Single cell type - SERPING1 - The Human Protein Atlas

SERPING1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SERPING1
Gene descriptionⁱ Full gene name according to HGNC.	Serpin family G member 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Candidate cardiovascular disease genes Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Fibroblasts - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Hepatocytes, Mesothelial cells, Fibroblasts, Leydig cells, Ductal cells, Cholangiocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.57
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Group enriched (Fibroblast, Pericyte, Vascular associated smooth muscle cell, Ependymal cell)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (neutrophil, plasmacytoid DC)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data.	Protein predicted to be secreted

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Hepatocytes, Mesothelial cells, Fibroblasts, Leydig cells, Ductal cells, Cholangiocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Group enriched (Fibroblast, Pericyte, Vascular associated smooth muscle cell, Ependymal cell)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (neutrophil, plasmacytoid DC)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

SERPING1 is part of cluster 53 Fibroblasts - ECM organization with confidenceⁱ 1
305 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
C1S	Complement C1s	0.9109	53
C1R	Complement C1r	0.8392	53
CFH	Complement factor H	0.7826	53
C1RL	Complement C1r subcomponent like	0.7598	53
C3	Complement C3	0.7570	62
FGF7	Fibroblast growth factor 7	0.7425	53
PODN	Podocan	0.7225	53
PRG4	Proteoglycan 4	0.7158	53
MMP2	Matrix metallopeptidase 2	0.6996	53
PROS1	Protein S	0.6772	53
SCARA5	Scavenger receptor class A member 5	0.6760	53
APOD	Apolipoprotein D	0.6731	53
ADH1B	Alcohol dehydrogenase 1B (class I), beta polypeptide	0.6724	43
DCN	Decorin	0.6628	53
F10	Coagulation factor X	0.6614	53

IMMUNE CELLS

SERPING1 is part of cluster 2 Dendritic cells - Unknown function with confidenceⁱ 0.71
342 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZMIZ1	Zinc finger MIZ-type containing 1	0.9762	2
APBB3	Amyloid beta precursor protein binding family B member 3	0.9762	2
ARID3A	AT-rich interaction domain 3A	0.9762	2
KLF16	KLF transcription factor 16	0.9762	2
MLLT1	MLLT1 super elongation complex subunit	0.9762	2
PDPK1	3-phosphoinositide dependent protein kinase 1	0.9762	2
ANKS1A	Ankyrin repeat and sterile alpha motif domain containing 1A	0.9524	2
C19orf54	Chromosome 19 open reading frame 54	0.9524	2
PAPLN	Papilin, proteoglycan like sulfated glycoprotein	0.9524	2
TRIM3	Tripartite motif containing 3	0.9524	2
ZFP91	ZFP91 zinc finger protein, atypical E3 ubiquitin ligase	0.9524	2
ZSWIM6	Zinc finger SWIM-type containing 6	0.9524	2
SIPA1L2	Signal induced proliferation associated 1 like 2	0.9286	2
KIAA0753	KIAA0753	0.9286	2
HPD	4-hydroxyphenylpyruvate dioxygenase	0.9286	2

Adipocytes	152.3 nTPM
Adipose tissue	159.0 nTPM
Breast	145.7 nTPM

Alveolar cells type 1	80.2 nTPM
Lung	80.2 nTPM

Alveolar cells type 2	83.5 nTPM
Lung	83.5 nTPM

Astrocytes	5.3 nTPM
Brain	5.3 nTPM

B-cells	12.0 nTPM
Skin	44.0 nTPM
Thymus	37.9 nTPM
Liver	29.0 nTPM
Lung	13.4 nTPM
Salivary gland	9.2 nTPM
Adipose tissue	7.0 nTPM
Esophagus	5.9 nTPM
Kidney	5.2 nTPM
Stomach	1.7 nTPM
PBMC	1.5 nTPM
Lymph node	1.1 nTPM
Spleen	0.5 nTPM
Bone marrow	0.0 nTPM

Ciliated cells	69.0 nTPM
Fallopian tube	136.6 nTPM
Endometrium	92.8 nTPM
Lung	37.5 nTPM
Bronchus	9.2 nTPM

Club cells	36.4 nTPM
Lung	53.0 nTPM
Prostate	51.7 nTPM
Bronchus	4.7 nTPM

Dendritic cells	28.7 nTPM
PBMC	46.8 nTPM
Adipose tissue	10.5 nTPM

Endothelial cells	165.3 nTPM
Esophagus	273.0 nTPM
Liver	263.3 nTPM
Thymus	237.0 nTPM
Heart muscle	222.0 nTPM
Fallopian tube	201.4 nTPM
Vascular	182.9 nTPM
Skeletal muscle	182.8 nTPM
Ovary	175.9 nTPM
Testis	165.7 nTPM
Skin	164.1 nTPM
Salivary gland	150.0 nTPM
Prostate	144.2 nTPM
Lung	139.4 nTPM
Placenta	132.3 nTPM
Breast	122.1 nTPM
Tongue	94.0 nTPM
Endometrium	64.1 nTPM
Pancreas	62.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	846.6 nTPM
Esophagus	1672.0 nTPM
Thymus	1489.2 nTPM
Adipose tissue	1433.0 nTPM
Salivary gland	1307.7 nTPM
Stomach	1276.8 nTPM
Vascular	1113.2 nTPM
Skeletal muscle	878.3 nTPM
Heart muscle	828.8 nTPM
Lung	772.7 nTPM
Skin	712.7 nTPM
Breast	613.4 nTPM
Prostate	514.8 nTPM
Fallopian tube	468.4 nTPM
Liver	249.0 nTPM
Placenta	139.7 nTPM
Pancreas	76.1 nTPM

Granulocytes	13.2 nTPM
Fallopian tube	26.3 nTPM
Lung	8.6 nTPM
Tongue	4.9 nTPM

Intestinal goblet cells	0.2 nTPM
Small intestine	0.7 nTPM
Colon	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	216.6 nTPM
Ovary	256.4 nTPM
Fallopian tube	176.7 nTPM

Macrophages	61.6 nTPM
Lung	401.6 nTPM
Vascular	133.4 nTPM
Skin	101.4 nTPM
Thymus	89.4 nTPM
Esophagus	74.5 nTPM
Fallopian tube	50.6 nTPM
Testis	44.6 nTPM
Skeletal muscle	39.4 nTPM
Endometrium	33.8 nTPM
Kidney	31.0 nTPM
Adipose tissue	31.0 nTPM
Breast	24.5 nTPM
Salivary gland	24.0 nTPM
Tongue	22.0 nTPM
Bone marrow	20.3 nTPM
Prostate	20.2 nTPM
Spleen	16.0 nTPM
Stomach	7.7 nTPM
Pancreas	4.1 nTPM

Basal keratinocytes	21.1 nTPM
Skin	31.4 nTPM
Tongue	10.8 nTPM

Basal prostatic cells	75.3 nTPM
Prostate	75.3 nTPM

Basal respiratory cells	6.9 nTPM
Bronchus	6.9 nTPM

Basal squamous epithelial cells	17.1 nTPM
Esophagus	17.1 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Plasma cells	25.4 nTPM
Liver	86.6 nTPM
Thymus	38.1 nTPM
Salivary gland	30.0 nTPM
Fallopian tube	26.1 nTPM
Esophagus	15.6 nTPM
Stomach	6.3 nTPM
Spleen	0.2 nTPM
Bone marrow	0.0 nTPM

Schwann cells	203.5 nTPM
Vascular	367.2 nTPM
Esophagus	239.6 nTPM
Adipose tissue	3.5 nTPM

Serous glandular cells	46.7 nTPM
Salivary gland	75.7 nTPM
Tongue	17.7 nTPM

Smooth muscle cells	423.6 nTPM
Thymus	878.4 nTPM
Tongue	740.7 nTPM
Placenta	664.9 nTPM
Lung	573.7 nTPM
Vascular	542.7 nTPM
Esophagus	538.2 nTPM
Adipose tissue	457.2 nTPM
Prostate	375.9 nTPM
Skeletal muscle	366.7 nTPM
Fallopian tube	323.0 nTPM
Salivary gland	271.3 nTPM
Liver	256.0 nTPM
Ovary	244.2 nTPM
Breast	240.1 nTPM
Skin	216.0 nTPM
Endometrium	88.2 nTPM

Suprabasal keratinocytes	10.5 nTPM
Skin	16.6 nTPM
Tongue	4.4 nTPM

T-cells	11.4 nTPM
Liver	54.0 nTPM
Vascular	49.8 nTPM
Skin	36.1 nTPM
Endometrium	22.4 nTPM
Skeletal muscle	13.2 nTPM
Esophagus	12.2 nTPM
Salivary gland	10.3 nTPM
Lung	9.6 nTPM
Fallopian tube	8.7 nTPM
Prostate	6.3 nTPM
Kidney	4.4 nTPM
Breast	3.2 nTPM
Tongue	2.7 nTPM
Thymus	1.8 nTPM
PBMC	1.2 nTPM
Colon	1.0 nTPM
Stomach	1.0 nTPM
Adipose tissue	0.6 nTPM
Spleen	0.3 nTPM
Lymph node	0.2 nTPM
Bone marrow	0.1 nTPM

Undifferentiated cells	0.3 nTPM
Colon	0.5 nTPM
Rectum	0.4 nTPM
Small intestine	0.0 nTPM

Amygdala excitatory	6.3 nTPM
Thalamus	13.2 nTPM
Hypothalamus	7.9 nTPM
Basal ganglia	5.2 nTPM
Amygdala	4.7 nTPM
Hippocampus	3.5 nTPM
Cerebral cortex	3.3 nTPM

Astrocyte	14.7 nTPM
Medulla oblongata	31.3 nTPM
Spinal cord	29.5 nTPM
Cerebellum	17.7 nTPM
Midbrain	13.2 nTPM
Pons	12.6 nTPM
Basal ganglia	12.1 nTPM
Hippocampus	10.6 nTPM
Hypothalamus	9.1 nTPM
Amygdala	8.9 nTPM
Thalamus	8.9 nTPM
Cerebral cortex	7.6 nTPM

Bergmann glia	23.5 nTPM
Pons	27.3 nTPM
Cerebellum	24.1 nTPM
Medulla oblongata	19.2 nTPM

Central nervous system macrophage	15.9 nTPM
Basal ganglia	19.8 nTPM
Cerebral cortex	19.1 nTPM
Midbrain	18.3 nTPM
Hippocampus	17.1 nTPM
Thalamus	16.3 nTPM
Medulla oblongata	15.4 nTPM
Spinal cord	15.3 nTPM
Amygdala	15.0 nTPM
Cerebellum	14.0 nTPM
Pons	13.3 nTPM
Hypothalamus	11.5 nTPM

Cerebellar inhibitory	4.8 nTPM
Spinal cord	11.0 nTPM
Pons	4.6 nTPM
Cerebellum	3.3 nTPM
Medulla oblongata	2.8 nTPM
Midbrain	2.5 nTPM

Cge interneuron	15.8 nTPM
Midbrain	18.6 nTPM
Hypothalamus	17.7 nTPM
Amygdala	16.4 nTPM
Basal ganglia	16.1 nTPM
Cerebral cortex	15.5 nTPM
Hippocampus	13.9 nTPM
Thalamus	12.8 nTPM

Choroid plexus epithelial cell	9.4 nTPM
Medulla oblongata	11.1 nTPM
Basal ganglia	10.0 nTPM
Hippocampus	8.3 nTPM
Thalamus	8.2 nTPM

Committed oligodendrocyte precursor	1.6 nTPM
Medulla oblongata	3.9 nTPM
Pons	3.5 nTPM
Midbrain	2.5 nTPM
Thalamus	2.5 nTPM
Basal ganglia	2.2 nTPM
Hippocampus	2.1 nTPM
Hypothalamus	0.7 nTPM
Amygdala	0.0 nTPM
Cerebellum	0.0 nTPM
Cerebral cortex	0.0 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	3.9 nTPM
Midbrain	6.7 nTPM
Basal ganglia	4.4 nTPM
Amygdala	3.3 nTPM
Hypothalamus	3.1 nTPM
Cerebral cortex	3.0 nTPM
Hippocampus	2.7 nTPM

Deep-layer intratelencephalic	6.4 nTPM
Hypothalamus	8.8 nTPM
Basal ganglia	7.0 nTPM
Cerebral cortex	7.0 nTPM
Amygdala	4.7 nTPM
Hippocampus	4.6 nTPM

Deep-layer near-projecting	11.7 nTPM
Hippocampus	14.0 nTPM
Hypothalamus	12.6 nTPM
Basal ganglia	11.9 nTPM
Amygdala	10.3 nTPM
Cerebral cortex	9.7 nTPM

Eccentric medium spiny neuron	2.0 nTPM
Hypothalamus	2.7 nTPM
Cerebral cortex	2.2 nTPM
Hippocampus	2.1 nTPM
Amygdala	2.0 nTPM
Thalamus	1.6 nTPM
Basal ganglia	1.3 nTPM