Single cell type - METTL21A - The Human Protein Atlas

METTL21A

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(6 genes):

BAG3 | HSPA2 | HSPA4 ...

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	METTL21A
Gene descriptionⁱ Full gene name according to HGNC.	Methyltransferase 21A, HSPA lysine
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Granulocytes - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Paneth cells, Langerhans cells, Granulocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.38
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Paneth cells, Langerhans cells, Granulocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

METTL21A is part of cluster 30 Granulocytes - Unknown function with confidenceⁱ 1
76 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RGS13	Regulator of G protein signaling 13	0.6357	30
PIK3R6	Phosphoinositide-3-kinase regulatory subunit 6	0.6329	30
OR14L1P	Olfactory receptor family 14 subfamily L member 1 pseudogene	0.6019	30
HPGDS	Hematopoietic prostaglandin D synthase	0.5945	30
CTSG	Cathepsin G	0.5814	30
TPSD1	Tryptase delta 1	0.5781	30
IL13	Interleukin 13	0.5677	36
MAS1L	MAS1 proto-oncogene like, G protein-coupled receptor	0.5632	30
GCSAML	Germinal center associated signaling and motility like	0.5626	30
MRGPRX2	MAS related GPR family member X2	0.5617	30
TPSAB1	Tryptase alpha/beta 1	0.5582	30
HDC	Histidine decarboxylase	0.5581	30
TPSB2	Tryptase beta 2	0.5561	30
CMA1	Chymase 1	0.5545	30
ADCYAP1	Adenylate cyclase activating polypeptide 1	0.5416	30

IMMUNE CELLS

METTL21A is part of cluster 29 Non-specific - Unknown function with confidenceⁱ 0.89
401 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CYSLTR1	Cysteinyl leukotriene receptor 1	1.0000	29
NOTCH2NLA	Notch 2 N-terminal like A	0.9762	29
RUNDC1	RUN domain containing 1	0.9762	29
GCNT1	Glucosaminyl (N-acetyl) transferase 1	0.9762	29
SNX3	Sorting nexin 3	0.9762	29
ARRDC4	Arrestin domain containing 4	0.9762	29
STEEP1	STING1 ER exit protein 1	0.9762	29
CBX8	Chromobox 8	0.9524	29
NUDT3	Nudix hydrolase 3	0.9524	29
CHCHD10	Coiled-coil-helix-coiled-coil-helix domain containing 10	0.9524	29
IRAK1	Interleukin 1 receptor associated kinase 1	0.9524	29
SSNA1	SS nuclear autoantigen 1	0.9524	29
SNF8	SNF8 subunit of ESCRT-II	0.9524	29
GUCD1	Guanylyl cyclase domain containing 1	0.9524	29
DLGAP4	DLG associated protein 4	0.9524	29

Adipocytes	29.1 nTPM
Breast	33.3 nTPM
Adipose tissue	24.9 nTPM

Alveolar cells type 1	8.0 nTPM
Lung	8.0 nTPM

Alveolar cells type 2	15.0 nTPM
Lung	15.0 nTPM

Astrocytes	15.2 nTPM
Brain	15.2 nTPM

B-cells	47.7 nTPM
Kidney	83.2 nTPM
Liver	67.6 nTPM
Spleen	61.0 nTPM
Bone marrow	54.1 nTPM
Adipose tissue	49.4 nTPM
Stomach	48.9 nTPM
Lymph node	43.7 nTPM
PBMC	43.1 nTPM
Thymus	42.2 nTPM
Skin	39.0 nTPM
Lung	37.6 nTPM
Salivary gland	32.3 nTPM
Esophagus	17.7 nTPM

Ciliated cells	14.0 nTPM
Lung	17.8 nTPM
Bronchus	14.1 nTPM
Endometrium	12.3 nTPM
Fallopian tube	12.1 nTPM

Club cells	16.1 nTPM
Bronchus	19.4 nTPM
Prostate	15.3 nTPM
Lung	13.4 nTPM

Dendritic cells	26.1 nTPM
PBMC	36.0 nTPM
Adipose tissue	16.2 nTPM

Endothelial cells	20.8 nTPM
Skin	85.6 nTPM
Heart muscle	30.3 nTPM
Fallopian tube	27.4 nTPM
Skeletal muscle	22.6 nTPM
Thymus	21.8 nTPM
Esophagus	19.5 nTPM
Pancreas	18.1 nTPM
Breast	17.6 nTPM
Ovary	15.7 nTPM
Testis	15.3 nTPM
Placenta	14.8 nTPM
Vascular	14.5 nTPM
Salivary gland	14.1 nTPM
Endometrium	12.8 nTPM
Lung	12.5 nTPM
Prostate	11.3 nTPM
Tongue	11.3 nTPM
Liver	8.8 nTPM

Enteroendocrine cells	10.8 nTPM
Colon	16.9 nTPM
Small intestine	10.3 nTPM
Rectum	5.0 nTPM

Fibroblasts	11.1 nTPM
Esophagus	17.1 nTPM
Fallopian tube	17.0 nTPM
Placenta	16.9 nTPM
Skin	16.5 nTPM
Liver	15.4 nTPM
Breast	13.7 nTPM
Thymus	11.0 nTPM
Pancreas	10.8 nTPM
Skeletal muscle	9.4 nTPM
Prostate	9.2 nTPM
Vascular	9.2 nTPM
Adipose tissue	9.0 nTPM
Lung	7.6 nTPM
Stomach	5.8 nTPM
Salivary gland	5.6 nTPM
Heart muscle	3.8 nTPM

Granulocytes	94.8 nTPM
Tongue	150.4 nTPM
Fallopian tube	87.1 nTPM
Lung	46.9 nTPM

Intestinal goblet cells	14.4 nTPM
Colon	19.2 nTPM
Rectum	12.8 nTPM
Small intestine	11.3 nTPM

Lymphatic endothelial cells	16.8 nTPM
Fallopian tube	17.3 nTPM
Ovary	16.4 nTPM

Macrophages	31.2 nTPM
Skin	65.7 nTPM
Adipose tissue	45.9 nTPM
Breast	44.4 nTPM
Esophagus	39.8 nTPM
Testis	36.0 nTPM
Skeletal muscle	35.2 nTPM
Spleen	35.1 nTPM
Pancreas	34.9 nTPM
Prostate	32.3 nTPM
Tongue	29.9 nTPM
Endometrium	27.7 nTPM
Fallopian tube	26.6 nTPM
Stomach	25.7 nTPM
Kidney	23.9 nTPM
Lung	20.5 nTPM
Salivary gland	18.5 nTPM
Vascular	17.6 nTPM
Thymus	16.3 nTPM
Bone marrow	16.2 nTPM

Basal prostatic cells	10.1 nTPM
Prostate	10.1 nTPM

Basal respiratory cells	24.8 nTPM
Bronchus	24.8 nTPM

Cholangiocytes	22.9 nTPM
Liver	22.9 nTPM

Collecting duct cells	15.6 nTPM
Kidney	15.6 nTPM

Paneth cells	110.7 nTPM
Colon	220.7 nTPM
Rectum	62.9 nTPM
Small intestine	48.4 nTPM

Plasma cells	17.4 nTPM
Liver	27.5 nTPM
Spleen	24.8 nTPM
Thymus	22.1 nTPM
Stomach	16.3 nTPM
Salivary gland	14.8 nTPM
Bone marrow	12.1 nTPM
Fallopian tube	10.9 nTPM
Esophagus	10.4 nTPM

Schwann cells	14.1 nTPM
Adipose tissue	18.7 nTPM
Esophagus	12.0 nTPM
Vascular	11.5 nTPM

Serous glandular cells	8.2 nTPM
Salivary gland	11.9 nTPM
Tongue	4.4 nTPM

Smooth muscle cells	13.2 nTPM
Skin	33.3 nTPM
Liver	22.1 nTPM
Placenta	19.2 nTPM
Esophagus	15.6 nTPM
Fallopian tube	14.2 nTPM
Lung	14.1 nTPM
Breast	13.1 nTPM
Endometrium	11.9 nTPM
Ovary	11.9 nTPM
Skeletal muscle	10.4 nTPM
Thymus	9.8 nTPM
Adipose tissue	8.9 nTPM
Salivary gland	8.0 nTPM
Vascular	6.9 nTPM
Tongue	6.6 nTPM
Prostate	4.9 nTPM

T-cells	21.2 nTPM
Skin	31.5 nTPM
PBMC	30.5 nTPM
Breast	30.3 nTPM
Spleen	28.7 nTPM
Colon	26.3 nTPM
Vascular	22.9 nTPM
Liver	22.7 nTPM
Thymus	22.6 nTPM
Lymph node	22.4 nTPM
Fallopian tube	21.8 nTPM
Kidney	21.3 nTPM
Prostate	20.8 nTPM
Lung	20.5 nTPM
Salivary gland	19.7 nTPM
Adipose tissue	19.0 nTPM
Bone marrow	18.7 nTPM
Stomach	15.6 nTPM
Esophagus	14.6 nTPM
Endometrium	12.1 nTPM
Tongue	12.0 nTPM
Skeletal muscle	11.7 nTPM

Undifferentiated cells	23.6 nTPM
Colon	31.3 nTPM
Small intestine	20.0 nTPM
Rectum	19.3 nTPM

Amygdala excitatory	22.5 nTPM
Cerebral cortex	26.2 nTPM
Hippocampus	24.6 nTPM
Hypothalamus	23.7 nTPM
Amygdala	21.1 nTPM
Thalamus	20.0 nTPM
Basal ganglia	19.4 nTPM

Astrocyte	26.2 nTPM
Hypothalamus	34.5 nTPM
Amygdala	33.3 nTPM
Basal ganglia	29.1 nTPM
Cerebral cortex	28.7 nTPM
Hippocampus	27.1 nTPM
Thalamus	26.9 nTPM
Midbrain	26.8 nTPM
Pons	23.0 nTPM
Medulla oblongata	21.6 nTPM
Cerebellum	20.0 nTPM
Spinal cord	17.2 nTPM

Bergmann glia	32.8 nTPM
Medulla oblongata	40.5 nTPM
Pons	31.6 nTPM
Cerebellum	26.4 nTPM

Central nervous system macrophage	99.2 nTPM
Amygdala	152.4 nTPM
Hypothalamus	112.0 nTPM
Thalamus	109.0 nTPM
Hippocampus	103.9 nTPM
Midbrain	100.1 nTPM
Cerebellum	95.4 nTPM
Cerebral cortex	89.6 nTPM
Basal ganglia	86.7 nTPM
Pons	84.6 nTPM
Medulla oblongata	79.8 nTPM
Spinal cord	77.7 nTPM

Cerebellar inhibitory	20.6 nTPM
Pons	24.8 nTPM
Spinal cord	22.0 nTPM
Medulla oblongata	19.7 nTPM
Midbrain	19.0 nTPM
Cerebellum	17.3 nTPM

Cge interneuron	19.4 nTPM
Thalamus	20.9 nTPM
Hippocampus	20.2 nTPM
Cerebral cortex	20.0 nTPM
Midbrain	19.9 nTPM
Amygdala	19.0 nTPM
Basal ganglia	17.9 nTPM
Hypothalamus	17.9 nTPM

Choroid plexus epithelial cell	50.1 nTPM
Basal ganglia	63.4 nTPM
Hippocampus	47.1 nTPM
Medulla oblongata	46.1 nTPM
Thalamus	43.8 nTPM

Committed oligodendrocyte precursor	26.8 nTPM
Cerebral cortex	41.2 nTPM
Amygdala	35.0 nTPM
Basal ganglia	29.0 nTPM
Medulla oblongata	28.4 nTPM
Cerebellum	27.0 nTPM
Pons	26.6 nTPM
Hippocampus	26.1 nTPM
Midbrain	23.5 nTPM
Hypothalamus	23.2 nTPM
Thalamus	20.3 nTPM
Spinal cord	14.7 nTPM

Deep-layer corticothalamic and 6b	18.4 nTPM
Cerebral cortex	20.5 nTPM
Hypothalamus	18.8 nTPM
Hippocampus	18.7 nTPM
Basal ganglia	18.6 nTPM
Amygdala	17.0 nTPM
Midbrain	16.6 nTPM

Deep-layer intratelencephalic	24.1 nTPM
Cerebral cortex	25.9 nTPM
Hypothalamus	25.5 nTPM
Hippocampus	25.0 nTPM
Amygdala	23.1 nTPM
Basal ganglia	20.9 nTPM

Deep-layer near-projecting	14.7 nTPM
Hippocampus	24.4 nTPM
Cerebral cortex	16.0 nTPM
Basal ganglia	12.6 nTPM
Amygdala	12.1 nTPM
Hypothalamus	8.3 nTPM

Eccentric medium spiny neuron	22.3 nTPM
Thalamus	24.7 nTPM
Basal ganglia	23.9 nTPM
Amygdala	23.2 nTPM
Hypothalamus	21.6 nTPM
Cerebral cortex	21.5 nTPM
Hippocampus	19.1 nTPM

Endothelial cell	38.2 nTPM
Amygdala	54.8 nTPM
Hypothalamus	44.7 nTPM
Hippocampus	42.3 nTPM
Pons	40.6 nTPM
Cerebral cortex	36.4 nTPM
Cerebellum	35.6 nTPM
Thalamus	35.6 nTPM
Midbrain	35.0 nTPM
Basal ganglia	33.6 nTPM
Spinal cord	31.1 nTPM
Medulla oblongata	30.8 nTPM