Single cell type - MSN - The Human Protein Atlas

MSN

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MSN
Gene descriptionⁱ Full gene name according to HGNC.	Moesin
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Monocytes, NK-cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.46
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Leukocyte, Endothelial cell, Central nervous system macrophage)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Monocytes, NK-cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Leukocyte, Endothelial cell, Central nervous system macrophage)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

MSN is part of cluster 45 Non-specific - Mixed function with confidenceⁱ 1
349 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PKN1	Protein kinase N1	0.6820	33
MYH9	Myosin heavy chain 9	0.6332	32
ITGA3	Integrin subunit alpha 3	0.6036	45
ARHGDIA	Rho GDP dissociation inhibitor alpha	0.5653	45
KCTD10	Potassium channel tetramerization domain containing 10	0.5640	32
FLII	FLII actin remodeling protein	0.5566	45
EIF4G2	Eukaryotic translation initiation factor 4 gamma 2	0.5295	45
TIMP1	TIMP metallopeptidase inhibitor 1	0.5173	29
FLNA	Filamin A	0.5173	32
ITGB1	Integrin subunit beta 1	0.5161	45
DIAPH1	Diaphanous related formin 1	0.5155	45
TXNRD1	Thioredoxin reductase 1	0.5121	72
TRIM47	Tripartite motif containing 47	0.5116	45
AGER	Advanced glycosylation end-product specific receptor	0.5098	72
TPM4	Tropomyosin 4	0.5017	45

IMMUNE CELLS

MSN is part of cluster 38 Monocytes & Neutrophils - Degranulation with confidenceⁱ 1
501 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IL10RB	Interleukin 10 receptor subunit beta	1.0000	38
DENND5A	DENN domain containing 5A	1.0000	38
BAIAP2	BAR/IMD domain containing adaptor protein 2	1.0000	38
COQ2	Coenzyme Q2, polyprenyltransferase	1.0000	38
ADAMTSL4	ADAMTS like 4	1.0000	38
CYBRD1	Cytochrome b reductase 1	1.0000	38
TMEM33	Transmembrane protein 33	0.9762	38
DGLUCY	D-glutamate cyclase	0.9762	37
SIGLEC9	Sialic acid binding Ig like lectin 9	0.9762	38
TM9SF2	Transmembrane 9 superfamily member 2	0.9762	38
TMEM30A	Transmembrane protein 30A	0.9762	37
AKAP10	A-kinase anchoring protein 10	0.9762	38
STK3	Serine/threonine kinase 3	0.9762	38
CPPED1	Calcineurin like phosphoesterase domain containing 1	0.9762	37
MON1B	MON1 homolog B, secretory trafficking associated	0.9762	38

Adipocytes	232.8 nTPM
Adipose tissue	283.5 nTPM
Breast	182.1 nTPM

Alveolar cells type 1	317.2 nTPM
Lung	317.2 nTPM

Alveolar cells type 2	233.2 nTPM
Lung	233.2 nTPM

Astrocytes	18.9 nTPM
Brain	18.9 nTPM

B-cells	164.7 nTPM
Salivary gland	261.2 nTPM
Thymus	241.9 nTPM
Lymph node	191.0 nTPM
Esophagus	182.9 nTPM
Stomach	178.0 nTPM
Adipose tissue	162.6 nTPM
Lung	162.3 nTPM
Spleen	138.8 nTPM
Skin	135.5 nTPM
PBMC	133.9 nTPM
Bone marrow	131.8 nTPM
Kidney	124.8 nTPM
Liver	96.6 nTPM

Ciliated cells	31.6 nTPM
Fallopian tube	38.6 nTPM
Lung	37.0 nTPM
Endometrium	36.8 nTPM
Bronchus	14.2 nTPM

Club cells	24.0 nTPM
Lung	48.5 nTPM
Prostate	12.7 nTPM
Bronchus	11.0 nTPM

Dendritic cells	81.7 nTPM
Adipose tissue	109.5 nTPM
PBMC	54.0 nTPM

Endothelial cells	243.8 nTPM
Lung	659.1 nTPM
Fallopian tube	527.8 nTPM
Pancreas	413.6 nTPM
Skin	364.8 nTPM
Thymus	270.7 nTPM
Vascular	242.8 nTPM
Salivary gland	232.6 nTPM
Skeletal muscle	229.8 nTPM
Endometrium	202.5 nTPM
Esophagus	186.2 nTPM
Placenta	167.5 nTPM
Tongue	156.4 nTPM
Heart muscle	140.3 nTPM
Testis	139.2 nTPM
Prostate	136.7 nTPM
Breast	129.2 nTPM
Ovary	112.9 nTPM
Liver	76.8 nTPM

Enteroendocrine cells	1.0 nTPM
Rectum	1.7 nTPM
Colon	1.4 nTPM
Small intestine	0.0 nTPM

Fibroblasts	90.4 nTPM
Pancreas	227.4 nTPM
Vascular	133.4 nTPM
Lung	127.3 nTPM
Skin	107.5 nTPM
Stomach	102.3 nTPM
Liver	96.1 nTPM
Thymus	92.3 nTPM
Heart muscle	87.1 nTPM
Skeletal muscle	84.2 nTPM
Salivary gland	81.9 nTPM
Fallopian tube	77.1 nTPM
Adipose tissue	63.6 nTPM
Prostate	62.7 nTPM
Esophagus	56.6 nTPM
Breast	35.6 nTPM
Placenta	10.9 nTPM

Granulocytes	170.0 nTPM
Fallopian tube	219.1 nTPM
Lung	174.5 nTPM
Tongue	116.4 nTPM

Intestinal goblet cells	2.2 nTPM
Rectum	3.4 nTPM
Small intestine	3.3 nTPM
Colon	0.0 nTPM

Lymphatic endothelial cells	168.6 nTPM
Fallopian tube	239.0 nTPM
Ovary	98.2 nTPM

Macrophages	260.5 nTPM
Fallopian tube	401.8 nTPM
Adipose tissue	391.7 nTPM
Skeletal muscle	331.7 nTPM
Lung	310.7 nTPM
Salivary gland	285.7 nTPM
Tongue	284.9 nTPM
Bone marrow	284.8 nTPM
Kidney	265.5 nTPM
Spleen	264.7 nTPM
Stomach	262.4 nTPM
Thymus	258.7 nTPM
Vascular	254.4 nTPM
Testis	248.0 nTPM
Prostate	219.2 nTPM
Pancreas	217.9 nTPM
Skin	188.3 nTPM
Endometrium	179.0 nTPM
Esophagus	173.4 nTPM
Breast	127.0 nTPM

Basal keratinocytes	151.8 nTPM
Skin	226.5 nTPM
Tongue	77.2 nTPM

Basal prostatic cells	40.2 nTPM
Prostate	40.2 nTPM

Basal respiratory cells	53.0 nTPM
Bronchus	53.0 nTPM

Basal squamous epithelial cells	34.3 nTPM
Esophagus	34.3 nTPM

Paneth cells	1.2 nTPM
Rectum	3.6 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	109.5 nTPM
Thymus	176.6 nTPM
Bone marrow	145.0 nTPM
Fallopian tube	120.6 nTPM
Salivary gland	112.4 nTPM
Spleen	98.4 nTPM
Stomach	91.7 nTPM
Liver	90.1 nTPM
Esophagus	41.6 nTPM

Schwann cells	170.8 nTPM
Adipose tissue	292.8 nTPM
Vascular	123.8 nTPM
Esophagus	95.8 nTPM

Serous glandular cells	57.9 nTPM
Salivary gland	71.6 nTPM
Tongue	44.2 nTPM

Smooth muscle cells	128.9 nTPM
Vascular	236.9 nTPM
Thymus	211.6 nTPM
Fallopian tube	177.8 nTPM
Skin	156.9 nTPM
Skeletal muscle	128.0 nTPM
Prostate	120.4 nTPM
Lung	117.6 nTPM
Adipose tissue	116.7 nTPM
Liver	115.0 nTPM
Salivary gland	114.6 nTPM
Breast	107.7 nTPM
Esophagus	104.5 nTPM
Ovary	102.3 nTPM
Endometrium	96.5 nTPM
Tongue	92.8 nTPM
Placenta	62.5 nTPM

Suprabasal keratinocytes	90.1 nTPM
Skin	154.0 nTPM
Tongue	26.2 nTPM

T-cells	231.2 nTPM
Fallopian tube	419.2 nTPM
Adipose tissue	342.0 nTPM
Lung	326.8 nTPM
Tongue	325.5 nTPM
Thymus	269.9 nTPM
Prostate	251.7 nTPM
Skeletal muscle	249.1 nTPM
Bone marrow	235.7 nTPM
Vascular	231.6 nTPM
Stomach	221.3 nTPM
Salivary gland	213.5 nTPM
Endometrium	209.4 nTPM
Kidney	186.2 nTPM
Breast	186.0 nTPM
Colon	184.3 nTPM
Esophagus	182.5 nTPM
Spleen	182.4 nTPM
Liver	175.6 nTPM
PBMC	167.5 nTPM
Skin	151.1 nTPM
Lymph node	144.3 nTPM

Undifferentiated cells	3.5 nTPM
Colon	8.8 nTPM
Rectum	1.5 nTPM
Small intestine	0.2 nTPM

Amygdala excitatory	1.5 nTPM
Basal ganglia	2.6 nTPM
Hypothalamus	1.6 nTPM
Amygdala	1.4 nTPM
Thalamus	1.4 nTPM
Cerebral cortex	1.2 nTPM
Hippocampus	1.1 nTPM

Astrocyte	53.3 nTPM
Spinal cord	153.8 nTPM
Medulla oblongata	72.5 nTPM
Cerebellum	61.0 nTPM
Hypothalamus	58.2 nTPM
Pons	41.0 nTPM
Hippocampus	35.7 nTPM
Basal ganglia	35.0 nTPM
Midbrain	34.3 nTPM
Amygdala	32.7 nTPM
Cerebral cortex	32.3 nTPM
Thalamus	30.2 nTPM

Bergmann glia	66.8 nTPM
Pons	70.5 nTPM
Cerebellum	68.2 nTPM
Medulla oblongata	61.8 nTPM

Central nervous system macrophage	212.6 nTPM
Hypothalamus	314.7 nTPM
Spinal cord	249.1 nTPM
Cerebellum	233.3 nTPM
Midbrain	206.7 nTPM
Basal ganglia	204.8 nTPM
Medulla oblongata	203.3 nTPM
Amygdala	200.2 nTPM
Pons	199.4 nTPM
Thalamus	186.4 nTPM
Hippocampus	173.6 nTPM
Cerebral cortex	167.3 nTPM

Cerebellar inhibitory	2.7 nTPM
Spinal cord	5.5 nTPM
Cerebellum	2.3 nTPM
Pons	2.0 nTPM
Midbrain	1.9 nTPM
Medulla oblongata	1.7 nTPM

Cge interneuron	10.3 nTPM
Hypothalamus	17.1 nTPM
Amygdala	11.8 nTPM
Basal ganglia	11.2 nTPM
Hippocampus	11.0 nTPM
Cerebral cortex	10.1 nTPM
Midbrain	5.5 nTPM
Thalamus	5.1 nTPM

Choroid plexus epithelial cell	42.3 nTPM
Basal ganglia	58.6 nTPM
Hippocampus	41.6 nTPM
Medulla oblongata	38.7 nTPM
Thalamus	30.1 nTPM

Committed oligodendrocyte precursor	12.0 nTPM
Basal ganglia	20.8 nTPM
Thalamus	19.1 nTPM
Cerebellum	15.9 nTPM
Hippocampus	15.8 nTPM
Cerebral cortex	12.0 nTPM
Hypothalamus	11.6 nTPM
Amygdala	10.7 nTPM
Pons	8.0 nTPM
Spinal cord	7.4 nTPM
Medulla oblongata	6.5 nTPM
Midbrain	4.2 nTPM

Deep-layer corticothalamic and 6b	1.1 nTPM
Hypothalamus	2.2 nTPM
Amygdala	1.2 nTPM
Cerebral cortex	1.2 nTPM
Basal ganglia	1.0 nTPM
Hippocampus	1.0 nTPM
Midbrain	0.0 nTPM

Deep-layer intratelencephalic	2.1 nTPM
Basal ganglia	2.8 nTPM
Hypothalamus	2.7 nTPM
Amygdala	1.8 nTPM
Cerebral cortex	1.8 nTPM
Hippocampus	1.2 nTPM

Deep-layer near-projecting	1.1 nTPM
Cerebral cortex	1.3 nTPM
Basal ganglia	1.2 nTPM
Hypothalamus	1.1 nTPM
Hippocampus	1.0 nTPM
Amygdala	0.7 nTPM

Eccentric medium spiny neuron	1.8 nTPM
Cerebral cortex	2.5 nTPM
Hippocampus	2.1 nTPM
Amygdala	1.7 nTPM
Basal ganglia	1.6 nTPM
Hypothalamus	1.5 nTPM
Thalamus	1.4 nTPM