Single cell type - RSPO2 - The Human Protein Atlas

RSPO2

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RSPO2
Gene descriptionⁱ Full gene name according to HGNC.	R-spondin 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neurons - Neuronal signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Oocytes, Inhibitory neurons, Excitatory neurons)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.94
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (MGE interneuron, Miscellaneous)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data.	Protein predicted to be secreted

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Group enriched (Oocytes, Inhibitory neurons, Excitatory neurons)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (MGE interneuron, Miscellaneous)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

RSPO2 is part of cluster 8 Neurons - Neuronal signaling with confidenceⁱ 0.99
265 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
COLEC10	Collectin subfamily member 10	0.6924	50
SMYD3	SET and MYND domain containing 3	0.6361	8
RBFOX1	RNA binding fox-1 homolog 1	0.6230	8
CEMIP	Cell migration inducing hyaluronidase 1	0.6190	34
BIVM-ERCC5	BIVM-ERCC5 readthrough	0.5991	8
RGS4	Regulator of G protein signaling 4	0.5978	50
KCNT1	Potassium sodium-activated channel subfamily T member 1	0.5923	8
SLC4A10	Solute carrier family 4 member 10	0.5879	8
OVCH1	Ovochymase 1	0.5845	8
SLIT2	Slit guidance ligand 2	0.5790	8
HTR4	5-hydroxytryptamine receptor 4	0.5668	8
USP45	Ubiquitin specific peptidase 45	0.5614	44
EIF4E1B	Eukaryotic translation initiation factor 4E family member 1B	0.5602	44
DLGAP2	DLG associated protein 2	0.5586	8
HCN1	Hyperpolarization activated cyclic nucleotide gated potassium channel 1	0.5572	8

Adipocytes	0.0 nTPM
Adipose tissue	0.0 nTPM
Breast	0.0 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	0.0 nTPM
Lung	0.0 nTPM

Astrocytes	4.3 nTPM
Brain	4.3 nTPM

B-cells	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM

Ciliated cells	0.0 nTPM
Endometrium	0.0 nTPM
Bronchus	0.0 nTPM
Lung	0.0 nTPM
Fallopian tube	0.0 nTPM

Club cells	0.0 nTPM
Bronchus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM

Endothelial cells	0.0 nTPM
Esophagus	0.5 nTPM
Ovary	0.3 nTPM
Testis	0.0 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.1 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	0.8 nTPM
Esophagus	4.3 nTPM
Lung	3.5 nTPM
Placenta	2.1 nTPM
Prostate	1.3 nTPM
Vascular	0.6 nTPM
Heart muscle	0.3 nTPM
Thymus	0.3 nTPM
Skeletal muscle	0.2 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

Granulocytes	0.0 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM
Fallopian tube	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	0.0 nTPM
Fallopian tube	0.0 nTPM
Ovary	0.0 nTPM

Macrophages	0.0 nTPM
Fallopian tube	0.2 nTPM
Testis	0.0 nTPM
Kidney	0.0 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Early spermatids	1.6 nTPM
Testis	1.6 nTPM

Plasma cells	0.0 nTPM
Thymus	0.1 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM
Fallopian tube	0.0 nTPM

Schwann cells	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Vascular	0.0 nTPM

Serous glandular cells	0.1 nTPM
Salivary gland	0.1 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	4.9 nTPM
Placenta	75.3 nTPM
Prostate	1.2 nTPM
Liver	0.4 nTPM
Skin	0.3 nTPM
Tongue	0.3 nTPM
Thymus	0.1 nTPM
Endometrium	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Salivary gland	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM
Ovary	0.0 nTPM

T-cells	0.0 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
Endometrium	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

Undifferentiated cells	0.0 nTPM
Colon	0.1 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Amygdala excitatory	44.6 nTPM
Cerebral cortex	95.8 nTPM
Hippocampus	76.5 nTPM
Amygdala	46.2 nTPM
Basal ganglia	25.7 nTPM
Hypothalamus	12.3 nTPM
Thalamus	10.9 nTPM

Astrocyte	17.0 nTPM
Hypothalamus	50.3 nTPM
Midbrain	26.4 nTPM
Basal ganglia	18.6 nTPM
Hippocampus	17.4 nTPM
Medulla oblongata	16.7 nTPM
Pons	16.4 nTPM
Thalamus	14.2 nTPM
Cerebellum	9.0 nTPM
Spinal cord	7.2 nTPM
Amygdala	5.9 nTPM
Cerebral cortex	4.8 nTPM

Bergmann glia	10.0 nTPM
Pons	14.4 nTPM
Cerebellum	13.5 nTPM
Medulla oblongata	2.1 nTPM

Central nervous system macrophage	1.1 nTPM
Cerebral cortex	3.7 nTPM
Hypothalamus	1.5 nTPM
Amygdala	1.2 nTPM
Hippocampus	1.0 nTPM
Medulla oblongata	1.0 nTPM
Midbrain	0.9 nTPM
Basal ganglia	0.8 nTPM
Cerebellum	0.7 nTPM
Pons	0.7 nTPM
Thalamus	0.7 nTPM
Spinal cord	0.6 nTPM

Cerebellar inhibitory	3.7 nTPM
Pons	7.4 nTPM
Cerebellum	4.6 nTPM
Medulla oblongata	3.7 nTPM
Midbrain	2.8 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	3.1 nTPM
Cerebral cortex	4.8 nTPM
Hippocampus	4.3 nTPM
Midbrain	3.4 nTPM
Amygdala	2.9 nTPM
Basal ganglia	2.4 nTPM
Hypothalamus	2.3 nTPM
Thalamus	1.7 nTPM

Choroid plexus epithelial cell	1.1 nTPM
Thalamus	2.7 nTPM
Basal ganglia	0.7 nTPM
Medulla oblongata	0.7 nTPM
Hippocampus	0.0 nTPM

Committed oligodendrocyte precursor	5.6 nTPM
Hypothalamus	17.8 nTPM
Amygdala	11.3 nTPM
Thalamus	10.6 nTPM
Cerebral cortex	5.7 nTPM
Hippocampus	5.2 nTPM
Basal ganglia	4.4 nTPM
Medulla oblongata	3.9 nTPM
Midbrain	2.5 nTPM
Pons	0.9 nTPM
Cerebellum	0.0 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	63.8 nTPM
Cerebral cortex	104.1 nTPM
Midbrain	82.1 nTPM
Amygdala	74.3 nTPM
Basal ganglia	44.0 nTPM
Hippocampus	43.5 nTPM
Hypothalamus	34.6 nTPM

Deep-layer intratelencephalic	37.3 nTPM
Cerebral cortex	51.1 nTPM
Hypothalamus	46.8 nTPM
Basal ganglia	35.0 nTPM
Amygdala	28.4 nTPM
Hippocampus	25.2 nTPM

Deep-layer near-projecting	6.5 nTPM
Cerebral cortex	11.3 nTPM
Hippocampus	8.5 nTPM
Amygdala	6.6 nTPM
Basal ganglia	4.0 nTPM
Hypothalamus	2.1 nTPM

Eccentric medium spiny neuron	2.2 nTPM
Amygdala	4.9 nTPM
Cerebral cortex	3.3 nTPM
Hypothalamus	1.6 nTPM
Thalamus	1.6 nTPM
Basal ganglia	1.4 nTPM
Hippocampus	0.4 nTPM

Endothelial cell	1.2 nTPM
Hypothalamus	2.5 nTPM
Basal ganglia	1.9 nTPM
Midbrain	1.9 nTPM
Spinal cord	1.7 nTPM
Cerebellum	1.5 nTPM
Cerebral cortex	1.3 nTPM
Amygdala	1.1 nTPM
Hippocampus	1.0 nTPM
Thalamus	0.6 nTPM
Medulla oblongata	0.0 nTPM
Pons	0.0 nTPM

Ependymal cell	50.5 nTPM
Basal ganglia	134.7 nTPM
Hypothalamus	113.3 nTPM
Thalamus	88.3 nTPM
Midbrain	42.5 nTPM
Hippocampus	26.6 nTPM
Medulla oblongata	22.6 nTPM
Pons	16.5 nTPM
Amygdala	6.3 nTPM
Spinal cord	3.8 nTPM