Single cell type - SENP7 - The Human Protein Atlas

SENP7

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SENP7
Gene descriptionⁱ Full gene name according to HGNC.	SUMO specific peptidase 7
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oligodendrocyte precursor cells, Oligodendrocytes, Inhibitory neurons)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.43
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (basophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oligodendrocyte precursor cells, Oligodendrocytes, Inhibitory neurons)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (basophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

SENP7 is part of cluster 55 Non-specific - Transcription with confidenceⁱ 1
709 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TUT4	Terminal uridylyl transferase 4	0.5957	55
CHD6	Chromodomain helicase DNA binding protein 6	0.5603	55
REV3L	REV3 like, DNA directed polymerase zeta catalytic subunit	0.5525	9
KRBOX4	KRAB box domain containing 4	0.5380	55
C17orf67	Chromosome 17 open reading frame 67	0.5258	54
PLEKHH2	Pleckstrin homology, MyTH4 and FERM domain containing H2	0.5189	9
MAP3K4	Mitogen-activated protein kinase kinase kinase 4	0.5148	55
EPC2	Enhancer of polycomb homolog 2	0.5050	55
FNBP4	Formin binding protein 4	0.4976	55
KLHL13	Kelch like family member 13	0.4954	76
ZNF708	Zinc finger protein 708	0.4954	55
NKTR	Natural killer cell triggering receptor	0.4889	55
METTL4	Methyltransferase 4, N6-adenosine	0.4877	55
NAA16	N-alpha-acetyltransferase 16, NatA auxiliary subunit	0.4841	78
EBF4	EBF family member 4	0.4738	76

IMMUNE CELLS

SENP7 is part of cluster 46 Basophils - Proteolysis with confidenceⁱ 1
156 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF638	Zinc finger protein 638	1.0000	46
ITGB8	Integrin subunit beta 8	1.0000	46
CABP5	Calcium binding protein 5	1.0000	46
CCNP	Cyclin P	1.0000	46
KLF5	KLF transcription factor 5	1.0000	46
MID1	Midline 1	1.0000	46
TPSD1	Tryptase delta 1	1.0000	46
L2HGDH	L-2-hydroxyglutarate dehydrogenase	1.0000	46
NLK	Nemo like kinase	1.0000	46
FRYL	FRY like transcription coactivator	1.0000	46
THSD7A	Thrombospondin type 1 domain containing 7A	1.0000	46
SEMA3C	Semaphorin 3C	1.0000	46
CTNNA2	Catenin alpha 2	1.0000	46
SNCAIP	Synuclein alpha interacting protein	1.0000	46
HIPK2	Homeodomain interacting protein kinase 2	1.0000	46

Adipocytes	41.6 nTPM
Adipose tissue	52.2 nTPM
Breast	31.0 nTPM

Alveolar cells type 1	12.3 nTPM
Lung	12.3 nTPM

Alveolar cells type 2	9.9 nTPM
Lung	9.9 nTPM

Astrocytes	74.3 nTPM
Brain	74.3 nTPM

B-cells	29.2 nTPM
Bone marrow	46.2 nTPM
Adipose tissue	45.3 nTPM
Salivary gland	39.3 nTPM
Spleen	36.6 nTPM
Lymph node	35.5 nTPM
Stomach	34.2 nTPM
Esophagus	29.5 nTPM
Lung	28.2 nTPM
Thymus	27.8 nTPM
PBMC	26.2 nTPM
Kidney	15.6 nTPM
Liver	9.7 nTPM
Skin	5.1 nTPM

Ciliated cells	20.0 nTPM
Endometrium	31.3 nTPM
Fallopian tube	23.5 nTPM
Lung	13.9 nTPM
Bronchus	11.5 nTPM

Club cells	13.2 nTPM
Prostate	15.7 nTPM
Lung	14.5 nTPM
Bronchus	9.3 nTPM

Endothelial cells	28.1 nTPM
Heart muscle	50.1 nTPM
Endometrium	46.9 nTPM
Breast	39.5 nTPM
Ovary	34.1 nTPM
Vascular	32.1 nTPM
Prostate	30.9 nTPM
Liver	30.2 nTPM
Skeletal muscle	29.9 nTPM
Salivary gland	29.9 nTPM
Testis	25.0 nTPM
Tongue	24.7 nTPM
Skin	22.8 nTPM
Thymus	22.6 nTPM
Placenta	21.6 nTPM
Esophagus	20.4 nTPM
Lung	19.3 nTPM
Fallopian tube	18.1 nTPM
Pancreas	7.8 nTPM

Enteroendocrine cells	6.2 nTPM
Rectum	8.4 nTPM
Colon	6.6 nTPM
Small intestine	3.4 nTPM

Fibroblasts	22.1 nTPM
Liver	47.4 nTPM
Fallopian tube	42.4 nTPM
Adipose tissue	35.9 nTPM
Breast	35.5 nTPM
Prostate	25.1 nTPM
Skeletal muscle	25.0 nTPM
Esophagus	21.8 nTPM
Skin	18.2 nTPM
Salivary gland	18.2 nTPM
Stomach	15.9 nTPM
Vascular	15.8 nTPM
Heart muscle	14.8 nTPM
Lung	11.1 nTPM
Thymus	11.0 nTPM
Placenta	10.8 nTPM
Pancreas	4.3 nTPM

Granulocytes	31.3 nTPM
Tongue	43.7 nTPM
Fallopian tube	27.1 nTPM
Lung	23.2 nTPM

Intestinal goblet cells	8.8 nTPM
Small intestine	13.9 nTPM
Colon	7.1 nTPM
Rectum	5.4 nTPM

Lymphatic endothelial cells	43.6 nTPM
Fallopian tube	43.6 nTPM
Ovary	43.6 nTPM

Macrophages	19.4 nTPM
Adipose tissue	37.2 nTPM
Skeletal muscle	27.4 nTPM
Salivary gland	24.7 nTPM
Breast	24.2 nTPM
Fallopian tube	23.3 nTPM
Esophagus	23.1 nTPM
Stomach	23.1 nTPM
Prostate	21.5 nTPM
Spleen	21.1 nTPM
Tongue	21.0 nTPM
Bone marrow	20.3 nTPM
Endometrium	18.4 nTPM
Vascular	18.3 nTPM
Skin	15.6 nTPM
Kidney	14.2 nTPM
Thymus	12.8 nTPM
Testis	11.8 nTPM
Lung	8.2 nTPM
Pancreas	2.1 nTPM

Paneth cells	4.1 nTPM
Rectum	8.7 nTPM
Colon	3.6 nTPM
Small intestine	0.0 nTPM

Basal prostatic cells	16.7 nTPM
Prostate	16.7 nTPM

Basal respiratory cells	7.0 nTPM
Bronchus	7.0 nTPM

Basal squamous epithelial cells	16.2 nTPM
Esophagus	16.2 nTPM

Bipolar cells	41.9 nTPM
Eye	41.9 nTPM

Plasma cells	18.5 nTPM
Fallopian tube	30.9 nTPM
Stomach	29.3 nTPM
Esophagus	26.0 nTPM
Salivary gland	16.6 nTPM
Spleen	14.2 nTPM
Liver	11.5 nTPM
Bone marrow	10.6 nTPM
Thymus	9.3 nTPM

Schwann cells	33.1 nTPM
Esophagus	47.9 nTPM
Vascular	36.0 nTPM
Adipose tissue	15.2 nTPM

Serous glandular cells	13.2 nTPM
Salivary gland	22.0 nTPM
Tongue	4.4 nTPM

Smooth muscle cells	24.3 nTPM
Adipose tissue	38.1 nTPM
Endometrium	35.6 nTPM
Ovary	34.9 nTPM
Fallopian tube	30.2 nTPM
Skeletal muscle	28.9 nTPM
Breast	25.8 nTPM
Salivary gland	25.4 nTPM
Liver	25.0 nTPM
Vascular	23.1 nTPM
Lung	21.2 nTPM
Tongue	20.4 nTPM
Prostate	19.5 nTPM
Esophagus	19.2 nTPM
Thymus	15.6 nTPM
Placenta	13.6 nTPM
Skin	12.4 nTPM

Suprabasal keratinocytes	12.7 nTPM
Tongue	13.8 nTPM
Skin	11.6 nTPM

T-cells	39.5 nTPM
Breast	62.1 nTPM
Endometrium	61.6 nTPM
Adipose tissue	56.9 nTPM
Fallopian tube	56.5 nTPM
Lung	52.9 nTPM
Salivary gland	52.4 nTPM
Lymph node	47.4 nTPM
Esophagus	43.8 nTPM
Prostate	41.6 nTPM
Vascular	40.2 nTPM
Tongue	37.6 nTPM
PBMC	36.3 nTPM
Thymus	34.0 nTPM
Bone marrow	33.9 nTPM
Stomach	31.2 nTPM
Skeletal muscle	30.2 nTPM
Spleen	29.1 nTPM
Skin	22.8 nTPM
Kidney	21.3 nTPM
Colon	19.5 nTPM
Liver	17.1 nTPM

Undifferentiated cells	5.4 nTPM
Rectum	7.7 nTPM
Colon	4.3 nTPM
Small intestine	4.3 nTPM

Amygdala excitatory	93.7 nTPM
Thalamus	156.1 nTPM
Hypothalamus	85.6 nTPM
Basal ganglia	83.2 nTPM
Cerebral cortex	80.0 nTPM
Hippocampus	80.0 nTPM
Amygdala	77.3 nTPM

Astrocyte	145.4 nTPM
Amygdala	220.9 nTPM
Cerebral cortex	174.2 nTPM
Hypothalamus	169.7 nTPM
Basal ganglia	157.3 nTPM
Hippocampus	155.8 nTPM
Thalamus	135.1 nTPM
Midbrain	126.5 nTPM
Medulla oblongata	123.1 nTPM
Spinal cord	122.8 nTPM
Pons	116.8 nTPM
Cerebellum	97.0 nTPM

Bergmann glia	197.1 nTPM
Cerebellum	223.1 nTPM
Pons	200.0 nTPM
Medulla oblongata	168.4 nTPM

Central nervous system macrophage	208.9 nTPM
Amygdala	295.7 nTPM
Hypothalamus	239.7 nTPM
Basal ganglia	217.1 nTPM
Thalamus	206.2 nTPM
Midbrain	200.9 nTPM
Hippocampus	198.4 nTPM
Cerebellum	196.2 nTPM
Pons	193.5 nTPM
Cerebral cortex	190.7 nTPM
Spinal cord	184.6 nTPM
Medulla oblongata	175.0 nTPM

Cerebellar inhibitory	142.1 nTPM
Midbrain	153.0 nTPM
Pons	142.1 nTPM
Medulla oblongata	140.5 nTPM
Cerebellum	139.9 nTPM
Spinal cord	134.7 nTPM

Cge interneuron	146.9 nTPM
Midbrain	156.9 nTPM
Amygdala	154.6 nTPM
Thalamus	154.4 nTPM
Basal ganglia	145.6 nTPM
Hypothalamus	143.9 nTPM
Cerebral cortex	138.5 nTPM
Hippocampus	134.2 nTPM

Choroid plexus epithelial cell	125.1 nTPM
Basal ganglia	154.2 nTPM
Thalamus	123.3 nTPM
Medulla oblongata	117.4 nTPM
Hippocampus	105.4 nTPM

Committed oligodendrocyte precursor	185.2 nTPM
Cerebellum	255.3 nTPM
Midbrain	209.2 nTPM
Amygdala	207.5 nTPM
Hypothalamus	205.5 nTPM
Hippocampus	197.4 nTPM
Cerebral cortex	190.0 nTPM
Medulla oblongata	176.9 nTPM
Pons	170.0 nTPM
Basal ganglia	149.5 nTPM
Spinal cord	147.2 nTPM
Thalamus	129.2 nTPM

Deep-layer corticothalamic and 6b	86.2 nTPM
Basal ganglia	95.4 nTPM
Midbrain	89.9 nTPM
Amygdala	88.9 nTPM
Hypothalamus	83.1 nTPM
Cerebral cortex	82.0 nTPM
Hippocampus	78.1 nTPM

Deep-layer intratelencephalic	71.0 nTPM
Cerebral cortex	75.6 nTPM
Amygdala	75.2 nTPM
Basal ganglia	71.2 nTPM
Hypothalamus	70.3 nTPM
Hippocampus	62.6 nTPM

Deep-layer near-projecting	116.4 nTPM
Amygdala	124.7 nTPM
Cerebral cortex	121.4 nTPM
Basal ganglia	116.2 nTPM
Hippocampus	111.6 nTPM
Hypothalamus	108.1 nTPM

Eccentric medium spiny neuron	147.9 nTPM
Amygdala	153.6 nTPM
Thalamus	153.1 nTPM
Hippocampus	150.9 nTPM
Basal ganglia	146.4 nTPM
Hypothalamus	145.6 nTPM
Cerebral cortex	137.6 nTPM

Endothelial cell	291.2 nTPM
Hypothalamus	356.1 nTPM
Amygdala	345.4 nTPM
Hippocampus	306.5 nTPM
Basal ganglia	290.8 nTPM
Cerebral cortex	290.2 nTPM
Cerebellum	279.5 nTPM
Thalamus	275.6 nTPM
Pons	274.0 nTPM
Midbrain	273.1 nTPM
Medulla oblongata	259.5 nTPM
Spinal cord	252.0 nTPM