Single cell type - TTC21B - The Human Protein Atlas

TTC21B

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TTC21B
Gene descriptionⁱ Full gene name according to HGNC.	Tetratricopeptide repeat domain 21B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Ciliated cells - Cilium assembly (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Ciliated cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.40
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Ciliated cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TTC21B is part of cluster 42 Ciliated cells - Cilium assembly with confidenceⁱ 1
429 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
C2orf50	Chromosome 2 open reading frame 50	0.6522	42
PLPPR3	Phospholipid phosphatase related 3	0.6520	42
STOML3	Stomatin like 3	0.6449	42
TMEM212	Transmembrane protein 212	0.6384	42
RSPH4A	Radial spoke head component 4A	0.6369	42
LDLRAD1	Low density lipoprotein receptor class A domain containing 1	0.6289	42
CAPS	Calcyphosine	0.6255	42
CCDC146	Coiled-coil domain containing 146	0.6177	42
DNAH5	Dynein axonemal heavy chain 5	0.6172	42
FAM216B	Family with sequence similarity 216 member B	0.6160	42
TMEM231	Transmembrane protein 231	0.6159	42
CFAP73	Cilia and flagella associated protein 73	0.6136	42
DNAH11	Dynein axonemal heavy chain 11	0.6029	42
CCDC96	Coiled-coil domain containing 96	0.6015	42
ANKRD66	Ankyrin repeat domain 66	0.6001	42

IMMUNE CELLS

TTC21B is part of cluster 14 Non-specific - Unknown function with confidenceⁱ 0.87
292 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
USP28	Ubiquitin specific peptidase 28	0.9762	14
TULP3	TUB like protein 3	0.9762	14
ZNF875	Zinc finger protein 875	0.9762	14
ARHGAP12	Rho GTPase activating protein 12	0.9762	14
SYNGR3	Synaptogyrin 3	0.9762	14
DNAH14	Dynein axonemal heavy chain 14	0.9524	24
KDM2A	Lysine demethylase 2A	0.9524	24
ZFAND4	Zinc finger AN1-type containing 4	0.9524	14
SMYD5	SMYD family member 5	0.9524	14
TESK1	Testis associated actin remodelling kinase 1	0.9524	14
WDR59	WD repeat domain 59	0.9524	24
TRPM7	Transient receptor potential cation channel subfamily M member 7	0.9524	24
METTL2A	Methyltransferase 2A, methylcytidine	0.9524	24
AKAP3	A-kinase anchoring protein 3	0.9286	24
CCDC93	Coiled-coil domain containing 93	0.9286	24

Adipocytes	15.4 nTPM
Adipose tissue	18.6 nTPM
Breast	12.3 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	25.4 nTPM
Lung	25.4 nTPM

Astrocytes	31.0 nTPM
Brain	31.0 nTPM

B-cells	20.0 nTPM
Salivary gland	34.9 nTPM
Adipose tissue	28.0 nTPM
Thymus	26.1 nTPM
Spleen	25.7 nTPM
Stomach	25.7 nTPM
Lymph node	21.4 nTPM
Bone marrow	21.3 nTPM
Esophagus	17.7 nTPM
Kidney	15.6 nTPM
PBMC	15.4 nTPM
Lung	14.8 nTPM
Liver	9.7 nTPM
Skin	3.4 nTPM

Ciliated cells	98.7 nTPM
Lung	116.5 nTPM
Fallopian tube	110.2 nTPM
Endometrium	110.0 nTPM
Bronchus	58.2 nTPM

Club cells	13.1 nTPM
Prostate	19.9 nTPM
Lung	13.4 nTPM
Bronchus	5.9 nTPM

Dendritic cells	43.5 nTPM
Adipose tissue	69.0 nTPM
PBMC	18.0 nTPM

Endothelial cells	17.0 nTPM
Heart muscle	28.5 nTPM
Salivary gland	25.2 nTPM
Prostate	23.9 nTPM
Skeletal muscle	22.4 nTPM
Vascular	21.2 nTPM
Ovary	20.4 nTPM
Endometrium	19.1 nTPM
Tongue	19.1 nTPM
Thymus	18.3 nTPM
Breast	15.8 nTPM
Esophagus	15.1 nTPM
Lung	15.0 nTPM
Testis	14.0 nTPM
Liver	13.9 nTPM
Fallopian tube	13.1 nTPM
Skin	10.2 nTPM
Placenta	8.5 nTPM
Pancreas	2.6 nTPM

Enteroendocrine cells	15.7 nTPM
Small intestine	17.2 nTPM
Rectum	16.8 nTPM
Colon	13.3 nTPM

Fibroblasts	21.5 nTPM
Liver	33.2 nTPM
Prostate	33.0 nTPM
Heart muscle	32.7 nTPM
Salivary gland	29.8 nTPM
Skeletal muscle	28.8 nTPM
Vascular	23.7 nTPM
Adipose tissue	23.2 nTPM
Fallopian tube	22.5 nTPM
Thymus	19.2 nTPM
Breast	19.1 nTPM
Skin	17.4 nTPM
Stomach	17.3 nTPM
Esophagus	14.2 nTPM
Lung	12.6 nTPM
Placenta	12.0 nTPM
Pancreas	4.8 nTPM

Granulocytes	31.5 nTPM
Fallopian tube	39.0 nTPM
Tongue	34.0 nTPM
Lung	21.7 nTPM

Intestinal goblet cells	11.3 nTPM
Small intestine	14.3 nTPM
Colon	10.6 nTPM
Rectum	8.9 nTPM

Lymphatic endothelial cells	24.1 nTPM
Ovary	27.3 nTPM
Fallopian tube	21.0 nTPM

Macrophages	13.3 nTPM
Salivary gland	20.4 nTPM
Esophagus	19.3 nTPM
Bone marrow	19.3 nTPM
Vascular	17.8 nTPM
Spleen	17.0 nTPM
Prostate	15.5 nTPM
Endometrium	15.4 nTPM
Tongue	15.2 nTPM
Adipose tissue	14.6 nTPM
Fallopian tube	13.9 nTPM
Skeletal muscle	13.4 nTPM
Thymus	11.9 nTPM
Skin	11.1 nTPM
Lung	10.1 nTPM
Breast	9.8 nTPM
Testis	8.7 nTPM
Stomach	7.7 nTPM
Kidney	7.1 nTPM
Pancreas	4.1 nTPM

Basal prostatic cells	18.1 nTPM
Prostate	18.1 nTPM

Basal respiratory cells	8.0 nTPM
Bronchus	8.0 nTPM

Basal squamous epithelial cells	24.6 nTPM
Esophagus	24.6 nTPM

Bipolar cells	36.8 nTPM
Eye	36.8 nTPM

Paneth cells	7.6 nTPM
Rectum	12.1 nTPM
Small intestine	6.9 nTPM
Colon	3.6 nTPM

Plasma cells	16.7 nTPM
Salivary gland	24.2 nTPM
Thymus	24.2 nTPM
Fallopian tube	22.8 nTPM
Bone marrow	19.6 nTPM
Stomach	18.0 nTPM
Spleen	16.1 nTPM
Liver	9.0 nTPM
Esophagus	0.0 nTPM

Schwann cells	32.3 nTPM
Vascular	54.8 nTPM
Esophagus	24.0 nTPM
Adipose tissue	18.0 nTPM

Serous glandular cells	22.9 nTPM
Salivary gland	45.9 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	18.4 nTPM
Adipose tissue	31.0 nTPM
Salivary gland	25.7 nTPM
Endometrium	24.8 nTPM
Tongue	24.2 nTPM
Skeletal muscle	23.3 nTPM
Prostate	21.9 nTPM
Ovary	19.3 nTPM
Vascular	17.8 nTPM
Thymus	14.7 nTPM
Esophagus	14.4 nTPM
Lung	14.1 nTPM
Fallopian tube	13.9 nTPM
Skin	13.8 nTPM
Liver	13.2 nTPM
Breast	13.1 nTPM
Placenta	9.0 nTPM

T-cells	24.4 nTPM
Fallopian tube	36.5 nTPM
Adipose tissue	35.9 nTPM
Salivary gland	34.2 nTPM
Vascular	33.8 nTPM
Skeletal muscle	30.6 nTPM
Prostate	28.2 nTPM
Endometrium	27.4 nTPM
Colon	27.3 nTPM
Esophagus	26.8 nTPM
Tongue	25.8 nTPM
Thymus	25.5 nTPM
Breast	24.6 nTPM
Lung	23.7 nTPM
Spleen	22.1 nTPM
PBMC	20.4 nTPM
Lymph node	17.7 nTPM
Bone marrow	17.7 nTPM
Stomach	17.7 nTPM
Kidney	14.2 nTPM
Liver	11.0 nTPM
Skin	10.9 nTPM

Undifferentiated cells	11.3 nTPM
Rectum	12.7 nTPM
Small intestine	10.8 nTPM
Colon	10.5 nTPM

Amygdala excitatory	96.9 nTPM
Hypothalamus	111.1 nTPM
Basal ganglia	107.9 nTPM
Amygdala	98.8 nTPM
Cerebral cortex	90.9 nTPM
Hippocampus	87.3 nTPM
Thalamus	85.3 nTPM

Astrocyte	74.1 nTPM
Amygdala	94.2 nTPM
Basal ganglia	82.5 nTPM
Hypothalamus	79.7 nTPM
Thalamus	78.3 nTPM
Midbrain	76.7 nTPM
Hippocampus	72.9 nTPM
Cerebral cortex	72.2 nTPM
Pons	69.6 nTPM
Cerebellum	65.8 nTPM
Medulla oblongata	63.2 nTPM
Spinal cord	60.5 nTPM

Bergmann glia	68.9 nTPM
Cerebellum	82.1 nTPM
Pons	73.4 nTPM
Medulla oblongata	51.1 nTPM

Central nervous system macrophage	74.1 nTPM
Amygdala	107.8 nTPM
Hypothalamus	79.8 nTPM
Midbrain	76.3 nTPM
Basal ganglia	75.1 nTPM
Hippocampus	74.7 nTPM
Thalamus	74.6 nTPM
Cerebral cortex	70.3 nTPM
Pons	68.3 nTPM
Cerebellum	67.8 nTPM
Spinal cord	65.1 nTPM
Medulla oblongata	55.1 nTPM

Cerebellar inhibitory	89.0 nTPM
Spinal cord	107.2 nTPM
Pons	89.7 nTPM
Cerebellum	85.4 nTPM
Midbrain	83.7 nTPM
Medulla oblongata	78.8 nTPM

Cge interneuron	125.5 nTPM
Amygdala	143.6 nTPM
Hypothalamus	130.7 nTPM
Basal ganglia	126.7 nTPM
Thalamus	124.5 nTPM
Midbrain	121.3 nTPM
Hippocampus	117.2 nTPM
Cerebral cortex	114.6 nTPM

Choroid plexus epithelial cell	67.5 nTPM
Basal ganglia	98.6 nTPM
Medulla oblongata	66.4 nTPM
Hippocampus	55.5 nTPM
Thalamus	49.3 nTPM

Committed oligodendrocyte precursor	110.1 nTPM
Spinal cord	176.6 nTPM
Midbrain	122.6 nTPM
Hippocampus	120.6 nTPM
Amygdala	120.1 nTPM
Hypothalamus	119.5 nTPM
Cerebral cortex	112.1 nTPM
Basal ganglia	95.8 nTPM
Thalamus	95.2 nTPM
Medulla oblongata	86.5 nTPM
Cerebellum	85.6 nTPM
Pons	76.1 nTPM

Deep-layer corticothalamic and 6b	119.2 nTPM
Midbrain	149.8 nTPM
Hippocampus	120.8 nTPM
Cerebral cortex	116.8 nTPM
Amygdala	111.1 nTPM
Hypothalamus	110.6 nTPM
Basal ganglia	105.9 nTPM

Deep-layer intratelencephalic	104.1 nTPM
Cerebral cortex	110.8 nTPM
Hypothalamus	105.7 nTPM
Amygdala	102.1 nTPM
Hippocampus	101.7 nTPM
Basal ganglia	100.2 nTPM

Deep-layer near-projecting	119.2 nTPM
Cerebral cortex	134.4 nTPM
Amygdala	127.6 nTPM
Basal ganglia	118.0 nTPM
Hypothalamus	114.3 nTPM
Hippocampus	101.5 nTPM

Eccentric medium spiny neuron	137.7 nTPM
Thalamus	146.0 nTPM
Amygdala	143.2 nTPM
Hippocampus	141.8 nTPM
Hypothalamus	133.5 nTPM
Basal ganglia	132.9 nTPM
Cerebral cortex	128.6 nTPM

Endothelial cell	88.3 nTPM
Amygdala	114.0 nTPM
Spinal cord	105.3 nTPM
Hypothalamus	100.5 nTPM
Hippocampus	94.2 nTPM
Pons	84.9 nTPM
Midbrain	84.1 nTPM
Basal ganglia	83.9 nTPM
Medulla oblongata	80.0 nTPM
Cerebral cortex	75.4 nTPM
Cerebellum	75.1 nTPM
Thalamus	73.4 nTPM