Single cell type - MEIS1 - The Human Protein Atlas

MEIS1

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MEIS1
Gene descriptionⁱ Full gene name according to HGNC.	Meis homeobox 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Endometrial stromal cells - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oligodendrocytes, Rod photoreceptor cells, Endometrial stromal cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.63
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Upper rhombic lip, Bergmann glia, Oligodendrocyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (NK-cell, plasmacytoid DC)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Rod photoreceptor cells, Endometrial stromal cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Upper rhombic lip, Bergmann glia, Oligodendrocyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (NK-cell, plasmacytoid DC)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

MEIS1 is part of cluster 9 Endometrial stromal cells - Transcription with confidenceⁱ 1
129 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
BTBD3	BTB domain containing 3	0.6962	9
PSD	Pleckstrin and Sec7 domain containing	0.5757	9
RORB	RAR related orphan receptor B	0.5531	9
CHODL	Chondrolectin	0.5328	9
HOXA11	Homeobox A11	0.5085	9
COL4A5	Collagen type IV alpha 5 chain	0.5060	51
WDR86	WD repeat domain 86	0.5015	9
RAMP1	Receptor activity modifying protein 1	0.4987	9
PGR	Progesterone receptor	0.4957	9
HRNR	Hornerin	0.4910	66
PLEKHH2	Pleckstrin homology, MyTH4 and FERM domain containing H2	0.4907	9
OR6B3	Olfactory receptor family 6 subfamily B member 3	0.4905	66
CPXM1	Carboxypeptidase X, M14 family member 1	0.4885	9
INTU	Inturned planar cell polarity protein	0.4839	66
SAMD11	Sterile alpha motif domain containing 11	0.4795	66

IMMUNE CELLS

MEIS1 is part of cluster 41 Basophils - Unknown function with confidenceⁱ 0.94
293 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
WIPF2	WAS/WASL interacting protein family member 2	0.9762	41
RMND5A	Required for meiotic nuclear division 5 homolog A	0.9762	41
PPIP5K2	Diphosphoinositol pentakisphosphate kinase 2	0.9762	41
TSC22D1	TSC22 domain family member 1	0.9762	41
CTSZ	Cathepsin Z	0.9524	10
GAB3	GRB2 associated binding protein 3	0.9524	41
BSDC1	BSD domain containing 1	0.9524	41
GNAQ	G protein subunit alpha q	0.9524	41
CPT1A	Carnitine palmitoyltransferase 1A	0.9524	41
TLE4	TLE family member 4, transcriptional corepressor	0.9524	41
GCLC	Glutamate-cysteine ligase catalytic subunit	0.9524	41
GPATCH2L	G-patch domain containing 2 like	0.9524	41
NCOA1	Nuclear receptor coactivator 1	0.9524	41
KDM5A	Lysine demethylase 5A	0.9524	41
THRAP3	Thyroid hormone receptor associated protein 3	0.9524	41

Adipocytes	0.5 nTPM
Breast	0.8 nTPM
Adipose tissue	0.2 nTPM

Alveolar cells type 1	1.6 nTPM
Lung	1.6 nTPM

Alveolar cells type 2	0.6 nTPM
Lung	0.6 nTPM

Astrocytes	52.6 nTPM
Brain	52.6 nTPM

B-cells	0.2 nTPM
Salivary gland	2.1 nTPM
Thymus	0.4 nTPM
Spleen	0.2 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM

Ciliated cells	24.4 nTPM
Fallopian tube	42.6 nTPM
Endometrium	34.0 nTPM
Bronchus	11.6 nTPM
Lung	9.3 nTPM

Club cells	11.9 nTPM
Prostate	15.6 nTPM
Lung	10.5 nTPM
Bronchus	9.5 nTPM

Endothelial cells	6.7 nTPM
Liver	26.5 nTPM
Lung	25.4 nTPM
Placenta	12.5 nTPM
Endometrium	11.7 nTPM
Prostate	9.4 nTPM
Heart muscle	8.0 nTPM
Ovary	5.3 nTPM
Salivary gland	4.4 nTPM
Fallopian tube	4.4 nTPM
Tongue	3.6 nTPM
Vascular	2.6 nTPM
Testis	1.8 nTPM
Esophagus	1.8 nTPM
Thymus	1.4 nTPM
Breast	0.9 nTPM
Skeletal muscle	0.8 nTPM
Skin	0.4 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	1.0 nTPM
Rectum	1.7 nTPM
Colon	1.4 nTPM
Small intestine	0.0 nTPM

Fibroblasts	24.2 nTPM
Fallopian tube	74.3 nTPM
Prostate	46.9 nTPM
Esophagus	42.8 nTPM
Lung	29.2 nTPM
Liver	27.3 nTPM
Breast	21.9 nTPM
Salivary gland	19.7 nTPM
Placenta	18.6 nTPM
Adipose tissue	18.0 nTPM
Skeletal muscle	16.7 nTPM
Vascular	16.6 nTPM
Thymus	16.4 nTPM
Skin	11.9 nTPM
Pancreas	11.8 nTPM
Stomach	11.5 nTPM
Heart muscle	4.2 nTPM

Granulocytes	1.6 nTPM
Fallopian tube	4.8 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	0.4 nTPM
Rectum	1.0 nTPM
Colon	0.2 nTPM
Small intestine	0.0 nTPM

Lymphatic endothelial cells	1.5 nTPM
Fallopian tube	2.9 nTPM
Ovary	0.0 nTPM

Macrophages	1.7 nTPM
Endometrium	9.8 nTPM
Salivary gland	5.5 nTPM
Fallopian tube	4.0 nTPM
Tongue	2.8 nTPM
Esophagus	2.6 nTPM
Skin	2.2 nTPM
Vascular	1.2 nTPM
Bone marrow	1.0 nTPM
Testis	0.6 nTPM
Thymus	0.4 nTPM
Breast	0.4 nTPM
Skeletal muscle	0.3 nTPM
Lung	0.3 nTPM
Adipose tissue	0.2 nTPM
Prostate	0.2 nTPM
Kidney	0.0 nTPM
Pancreas	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	67.4 nTPM
Small intestine	86.3 nTPM
Colon	68.8 nTPM
Rectum	47.1 nTPM

Basal keratinocytes	7.9 nTPM
Tongue	12.2 nTPM
Skin	3.5 nTPM

Basal squamous epithelial cells	14.4 nTPM
Esophagus	14.4 nTPM

Bipolar cells	17.6 nTPM
Eye	17.6 nTPM

Cholangiocytes	1.9 nTPM
Liver	1.9 nTPM

Plasma cells	1.7 nTPM
Fallopian tube	7.1 nTPM
Salivary gland	5.4 nTPM
Thymus	0.9 nTPM
Liver	0.5 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Schwann cells	6.3 nTPM
Esophagus	12.0 nTPM
Vascular	6.8 nTPM
Adipose tissue	0.0 nTPM

Serous glandular cells	28.4 nTPM
Salivary gland	47.9 nTPM
Tongue	8.8 nTPM

Smooth muscle cells	18.7 nTPM
Fallopian tube	53.4 nTPM
Endometrium	41.1 nTPM
Placenta	40.1 nTPM
Salivary gland	32.5 nTPM
Lung	23.5 nTPM
Ovary	23.2 nTPM
Esophagus	19.2 nTPM
Prostate	16.4 nTPM
Vascular	11.6 nTPM
Tongue	10.2 nTPM
Liver	9.3 nTPM
Thymus	6.6 nTPM
Breast	4.1 nTPM
Skin	3.5 nTPM
Adipose tissue	3.3 nTPM
Skeletal muscle	1.4 nTPM

Suprabasal keratinocytes	11.0 nTPM
Tongue	20.2 nTPM
Skin	1.9 nTPM

T-cells	1.3 nTPM
Endometrium	10.6 nTPM
Esophagus	4.9 nTPM
Salivary gland	3.2 nTPM
Fallopian tube	2.5 nTPM
Tongue	1.8 nTPM
Skeletal muscle	1.5 nTPM
Vascular	0.8 nTPM
Prostate	0.7 nTPM
PBMC	0.5 nTPM
Skin	0.4 nTPM
Lung	0.3 nTPM
Bone marrow	0.2 nTPM
Adipose tissue	0.1 nTPM
Stomach	0.1 nTPM
Breast	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
Lymph node	0.0 nTPM
Spleen	0.0 nTPM
Thymus	0.0 nTPM

Undifferentiated cells	1.0 nTPM
Rectum	2.1 nTPM
Colon	0.5 nTPM
Small intestine	0.4 nTPM

Amygdala excitatory	19.0 nTPM
Thalamus	25.4 nTPM
Basal ganglia	22.4 nTPM
Amygdala	19.7 nTPM
Cerebral cortex	19.0 nTPM
Hippocampus	15.1 nTPM
Hypothalamus	12.3 nTPM

Astrocyte	139.8 nTPM
Cerebellum	200.9 nTPM
Amygdala	196.6 nTPM
Medulla oblongata	190.7 nTPM
Pons	172.5 nTPM
Spinal cord	150.0 nTPM
Basal ganglia	139.4 nTPM
Midbrain	129.2 nTPM
Cerebral cortex	112.3 nTPM
Thalamus	92.1 nTPM
Hypothalamus	87.5 nTPM
Hippocampus	67.3 nTPM

Bergmann glia	402.4 nTPM
Cerebellum	425.3 nTPM
Medulla oblongata	400.6 nTPM
Pons	381.2 nTPM

Central nervous system macrophage	41.2 nTPM
Amygdala	57.3 nTPM
Midbrain	51.7 nTPM
Pons	44.0 nTPM
Basal ganglia	41.8 nTPM
Hippocampus	41.8 nTPM
Thalamus	39.7 nTPM
Hypothalamus	38.7 nTPM
Cerebral cortex	37.5 nTPM
Medulla oblongata	36.6 nTPM
Cerebellum	33.7 nTPM
Spinal cord	30.0 nTPM

Cerebellar inhibitory	42.9 nTPM
Spinal cord	71.5 nTPM
Medulla oblongata	41.4 nTPM
Pons	34.9 nTPM
Cerebellum	34.5 nTPM
Midbrain	32.3 nTPM

Cge interneuron	16.4 nTPM
Hypothalamus	23.3 nTPM
Basal ganglia	19.3 nTPM
Amygdala	18.3 nTPM
Cerebral cortex	15.5 nTPM
Hippocampus	15.3 nTPM
Midbrain	13.2 nTPM
Thalamus	10.3 nTPM

Choroid plexus epithelial cell	98.5 nTPM
Medulla oblongata	206.7 nTPM
Basal ganglia	96.4 nTPM
Thalamus	46.6 nTPM
Hippocampus	44.4 nTPM

Committed oligodendrocyte precursor	111.3 nTPM
Hypothalamus	193.9 nTPM
Amygdala	156.8 nTPM
Thalamus	141.2 nTPM
Pons	119.5 nTPM
Medulla oblongata	118.8 nTPM
Cerebellum	101.5 nTPM
Midbrain	92.4 nTPM
Cerebral cortex	85.5 nTPM
Basal ganglia	78.8 nTPM
Spinal cord	69.9 nTPM
Hippocampus	66.0 nTPM

Deep-layer corticothalamic and 6b	3.3 nTPM
Hypothalamus	6.4 nTPM
Amygdala	4.3 nTPM
Basal ganglia	4.1 nTPM
Cerebral cortex	3.8 nTPM
Hippocampus	1.1 nTPM
Midbrain	0.0 nTPM

Deep-layer intratelencephalic	6.2 nTPM
Amygdala	9.3 nTPM
Hypothalamus	6.7 nTPM
Basal ganglia	6.6 nTPM
Cerebral cortex	5.4 nTPM
Hippocampus	2.9 nTPM

Deep-layer near-projecting	1.5 nTPM
Amygdala	1.8 nTPM
Basal ganglia	1.8 nTPM
Cerebral cortex	1.5 nTPM
Hypothalamus	1.5 nTPM
Hippocampus	1.0 nTPM

Eccentric medium spiny neuron	187.0 nTPM
Amygdala	382.7 nTPM
Hippocampus	291.4 nTPM
Cerebral cortex	199.4 nTPM
Thalamus	137.3 nTPM
Basal ganglia	57.9 nTPM
Hypothalamus	53.5 nTPM

Endothelial cell	5.1 nTPM
Basal ganglia	23.3 nTPM
Spinal cord	12.1 nTPM
Cerebellum	4.6 nTPM
Pons	4.4 nTPM
Medulla oblongata	3.1 nTPM
Midbrain	2.8 nTPM
Hippocampus	1.6 nTPM
Cerebral cortex	1.3 nTPM
Hypothalamus	1.2 nTPM
Amygdala	1.1 nTPM
Thalamus	0.6 nTPM