Single cell type - BOD1 - The Human Protein Atlas

BOD1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BOD1
Gene descriptionⁱ Full gene name according to HGNC.	Biorientation of chromosomes in cell division 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Oocytes - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.36
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

BOD1 is part of cluster 44 Oocytes - Unknown function with confidenceⁱ 1
133 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PIGC	Phosphatidylinositol glycan anchor biosynthesis class C	0.5555	39
MYO1H	Myosin IH	0.5170	44
CCNB1IP1	Cyclin B1 interacting protein 1	0.5146	6
TMEM18	Transmembrane protein 18	0.4851	6
RBMX2	RNA binding motif protein X-linked 2	0.4807	44
LCMT1	Leucine carboxyl methyltransferase 1	0.4781	24
PAIP1	Poly(A) binding protein interacting protein 1	0.4747	44
NOB1	NIN1 (RPN12) binding protein 1 homolog	0.4718	64
COPS7B	COP9 signalosome subunit 7B	0.4637	44
TTC9C	Tetratricopeptide repeat domain 9C	0.4416	44
FOXO6	Forkhead box O6	0.4370	10
SLC38A8	Solute carrier family 38 member 8	0.4356	44
CHRNB4	Cholinergic receptor nicotinic beta 4 subunit	0.4308	11
H2BK1	H2B.K variant histone 1	0.4299	44
SGF29	SAGA complex associated factor 29	0.4287	11

IMMUNE CELLS

BOD1 is part of cluster 45 Eosinophils - Unknown function with confidenceⁱ 0.53
257 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ARID5A	AT-rich interaction domain 5A	1.0000	45
TMEM185A	Transmembrane protein 185A	0.9524	45
RNF115	Ring finger protein 115	0.9524	45
DNMT3A	DNA methyltransferase 3 alpha	0.9524	22
KLHL28	Kelch like family member 28	0.9524	45
FAM168B	Family with sequence similarity 168 member B	0.9524	45
KRT10	Keratin 10	0.9286	45
PPAN	Peter pan homolog	0.9286	45
ZNF428	Zinc finger protein 428	0.9286	45
MIEF2	Mitochondrial elongation factor 2	0.9286	45
PRMT2	Protein arginine methyltransferase 2	0.9286	45
GOLGA4	Golgin A4	0.9048	22
FBXL17	F-box and leucine rich repeat protein 17	0.9048	22
YY1	YY1 transcription factor	0.9048	45
SCRN2	Secernin 2	0.9048	45

Adipocytes	54.9 nTPM
Adipose tissue	59.1 nTPM
Breast	50.8 nTPM

Alveolar cells type 1	36.4 nTPM
Lung	36.4 nTPM

Alveolar cells type 2	41.2 nTPM
Lung	41.2 nTPM

Astrocytes	7.1 nTPM
Brain	7.1 nTPM

B-cells	21.8 nTPM
PBMC	29.2 nTPM
Bone marrow	28.0 nTPM
Lung	26.8 nTPM
Stomach	24.0 nTPM
Adipose tissue	23.5 nTPM
Salivary gland	23.4 nTPM
Skin	22.0 nTPM
Spleen	21.6 nTPM
Kidney	20.8 nTPM
Thymus	20.5 nTPM
Esophagus	17.7 nTPM
Liver	14.5 nTPM
Lymph node	10.8 nTPM

Ciliated cells	21.8 nTPM
Fallopian tube	28.4 nTPM
Lung	24.9 nTPM
Endometrium	24.2 nTPM
Bronchus	9.7 nTPM

Club cells	26.8 nTPM
Prostate	35.3 nTPM
Lung	32.5 nTPM
Bronchus	12.7 nTPM

Dendritic cells	20.2 nTPM
Adipose tissue	26.0 nTPM
PBMC	14.4 nTPM

Endothelial cells	42.6 nTPM
Breast	63.3 nTPM
Lung	61.8 nTPM
Skin	61.7 nTPM
Fallopian tube	58.7 nTPM
Placenta	51.1 nTPM
Skeletal muscle	49.7 nTPM
Pancreas	46.5 nTPM
Testis	42.1 nTPM
Thymus	41.8 nTPM
Ovary	41.7 nTPM
Endometrium	41.0 nTPM
Esophagus	40.5 nTPM
Salivary gland	36.1 nTPM
Prostate	33.8 nTPM
Tongue	33.8 nTPM
Vascular	31.0 nTPM
Liver	18.9 nTPM
Heart muscle	13.9 nTPM

Enteroendocrine cells	25.1 nTPM
Colon	33.1 nTPM
Rectum	25.2 nTPM
Small intestine	17.2 nTPM

Fibroblasts	47.7 nTPM
Placenta	81.9 nTPM
Adipose tissue	70.2 nTPM
Breast	57.1 nTPM
Fallopian tube	53.1 nTPM
Skeletal muscle	52.3 nTPM
Skin	52.2 nTPM
Salivary gland	50.5 nTPM
Thymus	48.9 nTPM
Prostate	45.5 nTPM
Lung	45.0 nTPM
Vascular	43.8 nTPM
Pancreas	41.0 nTPM
Esophagus	37.9 nTPM
Heart muscle	34.5 nTPM
Stomach	31.7 nTPM
Liver	17.8 nTPM

Granulocytes	25.5 nTPM
Fallopian tube	35.2 nTPM
Lung	26.7 nTPM
Tongue	14.6 nTPM

Intestinal goblet cells	25.0 nTPM
Rectum	34.4 nTPM
Colon	28.8 nTPM
Small intestine	11.9 nTPM

Lymphatic endothelial cells	45.5 nTPM
Fallopian tube	52.8 nTPM
Ovary	38.2 nTPM

Macrophages	16.4 nTPM
Lung	28.0 nTPM
Adipose tissue	25.8 nTPM
Skin	24.5 nTPM
Breast	21.5 nTPM
Prostate	21.2 nTPM
Endometrium	17.8 nTPM
Kidney	17.7 nTPM
Salivary gland	17.3 nTPM
Tongue	16.2 nTPM
Fallopian tube	15.4 nTPM
Thymus	15.2 nTPM
Vascular	14.5 nTPM
Testis	13.6 nTPM
Skeletal muscle	12.4 nTPM
Pancreas	12.3 nTPM
Esophagus	11.6 nTPM
Bone marrow	11.1 nTPM
Spleen	10.0 nTPM
Stomach	5.1 nTPM

Basal keratinocytes	52.0 nTPM
Skin	67.1 nTPM
Tongue	36.9 nTPM

Basal prostatic cells	30.6 nTPM
Prostate	30.6 nTPM

Basal respiratory cells	14.1 nTPM
Bronchus	14.1 nTPM

Basal squamous epithelial cells	35.5 nTPM
Esophagus	35.5 nTPM

Paneth cells	18.4 nTPM
Rectum	33.8 nTPM
Colon	18.1 nTPM
Small intestine	3.5 nTPM

Plasma cells	19.7 nTPM
Fallopian tube	33.1 nTPM
Stomach	32.7 nTPM
Salivary gland	21.9 nTPM
Bone marrow	18.1 nTPM
Thymus	15.6 nTPM
Liver	15.5 nTPM
Spleen	15.4 nTPM
Esophagus	5.2 nTPM

Schwann cells	17.3 nTPM
Vascular	27.2 nTPM
Adipose tissue	24.6 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	17.9 nTPM
Salivary gland	35.7 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	40.2 nTPM
Ovary	67.1 nTPM
Endometrium	57.6 nTPM
Placenta	51.0 nTPM
Fallopian tube	48.7 nTPM
Breast	47.2 nTPM
Adipose tissue	37.9 nTPM
Vascular	37.9 nTPM
Skin	37.7 nTPM
Skeletal muscle	36.3 nTPM
Prostate	35.3 nTPM
Salivary gland	32.5 nTPM
Liver	32.3 nTPM
Lung	31.7 nTPM
Tongue	31.1 nTPM
Thymus	29.7 nTPM
Esophagus	28.8 nTPM

Suprabasal keratinocytes	51.2 nTPM
Skin	79.2 nTPM
Tongue	23.3 nTPM

T-cells	17.5 nTPM
PBMC	25.4 nTPM
Adipose tissue	23.6 nTPM
Lung	23.0 nTPM
Thymus	21.9 nTPM
Kidney	21.3 nTPM
Breast	21.3 nTPM
Endometrium	20.7 nTPM
Prostate	20.5 nTPM
Salivary gland	20.1 nTPM
Skin	19.6 nTPM
Liver	17.5 nTPM
Colon	16.6 nTPM
Tongue	16.6 nTPM
Skeletal muscle	15.5 nTPM
Fallopian tube	14.6 nTPM
Bone marrow	14.3 nTPM
Vascular	14.1 nTPM
Stomach	13.2 nTPM
Spleen	11.6 nTPM
Lymph node	10.4 nTPM
Esophagus	4.9 nTPM

Undifferentiated cells	49.6 nTPM
Rectum	52.3 nTPM
Colon	51.9 nTPM
Small intestine	44.5 nTPM

Amygdala excitatory	10.3 nTPM
Basal ganglia	12.1 nTPM
Hippocampus	11.0 nTPM
Cerebral cortex	10.9 nTPM
Thalamus	10.0 nTPM
Amygdala	9.6 nTPM
Hypothalamus	8.4 nTPM

Astrocyte	15.4 nTPM
Cerebral cortex	18.2 nTPM
Amygdala	16.2 nTPM
Hippocampus	15.9 nTPM
Midbrain	15.9 nTPM
Thalamus	15.9 nTPM
Pons	15.1 nTPM
Basal ganglia	14.9 nTPM
Spinal cord	14.8 nTPM
Cerebellum	14.6 nTPM
Hypothalamus	14.1 nTPM
Medulla oblongata	14.0 nTPM

Bergmann glia	15.1 nTPM
Cerebellum	16.5 nTPM
Pons	15.8 nTPM
Medulla oblongata	12.8 nTPM

Central nervous system macrophage	17.1 nTPM
Thalamus	18.9 nTPM
Cerebral cortex	18.7 nTPM
Pons	18.0 nTPM
Amygdala	17.5 nTPM
Hypothalamus	17.2 nTPM
Cerebellum	17.1 nTPM
Medulla oblongata	17.0 nTPM
Midbrain	17.0 nTPM
Spinal cord	16.5 nTPM
Hippocampus	15.3 nTPM
Basal ganglia	15.1 nTPM

Cerebellar inhibitory	13.7 nTPM
Midbrain	16.8 nTPM
Cerebellum	14.5 nTPM
Pons	14.4 nTPM
Medulla oblongata	11.8 nTPM
Spinal cord	11.0 nTPM

Cge interneuron	16.3 nTPM
Thalamus	19.0 nTPM
Basal ganglia	18.3 nTPM
Midbrain	17.1 nTPM
Cerebral cortex	16.0 nTPM
Hippocampus	15.7 nTPM
Amygdala	14.7 nTPM
Hypothalamus	13.1 nTPM

Choroid plexus epithelial cell	11.3 nTPM
Hippocampus	16.6 nTPM
Medulla oblongata	11.8 nTPM
Basal ganglia	11.3 nTPM
Thalamus	5.5 nTPM

Committed oligodendrocyte precursor	20.5 nTPM
Spinal cord	29.4 nTPM
Cerebellum	25.4 nTPM
Hippocampus	25.4 nTPM
Cerebral cortex	24.1 nTPM
Midbrain	21.8 nTPM
Pons	20.4 nTPM
Amygdala	18.6 nTPM
Basal ganglia	17.0 nTPM
Medulla oblongata	15.5 nTPM
Hypothalamus	15.0 nTPM
Thalamus	13.1 nTPM

Deep-layer corticothalamic and 6b	9.8 nTPM
Basal ganglia	11.0 nTPM
Cerebral cortex	10.5 nTPM
Hippocampus	10.0 nTPM
Hypothalamus	10.0 nTPM
Amygdala	9.7 nTPM
Midbrain	7.8 nTPM

Deep-layer intratelencephalic	10.9 nTPM
Basal ganglia	12.2 nTPM
Cerebral cortex	11.6 nTPM
Hippocampus	11.5 nTPM
Amygdala	10.5 nTPM
Hypothalamus	8.8 nTPM

Deep-layer near-projecting	11.3 nTPM
Basal ganglia	13.3 nTPM
Hypothalamus	11.8 nTPM
Hippocampus	11.7 nTPM
Cerebral cortex	11.6 nTPM
Amygdala	8.2 nTPM

Eccentric medium spiny neuron	14.7 nTPM
Hypothalamus	17.6 nTPM
Basal ganglia	15.7 nTPM
Hippocampus	14.9 nTPM
Thalamus	13.9 nTPM
Cerebral cortex	13.3 nTPM
Amygdala	12.6 nTPM