Single cell type - HCRTR2 - The Human Protein Atlas

HCRTR2

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HCRTR2
Gene descriptionⁱ Full gene name according to HGNC.	Hypocretin receptor 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	FDA approved drug targets G-protein coupled receptors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neurons - Synaptic function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Inhibitory neurons, Excitatory neurons, Peritubular cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.97
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Lower rhombic lip, LAMP5-LHX6 and Chandelier, Deep-layer corticothalamic and 6b, Cerebellar inhibitory)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Inhibitory neurons, Excitatory neurons, Peritubular cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Lower rhombic lip, LAMP5-LHX6 and Chandelier, Deep-layer corticothalamic and 6b, Cerebellar inhibitory)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

HCRTR2 is part of cluster 65 Neurons - Synaptic function with confidenceⁱ 1
250 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OCA2	OCA2 melanosomal transmembrane protein	0.8742	65
EPHA5	EPH receptor A5	0.8515	69
RGS7BP	Regulator of G protein signaling 7 binding protein	0.8309	65
PAK5	P21 (RAC1) activated kinase 5	0.8151	8
OC90	Otoconin 90	0.8100	65
RGS7	Regulator of G protein signaling 7	0.8043	65
SH3RF3	SH3 domain containing ring finger 3	0.8041	65
MACROD2	Mono-ADP ribosylhydrolase 2	0.7970	65
KCNQ3	Potassium voltage-gated channel subfamily Q member 3	0.7960	65
GRM5	Glutamate metabotropic receptor 5	0.7857	65
RPH3A	Rabphilin 3A	0.7851	65
PLPPR4	Phospholipid phosphatase related 4	0.7805	65
GARNL3	GTPase activating Rap/RanGAP domain like 3	0.7772	69
RIMS1	Regulating synaptic membrane exocytosis 1	0.7770	65
CDH8	Cadherin 8	0.7739	69

Adipocytes	0.0 nTPM
Adipose tissue	0.0 nTPM
Breast	0.0 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	0.0 nTPM
Lung	0.0 nTPM

Astrocytes	0.3 nTPM
Brain	0.3 nTPM

B-cells	0.0 nTPM
Thymus	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Salivary gland	0.0 nTPM

Ciliated cells	0.0 nTPM
Endometrium	0.0 nTPM
Bronchus	0.0 nTPM
Lung	0.0 nTPM
Fallopian tube	0.0 nTPM

Club cells	0.0 nTPM
Bronchus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM

Endothelial cells	0.0 nTPM
Ovary	0.1 nTPM
Testis	0.0 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	0.1 nTPM
Skeletal muscle	0.3 nTPM
Lung	0.3 nTPM
Placenta	0.2 nTPM
Vascular	0.2 nTPM
Adipose tissue	0.1 nTPM
Salivary gland	0.1 nTPM
Thymus	0.1 nTPM
Fallopian tube	0.1 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Stomach	0.0 nTPM
Prostate	0.0 nTPM
Breast	0.0 nTPM

Granulocytes	0.0 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM
Fallopian tube	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	0.0 nTPM
Fallopian tube	0.0 nTPM
Ovary	0.0 nTPM

Macrophages	0.0 nTPM
Testis	0.0 nTPM
Kidney	0.0 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Plasma cells	0.0 nTPM
Thymus	0.1 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM
Fallopian tube	0.0 nTPM

Schwann cells	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Vascular	0.0 nTPM

Serous glandular cells	0.0 nTPM
Salivary gland	0.0 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	0.1 nTPM
Placenta	2.0 nTPM
Liver	0.0 nTPM
Endometrium	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM
Ovary	0.0 nTPM

T-cells	0.0 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
Endometrium	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

Undifferentiated cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Amygdala excitatory	50.3 nTPM
Thalamus	138.4 nTPM
Hypothalamus	64.6 nTPM
Basal ganglia	48.2 nTPM
Amygdala	18.9 nTPM
Cerebral cortex	18.6 nTPM
Hippocampus	13.0 nTPM

Astrocyte	1.2 nTPM
Hypothalamus	2.8 nTPM
Pons	1.9 nTPM
Thalamus	1.8 nTPM
Basal ganglia	1.1 nTPM
Medulla oblongata	1.1 nTPM
Spinal cord	1.0 nTPM
Cerebellum	0.9 nTPM
Amygdala	0.8 nTPM
Midbrain	0.8 nTPM
Cerebral cortex	0.6 nTPM
Hippocampus	0.4 nTPM

Bergmann glia	0.7 nTPM
Pons	1.4 nTPM
Cerebellum	0.8 nTPM
Medulla oblongata	0.0 nTPM

Central nervous system macrophage	0.8 nTPM
Pons	2.0 nTPM
Thalamus	1.4 nTPM
Cerebral cortex	0.9 nTPM
Hypothalamus	0.9 nTPM
Amygdala	0.7 nTPM
Basal ganglia	0.6 nTPM
Medulla oblongata	0.5 nTPM
Midbrain	0.5 nTPM
Hippocampus	0.4 nTPM
Cerebellum	0.3 nTPM
Spinal cord	0.3 nTPM

Cerebellar inhibitory	120.7 nTPM
Pons	311.8 nTPM
Midbrain	149.9 nTPM
Medulla oblongata	65.7 nTPM
Cerebellum	62.1 nTPM
Spinal cord	13.7 nTPM

Cge interneuron	22.9 nTPM
Hypothalamus	38.5 nTPM
Amygdala	31.1 nTPM
Cerebral cortex	25.4 nTPM
Basal ganglia	23.4 nTPM
Hippocampus	22.8 nTPM
Midbrain	11.4 nTPM
Thalamus	7.5 nTPM

Choroid plexus epithelial cell	0.4 nTPM
Medulla oblongata	1.3 nTPM
Basal ganglia	0.4 nTPM
Hippocampus	0.0 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	5.9 nTPM
Medulla oblongata	24.5 nTPM
Cerebellum	11.1 nTPM
Midbrain	7.6 nTPM
Pons	6.2 nTPM
Thalamus	5.6 nTPM
Basal ganglia	3.8 nTPM
Amygdala	2.8 nTPM
Hypothalamus	2.7 nTPM
Cerebral cortex	0.6 nTPM
Hippocampus	0.0 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	132.2 nTPM
Hippocampus	186.4 nTPM
Amygdala	154.9 nTPM
Basal ganglia	124.7 nTPM
Midbrain	117.6 nTPM
Cerebral cortex	113.4 nTPM
Hypothalamus	96.0 nTPM

Deep-layer intratelencephalic	11.2 nTPM
Amygdala	28.1 nTPM
Hypothalamus	12.8 nTPM
Cerebral cortex	7.1 nTPM
Basal ganglia	4.7 nTPM
Hippocampus	3.1 nTPM

Deep-layer near-projecting	60.1 nTPM
Hypothalamus	101.7 nTPM
Basal ganglia	81.9 nTPM
Amygdala	50.1 nTPM
Hippocampus	33.8 nTPM
Cerebral cortex	33.2 nTPM

Eccentric medium spiny neuron	35.2 nTPM
Amygdala	66.5 nTPM
Hippocampus	65.1 nTPM
Thalamus	31.4 nTPM
Cerebral cortex	23.0 nTPM
Hypothalamus	15.8 nTPM
Basal ganglia	9.7 nTPM

Endothelial cell	0.6 nTPM
Cerebellum	1.5 nTPM
Hypothalamus	1.2 nTPM
Thalamus	1.1 nTPM
Hippocampus	1.0 nTPM
Basal ganglia	0.9 nTPM
Cerebral cortex	0.6 nTPM
Pons	0.6 nTPM
Amygdala	0.0 nTPM
Medulla oblongata	0.0 nTPM
Midbrain	0.0 nTPM
Spinal cord	0.0 nTPM

Ependymal cell	0.5 nTPM
Amygdala	2.3 nTPM
Hypothalamus	0.9 nTPM
Basal ganglia	0.6 nTPM
Thalamus	0.4 nTPM
Hippocampus	0.3 nTPM
Medulla oblongata	0.2 nTPM
Midbrain	0.0 nTPM
Pons	0.0 nTPM
Spinal cord	0.0 nTPM