Single cell type - ZFHX2 - The Human Protein Atlas

ZFHX2

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZFHX2
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger homeobox 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Ciliated cells - Cilium assembly (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Early spermatids, Excitatory neurons, Late spermatids, Oligodendrocyte precursor cells, Astrocytes, Ciliated cells, Oligodendrocytes, Inhibitory neurons)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.72
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Early spermatids, Excitatory neurons, Late spermatids, Oligodendrocyte precursor cells, Astrocytes, Ciliated cells, Oligodendrocytes, Inhibitory neurons)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ZFHX2 is part of cluster 42 Ciliated cells - Cilium assembly with confidenceⁱ 1
429 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NEK11	NIMA related kinase 11	0.6383	42
C16orf46	Chromosome 16 open reading frame 46	0.6035	42
RPGRIP1L	RPGRIP1 like	0.5744	42
CFAP46	Cilia and flagella associated protein 46	0.5701	42
DYNC2H1	Dynein cytoplasmic 2 heavy chain 1	0.5632	42
DNAH6	Dynein axonemal heavy chain 6	0.5558	42
NEK4	NIMA related kinase 4	0.5525	31
ARMC2	Armadillo repeat containing 2	0.5480	42
KHDRBS3	KH RNA binding domain containing, signal transduction associated 3	0.5479	34
RFX3	Regulatory factor X3	0.5428	34
SPEF1	Sperm flagellar 1	0.5427	42
CEP126	Centrosomal protein 126	0.5414	42
FBXO15	F-box protein 15	0.5297	42
CCDC39	Coiled-coil domain containing 39	0.5266	42
DNAH7	Dynein axonemal heavy chain 7	0.5227	42

Adipocytes	0.5 nTPM
Breast	0.9 nTPM
Adipose tissue	0.2 nTPM

Alveolar cells type 1	1.0 nTPM
Lung	1.0 nTPM

Alveolar cells type 2	1.0 nTPM
Lung	1.0 nTPM

B-cells	0.8 nTPM
Liver	4.8 nTPM
Spleen	2.5 nTPM
Lymph node	1.2 nTPM
Thymus	0.8 nTPM
Bone marrow	0.7 nTPM
Adipose tissue	0.4 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Salivary gland	0.0 nTPM

Basal keratinocytes	0.2 nTPM
Tongue	0.4 nTPM
Skin	0.0 nTPM

Ciliated cells	21.1 nTPM
Lung	35.7 nTPM
Fallopian tube	17.3 nTPM
Bronchus	17.1 nTPM
Endometrium	14.3 nTPM

Club cells	2.1 nTPM
Prostate	2.8 nTPM
Lung	2.3 nTPM
Bronchus	1.2 nTPM

Endothelial cells	1.0 nTPM
Pancreas	2.6 nTPM
Testis	2.4 nTPM
Endometrium	2.0 nTPM
Prostate	1.4 nTPM
Liver	1.3 nTPM
Placenta	1.1 nTPM
Salivary gland	1.0 nTPM
Ovary	1.0 nTPM
Breast	0.9 nTPM
Esophagus	0.8 nTPM
Fallopian tube	0.8 nTPM
Thymus	0.7 nTPM
Skin	0.6 nTPM
Vascular	0.6 nTPM
Heart muscle	0.5 nTPM
Skeletal muscle	0.4 nTPM
Tongue	0.4 nTPM
Lung	0.3 nTPM

Enteroendocrine cells	4.8 nTPM
Rectum	10.1 nTPM
Small intestine	3.4 nTPM
Colon	0.9 nTPM

Fibroblasts	1.6 nTPM
Thymus	4.2 nTPM
Skeletal muscle	3.5 nTPM
Vascular	2.9 nTPM
Salivary gland	2.5 nTPM
Esophagus	2.2 nTPM
Stomach	1.4 nTPM
Breast	1.4 nTPM
Placenta	1.3 nTPM
Lung	1.2 nTPM
Skin	1.0 nTPM
Heart muscle	0.8 nTPM
Adipose tissue	0.8 nTPM
Pancreas	0.7 nTPM
Prostate	0.7 nTPM
Fallopian tube	0.7 nTPM
Liver	0.0 nTPM

Granulocytes	1.0 nTPM
Fallopian tube	1.9 nTPM
Lung	1.0 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	1.0 nTPM
Rectum	1.2 nTPM
Colon	1.0 nTPM
Small intestine	0.9 nTPM

Lymphatic endothelial cells	0.5 nTPM
Fallopian tube	1.0 nTPM
Ovary	0.0 nTPM

Macrophages	1.3 nTPM
Thymus	3.1 nTPM
Tongue	2.8 nTPM
Esophagus	2.6 nTPM
Lung	2.2 nTPM
Breast	1.9 nTPM
Fallopian tube	1.7 nTPM
Salivary gland	1.6 nTPM
Prostate	1.5 nTPM
Skeletal muscle	1.4 nTPM
Vascular	1.2 nTPM
Skin	1.1 nTPM
Bone marrow	1.0 nTPM
Spleen	1.0 nTPM
Adipose tissue	0.7 nTPM
Endometrium	0.6 nTPM
Testis	0.0 nTPM
Kidney	0.0 nTPM
Pancreas	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	2.4 nTPM
Small intestine	6.9 nTPM
Rectum	0.2 nTPM
Colon	0.0 nTPM

Astrocytes	21.4 nTPM
Brain	21.4 nTPM

Bipolar cells	8.7 nTPM
Eye	8.7 nTPM

Distal tubular cells	9.2 nTPM
Kidney	9.2 nTPM

Early spermatids	47.9 nTPM
Testis	47.9 nTPM

Plasma cells	0.4 nTPM
Salivary gland	1.3 nTPM
Fallopian tube	1.0 nTPM
Thymus	0.7 nTPM
Spleen	0.5 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM

Schwann cells	1.2 nTPM
Vascular	3.7 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	0.4 nTPM
Salivary gland	0.9 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	1.7 nTPM
Esophagus	4.8 nTPM
Prostate	3.0 nTPM
Liver	2.5 nTPM
Ovary	2.5 nTPM
Vascular	1.9 nTPM
Tongue	1.8 nTPM
Skin	1.7 nTPM
Fallopian tube	1.7 nTPM
Endometrium	1.6 nTPM
Thymus	1.3 nTPM
Breast	1.3 nTPM
Skeletal muscle	1.2 nTPM
Lung	1.2 nTPM
Placenta	0.6 nTPM
Adipose tissue	0.4 nTPM
Salivary gland	0.0 nTPM

T-cells	0.5 nTPM
Spleen	1.4 nTPM
Vascular	1.2 nTPM
Endometrium	1.1 nTPM
Skin	1.1 nTPM
Breast	0.9 nTPM
PBMC	0.8 nTPM
Skeletal muscle	0.8 nTPM
Liver	0.7 nTPM
Fallopian tube	0.7 nTPM
Stomach	0.6 nTPM
Lymph node	0.5 nTPM
Adipose tissue	0.3 nTPM
Lung	0.3 nTPM
Prostate	0.3 nTPM
Thymus	0.3 nTPM
Tongue	0.3 nTPM
Bone marrow	0.2 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Esophagus	0.0 nTPM
Salivary gland	0.0 nTPM

Undifferentiated cells	1.2 nTPM
Small intestine	1.5 nTPM
Rectum	1.5 nTPM
Colon	0.5 nTPM

Amygdala excitatory	50.1 nTPM
Hypothalamus	72.2 nTPM
Cerebral cortex	52.6 nTPM
Basal ganglia	49.3 nTPM
Hippocampus	47.5 nTPM
Amygdala	40.6 nTPM
Thalamus	38.6 nTPM

Astrocyte	55.2 nTPM
Amygdala	66.0 nTPM
Hypothalamus	62.8 nTPM
Cerebellum	60.8 nTPM
Cerebral cortex	60.5 nTPM
Thalamus	57.1 nTPM
Hippocampus	54.4 nTPM
Basal ganglia	53.8 nTPM
Midbrain	52.0 nTPM
Medulla oblongata	50.6 nTPM
Pons	45.0 nTPM
Spinal cord	44.2 nTPM

Bergmann glia	72.7 nTPM
Medulla oblongata	76.7 nTPM
Pons	76.2 nTPM
Cerebellum	65.1 nTPM

Central nervous system macrophage	9.8 nTPM
Cerebellum	12.1 nTPM
Amygdala	11.7 nTPM
Hypothalamus	11.6 nTPM
Thalamus	10.5 nTPM
Cerebral cortex	10.4 nTPM
Hippocampus	9.6 nTPM
Pons	9.2 nTPM
Midbrain	9.0 nTPM
Basal ganglia	8.3 nTPM
Medulla oblongata	8.3 nTPM
Spinal cord	6.8 nTPM

Cerebellar inhibitory	37.3 nTPM
Medulla oblongata	46.4 nTPM
Spinal cord	41.2 nTPM
Cerebellum	39.3 nTPM
Pons	30.2 nTPM
Midbrain	29.5 nTPM

Cge interneuron	44.3 nTPM
Amygdala	51.1 nTPM
Basal ganglia	47.4 nTPM
Hippocampus	46.4 nTPM
Cerebral cortex	45.4 nTPM
Hypothalamus	45.0 nTPM
Midbrain	38.3 nTPM
Thalamus	36.6 nTPM

Choroid plexus epithelial cell	34.8 nTPM
Basal ganglia	54.0 nTPM
Thalamus	35.6 nTPM
Hippocampus	25.0 nTPM
Medulla oblongata	24.5 nTPM

Committed oligodendrocyte precursor	31.9 nTPM
Cerebral cortex	45.6 nTPM
Amygdala	38.9 nTPM
Basal ganglia	33.4 nTPM
Hippocampus	33.1 nTPM
Medulla oblongata	32.3 nTPM
Spinal cord	29.4 nTPM
Thalamus	28.8 nTPM
Cerebellum	28.5 nTPM
Pons	28.3 nTPM
Midbrain	27.7 nTPM
Hypothalamus	24.6 nTPM

Deep-layer corticothalamic and 6b	59.8 nTPM
Hypothalamus	97.7 nTPM
Amygdala	56.7 nTPM
Cerebral cortex	56.2 nTPM
Midbrain	53.3 nTPM
Basal ganglia	47.8 nTPM
Hippocampus	46.9 nTPM

Deep-layer intratelencephalic	64.0 nTPM
Amygdala	85.2 nTPM
Hypothalamus	76.5 nTPM
Cerebral cortex	56.5 nTPM
Basal ganglia	53.8 nTPM
Hippocampus	48.1 nTPM

Deep-layer near-projecting	41.5 nTPM
Hypothalamus	48.8 nTPM
Amygdala	48.2 nTPM
Cerebral cortex	38.7 nTPM
Hippocampus	37.1 nTPM
Basal ganglia	34.7 nTPM

Eccentric medium spiny neuron	45.8 nTPM
Cerebral cortex	53.8 nTPM
Amygdala	47.3 nTPM
Thalamus	46.6 nTPM
Basal ganglia	46.3 nTPM
Hypothalamus	43.4 nTPM
Hippocampus	37.3 nTPM

Endothelial cell	11.3 nTPM
Thalamus	14.1 nTPM
Cerebellum	13.9 nTPM
Hypothalamus	13.6 nTPM
Midbrain	13.2 nTPM
Cerebral cortex	12.1 nTPM
Hippocampus	11.9 nTPM
Pons	10.6 nTPM
Spinal cord	10.4 nTPM
Basal ganglia	10.3 nTPM
Amygdala	10.1 nTPM
Medulla oblongata	4.1 nTPM

Ependymal cell	140.4 nTPM
Basal ganglia	186.8 nTPM
Amygdala	169.5 nTPM
Hypothalamus	169.5 nTPM
Hippocampus	152.4 nTPM
Thalamus	132.8 nTPM
Midbrain	131.4 nTPM
Pons	122.2 nTPM
Medulla oblongata	106.5 nTPM
Spinal cord	92.0 nTPM