Single cell type - FCHO1 - The Human Protein Atlas

FCHO1

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FCHO1
Gene descriptionⁱ Full gene name according to HGNC.	FCH and mu domain containing endocytic adaptor 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	38

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Platelets - Hemostasis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oligodendrocytes, Dendritic cells, Langerhans cells, Mesothelial cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.71
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Dendritic cells, Langerhans cells, Mesothelial cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

FCHO1 is part of cluster 57 Platelets - Hemostasis with confidenceⁱ 1
173 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
UBAC2	UBA domain containing 2	0.5271	57
SUSD3	Sushi domain containing 3	0.5024	7
ZGLP1	Zinc finger GATA like protein 1	0.5006	57
ARHGAP45	Rho GTPase activating protein 45	0.4846	19
LRCH4	Leucine rich repeats and calponin homology domain containing 4	0.4781	49
IFNA2	Interferon alpha 2	0.4775	80
C12orf76	Chromosome 12 open reading frame 76	0.4770	57
LRRC8D	Leucine rich repeat containing 8 VRAC subunit D	0.4769	51
NSL1	NSL1 component of MIS12 kinetochore complex	0.4730	55
PIK3CD	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	0.4719	7
GNAZ	G protein subunit alpha z	0.4718	57
RAB37	RAB37, member RAS oncogene family	0.4687	57
RASGRP2	RAS guanyl releasing protein 2	0.4677	57
CSK	C-terminal Src kinase	0.4634	73
RGS10	Regulator of G protein signaling 10	0.4622	57

IMMUNE CELLS

FCHO1 is part of cluster 2 Dendritic cells - Unknown function with confidenceⁱ 0.88
342 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
YBX3	Y-box binding protein 3	1.0000	2
PIERCE2	Piercer of microtubule wall 2	0.9762	23
ENSG00000288629	Novel protein	0.9524	2
TCTN1	Tectonic family member 1	0.9524	2
ZNF768	Zinc finger protein 768	0.9524	2
PLPP3	Phospholipid phosphatase 3	0.9524	23
TSPAN33	Tetraspanin 33	0.9524	2
ARHGAP22	Rho GTPase activating protein 22	0.9524	2
PLEKHM2	Pleckstrin homology and RUN domain containing M2	0.9286	2
ZNF672	Zinc finger protein 672	0.9286	2
FKBP15	FKBP prolyl isomerase family member 15	0.9048	2
MOB3B	MOB kinase activator 3B	0.9048	23
BTN2A2	Butyrophilin subfamily 2 member A2	0.9048	23
RUBCNL	Rubicon like autophagy enhancer	0.9048	23
MEF2C	Myocyte enhancer factor 2C	0.9048	23

Adipocytes	0.6 nTPM
Breast	1.2 nTPM
Adipose tissue	0.0 nTPM

Alveolar cells type 1	0.4 nTPM
Lung	0.4 nTPM

Alveolar cells type 2	9.4 nTPM
Lung	9.4 nTPM

Astrocytes	0.6 nTPM
Brain	0.6 nTPM

B-cells	15.0 nTPM
Bone marrow	31.2 nTPM
Lymph node	28.9 nTPM
Kidney	20.8 nTPM
Lung	16.1 nTPM
Spleen	15.7 nTPM
Liver	14.5 nTPM
Thymus	14.4 nTPM
Stomach	13.1 nTPM
PBMC	10.8 nTPM
Salivary gland	9.0 nTPM
Adipose tissue	8.2 nTPM
Skin	6.8 nTPM
Esophagus	5.9 nTPM

Ciliated cells	0.9 nTPM
Lung	1.5 nTPM
Bronchus	1.1 nTPM
Endometrium	0.5 nTPM
Fallopian tube	0.4 nTPM

Club cells	0.8 nTPM
Lung	1.2 nTPM
Bronchus	0.9 nTPM
Prostate	0.4 nTPM

Endothelial cells	1.8 nTPM
Testis	12.2 nTPM
Esophagus	4.7 nTPM
Pancreas	2.6 nTPM
Thymus	2.3 nTPM
Fallopian tube	1.8 nTPM
Skin	1.6 nTPM
Vascular	1.5 nTPM
Tongue	1.3 nTPM
Salivary gland	1.0 nTPM
Ovary	0.8 nTPM
Endometrium	0.7 nTPM
Lung	0.7 nTPM
Prostate	0.5 nTPM
Skeletal muscle	0.1 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Breast	0.0 nTPM

Enteroendocrine cells	1.9 nTPM
Colon	4.0 nTPM
Rectum	1.7 nTPM
Small intestine	0.0 nTPM

Fibroblasts	0.6 nTPM
Breast	3.0 nTPM
Liver	2.4 nTPM
Lung	1.5 nTPM
Pancreas	0.7 nTPM
Placenta	0.6 nTPM
Thymus	0.6 nTPM
Salivary gland	0.4 nTPM
Vascular	0.3 nTPM
Fallopian tube	0.3 nTPM
Skin	0.2 nTPM
Skeletal muscle	0.1 nTPM
Adipose tissue	0.1 nTPM
Heart muscle	0.0 nTPM
Esophagus	0.0 nTPM
Stomach	0.0 nTPM
Prostate	0.0 nTPM

Granulocytes	4.9 nTPM
Lung	7.1 nTPM
Tongue	4.9 nTPM
Fallopian tube	2.7 nTPM

Intestinal goblet cells	1.8 nTPM
Colon	2.5 nTPM
Rectum	2.3 nTPM
Small intestine	0.8 nTPM

Lymphatic endothelial cells	0.1 nTPM
Fallopian tube	0.1 nTPM
Ovary	0.0 nTPM

Macrophages	10.1 nTPM
Breast	22.7 nTPM
Kidney	19.5 nTPM
Testis	18.0 nTPM
Pancreas	16.4 nTPM
Lung	13.2 nTPM
Spleen	13.0 nTPM
Bone marrow	11.1 nTPM
Esophagus	10.3 nTPM
Fallopian tube	8.6 nTPM
Adipose tissue	8.3 nTPM
Stomach	7.7 nTPM
Prostate	7.7 nTPM
Endometrium	7.4 nTPM
Skeletal muscle	7.3 nTPM
Salivary gland	6.7 nTPM
Thymus	4.7 nTPM
Tongue	4.5 nTPM
Skin	2.2 nTPM
Vascular	2.0 nTPM

Paneth cells	1.9 nTPM
Colon	3.6 nTPM
Rectum	1.9 nTPM
Small intestine	0.0 nTPM

Bipolar cells	7.2 nTPM
Eye	7.2 nTPM

Cytotrophoblasts	3.2 nTPM
Placenta	3.2 nTPM

Plasma cells	4.3 nTPM
Thymus	6.2 nTPM
Stomach	5.9 nTPM
Esophagus	5.2 nTPM
Liver	5.0 nTPM
Spleen	3.8 nTPM
Salivary gland	3.1 nTPM
Bone marrow	3.0 nTPM
Fallopian tube	1.9 nTPM

Schwann cells	3.6 nTPM
Adipose tissue	10.9 nTPM
Esophagus	0.0 nTPM
Vascular	0.0 nTPM

Serous glandular cells	0.3 nTPM
Salivary gland	0.6 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	0.4 nTPM
Esophagus	1.2 nTPM
Lung	1.2 nTPM
Salivary gland	0.9 nTPM
Placenta	0.7 nTPM
Endometrium	0.5 nTPM
Thymus	0.5 nTPM
Breast	0.5 nTPM
Fallopian tube	0.4 nTPM
Skin	0.3 nTPM
Vascular	0.2 nTPM
Skeletal muscle	0.1 nTPM
Ovary	0.1 nTPM
Liver	0.0 nTPM
Adipose tissue	0.0 nTPM
Prostate	0.0 nTPM
Tongue	0.0 nTPM

T-cells	10.3 nTPM
Bone marrow	18.3 nTPM
Stomach	17.0 nTPM
Thymus	16.7 nTPM
Lymph node	16.3 nTPM
Breast	15.7 nTPM
Esophagus	14.6 nTPM
PBMC	14.2 nTPM
Salivary gland	10.8 nTPM
Skeletal muscle	10.6 nTPM
Spleen	9.5 nTPM
Liver	9.4 nTPM
Vascular	8.4 nTPM
Tongue	8.3 nTPM
Lung	7.6 nTPM
Fallopian tube	7.5 nTPM
Skin	7.0 nTPM
Prostate	6.3 nTPM
Endometrium	5.7 nTPM
Adipose tissue	4.8 nTPM
Kidney	4.4 nTPM
Colon	3.9 nTPM

Undifferentiated cells	6.3 nTPM
Colon	14.0 nTPM
Rectum	4.4 nTPM
Small intestine	0.6 nTPM

Amygdala excitatory	27.7 nTPM
Hypothalamus	30.8 nTPM
Cerebral cortex	29.8 nTPM
Hippocampus	29.3 nTPM
Amygdala	28.2 nTPM
Thalamus	24.5 nTPM
Basal ganglia	23.3 nTPM

Astrocyte	4.2 nTPM
Spinal cord	7.6 nTPM
Hypothalamus	5.3 nTPM
Cerebellum	5.2 nTPM
Pons	4.4 nTPM
Hippocampus	4.2 nTPM
Amygdala	3.6 nTPM
Medulla oblongata	3.6 nTPM
Midbrain	3.6 nTPM
Thalamus	3.5 nTPM
Cerebral cortex	3.2 nTPM
Basal ganglia	2.6 nTPM

Bergmann glia	0.5 nTPM
Cerebellum	1.6 nTPM
Medulla oblongata	0.0 nTPM
Pons	0.0 nTPM

Central nervous system macrophage	52.8 nTPM
Cerebellum	64.4 nTPM
Spinal cord	62.1 nTPM
Hypothalamus	57.0 nTPM
Midbrain	55.3 nTPM
Pons	55.2 nTPM
Amygdala	54.0 nTPM
Cerebral cortex	53.5 nTPM
Hippocampus	53.3 nTPM
Medulla oblongata	43.4 nTPM
Thalamus	41.7 nTPM
Basal ganglia	41.3 nTPM

Cerebellar inhibitory	30.0 nTPM
Spinal cord	35.7 nTPM
Cerebellum	34.7 nTPM
Midbrain	26.8 nTPM
Pons	26.7 nTPM
Medulla oblongata	26.3 nTPM

Cge interneuron	22.3 nTPM
Hypothalamus	34.1 nTPM
Amygdala	25.7 nTPM
Cerebral cortex	23.5 nTPM
Hippocampus	21.4 nTPM
Basal ganglia	21.0 nTPM
Midbrain	16.8 nTPM
Thalamus	14.0 nTPM

Choroid plexus epithelial cell	2.3 nTPM
Thalamus	5.5 nTPM
Medulla oblongata	3.0 nTPM
Basal ganglia	0.9 nTPM
Hippocampus	0.0 nTPM

Committed oligodendrocyte precursor	39.1 nTPM
Hypothalamus	92.2 nTPM
Thalamus	76.8 nTPM
Amygdala	72.2 nTPM
Hippocampus	37.0 nTPM
Basal ganglia	33.9 nTPM
Midbrain	32.8 nTPM
Cerebral cortex	31.0 nTPM
Pons	20.4 nTPM
Cerebellum	15.9 nTPM
Spinal cord	11.0 nTPM
Medulla oblongata	6.5 nTPM

Deep-layer corticothalamic and 6b	28.1 nTPM
Hypothalamus	35.1 nTPM
Hippocampus	28.3 nTPM
Midbrain	27.7 nTPM
Basal ganglia	26.4 nTPM
Cerebral cortex	26.1 nTPM
Amygdala	24.9 nTPM

Deep-layer intratelencephalic	25.2 nTPM
Hypothalamus	32.5 nTPM
Cerebral cortex	26.3 nTPM
Basal ganglia	24.5 nTPM
Hippocampus	22.1 nTPM
Amygdala	20.6 nTPM

Deep-layer near-projecting	39.4 nTPM
Hypothalamus	46.0 nTPM
Cerebral cortex	42.1 nTPM
Amygdala	40.1 nTPM
Basal ganglia	37.2 nTPM
Hippocampus	31.5 nTPM

Eccentric medium spiny neuron	28.2 nTPM
Hippocampus	34.4 nTPM
Basal ganglia	32.4 nTPM
Thalamus	31.0 nTPM
Amygdala	24.9 nTPM
Cerebral cortex	24.1 nTPM
Hypothalamus	22.7 nTPM

Endothelial cell	1.5 nTPM
Basal ganglia	3.7 nTPM
Thalamus	2.8 nTPM
Cerebral cortex	2.6 nTPM
Hypothalamus	2.5 nTPM
Hippocampus	1.9 nTPM
Midbrain	1.9 nTPM
Cerebellum	0.8 nTPM
Pons	0.6 nTPM
Amygdala	0.0 nTPM
Medulla oblongata	0.0 nTPM
Spinal cord	0.0 nTPM

Ependymal cell	1.9 nTPM
Amygdala	4.6 nTPM
Midbrain	2.5 nTPM
Thalamus	2.4 nTPM
Basal ganglia	2.1 nTPM
Hippocampus	2.1 nTPM
Medulla oblongata	1.3 nTPM
Pons	1.2 nTPM
Hypothalamus	0.9 nTPM
Spinal cord	0.0 nTPM