Single cell type - OPA3 - The Human Protein Atlas

OPA3

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	OPA3
Gene descriptionⁱ Full gene name according to HGNC.	Outer mitochondrial membrane lipid metabolism regulator OPA3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Smooth muscle cells - Signal transduction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.26
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

OPA3 is part of cluster 48 Smooth muscle cells - Signal transduction with confidenceⁱ 1
187 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
AKAP8	A-kinase anchoring protein 8	0.5228	80
TNFAIP8	TNF alpha induced protein 8	0.5137	29
DOT1L	DOT1 like histone lysine methyltransferase	0.5091	29
RELT	RELT TNF receptor	0.4997	29
HNRNPU	Heterogeneous nuclear ribonucleoprotein U	0.4874	29
CCL8	C-C motif chemokine ligand 8	0.4815	48
PLCXD1	Phosphatidylinositol specific phospholipase C X domain containing 1	0.4529	29
CHML	CHM like Rab escort protein	0.4525	28
CH25H	Cholesterol 25-hydroxylase	0.4514	48
IL6	Interleukin 6	0.4506	48
PPP1R15B	Protein phosphatase 1 regulatory subunit 15B	0.4471	29
CYCS	Cytochrome c, somatic	0.4286	48
MTHFR	Methylenetetrahydrofolate reductase	0.4271	29
SLC8B1	Solute carrier family 8 member B1	0.4212	58
PTGDR2	Prostaglandin D2 receptor 2	0.4207	48

IMMUNE CELLS

OPA3 is part of cluster 33 Non-specific - ATP binding with confidenceⁱ 0.98
757 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ATP2A2	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	0.9762	33
EMC1	ER membrane protein complex subunit 1	0.9762	33
SLC30A9	Solute carrier family 30 member 9	0.9524	13
FAM156A	Family with sequence similarity 156 member A	0.9524	33
ZNF408	Zinc finger protein 408	0.9524	33
CES2	Carboxylesterase 2	0.9524	33
PEX19	Peroxisomal biogenesis factor 19	0.9524	33
ZMYM2	Zinc finger MYM-type containing 2	0.9524	33
GIT1	GIT ArfGAP 1	0.9524	33
SARS2	Seryl-tRNA synthetase 2, mitochondrial	0.9524	33
CSNK2A1	Casein kinase 2 alpha 1	0.9524	33
TRMT2A	TRNA methyltransferase 2 homolog A	0.9524	33
HSPA9	Heat shock protein family A (Hsp70) member 9	0.9286	33
IQCG	IQ motif containing G	0.9286	33
EIF2S3	Eukaryotic translation initiation factor 2 subunit gamma	0.9286	13

Adipocytes	11.5 nTPM
Adipose tissue	12.9 nTPM
Breast	10.1 nTPM

Alveolar cells type 1	16.3 nTPM
Lung	16.3 nTPM

Alveolar cells type 2	15.7 nTPM
Lung	15.7 nTPM

Astrocytes	8.1 nTPM
Brain	8.1 nTPM

B-cells	16.5 nTPM
Adipose tissue	28.4 nTPM
Skin	22.0 nTPM
PBMC	21.6 nTPM
Salivary gland	20.4 nTPM
Stomach	19.0 nTPM
Lymph node	18.9 nTPM
Spleen	17.2 nTPM
Thymus	16.5 nTPM
Lung	14.8 nTPM
Kidney	10.4 nTPM
Liver	9.7 nTPM
Bone marrow	9.2 nTPM
Esophagus	5.9 nTPM

Ciliated cells	10.5 nTPM
Endometrium	12.2 nTPM
Lung	11.2 nTPM
Bronchus	10.0 nTPM
Fallopian tube	8.6 nTPM

Club cells	12.5 nTPM
Prostate	14.3 nTPM
Bronchus	11.7 nTPM
Lung	11.5 nTPM

Dendritic cells	20.4 nTPM
Adipose tissue	22.7 nTPM
PBMC	18.0 nTPM

Endothelial cells	13.0 nTPM
Skin	21.9 nTPM
Skeletal muscle	17.2 nTPM
Thymus	16.0 nTPM
Lung	15.6 nTPM
Liver	15.1 nTPM
Tongue	14.8 nTPM
Vascular	14.0 nTPM
Endometrium	13.8 nTPM
Fallopian tube	13.7 nTPM
Ovary	13.1 nTPM
Salivary gland	12.9 nTPM
Heart muscle	12.5 nTPM
Esophagus	12.1 nTPM
Prostate	11.4 nTPM
Pancreas	10.3 nTPM
Testis	8.5 nTPM
Placenta	8.5 nTPM
Breast	2.6 nTPM

Enteroendocrine cells	9.3 nTPM
Colon	12.8 nTPM
Rectum	8.4 nTPM
Small intestine	6.9 nTPM

Fibroblasts	9.5 nTPM
Heart muscle	15.2 nTPM
Fallopian tube	13.1 nTPM
Pancreas	12.8 nTPM
Lung	12.3 nTPM
Liver	10.7 nTPM
Stomach	10.1 nTPM
Placenta	10.0 nTPM
Skeletal muscle	9.6 nTPM
Prostate	8.6 nTPM
Salivary gland	8.6 nTPM
Thymus	8.6 nTPM
Vascular	8.4 nTPM
Skin	8.1 nTPM
Breast	6.5 nTPM
Esophagus	5.2 nTPM
Adipose tissue	4.6 nTPM

Granulocytes	24.1 nTPM
Tongue	38.8 nTPM
Fallopian tube	20.0 nTPM
Lung	13.6 nTPM

Intestinal goblet cells	13.7 nTPM
Colon	17.7 nTPM
Small intestine	12.8 nTPM
Rectum	10.6 nTPM

Lymphatic endothelial cells	10.7 nTPM
Ovary	10.9 nTPM
Fallopian tube	10.5 nTPM

Macrophages	18.5 nTPM
Adipose tissue	45.3 nTPM
Skeletal muscle	24.7 nTPM
Spleen	23.1 nTPM
Salivary gland	22.4 nTPM
Fallopian tube	20.6 nTPM
Breast	20.1 nTPM
Tongue	18.7 nTPM
Pancreas	18.5 nTPM
Skin	17.8 nTPM
Lung	17.2 nTPM
Bone marrow	16.2 nTPM
Thymus	16.1 nTPM
Vascular	15.5 nTPM
Endometrium	14.8 nTPM
Kidney	14.2 nTPM
Prostate	13.2 nTPM
Stomach	12.9 nTPM
Esophagus	12.8 nTPM
Testis	8.1 nTPM

Basal prostatic cells	13.3 nTPM
Prostate	13.3 nTPM

Bipolar cells	17.9 nTPM
Eye	17.9 nTPM

Cholangiocytes	15.3 nTPM
Liver	15.3 nTPM

Cone photoreceptor cells	30.6 nTPM
Eye	30.6 nTPM

Paneth cells	16.3 nTPM
Colon	21.7 nTPM
Small intestine	13.8 nTPM
Rectum	13.4 nTPM

Plasma cells	13.1 nTPM
Salivary gland	17.5 nTPM
Liver	17.0 nTPM
Bone marrow	15.1 nTPM
Thymus	14.8 nTPM
Spleen	12.7 nTPM
Esophagus	10.4 nTPM
Fallopian tube	9.0 nTPM
Stomach	8.0 nTPM

Schwann cells	8.0 nTPM
Adipose tissue	14.1 nTPM
Vascular	9.9 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	13.2 nTPM
Tongue	17.7 nTPM
Salivary gland	8.8 nTPM

Smooth muscle cells	20.3 nTPM
Skin	59.8 nTPM
Skeletal muscle	45.3 nTPM
Lung	24.7 nTPM
Adipose tissue	23.6 nTPM
Fallopian tube	22.2 nTPM
Esophagus	20.4 nTPM
Salivary gland	20.2 nTPM
Thymus	15.1 nTPM
Vascular	14.3 nTPM
Tongue	14.1 nTPM
Ovary	12.9 nTPM
Endometrium	12.6 nTPM
Liver	12.3 nTPM
Placenta	9.3 nTPM
Prostate	9.1 nTPM
Breast	8.9 nTPM

Suprabasal keratinocytes	19.4 nTPM
Skin	19.6 nTPM
Tongue	19.2 nTPM

T-cells	14.6 nTPM
Colon	25.3 nTPM
Skeletal muscle	21.5 nTPM
Salivary gland	21.2 nTPM
PBMC	17.7 nTPM
Thymus	16.6 nTPM
Endometrium	16.4 nTPM
Lymph node	16.3 nTPM
Skin	16.1 nTPM
Kidney	14.2 nTPM
Vascular	14.1 nTPM
Adipose tissue	13.9 nTPM
Breast	13.5 nTPM
Stomach	13.1 nTPM
Tongue	12.9 nTPM
Esophagus	12.2 nTPM
Prostate	12.2 nTPM
Spleen	12.1 nTPM
Fallopian tube	11.4 nTPM
Liver	11.2 nTPM
Lung	8.4 nTPM
Bone marrow	6.3 nTPM

Undifferentiated cells	12.4 nTPM
Colon	13.7 nTPM
Small intestine	12.5 nTPM
Rectum	10.9 nTPM

Amygdala excitatory	19.4 nTPM
Hypothalamus	31.8 nTPM
Amygdala	19.7 nTPM
Hippocampus	18.4 nTPM
Basal ganglia	18.1 nTPM
Cerebral cortex	17.5 nTPM
Thalamus	10.9 nTPM

Astrocyte	17.9 nTPM
Thalamus	21.3 nTPM
Cerebellum	20.7 nTPM
Midbrain	20.1 nTPM
Cerebral cortex	19.4 nTPM
Pons	18.7 nTPM
Hypothalamus	18.4 nTPM
Basal ganglia	18.1 nTPM
Amygdala	17.9 nTPM
Hippocampus	17.3 nTPM
Medulla oblongata	14.1 nTPM
Spinal cord	10.9 nTPM

Bergmann glia	7.7 nTPM
Cerebellum	10.9 nTPM
Medulla oblongata	6.4 nTPM
Pons	5.8 nTPM

Central nervous system macrophage	17.5 nTPM
Hippocampus	20.7 nTPM
Amygdala	20.5 nTPM
Cerebellum	20.0 nTPM
Cerebral cortex	19.8 nTPM
Thalamus	17.9 nTPM
Pons	17.8 nTPM
Midbrain	17.6 nTPM
Basal ganglia	16.3 nTPM
Hypothalamus	16.0 nTPM
Medulla oblongata	14.0 nTPM
Spinal cord	11.8 nTPM

Cerebellar inhibitory	25.9 nTPM
Spinal cord	35.7 nTPM
Medulla oblongata	24.9 nTPM
Cerebellum	24.5 nTPM
Midbrain	23.3 nTPM
Pons	20.8 nTPM

Cge interneuron	14.4 nTPM
Hypothalamus	18.6 nTPM
Midbrain	14.6 nTPM
Thalamus	14.2 nTPM
Hippocampus	14.1 nTPM
Amygdala	14.0 nTPM
Cerebral cortex	13.3 nTPM
Basal ganglia	12.2 nTPM

Choroid plexus epithelial cell	46.3 nTPM
Basal ganglia	78.9 nTPM
Medulla oblongata	43.0 nTPM
Thalamus	38.4 nTPM
Hippocampus	25.0 nTPM

Committed oligodendrocyte precursor	16.9 nTPM
Thalamus	23.9 nTPM
Cerebellum	22.2 nTPM
Medulla oblongata	19.4 nTPM
Hippocampus	18.6 nTPM
Spinal cord	18.4 nTPM
Midbrain	17.6 nTPM
Pons	16.8 nTPM
Amygdala	15.8 nTPM
Hypothalamus	13.0 nTPM
Basal ganglia	11.0 nTPM
Cerebral cortex	8.9 nTPM

Deep-layer corticothalamic and 6b	18.1 nTPM
Hypothalamus	27.3 nTPM
Amygdala	20.0 nTPM
Hippocampus	19.5 nTPM
Cerebral cortex	17.7 nTPM
Basal ganglia	13.8 nTPM
Midbrain	10.0 nTPM

Deep-layer intratelencephalic	20.5 nTPM
Hypothalamus	29.7 nTPM
Amygdala	19.4 nTPM
Hippocampus	19.0 nTPM
Cerebral cortex	17.9 nTPM
Basal ganglia	16.5 nTPM

Deep-layer near-projecting	18.1 nTPM
Hypothalamus	27.2 nTPM
Hippocampus	17.2 nTPM
Amygdala	17.0 nTPM
Cerebral cortex	15.7 nTPM
Basal ganglia	13.4 nTPM

Eccentric medium spiny neuron	15.8 nTPM
Hypothalamus	17.3 nTPM
Basal ganglia	16.5 nTPM
Thalamus	15.9 nTPM
Amygdala	15.6 nTPM
Hippocampus	14.9 nTPM
Cerebral cortex	14.7 nTPM