Single cell type - ITPRIP - The Human Protein Atlas

ITPRIP

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ITPRIP
Gene descriptionⁱ Full gene name according to HGNC.	Inositol 1,4,5-trisphosphate receptor interacting protein
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Squamous epithelial cells - Keratinization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Squamous epithelial cells, Adipocytes, Suprabasal keratinocytes, Basal squamous epithelial cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.59
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Group enriched (Endothelial cell, Vascular associated smooth muscle cell, Leukocyte, Central nervous system macrophage, Fibroblast, Pericyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (neutrophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Squamous epithelial cells, Adipocytes, Suprabasal keratinocytes, Basal squamous epithelial cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Group enriched (Endothelial cell, Vascular associated smooth muscle cell, Leukocyte, Central nervous system macrophage, Fibroblast, Pericyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (neutrophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ITPRIP is part of cluster 12 Squamous epithelial cells - Keratinization with confidenceⁱ 1
309 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ETS2	ETS proto-oncogene 2, transcription factor	0.7018	29
NFE2L2	NFE2 like bZIP transcription factor 2	0.6415	29
NKX2-3	NK2 homeobox 3	0.6289	12
SIM2	SIM bHLH transcription factor 2	0.6139	12
ITPKC	Inositol-trisphosphate 3-kinase C	0.5973	12
FOSL1	FOS like 1, AP-1 transcription factor subunit	0.5944	12
SOX15	SRY-box transcription factor 15	0.5803	12
BAG3	BAG cochaperone 3	0.5797	80
SOX7	SRY-box transcription factor 7	0.5782	41
LTB4R	Leukotriene B4 receptor	0.5633	12
LTB4R2	Leukotriene B4 receptor 2	0.5629	12
KLHL21	Kelch like family member 21	0.5584	12
KRTAP3-2	Keratin associated protein 3-2	0.5581	12
KRT31	Keratin 31	0.5575	12
ADRB2	Adrenoceptor beta 2	0.5523	12

IMMUNE CELLS

ITPRIP is part of cluster 38 Monocytes & Neutrophils - Degranulation with confidenceⁱ 0.92
501 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENC1	Ectodermal-neural cortex 1	1.0000	38
IFT20	Intraflagellar transport 20	1.0000	38
DPYD	Dihydropyrimidine dehydrogenase	0.9762	38
RBP7	Retinol binding protein 7	0.9762	38
IGSF6	Immunoglobulin superfamily member 6	0.9762	38
CCNY	Cyclin Y	0.9762	38
FCGRT	Fc gamma receptor and transporter	0.9762	38
DTX2	Deltex E3 ubiquitin ligase 2	0.9762	38
TNFSF13B	TNF superfamily member 13b	0.9524	38
POLD3	DNA polymerase delta 3, accessory subunit	0.9524	7
QSOX1	Quiescin sulfhydryl oxidase 1	0.9524	38
ATP6V0B	ATPase H+ transporting V0 subunit b	0.9524	7
SIRPD	Signal regulatory protein delta	0.9524	7
NUP214	Nucleoporin 214	0.9524	38
THEMIS2	Thymocyte selection associated family member 2	0.9524	38

Adipocytes	95.0 nTPM
Adipose tissue	179.1 nTPM
Breast	10.9 nTPM

Alveolar cells type 1	10.8 nTPM
Lung	10.8 nTPM

Alveolar cells type 2	18.1 nTPM
Lung	18.1 nTPM

Astrocytes	1.2 nTPM
Brain	1.2 nTPM

B-cells	11.1 nTPM
Lymph node	26.0 nTPM
Esophagus	17.7 nTPM
Adipose tissue	13.6 nTPM
Spleen	13.4 nTPM
Thymus	10.9 nTPM
Skin	10.2 nTPM
Liver	9.7 nTPM
Lung	9.4 nTPM
Stomach	9.3 nTPM
Salivary gland	8.5 nTPM
Bone marrow	7.9 nTPM
PBMC	7.7 nTPM
Kidney	0.0 nTPM

Ciliated cells	8.9 nTPM
Endometrium	11.2 nTPM
Bronchus	10.4 nTPM
Fallopian tube	9.4 nTPM
Lung	4.6 nTPM

Club cells	9.4 nTPM
Bronchus	12.3 nTPM
Lung	9.5 nTPM
Prostate	6.5 nTPM

Endothelial cells	53.7 nTPM
Skin	121.2 nTPM
Lung	120.5 nTPM
Liver	94.5 nTPM
Vascular	70.1 nTPM
Fallopian tube	60.6 nTPM
Skeletal muscle	59.0 nTPM
Tongue	58.1 nTPM
Thymus	56.0 nTPM
Prostate	55.0 nTPM
Salivary gland	52.9 nTPM
Esophagus	52.6 nTPM
Endometrium	38.9 nTPM
Ovary	35.0 nTPM
Placenta	28.4 nTPM
Pancreas	25.9 nTPM
Testis	19.8 nTPM
Heart muscle	12.0 nTPM
Breast	7.0 nTPM

Enteroendocrine cells	0.4 nTPM
Colon	1.2 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	17.8 nTPM
Liver	94.9 nTPM
Stomach	34.6 nTPM
Thymus	19.0 nTPM
Esophagus	17.9 nTPM
Pancreas	15.2 nTPM
Skin	15.0 nTPM
Skeletal muscle	14.7 nTPM
Fallopian tube	14.2 nTPM
Vascular	12.5 nTPM
Prostate	9.2 nTPM
Lung	8.5 nTPM
Salivary gland	8.0 nTPM
Placenta	7.8 nTPM
Heart muscle	5.2 nTPM
Breast	4.0 nTPM
Adipose tissue	3.8 nTPM

Granulocytes	17.0 nTPM
Tongue	29.1 nTPM
Lung	13.1 nTPM
Fallopian tube	8.8 nTPM

Intestinal goblet cells	3.1 nTPM
Small intestine	4.1 nTPM
Rectum	3.1 nTPM
Colon	2.2 nTPM

Lymphatic endothelial cells	36.2 nTPM
Fallopian tube	66.9 nTPM
Ovary	5.5 nTPM

Macrophages	37.6 nTPM
Fallopian tube	99.5 nTPM
Stomach	79.7 nTPM
Adipose tissue	75.0 nTPM
Skeletal muscle	48.2 nTPM
Esophagus	47.5 nTPM
Tongue	45.9 nTPM
Vascular	45.6 nTPM
Spleen	44.1 nTPM
Salivary gland	42.9 nTPM
Thymus	32.1 nTPM
Lung	29.8 nTPM
Endometrium	23.4 nTPM
Skin	22.3 nTPM
Bone marrow	21.3 nTPM
Testis	16.1 nTPM
Prostate	12.6 nTPM
Breast	12.4 nTPM
Pancreas	8.2 nTPM
Kidney	7.1 nTPM

Paneth cells	0.6 nTPM
Rectum	1.9 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Bipolar cells	1.1 nTPM
Eye	1.1 nTPM

Collecting duct cells	5.8 nTPM
Kidney	5.8 nTPM

Cytotrophoblasts	7.4 nTPM
Placenta	7.4 nTPM

Distal enterocytes	1.4 nTPM
Rectum	2.1 nTPM
Colon	0.7 nTPM

Plasma cells	10.1 nTPM
Esophagus	20.8 nTPM
Salivary gland	13.0 nTPM
Bone marrow	10.6 nTPM
Spleen	9.9 nTPM
Stomach	8.8 nTPM
Thymus	7.6 nTPM
Fallopian tube	6.1 nTPM
Liver	4.0 nTPM

Schwann cells	15.2 nTPM
Adipose tissue	20.7 nTPM
Vascular	13.1 nTPM
Esophagus	12.0 nTPM

Serous glandular cells	13.7 nTPM
Tongue	17.7 nTPM
Salivary gland	9.8 nTPM

Smooth muscle cells	21.4 nTPM
Liver	65.8 nTPM
Lung	44.7 nTPM
Tongue	25.1 nTPM
Skin	23.0 nTPM
Skeletal muscle	21.8 nTPM
Fallopian tube	20.0 nTPM
Ovary	19.9 nTPM
Prostate	19.5 nTPM
Adipose tissue	18.9 nTPM
Thymus	17.4 nTPM
Vascular	15.9 nTPM
Esophagus	14.4 nTPM
Endometrium	11.1 nTPM
Salivary gland	9.7 nTPM
Breast	9.4 nTPM
Placenta	6.4 nTPM

Suprabasal keratinocytes	93.6 nTPM
Tongue	98.1 nTPM
Skin	89.2 nTPM

T-cells	26.1 nTPM
Adipose tissue	63.3 nTPM
Spleen	49.3 nTPM
Lymph node	40.0 nTPM
Stomach	35.1 nTPM
Esophagus	34.1 nTPM
Colon	32.2 nTPM
Skeletal muscle	31.8 nTPM
Skin	31.2 nTPM
Endometrium	26.0 nTPM
Fallopian tube	24.4 nTPM
Breast	23.3 nTPM
Bone marrow	22.6 nTPM
Lung	22.3 nTPM
Thymus	21.5 nTPM
Vascular	20.9 nTPM
Tongue	19.1 nTPM
Salivary gland	16.7 nTPM
Liver	14.5 nTPM
Prostate	10.1 nTPM
PBMC	6.5 nTPM
Kidney	2.7 nTPM

Undifferentiated cells	2.2 nTPM
Rectum	2.8 nTPM
Colon	2.6 nTPM
Small intestine	1.2 nTPM

Amygdala excitatory	0.7 nTPM
Hippocampus	1.1 nTPM
Basal ganglia	1.0 nTPM
Cerebral cortex	0.9 nTPM
Amygdala	0.6 nTPM
Thalamus	0.5 nTPM
Hypothalamus	0.3 nTPM

Astrocyte	5.5 nTPM
Spinal cord	10.0 nTPM
Pons	9.7 nTPM
Midbrain	8.7 nTPM
Thalamus	5.6 nTPM
Medulla oblongata	5.5 nTPM
Cerebellum	4.5 nTPM
Cerebral cortex	3.7 nTPM
Hypothalamus	3.7 nTPM
Basal ganglia	3.4 nTPM
Hippocampus	3.0 nTPM
Amygdala	2.2 nTPM

Bergmann glia	1.3 nTPM
Medulla oblongata	2.1 nTPM
Cerebellum	1.8 nTPM
Pons	0.0 nTPM

Central nervous system macrophage	27.5 nTPM
Hippocampus	33.3 nTPM
Cerebral cortex	31.5 nTPM
Medulla oblongata	29.8 nTPM
Pons	28.1 nTPM
Thalamus	28.0 nTPM
Midbrain	27.7 nTPM
Cerebellum	27.2 nTPM
Basal ganglia	26.6 nTPM
Amygdala	25.8 nTPM
Hypothalamus	23.0 nTPM
Spinal cord	21.2 nTPM

Cerebellar inhibitory	0.1 nTPM
Medulla oblongata	0.2 nTPM
Cerebellum	0.1 nTPM
Pons	0.1 nTPM
Midbrain	0.0 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	0.8 nTPM
Midbrain	1.1 nTPM
Cerebral cortex	1.0 nTPM
Hippocampus	1.0 nTPM
Thalamus	0.8 nTPM
Basal ganglia	0.6 nTPM
Amygdala	0.4 nTPM
Hypothalamus	0.3 nTPM

Choroid plexus epithelial cell	5.2 nTPM
Basal ganglia	9.9 nTPM
Hippocampus	5.5 nTPM
Medulla oblongata	5.3 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	0.7 nTPM
Cerebral cortex	1.9 nTPM
Medulla oblongata	1.3 nTPM
Amygdala	1.1 nTPM
Basal ganglia	1.1 nTPM
Thalamus	0.9 nTPM
Hypothalamus	0.7 nTPM
Hippocampus	0.5 nTPM
Cerebellum	0.0 nTPM
Midbrain	0.0 nTPM
Pons	0.0 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	1.1 nTPM
Hypothalamus	1.9 nTPM
Basal ganglia	1.5 nTPM
Amygdala	1.2 nTPM
Cerebral cortex	1.2 nTPM
Hippocampus	1.0 nTPM
Midbrain	0.0 nTPM

Deep-layer intratelencephalic	0.5 nTPM
Hippocampus	0.7 nTPM
Amygdala	0.5 nTPM
Cerebral cortex	0.5 nTPM
Hypothalamus	0.3 nTPM
Basal ganglia	0.2 nTPM

Deep-layer near-projecting	1.8 nTPM
Hypothalamus	2.4 nTPM
Hippocampus	2.3 nTPM
Basal ganglia	2.0 nTPM
Amygdala	1.4 nTPM
Cerebral cortex	1.0 nTPM

Eccentric medium spiny neuron	2.9 nTPM
Amygdala	3.4 nTPM
Hippocampus	3.3 nTPM
Cerebral cortex	3.2 nTPM
Hypothalamus	2.8 nTPM
Thalamus	2.6 nTPM
Basal ganglia	2.2 nTPM

Endothelial cell	51.8 nTPM
Hypothalamus	120.3 nTPM
Basal ganglia	93.2 nTPM
Amygdala	51.4 nTPM
Cerebellum	50.3 nTPM
Midbrain	49.1 nTPM
Medulla oblongata	48.2 nTPM
Cerebral cortex	42.8 nTPM
Pons	33.1 nTPM
Hippocampus	27.9 nTPM
Thalamus	27.7 nTPM
Spinal cord	25.9 nTPM