Single cell type - FGF2 - The Human Protein Atlas

FGF2

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FGF2
Gene descriptionⁱ Full gene name according to HGNC.	Fibroblast growth factor 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Candidate cardiovascular disease genes FDA approved drug targets RAS pathway related proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Adipocytes & Endothelial cells - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Astrocytes, Schwann cells, Oligodendrocyte precursor cells, Endometrial stromal cells, Secretory cells, Adipocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.72
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Astrocyte, Bergmann glia, Choroid plexus epithelial cell)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data.	Protein predicted to be secreted

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Astrocytes, Schwann cells, Oligodendrocyte precursor cells, Endometrial stromal cells, Secretory cells, Adipocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Astrocyte, Bergmann glia, Choroid plexus epithelial cell)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

FGF2 is part of cluster 41 Adipocytes & Endothelial cells - Mixed function with confidenceⁱ 1
325 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
EVC	EvC ciliary complex subunit 1	0.5024	47
ADRA2C	Adrenoceptor alpha 2C	0.4976	9
GASK1A	Golgi associated kinase 1A	0.4967	47
PTGIS	Prostaglandin I2 synthase	0.4923	53
IL15RA	Interleukin 15 receptor subunit alpha	0.4744	53
CHST3	Carbohydrate sulfotransferase 3	0.4741	32
MAK16	MAK16 homolog	0.4672	39
ZHX3	Zinc fingers and homeoboxes 3	0.4595	47
SH3PXD2B	SH3 and PX domains 2B	0.4583	53
VEGFC	Vascular endothelial growth factor C	0.4580	41
NSMF	NMDA receptor synaptonuclear signaling and neuronal migration factor	0.4572	34
ZCCHC24	Zinc finger CCHC-type containing 24	0.4520	32
TXNRD1	Thioredoxin reductase 1	0.4510	72
FERMT2	FERM domain containing kindlin 2	0.4485	32
RBMS2	RNA binding motif single stranded interacting protein 2	0.4450	41

Adipocytes	33.5 nTPM
Adipose tissue	45.1 nTPM
Breast	21.8 nTPM

Alveolar cells type 1	31.2 nTPM
Lung	31.2 nTPM

Alveolar cells type 2	0.3 nTPM
Lung	0.3 nTPM

B-cells	0.4 nTPM
Adipose tissue	2.5 nTPM
Thymus	0.8 nTPM
Bone marrow	0.7 nTPM
Salivary gland	0.6 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM

Basal keratinocytes	1.0 nTPM
Skin	1.2 nTPM
Tongue	0.7 nTPM

Ciliated cells	3.4 nTPM
Fallopian tube	12.2 nTPM
Endometrium	1.4 nTPM
Bronchus	0.0 nTPM
Lung	0.0 nTPM

Club cells	0.8 nTPM
Prostate	2.2 nTPM
Lung	0.3 nTPM
Bronchus	0.1 nTPM

Endothelial cells	20.0 nTPM
Vascular	51.2 nTPM
Thymus	45.8 nTPM
Salivary gland	41.4 nTPM
Fallopian tube	41.1 nTPM
Tongue	37.8 nTPM
Prostate	24.6 nTPM
Esophagus	21.5 nTPM
Skeletal muscle	20.8 nTPM
Skin	15.7 nTPM
Lung	15.4 nTPM
Heart muscle	13.8 nTPM
Liver	8.8 nTPM
Ovary	6.3 nTPM
Placenta	6.2 nTPM
Endometrium	4.3 nTPM
Testis	3.4 nTPM
Breast	2.6 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	28.2 nTPM
Lung	78.8 nTPM
Fallopian tube	51.6 nTPM
Skeletal muscle	46.3 nTPM
Adipose tissue	44.6 nTPM
Prostate	31.7 nTPM
Vascular	30.0 nTPM
Pancreas	28.8 nTPM
Salivary gland	23.7 nTPM
Thymus	23.5 nTPM
Esophagus	22.1 nTPM
Stomach	20.2 nTPM
Breast	19.1 nTPM
Skin	17.6 nTPM
Heart muscle	11.2 nTPM
Placenta	2.5 nTPM
Liver	0.0 nTPM

Granulocytes	0.3 nTPM
Fallopian tube	1.0 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Rectum	0.1 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Lymphatic endothelial cells	0.5 nTPM
Fallopian tube	1.0 nTPM
Ovary	0.0 nTPM

Macrophages	0.6 nTPM
Skeletal muscle	2.3 nTPM
Vascular	2.1 nTPM
Esophagus	1.3 nTPM
Endometrium	1.2 nTPM
Thymus	1.2 nTPM
Fallopian tube	0.9 nTPM
Tongue	0.7 nTPM
Breast	0.5 nTPM
Salivary gland	0.4 nTPM
Prostate	0.2 nTPM
Lung	0.1 nTPM
Testis	0.0 nTPM
Kidney	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Astrocytes	105.3 nTPM
Brain	105.3 nTPM

Collecting duct cells	17.5 nTPM
Kidney	17.5 nTPM

Distal tubular cells	3.1 nTPM
Kidney	3.1 nTPM

Early spermatids	11.9 nTPM
Testis	11.9 nTPM

Plasma cells	2.3 nTPM
Fallopian tube	9.0 nTPM
Salivary gland	4.9 nTPM
Bone marrow	1.5 nTPM
Thymus	1.5 nTPM
Stomach	0.8 nTPM
Liver	0.5 nTPM
Spleen	0.2 nTPM
Esophagus	0.0 nTPM

Schwann cells	56.0 nTPM
Vascular	120.1 nTPM
Esophagus	47.9 nTPM
Adipose tissue	0.0 nTPM

Serous glandular cells	3.1 nTPM
Tongue	4.4 nTPM
Salivary gland	1.8 nTPM

Smooth muscle cells	18.0 nTPM
Vascular	39.7 nTPM
Lung	37.6 nTPM
Fallopian tube	31.8 nTPM
Prostate	27.4 nTPM
Liver	22.9 nTPM
Tongue	19.2 nTPM
Endometrium	18.7 nTPM
Salivary gland	14.9 nTPM
Thymus	14.4 nTPM
Skeletal muscle	11.7 nTPM
Adipose tissue	10.7 nTPM
Skin	8.8 nTPM
Esophagus	8.4 nTPM
Breast	8.1 nTPM
Placenta	7.3 nTPM
Ovary	6.3 nTPM

T-cells	0.4 nTPM
Endometrium	2.5 nTPM
Skeletal muscle	1.5 nTPM
Fallopian tube	1.4 nTPM
Skin	0.7 nTPM
Breast	0.6 nTPM
Prostate	0.4 nTPM
Vascular	0.4 nTPM
Lung	0.3 nTPM
Lymph node	0.2 nTPM
Salivary gland	0.2 nTPM
Adipose tissue	0.1 nTPM
Tongue	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Thymus	0.0 nTPM

Undifferentiated cells	0.2 nTPM
Colon	0.6 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Amygdala excitatory	3.4 nTPM
Thalamus	10.0 nTPM
Basal ganglia	4.9 nTPM
Hypothalamus	1.8 nTPM
Amygdala	1.7 nTPM
Cerebral cortex	1.1 nTPM
Hippocampus	1.1 nTPM

Astrocyte	189.6 nTPM
Amygdala	293.7 nTPM
Hippocampus	213.7 nTPM
Basal ganglia	211.1 nTPM
Cerebral cortex	203.8 nTPM
Hypothalamus	201.2 nTPM
Thalamus	183.3 nTPM
Midbrain	179.5 nTPM
Pons	167.2 nTPM
Cerebellum	146.2 nTPM
Spinal cord	143.5 nTPM
Medulla oblongata	142.0 nTPM

Bergmann glia	186.9 nTPM
Cerebellum	205.2 nTPM
Pons	191.3 nTPM
Medulla oblongata	164.1 nTPM

Central nervous system macrophage	15.3 nTPM
Thalamus	23.9 nTPM
Basal ganglia	23.2 nTPM
Cerebral cortex	21.1 nTPM
Hypothalamus	18.2 nTPM
Hippocampus	17.4 nTPM
Medulla oblongata	17.4 nTPM
Midbrain	13.9 nTPM
Pons	10.9 nTPM
Cerebellum	10.2 nTPM
Amygdala	9.6 nTPM
Spinal cord	2.6 nTPM

Cerebellar inhibitory	3.3 nTPM
Pons	6.2 nTPM
Medulla oblongata	3.9 nTPM
Midbrain	3.7 nTPM
Cerebellum	2.9 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	13.5 nTPM
Hypothalamus	19.1 nTPM
Amygdala	15.9 nTPM
Hippocampus	14.4 nTPM
Basal ganglia	13.8 nTPM
Cerebral cortex	13.7 nTPM
Thalamus	9.2 nTPM
Midbrain	8.6 nTPM

Choroid plexus epithelial cell	151.3 nTPM
Basal ganglia	233.1 nTPM
Thalamus	142.5 nTPM
Medulla oblongata	116.1 nTPM
Hippocampus	113.7 nTPM

Committed oligodendrocyte precursor	20.8 nTPM
Medulla oblongata	40.0 nTPM
Basal ganglia	27.9 nTPM
Spinal cord	25.8 nTPM
Cerebral cortex	22.8 nTPM
Hippocampus	19.9 nTPM
Hypothalamus	19.8 nTPM
Pons	19.5 nTPM
Cerebellum	17.4 nTPM
Amygdala	16.4 nTPM
Thalamus	9.9 nTPM
Midbrain	9.2 nTPM

Deep-layer corticothalamic and 6b	3.4 nTPM
Basal ganglia	6.1 nTPM
Cerebral cortex	5.4 nTPM
Hypothalamus	3.4 nTPM
Midbrain	2.2 nTPM
Amygdala	1.8 nTPM
Hippocampus	1.3 nTPM

Deep-layer intratelencephalic	3.2 nTPM
Amygdala	6.9 nTPM
Basal ganglia	4.5 nTPM
Cerebral cortex	2.7 nTPM
Hippocampus	0.9 nTPM
Hypothalamus	0.9 nTPM

Deep-layer near-projecting	1.1 nTPM
Basal ganglia	1.6 nTPM
Hippocampus	1.3 nTPM
Cerebral cortex	1.2 nTPM
Hypothalamus	0.9 nTPM
Amygdala	0.7 nTPM

Eccentric medium spiny neuron	2.4 nTPM
Amygdala	4.0 nTPM
Thalamus	3.6 nTPM
Hippocampus	2.5 nTPM
Cerebral cortex	1.9 nTPM
Hypothalamus	1.3 nTPM
Basal ganglia	1.1 nTPM

Endothelial cell	39.1 nTPM
Hypothalamus	81.9 nTPM
Medulla oblongata	52.3 nTPM
Basal ganglia	46.6 nTPM
Amygdala	42.5 nTPM
Cerebral cortex	40.9 nTPM
Cerebellum	33.3 nTPM
Pons	31.2 nTPM
Hippocampus	29.2 nTPM
Spinal cord	25.9 nTPM
Thalamus	25.4 nTPM
Midbrain	20.8 nTPM

Ependymal cell	93.6 nTPM
Amygdala	122.3 nTPM
Hypothalamus	113.3 nTPM
Basal ganglia	108.5 nTPM
Thalamus	103.3 nTPM
Pons	89.6 nTPM
Hippocampus	86.4 nTPM
Midbrain	85.1 nTPM
Spinal cord	76.7 nTPM
Medulla oblongata	57.3 nTPM