Single cell type - MRAP2 - The Human Protein Atlas

MRAP2

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MRAP2
Gene descriptionⁱ Full gene name according to HGNC.	Melanocortin 2 receptor accessory protein 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neurons - Neuronal signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Excitatory neurons, Inhibitory neurons, Oocytes, Gastric mucus-secreting cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.77
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Eccentric medium spiny neuron)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Excitatory neurons, Inhibitory neurons, Oocytes, Gastric mucus-secreting cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Eccentric medium spiny neuron)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

MRAP2 is part of cluster 69 Neurons - Neuronal signaling with confidenceⁱ 1
331 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HTR1F	5-hydroxytryptamine receptor 1F	0.7307	34
KCNB2	Potassium voltage-gated channel subfamily B member 2	0.7030	69
OLFM3	Olfactomedin 3	0.6501	34
SCN2A	Sodium voltage-gated channel alpha subunit 2	0.6495	69
CDH10	Cadherin 10	0.6486	34
FRMPD4	FERM and PDZ domain containing 4	0.6483	69
OR2AG2	Olfactory receptor family 2 subfamily AG member 2	0.6458	34
ENTREP2	Endosomal transmembrane epsin interactor 2	0.6446	69
NBEA	Neurobeachin	0.6442	69
SLC5A4	Solute carrier family 5 member 4	0.6408	69
SCN3A	Sodium voltage-gated channel alpha subunit 3	0.6339	34
RTN1	Reticulon 1	0.6323	69
ITGA8	Integrin subunit alpha 8	0.6312	32
MYT1L	Myelin transcription factor 1 like	0.6308	69
SNTG1	Syntrophin gamma 1	0.6225	69

Adipocytes	1.6 nTPM
Breast	2.3 nTPM
Adipose tissue	0.8 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	0.8 nTPM
Lung	0.8 nTPM

Astrocytes	3.1 nTPM
Brain	3.1 nTPM

B-cells	0.0 nTPM
Salivary gland	0.2 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Thymus	0.0 nTPM

Ciliated cells	6.5 nTPM
Fallopian tube	11.3 nTPM
Endometrium	5.9 nTPM
Lung	4.6 nTPM
Bronchus	4.1 nTPM

Club cells	2.3 nTPM
Lung	3.4 nTPM
Prostate	2.3 nTPM
Bronchus	1.3 nTPM

Endothelial cells	1.9 nTPM
Skin	13.8 nTPM
Placenta	5.1 nTPM
Esophagus	3.4 nTPM
Breast	2.6 nTPM
Vascular	1.6 nTPM
Liver	1.3 nTPM
Fallopian tube	1.3 nTPM
Salivary gland	1.2 nTPM
Tongue	0.9 nTPM
Prostate	0.7 nTPM
Thymus	0.6 nTPM
Heart muscle	0.5 nTPM
Testis	0.3 nTPM
Skeletal muscle	0.3 nTPM
Ovary	0.3 nTPM
Endometrium	0.1 nTPM
Pancreas	0.0 nTPM
Lung	0.0 nTPM

Enteroendocrine cells	3.7 nTPM
Colon	6.0 nTPM
Small intestine	3.4 nTPM
Rectum	1.7 nTPM

Fibroblasts	1.0 nTPM
Vascular	4.1 nTPM
Skin	2.8 nTPM
Prostate	2.0 nTPM
Breast	1.9 nTPM
Pancreas	1.4 nTPM
Adipose tissue	1.2 nTPM
Skeletal muscle	0.9 nTPM
Thymus	0.9 nTPM
Esophagus	0.3 nTPM
Lung	0.3 nTPM
Salivary gland	0.3 nTPM
Fallopian tube	0.3 nTPM
Placenta	0.2 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Stomach	0.0 nTPM

Granulocytes	0.1 nTPM
Fallopian tube	0.4 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	13.3 nTPM
Small intestine	14.2 nTPM
Rectum	13.8 nTPM
Colon	12.1 nTPM

Lymphatic endothelial cells	0.5 nTPM
Fallopian tube	0.9 nTPM
Ovary	0.0 nTPM

Macrophages	0.2 nTPM
Endometrium	1.2 nTPM
Testis	0.6 nTPM
Vascular	0.5 nTPM
Salivary gland	0.4 nTPM
Prostate	0.3 nTPM
Tongue	0.2 nTPM
Fallopian tube	0.2 nTPM
Kidney	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Thymus	0.0 nTPM
Breast	0.0 nTPM

Paneth cells	8.8 nTPM
Colon	14.5 nTPM
Rectum	8.5 nTPM
Small intestine	3.5 nTPM

Basal squamous epithelial cells	2.2 nTPM
Esophagus	2.2 nTPM

Collecting duct cells	13.6 nTPM
Kidney	13.6 nTPM

Distal enterocytes	5.5 nTPM
Rectum	9.0 nTPM
Colon	2.1 nTPM

Excitatory neurons	54.6 nTPM
Brain	54.6 nTPM

Plasma cells	0.1 nTPM
Salivary gland	0.4 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Thymus	0.0 nTPM
Fallopian tube	0.0 nTPM

Schwann cells	0.9 nTPM
Vascular	2.6 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	2.2 nTPM
Salivary gland	4.4 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	5.7 nTPM
Vascular	34.1 nTPM
Ovary	10.5 nTPM
Esophagus	9.6 nTPM
Prostate	6.7 nTPM
Liver	5.9 nTPM
Fallopian tube	5.1 nTPM
Thymus	4.5 nTPM
Breast	4.1 nTPM
Lung	3.5 nTPM
Salivary gland	2.6 nTPM
Adipose tissue	1.3 nTPM
Skeletal muscle	0.9 nTPM
Skin	0.6 nTPM
Tongue	0.6 nTPM
Placenta	0.2 nTPM
Endometrium	0.2 nTPM

T-cells	0.2 nTPM
Vascular	2.4 nTPM
Colon	1.0 nTPM
Endometrium	1.0 nTPM
Prostate	0.2 nTPM
Salivary gland	0.2 nTPM
Fallopian tube	0.2 nTPM
Tongue	0.1 nTPM
Breast	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Thymus	0.0 nTPM

Undifferentiated cells	6.4 nTPM
Small intestine	13.1 nTPM
Colon	4.3 nTPM
Rectum	1.9 nTPM

Amygdala excitatory	46.7 nTPM
Hypothalamus	94.0 nTPM
Thalamus	54.0 nTPM
Basal ganglia	39.8 nTPM
Cerebral cortex	36.6 nTPM
Amygdala	28.0 nTPM
Hippocampus	27.8 nTPM

Astrocyte	1.3 nTPM
Thalamus	3.2 nTPM
Hypothalamus	2.0 nTPM
Medulla oblongata	2.0 nTPM
Cerebral cortex	1.5 nTPM
Amygdala	1.3 nTPM
Basal ganglia	1.0 nTPM
Pons	0.8 nTPM
Cerebellum	0.7 nTPM
Midbrain	0.7 nTPM
Spinal cord	0.7 nTPM
Hippocampus	0.4 nTPM

Bergmann glia	37.9 nTPM
Cerebellum	47.9 nTPM
Pons	36.0 nTPM
Medulla oblongata	29.8 nTPM

Central nervous system macrophage	1.0 nTPM
Thalamus	3.4 nTPM
Hypothalamus	1.6 nTPM
Medulla oblongata	1.6 nTPM
Cerebral cortex	1.5 nTPM
Hippocampus	0.8 nTPM
Amygdala	0.6 nTPM
Basal ganglia	0.6 nTPM
Cerebellum	0.5 nTPM
Midbrain	0.3 nTPM
Spinal cord	0.3 nTPM
Pons	0.2 nTPM

Cerebellar inhibitory	8.5 nTPM
Cerebellum	11.9 nTPM
Medulla oblongata	11.0 nTPM
Midbrain	7.5 nTPM
Pons	6.7 nTPM
Spinal cord	5.5 nTPM

Cge interneuron	39.0 nTPM
Hypothalamus	58.2 nTPM
Amygdala	48.7 nTPM
Cerebral cortex	45.2 nTPM
Basal ganglia	45.0 nTPM
Hippocampus	33.0 nTPM
Midbrain	22.1 nTPM
Thalamus	20.7 nTPM

Choroid plexus epithelial cell	24.3 nTPM
Basal ganglia	43.8 nTPM
Thalamus	30.1 nTPM
Medulla oblongata	15.1 nTPM
Hippocampus	8.3 nTPM

Committed oligodendrocyte precursor	8.0 nTPM
Thalamus	26.3 nTPM
Medulla oblongata	23.2 nTPM
Pons	8.9 nTPM
Basal ganglia	8.8 nTPM
Midbrain	5.9 nTPM
Cerebral cortex	5.1 nTPM
Hypothalamus	4.1 nTPM
Hippocampus	2.1 nTPM
Amygdala	1.7 nTPM
Cerebellum	1.6 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	92.6 nTPM
Amygdala	136.2 nTPM
Basal ganglia	111.4 nTPM
Hypothalamus	96.2 nTPM
Cerebral cortex	91.7 nTPM
Hippocampus	65.5 nTPM
Midbrain	54.4 nTPM

Deep-layer intratelencephalic	59.1 nTPM
Hypothalamus	82.4 nTPM
Amygdala	60.2 nTPM
Hippocampus	56.6 nTPM
Cerebral cortex	48.4 nTPM
Basal ganglia	48.2 nTPM

Deep-layer near-projecting	40.1 nTPM
Hypothalamus	60.6 nTPM
Amygdala	46.0 nTPM
Basal ganglia	39.2 nTPM
Cerebral cortex	37.0 nTPM
Hippocampus	17.9 nTPM

Eccentric medium spiny neuron	137.7 nTPM
Amygdala	179.7 nTPM
Hippocampus	155.0 nTPM
Thalamus	148.7 nTPM
Cerebral cortex	130.6 nTPM
Hypothalamus	124.6 nTPM
Basal ganglia	87.4 nTPM

Endothelial cell	1.6 nTPM
Thalamus	5.1 nTPM
Amygdala	4.5 nTPM
Cerebral cortex	2.6 nTPM
Hippocampus	1.6 nTPM
Hypothalamus	1.2 nTPM
Midbrain	0.9 nTPM
Cerebellum	0.8 nTPM
Pons	0.6 nTPM
Basal ganglia	0.0 nTPM
Medulla oblongata	0.0 nTPM
Spinal cord	0.0 nTPM

Ependymal cell	38.9 nTPM
Hypothalamus	66.9 nTPM
Amygdala	40.4 nTPM
Basal ganglia	39.8 nTPM
Midbrain	37.5 nTPM
Pons	37.3 nTPM
Medulla oblongata	36.0 nTPM
Hippocampus	35.5 nTPM
Thalamus	30.0 nTPM
Spinal cord	26.8 nTPM