPM
Ovary	2.3 nTPM

T-cells	0.4 nTPM
Skin	2.5 nTPM
Endometrium	2.0 nTPM
Skeletal muscle	1.1 nTPM
Vascular	0.8 nTPM
Fallopian tube	0.7 nTPM
Breast	0.5 nTPM
Stomach	0.2 nTPM
Prostate	0.2 nTPM
Salivary gland	0.2 nTPM
Tongue	0.2 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Lung	0.0 nTPM
Thymus	0.0 nTPM

Undifferentiated cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Amygdala excitatory	0.3 nTPM
Amygdala	0.5 nTPM
Hypothalamus	0.5 nTPM
Cerebral cortex	0.4 nTPM
Hippocampus	0.2 nTPM
Basal ganglia	0.1 nTPM
Thalamus	0.0 nTPM

Astrocyte	22.9 nTPM
Midbrain	35.8 nTPM
Pons	34.7 nTPM
Hypothalamus	31.4 nTPM
Cerebral cortex	27.9 nTPM
Medulla oblongata	23.4 nTPM
Thalamus	21.3 nTPM
Amygdala	20.8 nTPM
Basal ganglia	20.8 nTPM
Hippocampus	16.7 nTPM
Spinal cord	10.3 nTPM
Cerebellum	9.1 nTPM

Bergmann glia	56.3 nTPM
Cerebellum	73.7 nTPM
Pons	54.7 nTPM
Medulla oblongata	40.5 nTPM

Central nervous system macrophage	0.8 nTPM
Pons	2.6 nTPM
Cerebral cortex	1.1 nTPM
Cerebellum	1.0 nTPM
Spinal cord	0.9 nTPM
Medulla oblongata	0.7 nTPM
Hippocampus	0.6 nTPM
Midbrain	0.5 nTPM
Basal ganglia	0.4 nTPM
Amygdala	0.3 nTPM
Hypothalamus	0.3 nTPM
Thalamus	0.3 nTPM

Cerebellar inhibitory	0.8 nTPM
Spinal cord	2.7 nTPM
Medulla oblongata	0.4 nTPM
Cerebellum	0.3 nTPM
Midbrain	0.3 nTPM
Pons	0.3 nTPM

Cge interneuron	24.3 nTPM
Cerebral cortex	43.1 nTPM
Hypothalamus	28.7 nTPM
Basal ganglia	25.1 nTPM
Hippocampus	21.9 nTPM
Midbrain	20.5 nTPM
Amygdala	18.1 nTPM
Thalamus	12.8 nTPM

Choroid plexus epithelial cell	1.2 nTPM
Medulla oblongata	3.3 nTPM
Basal ganglia	1.6 nTPM
Hippocampus	0.0 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	152.3 nTPM
Cerebellum	280.6 nTPM
Hippocampus	269.0 nTPM
Cerebral cortex	260.9 nTPM
Spinal cord	228.1 nTPM
Midbrain	192.4 nTPM
Pons	155.8 nTPM
Basal ganglia	84.9 nTPM
Amygdala	84.6 nTPM
Medulla oblongata	59.4 nTPM
Hypothalamus	37.6 nTPM
Thalamus	22.1 nTPM

Deep-layer corticothalamic and 6b	1.1 nTPM
Midbrain	4.4 nTPM
Hypothalamus	0.8 nTPM
Cerebral cortex	0.7 nTPM
Hippocampus	0.4 nTPM
Amygdala	0.3 nTPM
Basal ganglia	0.3 nTPM

Deep-layer intratelencephalic	0.3 nTPM
Cerebral cortex	0.6 nTPM
Hypothalamus	0.4 nTPM
Basal ganglia	0.3 nTPM
Hippocampus	0.2 nTPM
Amygdala	0.1 nTPM

Deep-layer near-projecting	0.4 nTPM
Hypothalamus	1.5 nTPM
Cerebral cortex	0.3 nTPM
Basal ganglia	0.2 nTPM
Amygdala	0.0 nTPM
Hippocampus	0.0 nTPM

Eccentric medium spiny neuron	0.1 nTPM
Thalamus	0.2 nTPM
Amygdala	0.1 nTPM
Basal ganglia	0.1 nTPM
Cerebral cortex	0.1 nTPM
Hypothalamus	0.1 nTPM
Hippocampus	0.0 nTPM

Endothelial cell	1.5 nTPM
Hypothalamus	5.0 nTPM
Pons	3.1 nTPM
Hippocampus	2.6 nTPM
Cerebellum	2.3 nTPM
Cerebral cortex	1.3 nTPM
Medulla oblongata	1.0 nTPM
Midbrain	0.9 nTPM
Amygdala	0.0 nTPM
Basal ganglia	0.0 nTPM
Spinal cord	0.0 nTPM
Thalamus	0.0 nTPM

Ependymal cell	1.7 nTPM
Hypothalamus	3.6 nTPM
Pons	3.1 nTPM
Amygdala	2.3 nTPM
Medulla oblongata	1.8 nTPM
Basal ganglia	1.7 nTPM
Hippocampus	1.4 nTPM
Thalamus	1.2 nTPM
Midbrain	0.6 nTPM
Spinal cord	0.0 nTPM