Single cell type - DLG4 - The Human Protein Atlas

DLG4

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DLG4
Gene descriptionⁱ Full gene name according to HGNC.	Discs large MAGUK scaffold protein 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	19

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Photoreceptor cells - Visual perception (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Cone photoreceptor cells, Rod photoreceptor cells, Bipolar cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.71
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Cone photoreceptor cells, Rod photoreceptor cells, Bipolar cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

DLG4 is part of cluster 66 Photoreceptor cells - Visual perception with confidenceⁱ 1
340 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
P3H3	Prolyl 3-hydroxylase 3	0.7515	66
GRK7	G protein-coupled receptor kinase 7	0.7508	66
ENSG00000283536	Novel protein	0.7378	66
CNGA3	Cyclic nucleotide gated channel subunit alpha 3	0.7351	66
PSKH2	Protein serine kinase H2	0.7319	66
GJD2	Gap junction protein delta 2	0.7318	66
PDE6C	Phosphodiesterase 6C	0.7257	66
MPP4	MAGUK p55 scaffold protein 4	0.7191	66
ENSG00000288593	Novel protein	0.7120	66
UBAP1L	Ubiquitin associated protein 1 like	0.7115	66
RP1L1	RP1 like 1	0.7101	66
NTNG2	Netrin G2	0.7082	66
GUCA1B	Guanylate cyclase activator 1B	0.7073	66
OPN1SW	Opsin 1, short wave sensitive	0.7025	66
GUCA1A	Guanylate cyclase activator 1A	0.6999	66

Adipocytes	4.1 nTPM
Adipose tissue	4.2 nTPM
Breast	4.1 nTPM

Alveolar cells type 1	0.2 nTPM
Lung	0.2 nTPM

Alveolar cells type 2	3.2 nTPM
Lung	3.2 nTPM

Astrocytes	13.3 nTPM
Brain	13.3 nTPM

B-cells	1.1 nTPM
Kidney	5.2 nTPM
Thymus	2.3 nTPM
Skin	1.7 nTPM
Lymph node	1.4 nTPM
Spleen	1.4 nTPM
Lung	1.3 nTPM
Salivary gland	0.5 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM

Ciliated cells	3.0 nTPM
Bronchus	4.8 nTPM
Lung	4.0 nTPM
Endometrium	2.3 nTPM
Fallopian tube	1.1 nTPM

Club cells	2.0 nTPM
Bronchus	2.3 nTPM
Prostate	2.0 nTPM
Lung	1.8 nTPM

Endothelial cells	5.9 nTPM
Esophagus	12.5 nTPM
Placenta	11.4 nTPM
Ovary	11.4 nTPM
Endometrium	11.1 nTPM
Testis	10.7 nTPM
Skin	7.9 nTPM
Thymus	7.8 nTPM
Vascular	5.2 nTPM
Salivary gland	4.0 nTPM
Lung	3.9 nTPM
Liver	3.8 nTPM
Fallopian tube	3.5 nTPM
Prostate	3.1 nTPM
Tongue	2.8 nTPM
Pancreas	2.6 nTPM
Breast	2.6 nTPM
Skeletal muscle	1.4 nTPM
Heart muscle	0.2 nTPM

Enteroendocrine cells	9.8 nTPM
Rectum	18.4 nTPM
Small intestine	10.3 nTPM
Colon	0.7 nTPM

Fibroblasts	6.2 nTPM
Esophagus	12.1 nTPM
Breast	10.0 nTPM
Thymus	8.7 nTPM
Fallopian tube	8.0 nTPM
Skin	7.7 nTPM
Adipose tissue	6.8 nTPM
Placenta	6.4 nTPM
Lung	6.4 nTPM
Vascular	5.9 nTPM
Stomach	5.8 nTPM
Liver	4.7 nTPM
Pancreas	4.7 nTPM
Skeletal muscle	4.6 nTPM
Prostate	4.0 nTPM
Salivary gland	3.4 nTPM
Heart muscle	0.0 nTPM

Granulocytes	2.7 nTPM
Lung	4.5 nTPM
Fallopian tube	3.5 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	1.0 nTPM
Colon	1.7 nTPM
Rectum	0.8 nTPM
Small intestine	0.7 nTPM

Lymphatic endothelial cells	10.0 nTPM
Ovary	16.4 nTPM
Fallopian tube	3.5 nTPM

Macrophages	8.3 nTPM
Stomach	15.4 nTPM
Bone marrow	15.2 nTPM
Adipose tissue	14.6 nTPM
Endometrium	10.5 nTPM
Pancreas	10.3 nTPM
Skin	10.0 nTPM
Fallopian tube	9.4 nTPM
Thymus	9.3 nTPM
Skeletal muscle	8.2 nTPM
Spleen	8.0 nTPM
Esophagus	7.7 nTPM
Vascular	6.3 nTPM
Kidney	6.2 nTPM
Salivary gland	5.6 nTPM
Tongue	5.6 nTPM
Lung	5.2 nTPM
Breast	4.5 nTPM
Testis	3.7 nTPM
Prostate	1.2 nTPM

Paneth cells	0.2 nTPM
Rectum	0.5 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Basal squamous epithelial cells	6.6 nTPM
Esophagus	6.6 nTPM

Cholangiocytes	1.9 nTPM
Liver	1.9 nTPM

Cone photoreceptor cells	122.3 nTPM
Eye	122.3 nTPM

Endometrial stromal cells	9.7 nTPM
Endometrium	9.7 nTPM

Plasma cells	1.1 nTPM
Salivary gland	3.1 nTPM
Liver	2.0 nTPM
Fallopian tube	1.6 nTPM
Stomach	1.3 nTPM
Thymus	0.5 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Schwann cells	5.1 nTPM
Esophagus	12.0 nTPM
Vascular	2.1 nTPM
Adipose tissue	1.2 nTPM

Serous glandular cells	0.5 nTPM
Salivary gland	1.1 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	6.0 nTPM
Lung	11.8 nTPM
Liver	11.5 nTPM
Placenta	8.5 nTPM
Endometrium	8.4 nTPM
Esophagus	8.4 nTPM
Ovary	7.2 nTPM
Fallopian tube	6.6 nTPM
Adipose tissue	6.0 nTPM
Thymus	5.8 nTPM
Breast	4.8 nTPM
Vascular	4.3 nTPM
Skin	3.8 nTPM
Tongue	3.3 nTPM
Skeletal muscle	3.0 nTPM
Prostate	1.8 nTPM
Salivary gland	1.4 nTPM

T-cells	1.4 nTPM
Stomach	3.1 nTPM
Thymus	3.1 nTPM
Skin	2.5 nTPM
Endometrium	2.3 nTPM
Lymph node	2.1 nTPM
Spleen	1.4 nTPM
Lung	1.3 nTPM
PBMC	1.2 nTPM
Vascular	1.2 nTPM
Skeletal muscle	1.1 nTPM
Bone marrow	1.1 nTPM
Colon	1.0 nTPM
Liver	1.0 nTPM
Prostate	1.0 nTPM
Breast	1.0 nTPM
Kidney	0.9 nTPM
Salivary gland	0.9 nTPM
Tongue	0.9 nTPM
Adipose tissue	0.8 nTPM
Fallopian tube	0.8 nTPM
Esophagus	0.0 nTPM

Undifferentiated cells	0.9 nTPM
Colon	0.9 nTPM
Rectum	0.9 nTPM
Small intestine	0.8 nTPM

Amygdala excitatory	45.2 nTPM
Hypothalamus	66.8 nTPM
Basal ganglia	44.4 nTPM
Thalamus	42.7 nTPM
Amygdala	40.0 nTPM
Hippocampus	39.3 nTPM
Cerebral cortex	37.7 nTPM

Astrocyte	29.4 nTPM
Cerebellum	40.7 nTPM
Spinal cord	33.4 nTPM
Pons	31.2 nTPM
Midbrain	30.1 nTPM
Thalamus	29.9 nTPM
Cerebral cortex	29.0 nTPM
Hippocampus	28.1 nTPM
Amygdala	26.8 nTPM
Hypothalamus	26.5 nTPM
Basal ganglia	25.1 nTPM
Medulla oblongata	23.2 nTPM

Bergmann glia	22.0 nTPM
Medulla oblongata	29.8 nTPM
Cerebellum	21.8 nTPM
Pons	14.4 nTPM

Central nervous system macrophage	11.6 nTPM
Cerebral cortex	14.9 nTPM
Hippocampus	14.8 nTPM
Amygdala	14.5 nTPM
Thalamus	13.3 nTPM
Hypothalamus	13.2 nTPM
Basal ganglia	10.5 nTPM
Cerebellum	10.2 nTPM
Pons	10.1 nTPM
Midbrain	10.0 nTPM
Spinal cord	9.4 nTPM
Medulla oblongata	6.3 nTPM

Cerebellar inhibitory	97.0 nTPM
Midbrain	120.7 nTPM
Spinal cord	115.5 nTPM
Cerebellum	115.3 nTPM
Medulla oblongata	70.3 nTPM
Pons	63.2 nTPM

Cge interneuron	39.4 nTPM
Hypothalamus	69.6 nTPM
Amygdala	35.9 nTPM
Thalamus	35.4 nTPM
Cerebral cortex	34.5 nTPM
Midbrain	33.7 nTPM
Hippocampus	33.3 nTPM
Basal ganglia	33.1 nTPM

Choroid plexus epithelial cell	37.0 nTPM
Basal ganglia	62.5 nTPM
Medulla oblongata	38.6 nTPM
Thalamus	27.4 nTPM
Hippocampus	19.4 nTPM

Committed oligodendrocyte precursor	15.6 nTPM
Basal ganglia	21.4 nTPM
Amygdala	20.3 nTPM
Hypothalamus	18.4 nTPM
Medulla oblongata	18.1 nTPM
Midbrain	17.6 nTPM
Thalamus	16.0 nTPM
Spinal cord	14.7 nTPM
Hippocampus	14.5 nTPM
Cerebral cortex	13.3 nTPM
Pons	8.9 nTPM
Cerebellum	7.9 nTPM

Deep-layer corticothalamic and 6b	41.6 nTPM
Hypothalamus	81.6 nTPM
Amygdala	43.6 nTPM
Cerebral cortex	40.6 nTPM
Basal ganglia	35.1 nTPM
Hippocampus	33.9 nTPM
Midbrain	14.4 nTPM

Deep-layer intratelencephalic	47.3 nTPM
Hypothalamus	95.1 nTPM
Amygdala	39.4 nTPM
Cerebral cortex	38.2 nTPM
Hippocampus	32.9 nTPM
Basal ganglia	30.9 nTPM

Deep-layer near-projecting	42.5 nTPM
Hypothalamus	84.8 nTPM
Amygdala	35.7 nTPM
Cerebral cortex	35.5 nTPM
Basal ganglia	33.6 nTPM
Hippocampus	23.1 nTPM

Eccentric medium spiny neuron	52.3 nTPM
Hypothalamus	61.5 nTPM
Thalamus	55.1 nTPM
Basal ganglia	51.9 nTPM
Cerebral cortex	49.5 nTPM
Amygdala	48.8 nTPM
Hippocampus	46.8 nTPM

Endothelial cell	6.2 nTPM
Basal ganglia	14.9 nTPM
Hypothalamus	12.4 nTPM
Cerebellum	7.0 nTPM
Cerebral cortex	6.4 nTPM
Amygdala	5.6 nTPM
Hippocampus	5.4 nTPM
Medulla oblongata	5.1 nTPM
Thalamus	4.0 nTPM
Pons	3.1 nTPM
Midbrain	2.8 nTPM
Spinal cord	1.7 nTPM

Ependymal cell	31.6 nTPM
Basal ganglia	46.4 nTPM
Hippocampus	38.0 nTPM
Midbrain	36.2 nTPM
Hypothalamus	34.8 nTPM
Amygdala	32.4 nTPM
Pons	31.4 nTPM
Thalamus	30.0 nTPM
Medulla oblongata	23.9 nTPM
Spinal cord	11.5 nTPM